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PO16-452 HIGH SENSITIVITY C REACTIVE PROTEIN AND VASCULAR DISEASE IN DIFFERENT TERRITORIES
128 PO16-451
Poster Sessions PO16 Epidemiology of cardiovascular diseases and risk factors SMOKING IN RELATION WITH ATHEROSCLEROSIS RISK FACTORS. EXPERIENCE FROM THE SMOKING CESSATION PROGRAM
E. Paschalidou, I. Efthimiadis, A. Efthimiadis, M. Raptopoulou-Gigi. Atherosclerosis Clinic, 2nd Department of Internal Medicine, Hippocratio University Hospital, Thessaloniki, Greece Background and Aims: To investigate the relation of smoking habit with other atherosclerosis risk factors and to evaluate the effectiveness of the smoking cessation method. Methods: From 12/2003 to 06/2006, 300 patients (171 women and 129 men), aged 45 ± 15 years participated in the smoking cessation program of our clinic. Every visit included detailed medical history, clinical examination, ECG and blood sample for determination of blood glucose and lipid profile. All patients received bupropion 300mg daily for two months. Results: From the 300 patients, 35% had hypercholesterolemia, 30% found to be hypertensive, 10% were obese and 25% had no other atherosclerosis risk factors but smoking. Bupropion administration led 45% of patients in successful smoking cessation till today. No side effects were reported and there was no influence of liver and/or renal function. Conclusions: Smoking is considered to be one of the major atherosclerosis risk factors. In 75% of cases studied in our clinic smoking found to coexist with other risk factors. Every smoker should be considered as a patient and examined thoroughly for the existence of other risk factors. Bupropion found to be a potent drug for smoking cessation. When administered for specific period of time and in a dose of 300mg/daily is being well tolerated by the patients with excellent efficacy and no side effects. PO16-452
HIGH SENSITIVITY C REACTIVE PROTEIN AND VASCULAR DISEASE IN DIFFERENT TERRITORIES
M.A. Soliman 1 , A.M. El Sherif 2 , A.A. Omar 3 . 1 Cardiology Department,Menoufyia University Hospital, Shebin El Kom, Egypt; 2 Neurology Department,Menoufyia University Hospital, Shebin El Kom, Egypt; 3 General Surgery Department,Menoufyia University Hospital, Shebin El Kom, Egypt Back ground: Inflammation plays a key role in the pathogenesis of atherosclerosis. Aim: 1. To assess hs CRP levels in patients with: coronary, cerebrovascular & peripheral vascular diseases. 2. To assess the relationship between hs CRP levels and extent or severity of vascular disease. Subjects & Methods: This study included 130 patients: 54 patients with coronary artery disease, 50 patients with stroke and 26 patients with peripheral vascular disease. Results: 1. Each group of patients has higher hs CRP level when compared with control subjects (P<0.001). but the difference was not significant when compared with each other (P>0.05). 2. In coronary group, hs CRP correlates with LDL only, but not with the number of vessels. 3. In cerebravascular group, there is no significant difference between those with ischaemic or haemorrhagic stroke. 4. In peripheral disease patients, hs CRP does not correlates with the ankle brachial index. Conclusion: hs CRP levels were higher in patients with vascular disease than normal subjects but did not differ in different beds. hs CRP levels did not correlate with the extent of coronary artery disease or the severity of peripheral artery disease & did not differ in those with ischaemic or haemorrhagic stroke. PO16-453
CARDIOVASCULAR RISK STRATIFICATION IN THE SPANISH WORKING POPULATION. GEOGRAPHICAL AND PROFFESIONAL ACTIVITY SECTORS DISTRIBUTION. IBERMUTUAMUR CARDIOVASCULAR INVESTIGATION PLAN
M.A. Sánchez Chaparro, J. Román García, E. Calvo Bonacho, M. Cabrera Sierra, J.C. Sainz Gutiérrez, A. Fernández-Meseguer, A. García García, E. Farre Perejuan, H. Bohorquez Heras, E. Barrera Caballero, M.I. Galán Octavio, I. Bonet García, S. Castro Casaus, R. Ávila González, A. Gálvez Moraleda, A. González Quintela. Ibermutuamur Cardiovascular Investigation Plan, Madrid, Spain Introduction and Aim: Cardiovascular risk SCORE is an useful clinical
tool to establish priorities on cardiovascular prevention. This study assess the geographical distribution of cardiovascular risk by means of SCORE and by professional activity sectors in the Spanish labor population. Subjects and Methods: A total of 405,123 individuals were checked between May 2004 and June 2005. 309,955 individuals presented all data needed for assessment of cardiovascular risk and were included. The proportion of males was 72.5%. Mean age of participants was 36.0 years (37.0 years in males and 35.1 years in females). Cardiovascular risk was stratified following the cardiovascular SCORE for low-risk European countries. Individuals with a relative risk higher than 4 were also considered as high-risk. Low (L) mortality area (<175/100,000 p.y): Aragon, Cantabria, Castilla y Leon, Cataluña, La Rioja, Comunidad de Madrid, Comunidad Foral de Navarra and País Vasco; Intermediate (I) mortality area (175-200/100,000 p.y): Principado de Asturias, Extremadura, Castilla-La Mancha and Galicia; High (H) mortality area: (>200/100,000 p.y): Andalucía, Islas Baleares, Canarias, Comunidad Valenciana and Región de Murcia). Results: 6.1% (IC 95% 6,0-6,2) workers showed high risk and 0.90% (IC 95% 0,87-0,93) a moderate risk. The prevalence of subjects with high risk was greater in men and in the agrarian and construction sectors, and increased with the age. The smaller prevalence of high risk was observed in the geographic area with smaller cardiovascular mortality. Conclusions: The knowledge of this prevalence, and its geographical distribution, can serve as a basis for preventive strategies. PO16-454
RENAL FUNCTION STRATIFICATION (CREATININE AND CREATININE CLEARANCE) BY CARDIOVASCULAR MORTALITY AREAS IN THE SPANISH WORKING POPULATION. IBERMUTUAMUR CARDIOVASCULAR INVESTIGATION PLAN
M.A. Sanchez Chaparro, J. Roman Garcia, E. Calvo Bonacho, M. Cabrera Sierra, J.C. Sainz Gutierrez, C. Fernandez-Labandera, A. Fernandez-Meseguer, P. Gomez Martinez, I. Genis Giner, I.M. Cruz Garcia, C. Ayuso Raya, O.I. Ferrat Zaldo, A. Cobreros Vime, M. Egüez Arca, F. Martin Garcia, A. Galvez Moraleda, A. Gonzalez- Quintela. Ibermutuamur Cardiovascular Investigation Plan, Madrid, Spain Introduction and Aim: Creatinine levels (Cr) > 1,4 mg/dl in females (F), > 1,5 mg/dl in males (M), or estimated creatinine clearance (CrCl) < 60 ml/min/1,73m2 , are considered clinical cardiovascular disease equivalents. This study assess Cr stratification and CrCl by cardiovascular mortality areas (CVMA) in the spanish working population. Subjects and Methods: A total of 405,123 individuals were checked between May 2004 and June 2005. 259,602 individuals presented all data needed for assessment of renal function and were included. Cr values (mg/dl) was stratified in level 1: Cr < 1,2 in females (F) y < 1,3 in males (M); level 2: Cr 1,2-1,4 (F) y 1,3-1,5 (M); level 3: Cr > 1,4 (F) y Cr > 1,5 (M). CrCl (ml/min/1,73m2 ) was calculated by abbreviated Modified Diet in Renal Disease study’s (MDRD) and Cockcroft-Gault/DuBois (CG/DB) equations. Low (L) CVMA (< 175/100,000 p.y); Intermediate (I) CVMA (175-200/100,000 p.y.); High (H) CVMA (>200/100,000 p.y.). Results: Cr level 2 prevalence by CVMA was: 6,2% (L); 5,6% (I); 9,6% (H) and Cr level 3 prevalence was: 0,51% (L); 0,6% (I); 1,0% (H). The prevalence of CrCl < 60ml/min/1,73 m2 by CVMA was: 6,0% (L); 4,1% (I); 6,0% (H) by MDRD and 7,3% (L); 5,5%(I); 6,7% (H) by CG/DB equation. Conclusions: Prevalence of renal insuficiency detected by CrCl < 60 ml/min/1,73m2 was at least six times the prevalence detected by Cr >1,4 mg/dl (F)/>1,5 mg/dl. Implementation of automatic CrCl reporting, can contribute to early detection of individuals with high cardiovascular and renal risk. PO16-455
CORONARY ARTERY DISEASE, ESSENTIAL HYPERTENSION, TYPE 2 DIABETES MELLITUS AND ATHEROSCLEROTIC CEREBROVASCULAR ACCIDENT: A CARDIOVASCULAR CONTINUUM
S. Dwivedi, A. Aggarwal. Department of Medicine, Preventive Cardiology,University College of Medical Sciences (University of Delhi) – GTB Hospital, Delhi, India Hypertension (HTN) and type 2 diabetes mellitus (T2 DM) are two clinical entities which often herald the imminent CAD. It is being surmised that CAD, T2DM and HTN are continuum of same clinical spectrum.
76th Congress of the European Atherosclerosis Society, June 10–13, 2007, Helsinki, Finland
Poster Sessions PO16 Epidemiology of cardiovascular diseases and risk factors SMOKING IN RELATION WITH ATHEROSCLEROSIS RISK FACTORS. EXPERIENCE FROM THE SMOKING CESSATION PROGRAM
E. Paschalidou, I. Efthimiadis, A. Efthimiadis, M. Raptopoulou-Gigi. Atherosclerosis Clinic, 2nd Department of Internal Medicine, Hippocratio University Hospital, Thessaloniki, Greece Background and Aims: To investigate the relation of smoking habit with other atherosclerosis risk factors and to evaluate the effectiveness of the smoking cessation method. Methods: From 12/2003 to 06/2006, 300 patients (171 women and 129 men), aged 45 ± 15 years participated in the smoking cessation program of our clinic. Every visit included detailed medical history, clinical examination, ECG and blood sample for determination of blood glucose and lipid profile. All patients received bupropion 300mg daily for two months. Results: From the 300 patients, 35% had hypercholesterolemia, 30% found to be hypertensive, 10% were obese and 25% had no other atherosclerosis risk factors but smoking. Bupropion administration led 45% of patients in successful smoking cessation till today. No side effects were reported and there was no influence of liver and/or renal function. Conclusions: Smoking is considered to be one of the major atherosclerosis risk factors. In 75% of cases studied in our clinic smoking found to coexist with other risk factors. Every smoker should be considered as a patient and examined thoroughly for the existence of other risk factors. Bupropion found to be a potent drug for smoking cessation. When administered for specific period of time and in a dose of 300mg/daily is being well tolerated by the patients with excellent efficacy and no side effects. PO16-452
HIGH SENSITIVITY C REACTIVE PROTEIN AND VASCULAR DISEASE IN DIFFERENT TERRITORIES
M.A. Soliman 1 , A.M. El Sherif 2 , A.A. Omar 3 . 1 Cardiology Department,Menoufyia University Hospital, Shebin El Kom, Egypt; 2 Neurology Department,Menoufyia University Hospital, Shebin El Kom, Egypt; 3 General Surgery Department,Menoufyia University Hospital, Shebin El Kom, Egypt Back ground: Inflammation plays a key role in the pathogenesis of atherosclerosis. Aim: 1. To assess hs CRP levels in patients with: coronary, cerebrovascular & peripheral vascular diseases. 2. To assess the relationship between hs CRP levels and extent or severity of vascular disease. Subjects & Methods: This study included 130 patients: 54 patients with coronary artery disease, 50 patients with stroke and 26 patients with peripheral vascular disease. Results: 1. Each group of patients has higher hs CRP level when compared with control subjects (P<0.001). but the difference was not significant when compared with each other (P>0.05). 2. In coronary group, hs CRP correlates with LDL only, but not with the number of vessels. 3. In cerebravascular group, there is no significant difference between those with ischaemic or haemorrhagic stroke. 4. In peripheral disease patients, hs CRP does not correlates with the ankle brachial index. Conclusion: hs CRP levels were higher in patients with vascular disease than normal subjects but did not differ in different beds. hs CRP levels did not correlate with the extent of coronary artery disease or the severity of peripheral artery disease & did not differ in those with ischaemic or haemorrhagic stroke. PO16-453
CARDIOVASCULAR RISK STRATIFICATION IN THE SPANISH WORKING POPULATION. GEOGRAPHICAL AND PROFFESIONAL ACTIVITY SECTORS DISTRIBUTION. IBERMUTUAMUR CARDIOVASCULAR INVESTIGATION PLAN
M.A. Sánchez Chaparro, J. Román García, E. Calvo Bonacho, M. Cabrera Sierra, J.C. Sainz Gutiérrez, A. Fernández-Meseguer, A. García García, E. Farre Perejuan, H. Bohorquez Heras, E. Barrera Caballero, M.I. Galán Octavio, I. Bonet García, S. Castro Casaus, R. Ávila González, A. Gálvez Moraleda, A. González Quintela. Ibermutuamur Cardiovascular Investigation Plan, Madrid, Spain Introduction and Aim: Cardiovascular risk SCORE is an useful clinical
tool to establish priorities on cardiovascular prevention. This study assess the geographical distribution of cardiovascular risk by means of SCORE and by professional activity sectors in the Spanish labor population. Subjects and Methods: A total of 405,123 individuals were checked between May 2004 and June 2005. 309,955 individuals presented all data needed for assessment of cardiovascular risk and were included. The proportion of males was 72.5%. Mean age of participants was 36.0 years (37.0 years in males and 35.1 years in females). Cardiovascular risk was stratified following the cardiovascular SCORE for low-risk European countries. Individuals with a relative risk higher than 4 were also considered as high-risk. Low (L) mortality area (<175/100,000 p.y): Aragon, Cantabria, Castilla y Leon, Cataluña, La Rioja, Comunidad de Madrid, Comunidad Foral de Navarra and País Vasco; Intermediate (I) mortality area (175-200/100,000 p.y): Principado de Asturias, Extremadura, Castilla-La Mancha and Galicia; High (H) mortality area: (>200/100,000 p.y): Andalucía, Islas Baleares, Canarias, Comunidad Valenciana and Región de Murcia). Results: 6.1% (IC 95% 6,0-6,2) workers showed high risk and 0.90% (IC 95% 0,87-0,93) a moderate risk. The prevalence of subjects with high risk was greater in men and in the agrarian and construction sectors, and increased with the age. The smaller prevalence of high risk was observed in the geographic area with smaller cardiovascular mortality. Conclusions: The knowledge of this prevalence, and its geographical distribution, can serve as a basis for preventive strategies. PO16-454
RENAL FUNCTION STRATIFICATION (CREATININE AND CREATININE CLEARANCE) BY CARDIOVASCULAR MORTALITY AREAS IN THE SPANISH WORKING POPULATION. IBERMUTUAMUR CARDIOVASCULAR INVESTIGATION PLAN
M.A. Sanchez Chaparro, J. Roman Garcia, E. Calvo Bonacho, M. Cabrera Sierra, J.C. Sainz Gutierrez, C. Fernandez-Labandera, A. Fernandez-Meseguer, P. Gomez Martinez, I. Genis Giner, I.M. Cruz Garcia, C. Ayuso Raya, O.I. Ferrat Zaldo, A. Cobreros Vime, M. Egüez Arca, F. Martin Garcia, A. Galvez Moraleda, A. Gonzalez- Quintela. Ibermutuamur Cardiovascular Investigation Plan, Madrid, Spain Introduction and Aim: Creatinine levels (Cr) > 1,4 mg/dl in females (F), > 1,5 mg/dl in males (M), or estimated creatinine clearance (CrCl) < 60 ml/min/1,73m2 , are considered clinical cardiovascular disease equivalents. This study assess Cr stratification and CrCl by cardiovascular mortality areas (CVMA) in the spanish working population. Subjects and Methods: A total of 405,123 individuals were checked between May 2004 and June 2005. 259,602 individuals presented all data needed for assessment of renal function and were included. Cr values (mg/dl) was stratified in level 1: Cr < 1,2 in females (F) y < 1,3 in males (M); level 2: Cr 1,2-1,4 (F) y 1,3-1,5 (M); level 3: Cr > 1,4 (F) y Cr > 1,5 (M). CrCl (ml/min/1,73m2 ) was calculated by abbreviated Modified Diet in Renal Disease study’s (MDRD) and Cockcroft-Gault/DuBois (CG/DB) equations. Low (L) CVMA (< 175/100,000 p.y); Intermediate (I) CVMA (175-200/100,000 p.y.); High (H) CVMA (>200/100,000 p.y.). Results: Cr level 2 prevalence by CVMA was: 6,2% (L); 5,6% (I); 9,6% (H) and Cr level 3 prevalence was: 0,51% (L); 0,6% (I); 1,0% (H). The prevalence of CrCl < 60ml/min/1,73 m2 by CVMA was: 6,0% (L); 4,1% (I); 6,0% (H) by MDRD and 7,3% (L); 5,5%(I); 6,7% (H) by CG/DB equation. Conclusions: Prevalence of renal insuficiency detected by CrCl < 60 ml/min/1,73m2 was at least six times the prevalence detected by Cr >1,4 mg/dl (F)/>1,5 mg/dl. Implementation of automatic CrCl reporting, can contribute to early detection of individuals with high cardiovascular and renal risk. PO16-455
CORONARY ARTERY DISEASE, ESSENTIAL HYPERTENSION, TYPE 2 DIABETES MELLITUS AND ATHEROSCLEROTIC CEREBROVASCULAR ACCIDENT: A CARDIOVASCULAR CONTINUUM
S. Dwivedi, A. Aggarwal. Department of Medicine, Preventive Cardiology,University College of Medical Sciences (University of Delhi) – GTB Hospital, Delhi, India Hypertension (HTN) and type 2 diabetes mellitus (T2 DM) are two clinical entities which often herald the imminent CAD. It is being surmised that CAD, T2DM and HTN are continuum of same clinical spectrum.
76th Congress of the European Atherosclerosis Society, June 10–13, 2007, Helsinki, Finland