- Email: [email protected]
PO21-632 QUANTIFICATION OF LIVER FAT BY PROTON MAGNETIC RESONANCE SPECTROSCOPY IN 271 SUBJECTS WITH AND WITHOUT THE METABOLIC SYNDROME
Poster Sessions PO21 Obesity/Metabolic syndrome
PO21 OBESITY/METABOLIC SYNDROME PO21-630
THE ASSOCIATION BETWEEN SERUM MONOCYTE CHEMOATTRACTANT PROTEIN-1(MCP-1) AND THE METABOLIC SYNDROME
A. Fukami, H. Adachi, M. Enomoto, S. Kumagae, M. Otsuka, Y. Shigetoh, K. Furuki, A. Satoh, T. Imaizumi. Div. of Cardiovascular Medicine, Dept. of Internal Medicine, Kurume Univ. School of Medicine, Kurume, Japan
Objective: To quantitate the amount of fat in the liver in subjects with and without the metabolic syndrome and to examine the relationships between liver fat and components of the metabolic syndrome. Methods: Components of the metabolic syndrome were measured as defined by IDF. Liver fat content was measured by proton magnetic resonance spectroscopy and intra-abdominal and subcutaneous fat volumes by MRI. Results: Liver fat was 4-fold higher in subjects with [n=116; median 8.2% (interquartile range 3.2%-18.7%)] than without [n=155; 2.0% (1.0%-5.0%); p<0.0001] the metabolic syndrome. This increase in liver fat remained significant after adjusting for age, gender and BMI. All components of the metabolic syndrome correlated with liver fat content. Liver fat content was strongly correlated with intra-abdominal (r=0.66, p<0.0001 for women; r=0.62, p<0.0001 for men) and abdominal subcutaneous fat (r=0.43, p<0.0001 for women; r=0.45, p<0.0001 for men). After adjustment for age and BMI, men had higher amount of liver and intra-abdominal fat than women. Liver fat correlated significantly with serum ALT (r=0.39, p<0.0001 for women; r=0.44, p<0.0001 for men) and AST (r=0.27, p=0.0005 for women; r=0.31, p=0.0012 for men) levels. The strongest correlates of liver fat were fS-insulin (r=0.61; p<0.0001) and C-peptide (r=0.62; p<0.0001). Conclusions: Liver fat content is significantly increased in subjects with the metabolic syndrome compared to those without the metabolic syndrome, independently of age, gender and BMI. PO21-633
THE METABOLIC SYNDROME AND THE RISK OF NEW VASCULAR EVENTS IN PATIENTS WITH DIFFERENT MANIFESTATIONS OF ATHEROSCLEROTIC VASCULAR DISEASE
A.M. Wassink 1 , Y. van der Graaf 2 , J.K. Olijhoek 1 , F.L. Visseren 1 . Medicine, Section of Vascular Medicine, University Medical Centre Utrecht, Utrecht, The Netherlands; 2 Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands 1 Internal
PO21-631
POSTPRANDIAL BLOOD LEVEL OF GHRELIN AND LEPTIN AND ITS CORRELATION WITH METABOLIC PARAMETERS IN PATIENTS WITH OBESITY
I. Leszczynska-Golabek, M. Malczewska-Malec, L. Partyka, D. Siedlecka, M. Klimczak, A. Zdzienicka, A. Dembinska-Kiec. Dept. of Clinical Biochemistry, Jagiellonian University Medical College, Krakow, Poland Objective: Ghrelin and leptin play a key role in control of food intake and obesity. Long lasting obesity is often correlated with metabolic complications like hiperinsulinemia, hiperlipemia, and insulin resistance. The aim of our study was to investigate changes in leptin and ghrelin concentration during oral lipid tolerance test (OLTT). We also examined whether ghrelin and leptin plasma concentrations correlates with fasting and postprandial metabolic parameters (glucose concentration, insulin concentration, HOMA-IR) in subjects with obesity Material and methods: 30 obese patient BMI > 30 kg/m2 (Study group) and 10 normal patient BMI 18-25 kg/m2 (Control group) was included to the study. Oral Lipid Tolerance Test according to Couldrec was performed. The fasting and in the following points of time: 1h, 2h, 4h, 6h, 8h. the venous blood was sampled for measurement of glucose, insulin, ghrelin, leptin concentration Results and conclusions: Fasting and postprandial leptin and ghrelin concentration were significantly higher in obese patient and in women compared to patient with normal weight and men. There was no significant change in leptin concentration during OLTT. The lowest ghrelin concentration was observed in 2 hour of OLTT. Ghrelin and leptin significantly correlated with concentration and insulin resistance (HOMA >2).
Background: Little is known about the various metabolic syndrome (MetS) definitions and the risk of subsequent vascular events in patients with different manifestations of atherosclerotic vascular disease. Methods: A prospective study of 3196 patients with manifest vascular diseases enrolled in the Second Manifestations of ARTerial disease (SMART)study. During the follow-up period, vascular events (vascular death, ischemic stroke, myocardial infarction), vascular interventions and mortality were recorded. Results: ATPIII-defined MetS was present in 50% (n=1601) and IDFdefined MetS was present in 43% (n=1375). During a mean follow-up of 3.5 years (range 0.5 -8.5 years), 373 patients (12%) experienced a first vascular event, 331 patients (10%) died and 939 patients (29%) had either an event or vascular intervention. ATPIII-defined MetS was associated with increased risk of vascular events (age, gender, LDL-c and current smoking adjusted HR 1.51 {95% CI 1.22-1.87}), mortality (HR 1.40 {1.12-1.75}) and combined endpoint of vascular event or intervention (HR 1.35 {1.18-1.54}). IDF-defined metabolic syndrome was not associated with increased risk of vascular events (HR 1.11 {0.97-1.27}), mortality (HR 1.10 {0.92-1.31}) or combined endpoint (HR 1.05 {0.95-1.16}). Results were similar in the 2717 patients without type 2 diabetes. The association was observed in patients with coronary artery disease (CAD) or peripheral artery disease (PAD), not in those with cerebrovascular disease or abdominal aortic aneurysm. Conclusion: In patients with CAD and PAD, the ATPIII-defined MetS but not the IDF-defined MetS is associated with the occurrence of new vascular events, independently of the presence of type 2 diabetes. PO21-634
PO21-632
QUANTIFICATION OF LIVER FAT BY PROTON MAGNETIC RESONANCE SPECTROSCOPY IN 271 SUBJECTS WITH AND WITHOUT THE METABOLIC SYNDROME
A. Kotronen 1 , J. Westerbacka 1 , R. Bergholm 1 , K.H. Pietilainen 2 , L. Juurinen 1 , H. Yki-Jarvinen 1 . 1 Dept. of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland; 2 The Finnish Twin Cohort Study, Dept. of Public Health, University of Helsinki, Helsinki, Finland Background: The liver, once fatty, overproduces components of the metabolic syndrome. The amount of liver fat in subjects with and without the metabolic syndrome has not been determined.
METABOLIC SYNDROME AND RISK OF ACUTE CORONARY SYNDROMES IN SUBJECTS YOUNGER THAN 45 YEARS OF AGE
H.J. Milionis 1 , K.J. Kalantzi 2 , A.J. Papathanasiou 2 , A.A. Kosovitsas 2 , M.T. Doumas 1 , J.A. Goudevenos 2 . 1 Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece; 2 Department of Cardiology, School of Medicine, University of Ioannina, Ioannina, Greece Background and Aims: There is a paucity of data with regard to the association of the metabolic syndrome (MetS) with cardiovascular risk in young adults. We investigated the association of MetS with acute coronary syndrome (ACS) in adults aged 45 years or younger.
76th Congress of the European Atherosclerosis Society, June 10–13, 2007, Helsinki, Finland
POSTER SESSIONS
Inflammation plays an essential role in the atherosclerotic process. MCP-1 is a chemokine responsible for the recruitment of monocytes to sites of inflammation. A possible common inflammatory basis for the pathogenesis of the metabolic syndrome has been suggested. We evaluated whether elevated serum level of MCP-1 are related to the metabolic syndrome in a general population. We performed a health examination in a rural community in Japan. Complete datasets including MCP-1 were available in 622 subjects (226 males and 396 females). We measured blood pressure, waist circumference, lipid profiles, fasting plasma glucose and inflammatory markers such as high-sensitive CRP (Hs-CRP). We adopted Japanese Criteria of the metabolic syndrome. The metabolic syndrome was defined as the presence of at least 3 of these components. We analyzed the association between MCP-1 and the number of the component of the metabolic syndrome using analysis of covariance adjusted for age and sex. The average MCP-1 levels were 248.5pg/ml in males and 208.2pg/ml in females, respectively. MCP-1 levels were higher (P<0.05 for trend) in proportion to accumulation of the number of the component of the metabolic syndrome. A significant association (P<0.05) was shown between Hs-CRP levels and the degree of abnormality of the components of the metabolic syndrome. These findings may support the potential role of MCP-1 as an inflammatory biomarker.
171
PO21 OBESITY/METABOLIC SYNDROME PO21-630
THE ASSOCIATION BETWEEN SERUM MONOCYTE CHEMOATTRACTANT PROTEIN-1(MCP-1) AND THE METABOLIC SYNDROME
A. Fukami, H. Adachi, M. Enomoto, S. Kumagae, M. Otsuka, Y. Shigetoh, K. Furuki, A. Satoh, T. Imaizumi. Div. of Cardiovascular Medicine, Dept. of Internal Medicine, Kurume Univ. School of Medicine, Kurume, Japan
Objective: To quantitate the amount of fat in the liver in subjects with and without the metabolic syndrome and to examine the relationships between liver fat and components of the metabolic syndrome. Methods: Components of the metabolic syndrome were measured as defined by IDF. Liver fat content was measured by proton magnetic resonance spectroscopy and intra-abdominal and subcutaneous fat volumes by MRI. Results: Liver fat was 4-fold higher in subjects with [n=116; median 8.2% (interquartile range 3.2%-18.7%)] than without [n=155; 2.0% (1.0%-5.0%); p<0.0001] the metabolic syndrome. This increase in liver fat remained significant after adjusting for age, gender and BMI. All components of the metabolic syndrome correlated with liver fat content. Liver fat content was strongly correlated with intra-abdominal (r=0.66, p<0.0001 for women; r=0.62, p<0.0001 for men) and abdominal subcutaneous fat (r=0.43, p<0.0001 for women; r=0.45, p<0.0001 for men). After adjustment for age and BMI, men had higher amount of liver and intra-abdominal fat than women. Liver fat correlated significantly with serum ALT (r=0.39, p<0.0001 for women; r=0.44, p<0.0001 for men) and AST (r=0.27, p=0.0005 for women; r=0.31, p=0.0012 for men) levels. The strongest correlates of liver fat were fS-insulin (r=0.61; p<0.0001) and C-peptide (r=0.62; p<0.0001). Conclusions: Liver fat content is significantly increased in subjects with the metabolic syndrome compared to those without the metabolic syndrome, independently of age, gender and BMI. PO21-633
THE METABOLIC SYNDROME AND THE RISK OF NEW VASCULAR EVENTS IN PATIENTS WITH DIFFERENT MANIFESTATIONS OF ATHEROSCLEROTIC VASCULAR DISEASE
A.M. Wassink 1 , Y. van der Graaf 2 , J.K. Olijhoek 1 , F.L. Visseren 1 . Medicine, Section of Vascular Medicine, University Medical Centre Utrecht, Utrecht, The Netherlands; 2 Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands 1 Internal
PO21-631
POSTPRANDIAL BLOOD LEVEL OF GHRELIN AND LEPTIN AND ITS CORRELATION WITH METABOLIC PARAMETERS IN PATIENTS WITH OBESITY
I. Leszczynska-Golabek, M. Malczewska-Malec, L. Partyka, D. Siedlecka, M. Klimczak, A. Zdzienicka, A. Dembinska-Kiec. Dept. of Clinical Biochemistry, Jagiellonian University Medical College, Krakow, Poland Objective: Ghrelin and leptin play a key role in control of food intake and obesity. Long lasting obesity is often correlated with metabolic complications like hiperinsulinemia, hiperlipemia, and insulin resistance. The aim of our study was to investigate changes in leptin and ghrelin concentration during oral lipid tolerance test (OLTT). We also examined whether ghrelin and leptin plasma concentrations correlates with fasting and postprandial metabolic parameters (glucose concentration, insulin concentration, HOMA-IR) in subjects with obesity Material and methods: 30 obese patient BMI > 30 kg/m2 (Study group) and 10 normal patient BMI 18-25 kg/m2 (Control group) was included to the study. Oral Lipid Tolerance Test according to Couldrec was performed. The fasting and in the following points of time: 1h, 2h, 4h, 6h, 8h. the venous blood was sampled for measurement of glucose, insulin, ghrelin, leptin concentration Results and conclusions: Fasting and postprandial leptin and ghrelin concentration were significantly higher in obese patient and in women compared to patient with normal weight and men. There was no significant change in leptin concentration during OLTT. The lowest ghrelin concentration was observed in 2 hour of OLTT. Ghrelin and leptin significantly correlated with concentration and insulin resistance (HOMA >2).
Background: Little is known about the various metabolic syndrome (MetS) definitions and the risk of subsequent vascular events in patients with different manifestations of atherosclerotic vascular disease. Methods: A prospective study of 3196 patients with manifest vascular diseases enrolled in the Second Manifestations of ARTerial disease (SMART)study. During the follow-up period, vascular events (vascular death, ischemic stroke, myocardial infarction), vascular interventions and mortality were recorded. Results: ATPIII-defined MetS was present in 50% (n=1601) and IDFdefined MetS was present in 43% (n=1375). During a mean follow-up of 3.5 years (range 0.5 -8.5 years), 373 patients (12%) experienced a first vascular event, 331 patients (10%) died and 939 patients (29%) had either an event or vascular intervention. ATPIII-defined MetS was associated with increased risk of vascular events (age, gender, LDL-c and current smoking adjusted HR 1.51 {95% CI 1.22-1.87}), mortality (HR 1.40 {1.12-1.75}) and combined endpoint of vascular event or intervention (HR 1.35 {1.18-1.54}). IDF-defined metabolic syndrome was not associated with increased risk of vascular events (HR 1.11 {0.97-1.27}), mortality (HR 1.10 {0.92-1.31}) or combined endpoint (HR 1.05 {0.95-1.16}). Results were similar in the 2717 patients without type 2 diabetes. The association was observed in patients with coronary artery disease (CAD) or peripheral artery disease (PAD), not in those with cerebrovascular disease or abdominal aortic aneurysm. Conclusion: In patients with CAD and PAD, the ATPIII-defined MetS but not the IDF-defined MetS is associated with the occurrence of new vascular events, independently of the presence of type 2 diabetes. PO21-634
PO21-632
QUANTIFICATION OF LIVER FAT BY PROTON MAGNETIC RESONANCE SPECTROSCOPY IN 271 SUBJECTS WITH AND WITHOUT THE METABOLIC SYNDROME
A. Kotronen 1 , J. Westerbacka 1 , R. Bergholm 1 , K.H. Pietilainen 2 , L. Juurinen 1 , H. Yki-Jarvinen 1 . 1 Dept. of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland; 2 The Finnish Twin Cohort Study, Dept. of Public Health, University of Helsinki, Helsinki, Finland Background: The liver, once fatty, overproduces components of the metabolic syndrome. The amount of liver fat in subjects with and without the metabolic syndrome has not been determined.
METABOLIC SYNDROME AND RISK OF ACUTE CORONARY SYNDROMES IN SUBJECTS YOUNGER THAN 45 YEARS OF AGE
H.J. Milionis 1 , K.J. Kalantzi 2 , A.J. Papathanasiou 2 , A.A. Kosovitsas 2 , M.T. Doumas 1 , J.A. Goudevenos 2 . 1 Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece; 2 Department of Cardiology, School of Medicine, University of Ioannina, Ioannina, Greece Background and Aims: There is a paucity of data with regard to the association of the metabolic syndrome (MetS) with cardiovascular risk in young adults. We investigated the association of MetS with acute coronary syndrome (ACS) in adults aged 45 years or younger.
76th Congress of the European Atherosclerosis Society, June 10–13, 2007, Helsinki, Finland
POSTER SESSIONS
Inflammation plays an essential role in the atherosclerotic process. MCP-1 is a chemokine responsible for the recruitment of monocytes to sites of inflammation. A possible common inflammatory basis for the pathogenesis of the metabolic syndrome has been suggested. We evaluated whether elevated serum level of MCP-1 are related to the metabolic syndrome in a general population. We performed a health examination in a rural community in Japan. Complete datasets including MCP-1 were available in 622 subjects (226 males and 396 females). We measured blood pressure, waist circumference, lipid profiles, fasting plasma glucose and inflammatory markers such as high-sensitive CRP (Hs-CRP). We adopted Japanese Criteria of the metabolic syndrome. The metabolic syndrome was defined as the presence of at least 3 of these components. We analyzed the association between MCP-1 and the number of the component of the metabolic syndrome using analysis of covariance adjusted for age and sex. The average MCP-1 levels were 248.5pg/ml in males and 208.2pg/ml in females, respectively. MCP-1 levels were higher (P<0.05 for trend) in proportion to accumulation of the number of the component of the metabolic syndrome. A significant association (P<0.05) was shown between Hs-CRP levels and the degree of abnormality of the components of the metabolic syndrome. These findings may support the potential role of MCP-1 as an inflammatory biomarker.
171