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PO19-562 ASSOCIATIONS BETWEEN CARDIORESPIRATORY FITNESS AND CARDIOVASCULAR RISK FACTORS IN YOUNG ADULTS: THE CARDIOVASCULAR RISK IN YOUNG FINNS STUDY
Poster Sessions PO19 Novel and classical CV risk factors and markers Compared with control subjects, viral carriers examined did not show high values beyond normal range in chemical analysis data.On the other hand, HTLV-1 carriers showed significantly both higher value of MAX-IMT and PWV than those in other persistant viral carriers and control subjects.Moreover, in multiple regression analysis for MAX-IMT over 1.1mm, HTLV-1 infection was found as an independent factor for atherosclerotic induction. We revealed that HTLV-1 infection caused early onset of atherosclerosis, indicating that HTLV-1 infection was one of risk factors for athrosclerosis. PO19-561
ACUTE LIPID PROFILE MODIFICATIONS AS A RESULT OF A SINGLE SESSION OF SUBMAXIMAL EXERCISE IN HYPERTENSIVE HYPERCHOLESTEROLEMIC PATIENTS
V. Galea 1 , T. Theodoridis 1 , M. El Ali 1 , H. Triantafyllidi 2 , M. Koutroubi 2 , J. Lekakis 2 , V. Christopoulou-Cokkinou 1 , D. Kremastinos 2 . 1 Haematology Laboratory, Evangelismos Hospital, Athens, Greece; 2 2nd Cardiology Dept, Medical School, University of Athens, Attikon Hospital, Athens, Greece
PO19-562
ASSOCIATIONS BETWEEN CARDIORESPIRATORY FITNESS AND CARDIOVASCULAR RISK FACTORS IN YOUNG ADULTS: THE CARDIOVASCULAR RISK IN YOUNG FINNS STUDY
K.S. Mansikkaniemi 1 , O. Wanne 2 , R. Telama 3 , J.S. Viikari 4 , O.T. Raitakari 5 . 1 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; 2 Central Hospital of Pori, Pori, Finland; 3 LIKES Research Center, Jyvaskyla, Finland; 4 Department of Medicine, University of Turku, Turku, Finland; 5 Department of Clinical Physiology, University of Turku, Turku, Finland Background and Aims: To assess the relations of cardiorespiratory fitness to self-reported physical activity and cardiovascular risk factors in healthy young adults. Methods: As a part of the longitudinal follow-up study, we measured waist circumference, blood pressure, serum lipids, C-reactive protein (CRP), glucose, insulin, homocysteine, asymmetric dimethyl arginine (ADMA), apolipoproteins A-1 and B, leptin and adiponectin, and assessed smoking and drinking habits and participation in physical activities in 102 subjects (48 women), who completed a bicycle ergometer exercise test. The age
of subjects varied between 24 to 39 years. The percentage value of the hypothetical maximal workload sustainable for 6 min during the exercise test (Wmax6) was measured as the index of fitness. Results: Wmax6 was directly associated with physical activity, both in women (r=0.5246, p=0.0003) and in men (r=0.5206, p=0.0001). These relations remained significant after adjustments for age and waist circumference. In women, Wmax6 was inversely associated with smoking (r=-0.3244, p=0.0279) and this result remained after adjustments for age and waist circumference. In women, but not in men, Wmax6 associated inversely with leptin (r=-0.2902, p=0.0478) and systolic blood pressure (r=-0.3529, p=0.0139), but these relations did not remain significant after adjustment for age. Wmax6 was not significantly associated with other cardiovascular risk factors in either sex. Conclusion: We conclude that cardiorespiratory fitness is directly related with self-reported physical activity level, but it is not a major determinant of cardiovascular risk profile in healthy young adults.
PO19-563
ABSTRACT WITHDRAWN
PO19-564
INFLUENCE OF HIGH-DENSITY LIPOPROTEIN ON INFLAMMATORY MARKERS CONCENTRATIONS IN SUBJECTS AT HIGH CARDIOVASCULAR RISK
L.M. Blanco-Colio 1 , J.L. Martin-Ventura 1 , X. Masramon 2 , J. Egido 1 . Research Lab. Fundacion Jimenez Diaz. Autonoma University, Madrid, Spain; 2 European Biometrics Institute, Pfizer, Madrid, Spain 1 Vascular
Background and Aims: High density lipoprotein-cholesterol (HDL-C) levels are a powerful negative predictor of premature coronary heart disease (CHD) in human prospective population studies. In fact, high HDL-C concentrations protect against the development of atherosclerosis. However, the mechanisms involving this protective effect remain unknown. We have analysed the association between HDL-C and inflammatory markers [C-reactive protein (CRP), monocyte chemoatractant protein-1 (sMCP-1), intercellular adhesion molecule-1 (sICAM-1), sFas and Fas ligand (sFasL)] concentration in 978 subjects with CHD, CHD-equivalent (defined as diabetes, peripheral vascular disease or cerebrovascular disease) or a 10-year CHD-risk > 20% from the ACTFAST study. Methods and Results: Subjects at high cardiovascular risk have increased CRP, sMCP-1, sICAM-1, sFas and diminished sFasL plasma levels as compared with healthy age- and sex-matched volunteers (N=130). When subjects were divided in relation to HDL-C concentrations [<40 (N=208), 40-60 (N=603), >60 (N=167) mg/dL], we observed an inverse association between HDL-C and CRP (3.8; 3.0; 2.7 g/dL; respectively; p for trend =0.0004), sMCP-1 (176.6; 161.3; 159 pg/mL; p=0.0081) and sICAM-1 (304.7; 277.5; 281.5 ng/mL; p=0.0096). No association was observed between sFas and HDL-C concentrations (7,592; 7,287; 7,525 pg/mL; N.S.). Furthermore, a positive association was observed between HDL-C and sFasL concentrations (56.5; 58.5; 63.6 pg/mL; p=0.0052). These associations remained significant after adjusted for other lipid parameters. Conclusions: HDL-C concentrations show an important association with different inflammatory biomarkers. Our data reinforce the idea about the anti-inflammatory properties of HDL-C and the potential beneficial effects of drugs enhancing HDL-C plasma levels in subjects at high cardiovascular risk. PO19-565
THE REGULATORY ROLE OF C-REACTIVE PROTEIN (CRP) ON PLATELET ACTIVATION
C. Skoglund 1,2 , J. Wetterö 3 , C. Sjöwall 3 , T. Skogh 3 , P. Tengvall 1 , T. Bengtsson 1,2 . 1 Materials in Medicine, Division of Applied Physics, Department of Physics, Chemistry and Biology, Linköping University, Linköping, Sweden; 2 Cardiovascular Inflammation Research Center, Division of Pharmacology, Department of Medicine and Care, Linköping University, Linköping, Sweden; 3 Division of Rheumatology, Autoimmunity and Immune Regulation Unit (AIR), Department of Molecular and Clinical Medicine, Linköping University, Linköping, Sweden Introduction: C-reactive protein (CRP) represents a powerful predictor of coronary artery disease. However, its physiological role is not fully understood. The binding of CRP to its ligand phosphorylcholine activates (via C1q and the classical pathway) the initial stages of the complement system, i.e. no membrane attack complex is formed.
76th Congress of the European Atherosclerosis Society, June 10–13, 2007, Helsinki, Finland
POSTER SESSIONS
Background: Exercise training is a lifestyle improvement with a role in the management of hypertension and hyperlipidaemia. Equally, a positive alteration of lipid profile favourably modulates inflammatory mediators known to contribute in atherogenesis mechanisms. Aim: We examined the immediate effects of a single session of submaximal exercise in hypertensive, sedentary, hypercholesterolemic patients, focusing on serum lipid alterations and inflammation markers. Patients and Methods: Twenty newly-diagnosed hypertensive, hypercholesterolemic patients (mean office blood pressure 157/93 mmHg, total cholesterol: 208,7±23,9mg/dl) participated in a bicycle ergometer 45 min submaximal exercise test. Blood samples were drawn immediately before, after and one hour after completion of the exercise. Lipid profile included total cholesterol (TC), triglycerides (TG), highdensity lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol(LDL-C). High-sensitivity C-reactive protein(CRPhs) served as an inflammatory marker. Results: Immediate post-exercise as compared to baseline TC levels significantly increased (215,7±24,7mg/dl vs 208,7±23,9mg/dl, p=0,05), whereas 1 hour after exercise, levels of TC, HDL-C, LDL-C and CRPhs significantly decreased (208±24,2mg/dl vs 215,7±24,7mg/dl, p=0,008), (52,4±15,3mg/dl vs 55,7±16,1mg/dl, p=0,001), (129±24mg/dl vs 136,4±23,6mg/dl, p=0,001) and (0,37±0,3mg/dl vs 0,44±0,3mg/dl, p<0,001), respectively. There were no significant TG changes. It should be noted that pre-exercise levels of CRPhs were negatively correlated with baseline levels of HDL-C (r=-0,5, p=0,05). Conclusions: It is obvious that a single session of submaximal exerecise can favourably change an atherogenic profile by lowering levels of LDL-C and CRPhs. One might be tempted to assume that the above mentioned changes might offer an additional reason why regular exercise sessions could exert an overall beneficial effect on hypertensive, hypercholesterolemic patients.
155
ACUTE LIPID PROFILE MODIFICATIONS AS A RESULT OF A SINGLE SESSION OF SUBMAXIMAL EXERCISE IN HYPERTENSIVE HYPERCHOLESTEROLEMIC PATIENTS
V. Galea 1 , T. Theodoridis 1 , M. El Ali 1 , H. Triantafyllidi 2 , M. Koutroubi 2 , J. Lekakis 2 , V. Christopoulou-Cokkinou 1 , D. Kremastinos 2 . 1 Haematology Laboratory, Evangelismos Hospital, Athens, Greece; 2 2nd Cardiology Dept, Medical School, University of Athens, Attikon Hospital, Athens, Greece
PO19-562
ASSOCIATIONS BETWEEN CARDIORESPIRATORY FITNESS AND CARDIOVASCULAR RISK FACTORS IN YOUNG ADULTS: THE CARDIOVASCULAR RISK IN YOUNG FINNS STUDY
K.S. Mansikkaniemi 1 , O. Wanne 2 , R. Telama 3 , J.S. Viikari 4 , O.T. Raitakari 5 . 1 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; 2 Central Hospital of Pori, Pori, Finland; 3 LIKES Research Center, Jyvaskyla, Finland; 4 Department of Medicine, University of Turku, Turku, Finland; 5 Department of Clinical Physiology, University of Turku, Turku, Finland Background and Aims: To assess the relations of cardiorespiratory fitness to self-reported physical activity and cardiovascular risk factors in healthy young adults. Methods: As a part of the longitudinal follow-up study, we measured waist circumference, blood pressure, serum lipids, C-reactive protein (CRP), glucose, insulin, homocysteine, asymmetric dimethyl arginine (ADMA), apolipoproteins A-1 and B, leptin and adiponectin, and assessed smoking and drinking habits and participation in physical activities in 102 subjects (48 women), who completed a bicycle ergometer exercise test. The age
of subjects varied between 24 to 39 years. The percentage value of the hypothetical maximal workload sustainable for 6 min during the exercise test (Wmax6) was measured as the index of fitness. Results: Wmax6 was directly associated with physical activity, both in women (r=0.5246, p=0.0003) and in men (r=0.5206, p=0.0001). These relations remained significant after adjustments for age and waist circumference. In women, Wmax6 was inversely associated with smoking (r=-0.3244, p=0.0279) and this result remained after adjustments for age and waist circumference. In women, but not in men, Wmax6 associated inversely with leptin (r=-0.2902, p=0.0478) and systolic blood pressure (r=-0.3529, p=0.0139), but these relations did not remain significant after adjustment for age. Wmax6 was not significantly associated with other cardiovascular risk factors in either sex. Conclusion: We conclude that cardiorespiratory fitness is directly related with self-reported physical activity level, but it is not a major determinant of cardiovascular risk profile in healthy young adults.
PO19-563
ABSTRACT WITHDRAWN
PO19-564
INFLUENCE OF HIGH-DENSITY LIPOPROTEIN ON INFLAMMATORY MARKERS CONCENTRATIONS IN SUBJECTS AT HIGH CARDIOVASCULAR RISK
L.M. Blanco-Colio 1 , J.L. Martin-Ventura 1 , X. Masramon 2 , J. Egido 1 . Research Lab. Fundacion Jimenez Diaz. Autonoma University, Madrid, Spain; 2 European Biometrics Institute, Pfizer, Madrid, Spain 1 Vascular
Background and Aims: High density lipoprotein-cholesterol (HDL-C) levels are a powerful negative predictor of premature coronary heart disease (CHD) in human prospective population studies. In fact, high HDL-C concentrations protect against the development of atherosclerosis. However, the mechanisms involving this protective effect remain unknown. We have analysed the association between HDL-C and inflammatory markers [C-reactive protein (CRP), monocyte chemoatractant protein-1 (sMCP-1), intercellular adhesion molecule-1 (sICAM-1), sFas and Fas ligand (sFasL)] concentration in 978 subjects with CHD, CHD-equivalent (defined as diabetes, peripheral vascular disease or cerebrovascular disease) or a 10-year CHD-risk > 20% from the ACTFAST study. Methods and Results: Subjects at high cardiovascular risk have increased CRP, sMCP-1, sICAM-1, sFas and diminished sFasL plasma levels as compared with healthy age- and sex-matched volunteers (N=130). When subjects were divided in relation to HDL-C concentrations [<40 (N=208), 40-60 (N=603), >60 (N=167) mg/dL], we observed an inverse association between HDL-C and CRP (3.8; 3.0; 2.7 g/dL; respectively; p for trend =0.0004), sMCP-1 (176.6; 161.3; 159 pg/mL; p=0.0081) and sICAM-1 (304.7; 277.5; 281.5 ng/mL; p=0.0096). No association was observed between sFas and HDL-C concentrations (7,592; 7,287; 7,525 pg/mL; N.S.). Furthermore, a positive association was observed between HDL-C and sFasL concentrations (56.5; 58.5; 63.6 pg/mL; p=0.0052). These associations remained significant after adjusted for other lipid parameters. Conclusions: HDL-C concentrations show an important association with different inflammatory biomarkers. Our data reinforce the idea about the anti-inflammatory properties of HDL-C and the potential beneficial effects of drugs enhancing HDL-C plasma levels in subjects at high cardiovascular risk. PO19-565
THE REGULATORY ROLE OF C-REACTIVE PROTEIN (CRP) ON PLATELET ACTIVATION
C. Skoglund 1,2 , J. Wetterö 3 , C. Sjöwall 3 , T. Skogh 3 , P. Tengvall 1 , T. Bengtsson 1,2 . 1 Materials in Medicine, Division of Applied Physics, Department of Physics, Chemistry and Biology, Linköping University, Linköping, Sweden; 2 Cardiovascular Inflammation Research Center, Division of Pharmacology, Department of Medicine and Care, Linköping University, Linköping, Sweden; 3 Division of Rheumatology, Autoimmunity and Immune Regulation Unit (AIR), Department of Molecular and Clinical Medicine, Linköping University, Linköping, Sweden Introduction: C-reactive protein (CRP) represents a powerful predictor of coronary artery disease. However, its physiological role is not fully understood. The binding of CRP to its ligand phosphorylcholine activates (via C1q and the classical pathway) the initial stages of the complement system, i.e. no membrane attack complex is formed.
76th Congress of the European Atherosclerosis Society, June 10–13, 2007, Helsinki, Finland
POSTER SESSIONS
Background: Exercise training is a lifestyle improvement with a role in the management of hypertension and hyperlipidaemia. Equally, a positive alteration of lipid profile favourably modulates inflammatory mediators known to contribute in atherogenesis mechanisms. Aim: We examined the immediate effects of a single session of submaximal exercise in hypertensive, sedentary, hypercholesterolemic patients, focusing on serum lipid alterations and inflammation markers. Patients and Methods: Twenty newly-diagnosed hypertensive, hypercholesterolemic patients (mean office blood pressure 157/93 mmHg, total cholesterol: 208,7±23,9mg/dl) participated in a bicycle ergometer 45 min submaximal exercise test. Blood samples were drawn immediately before, after and one hour after completion of the exercise. Lipid profile included total cholesterol (TC), triglycerides (TG), highdensity lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol(LDL-C). High-sensitivity C-reactive protein(CRPhs) served as an inflammatory marker. Results: Immediate post-exercise as compared to baseline TC levels significantly increased (215,7±24,7mg/dl vs 208,7±23,9mg/dl, p=0,05), whereas 1 hour after exercise, levels of TC, HDL-C, LDL-C and CRPhs significantly decreased (208±24,2mg/dl vs 215,7±24,7mg/dl, p=0,008), (52,4±15,3mg/dl vs 55,7±16,1mg/dl, p=0,001), (129±24mg/dl vs 136,4±23,6mg/dl, p=0,001) and (0,37±0,3mg/dl vs 0,44±0,3mg/dl, p<0,001), respectively. There were no significant TG changes. It should be noted that pre-exercise levels of CRPhs were negatively correlated with baseline levels of HDL-C (r=-0,5, p=0,05). Conclusions: It is obvious that a single session of submaximal exerecise can favourably change an atherogenic profile by lowering levels of LDL-C and CRPhs. One might be tempted to assume that the above mentioned changes might offer an additional reason why regular exercise sessions could exert an overall beneficial effect on hypertensive, hypercholesterolemic patients.
155