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PO24-TH-08 Prevalence of non-motor symptoms in Thai Parkinson's disease patients
19th World Congress of Neurology, Poster Abstracts / Journal of the Neurological Sciences 285 S1 (2009) S155–S339
Conclusion: Due to the expense and complexity of the project, the registry will be developed into several stages. Collecting the information in a whole nation will provide essential data about PD in Thailand to ensure adequate health resources available to most if not all PD pts. PO24-TH-05 Parkinson’s disease-frequency and clinical characteristics at LAUTECH Teaching Hospital Osogbo Nigeria A.F. Mustapha. Medicine, College of Health Sciences Lautech, Osogbo, Nigeria Purpose: 1. To determine the frequency of Parkinson’s disease at the neurology clinic of LAUTECH Teaching Hospital. 2. To explore the differences in frequency in respect to gender and age. 3: To assess the presence of non-motor symptoms. Methods: This study was both retrospective and descriptive. Case notes of patients managed for parkinson’s disease at the neurology clinic of LAUTECH Teaching Hospital Osogbo from June 2005 till October 2008 were retrieved. Demographic data, clinical details of the disease, results of investigations as well as presence of nonmotor symptoms were obtained and analyzed. Results: Parkinson’s disease was diagnosed among 24 patients (6.1%) of a total number of 393 patients seen during the period. This comprising of 19 males (79.1%) and 5 females (21.9). The age range was 40–80 years. Mean age was 61.5% with males having a higher mean age of 63.2 years as against 55.8 years for females. Tremor was the most common clinical finding 75% (n = 24) followed by rigidity (50%) and bradykinesia (45.8%). Cogwheel rigidity was slightly more frequent than leadpipe rigidity. Non-motor symptoms included dementia (4 cases), depression (3 cases) and hallucinations and psychosis-1 case. Conclusions: Parkinson’s disease is a disease of the middleaged and elderly in this Nigerian population with a male sex preponderance and higher mean age. PO24-TH-06 Movement disorder among new Parkinson disease patients in China Y.W. Luo1 , X.D. Tan2 , P.Q. Wang1 . 1 1st People’s Hospital, Xiangfan Hubei, China; 2 School of Public Health, Wuhan University, Wuhan, China PD is becoming known recently in China as Chinese lives longer. BUT PD epidemiology is not clear yet. The present study examined PD signs among the new diagnosed PD patients. Subjects comprised 88 Parkinson’s disease patients (88 men, 84 women, mean (±SD) age, 64.3±9.6 years) who had been patients for <3 years, and sex- and age-matched (<2 years old) controls with no Parkinson’s disease, but with headache, dizziness etc. attending the inpatient clinic of No. 1 People’s Hospital in Xiangfan and Jingmen, Hubei, China. All clinical examination data was input a database and statistical analyzed with SPSS 13.0. The authors found that: Chief Complaint all the PD patients due to the thrill and/or movement difficult of the four limbs, among these patients, there were only 32 persons (36.4%) seek clinical aids within one year since they had medical problems, 19 persons (21.6%), 19 persons (21.6%), 18 persons (21.5%) go to hospital in 1-, 2- and longer than 3 years, respectively. The authors also found that 16 PD patients (18.2%) had thrill of limbs, and there are 13 (81.3%) patients had hemi-thrill, only 3 PD (8.7%) patients had bilateral thrills. Concerning the thrill ranges of these PD patients, 10 (62.5%) subjects limit on the arms, 4 subjects (25%) thrill on all of the four limbs, only 2 subjects had a body’s thrills. There were 18 subjects showed an increase muscular tension, one showed decrease muscular tension. There were 15 patients had orofacial dyskinesia, and 15 patients appeared body movement difficult. Authors’ suggestion: PD should be pay more attention both on clinical doctors and citizens.
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PO24-TH-07 Prodromal non-motor symptoms of Parkinson’s disease, longterm uneffective nondopaminergic treatment and subsequent response to dopaminergic medication: a retrospective study K. Farnikova, P. Kanovsky. Department of Neurology, Palacky University, University Hospital Olomouc, Olomouc, Czech Republic Introduction: Parkinson’s disease (PD) in many patients will in hindsight recall a prodromal phase including non-motor symptoms (NMS). The aim of this study were to review the prevalence of NMS as presenting complaints in cases of PD that approved the most often as musculoskeletal problems. Methods: A retrospective review of cases of patients suffering from PD has been performed. There were 82 cases, 52 men and 30 women. The mean age was 61.5 years in men and 66.2 years in women. The mean disease duration was 5.3 years in men and 6.1 years in women. The hospital inpatient notes and emergency room admission notes were reviewed. The initial presenting complain prompting patients to attend medical services was noted and early diagnoses made were documented. The included symptoms were considered retrospectively to be associated with PD. Results: NMS as prodromal PD symptoms were present in personal history in 27 (33%) cases, 14 men and 13 women), which were initially diagnosed with the osteoarthritis, degenerative spinal disease and frozen shoulder. The mean time from appearance of first signs to dopaminergic treatment initiation was 6.6 years in NMS group and 2.3 years in group with typical PD signs. Significant improvement of NMS after dopaminergic treatment initiation was present in 23 (85%) cases, 12 men and 11 women. Conclusion: 33% of PD population assessed in this study who went on to develop motor features of PD, descibed their initial symptoms in exclusively NMS terms. NMS presentations of PD were frequently misdiagnosed, leading to a high proportion of potentially inappropriate specialist referrals and treatments including long-term ineffective physiotherapy, steroid injections to frozen shoulders and surgical interventions for degenerative spinal disease or carpal tunnel syndromes. A good response to L-DOPA therapy was seen in 85% cases with presenting NMS. Our findings suggest that NMS may be significant features in earlier PD. PO24-TH-08 Prevalence of non-motor symptoms in Thai Parkinson’s disease patients K. Vongvaivanich. Neurology, Phramongkutklao Hospital, Bangkok, Thailand Background: Although motor problems of Parkinson’s disease (PD) are as important and many researchers have been trying to find the best treatment, during the past 5 years non-motor symptoms (NMS) of PD have also been recently recognized as problematic as the cause of major disability in PD patients. Neurologists over 50% who treat PD patients do not recognize NMS. PD non-motor group developed NMS screening questionnaire (NMSQuest). Objective: We aim to evaluate prevalence of NMS and correlation of NMS with demographic and historical factors in Thai PD patients. Methods: Data were collected from January 2008 to December 2008. 182 patients were enrolled in study, 17 patients were excluded. NMSQ was translated into the Thai language (NMSQT). NMSQ-T were completed by 165 patients. Demographic data, duration of the disease, Hoehn and Yahr stages, levodopa dosage, numbers and types of antiparkinsonian drugs were recorded. Descriptive statistic analysis was employed to calculate prevalence of NMS by individual symptom and domains, and regression analysis was used to calculate correlation of total NMSQ-T to demographic and historical factors. Results: The 165 patients were diagnosed to probably idiopathic PD: mean age 68.55±9.35 yr, male 56.4%, female 43.6%, mean duration of disease 5.39±4.16 yr, mean dose of levodopa
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19th World Congress of Neurology, Poster Abstracts / Journal of the Neurological Sciences 285 S1 (2009) S155–S339
456.38±305.97 mg/d. Only 5 patients (3%) denied all of NMS. Mean total score of NMSQ-T was 9.54±5.51. Most prevalence of NMS was nocturia (64.2%). The most positive answers domain were urinary domains (54.55%). Total NMSQ-T was significantly correlated with Hoehn and Yahr stages (p < 0.0001), levodopa doses (p < 0.0001), duration of disease (p = 0.004), and age and age at onset (p < 0.011). Conclusion: NMS in Thai PD patients were found in high prevalence, almost all patients had NMS. Screening all PD patients in outpatient setting should be done with NMSQ-T to recognize NMS and early treat appropriately. PO24-TH-09 The impact of non motor symptoms in Parkinson’s disease D.K. Pokharel. Neurology-Neurosurgery and Medical Genetics, Tver State Medical Academy, Tver, Russian Federation Purpose: Recognition and assessment of NMS in PD (including pre clinical manifestations). Method: 63 patients with idiopathic PD were observed, age between 55–75. Disease course-3.1±2.5 years, dopaminergic therapy2.8±2.4 years. Analysis of anamnesis, neurologic exam, UPDRS tool, modified Hoehn Yahr Staging, Schwab and England Activities of Daily Living and PD Non-Motor Group-NMS questionnaire was performed to each patient. Results: Impaired olfaction – 49 (77.7%). 31 of them had paraosmia before the disease. Sleep disorders – 58 (92%) patients, in the form of insomnia, sleep fragmentation, REM sleep behaviour disorders, excessive daytime sleepiness and involuntary dozing. In 25 of them, sleep disorders overcame the motor symptoms. Pain and somatosensory complaints – in 44 (69.8%). 11 of them experienced preceding motor parkinsonism. Fatigue-in all patients. Symptoms of dysautonomia was found in 37 (58.7%) including orthostatic hypotension, bladder, gastrointestinal, respiratory, sexual, thermoregulatory dysfunctions, papillary abnormalities, hyperhidrosis. In 25 of them, symptoms became prominent after dopaminergic therapy. Neuropsychiatric disturbances – 27 (42.8%) had either isolated or combined form of apathy, anxiety, depression, anhedonia, panic attacks, impulse control disorders, cognitive impairment, dementia, attention deficit. Depression-the most common, affecting 22 (81.4%) of them. 9 of them explained such disturbances as pre motor. Dopamine dysregulation syndromepathologic gambling and compulsive shopping was noticed in 2 patients getting therapy for >3 years. Wearing-off phenomenonobserved in 11 patients who experienced NMS like dyspnoea, nausea, abdominal pain, facial flushing, hunger and pain. Conclusion: During the pre motor and motor course of PD, varying Non Motor Symptoms were observed, sleep disorders, pain and dysautonomia being very common. Delayed detection of NMS may lead to disability and poor quality of life. Recognition of NMS is essential for the holistic management of PD. PO24-TH-10 Gender differences in motor and non-motor clinical manifestation of Parkinson’s disease: analysis of the E.W.O study I. Rektorova1 , M. Bares1 , R. Jech2 , K. Farnikova3 , I. Rektor1 , J. Roth2 , E. Ruzicka2 , P. Kanovsky3 , K. Chroust4 , T. Pavlik4 . 1 First Department of Neurology, Medical Faculty Masaryk University, Brno, Czech Republic; 2 Department of Neurology, 1st Medical Faculty Charles University, Prague, Czech Republic; 3 Department of Neurology, Medical Faculty Palacky University, Olomouc, Czech Republic; 4 Institute for Biomedical Analysis, Masaryk University, Brno, Czech Republic Purpose: To compare the differences between men and women with respect to both motor and non-motor clinical manifestation of Parkinson’s disease (PD) based on the results from a national, multicenter, epidemiological E.W.O study (Epidemiology
of Wearing-Off symptoms in PD patients chronically treated with L-dopa for ≤10 years). Methods: Data analyzed from 563 consecutive PD patients (219 women, 344 men), detailed records on medical and drug history, clinicians’ assessment, and WOQ-9 questionnaire used. Additional testing of non-motor symptoms of PD (as measured by NMS30, MADRS, HAMA, MOCA) performed by movement disorders specialists in 217 out of 563 patients (83 women, 34 men). Results: No differences between both groups found with respect to age, age at symptoms onset, laterality and clinical manifestation of the first motor symptom of PD, Hoehn and Yahr (H-Y) stage, prevalence of wearing-off symptoms. Median L-dopa equivalent dose was similar in both groups. Regarding NMS 30 results, both groups differed significantly only in the subscore evaluating sexual dysfunctions (indicated by 26% of women and 45.5% of men, p = 0.006). When selected questions from the questionnaire were taken into consideration, drooling and excessive saliva was indicated significantly more frequently in men compared to women (18.1% of women and 32.1% of men, p = 0.027) whilst women expressed sad/ depressed mood feelings significantly more frequently than men (50.6% of women and 33.6% of men, p = 0.016). Concerning other scales, no significant differences were observed between both sexes. Conclusion: We found no differences between men and women with respect to motor manifestation of PD or the prevalence of wearing off phenomena. Regarding non-motor outcomes, slight differences were identified between both sexes, including the presence of sexual dysfunction and drooling (more frequent in men), and sad/ depressed mood feelings (more frequent in women). PO24-TH-11 Prevalence and risk factors of constipation in Thai Parkinson’s disease patients S. E-la1 , S. Gonlachanvit2 , R. Bhidayasiri1 . 1 Chulalongkorn Comprehensive Movement Disorders Center, Chulalongkorn University, Bangkok, Thailand; 2 Division of Gastroenterology, Chulalongkorn University, Bangkok, Thailand Objective: To determine the prevalence and risk factors of constipation among Thai Parkinson’s disease (PD) patients. Background: Constipation is considered to be the most common manifestation of autonomic dysfunction in PD. Compared to agematched and sex-matched controls, constipation is two to four times more common in patients with PD. Methods: 200 PD patients (pts) with various Hoehn & Yahr (H&Y) stages completed the Rome III criteria constipation module. In addition to clinical data on PD, constipation characteristics and treatment response of constipation were collected. Subjects were then divided into ‘constipation’ (A) and ‘no-constipation’ (B) groups in order to identify clinical characteristics and risk factors of constipation. Results: In 200 pts, there were 103 males and 97 females. 130 pts constipated. Mean age of pts was 63.5 yrs in A and 62.7 yrs in B (p < 0.05). Duration of PD was 7.4 yrs in A and 6.1 yrs in B (p = 0.1). The frequency of constipation was 55.7% in H&Y 1, 65.6% H&Y 2, 85.1% H&Y 2.5, 69.2% H&Y 3, 70% H&Y 4, and 66.67% H&Y 5. There were no statistically significant between PD cardinal symptoms between A and B (Tremor: 82.3% vs. 81.42%, p = 0.99, Rigidity: 77.69% vs. 64.29%, p = 0.061, Bradykinesia: 92.31% vs. 90.0%, p = 0.77, Postural instability: 90.77% vs. 87.14%, p = 0.58). There was no difference on the use of antiparkinsonian medication between two groups. Pts in A reported more problems with straining, hard stool, sensation of incomplete evacuation and blockage, <2 bowel movements per week and more frequent use of laxatives. Conclusion: Constipation is a frequent disabling symptom in PD, affecting more than 50% in all stages of PD severity. No associations were identified between the increased frequency of constipation
Conclusion: Due to the expense and complexity of the project, the registry will be developed into several stages. Collecting the information in a whole nation will provide essential data about PD in Thailand to ensure adequate health resources available to most if not all PD pts. PO24-TH-05 Parkinson’s disease-frequency and clinical characteristics at LAUTECH Teaching Hospital Osogbo Nigeria A.F. Mustapha. Medicine, College of Health Sciences Lautech, Osogbo, Nigeria Purpose: 1. To determine the frequency of Parkinson’s disease at the neurology clinic of LAUTECH Teaching Hospital. 2. To explore the differences in frequency in respect to gender and age. 3: To assess the presence of non-motor symptoms. Methods: This study was both retrospective and descriptive. Case notes of patients managed for parkinson’s disease at the neurology clinic of LAUTECH Teaching Hospital Osogbo from June 2005 till October 2008 were retrieved. Demographic data, clinical details of the disease, results of investigations as well as presence of nonmotor symptoms were obtained and analyzed. Results: Parkinson’s disease was diagnosed among 24 patients (6.1%) of a total number of 393 patients seen during the period. This comprising of 19 males (79.1%) and 5 females (21.9). The age range was 40–80 years. Mean age was 61.5% with males having a higher mean age of 63.2 years as against 55.8 years for females. Tremor was the most common clinical finding 75% (n = 24) followed by rigidity (50%) and bradykinesia (45.8%). Cogwheel rigidity was slightly more frequent than leadpipe rigidity. Non-motor symptoms included dementia (4 cases), depression (3 cases) and hallucinations and psychosis-1 case. Conclusions: Parkinson’s disease is a disease of the middleaged and elderly in this Nigerian population with a male sex preponderance and higher mean age. PO24-TH-06 Movement disorder among new Parkinson disease patients in China Y.W. Luo1 , X.D. Tan2 , P.Q. Wang1 . 1 1st People’s Hospital, Xiangfan Hubei, China; 2 School of Public Health, Wuhan University, Wuhan, China PD is becoming known recently in China as Chinese lives longer. BUT PD epidemiology is not clear yet. The present study examined PD signs among the new diagnosed PD patients. Subjects comprised 88 Parkinson’s disease patients (88 men, 84 women, mean (±SD) age, 64.3±9.6 years) who had been patients for <3 years, and sex- and age-matched (<2 years old) controls with no Parkinson’s disease, but with headache, dizziness etc. attending the inpatient clinic of No. 1 People’s Hospital in Xiangfan and Jingmen, Hubei, China. All clinical examination data was input a database and statistical analyzed with SPSS 13.0. The authors found that: Chief Complaint all the PD patients due to the thrill and/or movement difficult of the four limbs, among these patients, there were only 32 persons (36.4%) seek clinical aids within one year since they had medical problems, 19 persons (21.6%), 19 persons (21.6%), 18 persons (21.5%) go to hospital in 1-, 2- and longer than 3 years, respectively. The authors also found that 16 PD patients (18.2%) had thrill of limbs, and there are 13 (81.3%) patients had hemi-thrill, only 3 PD (8.7%) patients had bilateral thrills. Concerning the thrill ranges of these PD patients, 10 (62.5%) subjects limit on the arms, 4 subjects (25%) thrill on all of the four limbs, only 2 subjects had a body’s thrills. There were 18 subjects showed an increase muscular tension, one showed decrease muscular tension. There were 15 patients had orofacial dyskinesia, and 15 patients appeared body movement difficult. Authors’ suggestion: PD should be pay more attention both on clinical doctors and citizens.
S287
PO24-TH-07 Prodromal non-motor symptoms of Parkinson’s disease, longterm uneffective nondopaminergic treatment and subsequent response to dopaminergic medication: a retrospective study K. Farnikova, P. Kanovsky. Department of Neurology, Palacky University, University Hospital Olomouc, Olomouc, Czech Republic Introduction: Parkinson’s disease (PD) in many patients will in hindsight recall a prodromal phase including non-motor symptoms (NMS). The aim of this study were to review the prevalence of NMS as presenting complaints in cases of PD that approved the most often as musculoskeletal problems. Methods: A retrospective review of cases of patients suffering from PD has been performed. There were 82 cases, 52 men and 30 women. The mean age was 61.5 years in men and 66.2 years in women. The mean disease duration was 5.3 years in men and 6.1 years in women. The hospital inpatient notes and emergency room admission notes were reviewed. The initial presenting complain prompting patients to attend medical services was noted and early diagnoses made were documented. The included symptoms were considered retrospectively to be associated with PD. Results: NMS as prodromal PD symptoms were present in personal history in 27 (33%) cases, 14 men and 13 women), which were initially diagnosed with the osteoarthritis, degenerative spinal disease and frozen shoulder. The mean time from appearance of first signs to dopaminergic treatment initiation was 6.6 years in NMS group and 2.3 years in group with typical PD signs. Significant improvement of NMS after dopaminergic treatment initiation was present in 23 (85%) cases, 12 men and 11 women. Conclusion: 33% of PD population assessed in this study who went on to develop motor features of PD, descibed their initial symptoms in exclusively NMS terms. NMS presentations of PD were frequently misdiagnosed, leading to a high proportion of potentially inappropriate specialist referrals and treatments including long-term ineffective physiotherapy, steroid injections to frozen shoulders and surgical interventions for degenerative spinal disease or carpal tunnel syndromes. A good response to L-DOPA therapy was seen in 85% cases with presenting NMS. Our findings suggest that NMS may be significant features in earlier PD. PO24-TH-08 Prevalence of non-motor symptoms in Thai Parkinson’s disease patients K. Vongvaivanich. Neurology, Phramongkutklao Hospital, Bangkok, Thailand Background: Although motor problems of Parkinson’s disease (PD) are as important and many researchers have been trying to find the best treatment, during the past 5 years non-motor symptoms (NMS) of PD have also been recently recognized as problematic as the cause of major disability in PD patients. Neurologists over 50% who treat PD patients do not recognize NMS. PD non-motor group developed NMS screening questionnaire (NMSQuest). Objective: We aim to evaluate prevalence of NMS and correlation of NMS with demographic and historical factors in Thai PD patients. Methods: Data were collected from January 2008 to December 2008. 182 patients were enrolled in study, 17 patients were excluded. NMSQ was translated into the Thai language (NMSQT). NMSQ-T were completed by 165 patients. Demographic data, duration of the disease, Hoehn and Yahr stages, levodopa dosage, numbers and types of antiparkinsonian drugs were recorded. Descriptive statistic analysis was employed to calculate prevalence of NMS by individual symptom and domains, and regression analysis was used to calculate correlation of total NMSQ-T to demographic and historical factors. Results: The 165 patients were diagnosed to probably idiopathic PD: mean age 68.55±9.35 yr, male 56.4%, female 43.6%, mean duration of disease 5.39±4.16 yr, mean dose of levodopa
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19th World Congress of Neurology, Poster Abstracts / Journal of the Neurological Sciences 285 S1 (2009) S155–S339
456.38±305.97 mg/d. Only 5 patients (3%) denied all of NMS. Mean total score of NMSQ-T was 9.54±5.51. Most prevalence of NMS was nocturia (64.2%). The most positive answers domain were urinary domains (54.55%). Total NMSQ-T was significantly correlated with Hoehn and Yahr stages (p < 0.0001), levodopa doses (p < 0.0001), duration of disease (p = 0.004), and age and age at onset (p < 0.011). Conclusion: NMS in Thai PD patients were found in high prevalence, almost all patients had NMS. Screening all PD patients in outpatient setting should be done with NMSQ-T to recognize NMS and early treat appropriately. PO24-TH-09 The impact of non motor symptoms in Parkinson’s disease D.K. Pokharel. Neurology-Neurosurgery and Medical Genetics, Tver State Medical Academy, Tver, Russian Federation Purpose: Recognition and assessment of NMS in PD (including pre clinical manifestations). Method: 63 patients with idiopathic PD were observed, age between 55–75. Disease course-3.1±2.5 years, dopaminergic therapy2.8±2.4 years. Analysis of anamnesis, neurologic exam, UPDRS tool, modified Hoehn Yahr Staging, Schwab and England Activities of Daily Living and PD Non-Motor Group-NMS questionnaire was performed to each patient. Results: Impaired olfaction – 49 (77.7%). 31 of them had paraosmia before the disease. Sleep disorders – 58 (92%) patients, in the form of insomnia, sleep fragmentation, REM sleep behaviour disorders, excessive daytime sleepiness and involuntary dozing. In 25 of them, sleep disorders overcame the motor symptoms. Pain and somatosensory complaints – in 44 (69.8%). 11 of them experienced preceding motor parkinsonism. Fatigue-in all patients. Symptoms of dysautonomia was found in 37 (58.7%) including orthostatic hypotension, bladder, gastrointestinal, respiratory, sexual, thermoregulatory dysfunctions, papillary abnormalities, hyperhidrosis. In 25 of them, symptoms became prominent after dopaminergic therapy. Neuropsychiatric disturbances – 27 (42.8%) had either isolated or combined form of apathy, anxiety, depression, anhedonia, panic attacks, impulse control disorders, cognitive impairment, dementia, attention deficit. Depression-the most common, affecting 22 (81.4%) of them. 9 of them explained such disturbances as pre motor. Dopamine dysregulation syndromepathologic gambling and compulsive shopping was noticed in 2 patients getting therapy for >3 years. Wearing-off phenomenonobserved in 11 patients who experienced NMS like dyspnoea, nausea, abdominal pain, facial flushing, hunger and pain. Conclusion: During the pre motor and motor course of PD, varying Non Motor Symptoms were observed, sleep disorders, pain and dysautonomia being very common. Delayed detection of NMS may lead to disability and poor quality of life. Recognition of NMS is essential for the holistic management of PD. PO24-TH-10 Gender differences in motor and non-motor clinical manifestation of Parkinson’s disease: analysis of the E.W.O study I. Rektorova1 , M. Bares1 , R. Jech2 , K. Farnikova3 , I. Rektor1 , J. Roth2 , E. Ruzicka2 , P. Kanovsky3 , K. Chroust4 , T. Pavlik4 . 1 First Department of Neurology, Medical Faculty Masaryk University, Brno, Czech Republic; 2 Department of Neurology, 1st Medical Faculty Charles University, Prague, Czech Republic; 3 Department of Neurology, Medical Faculty Palacky University, Olomouc, Czech Republic; 4 Institute for Biomedical Analysis, Masaryk University, Brno, Czech Republic Purpose: To compare the differences between men and women with respect to both motor and non-motor clinical manifestation of Parkinson’s disease (PD) based on the results from a national, multicenter, epidemiological E.W.O study (Epidemiology
of Wearing-Off symptoms in PD patients chronically treated with L-dopa for ≤10 years). Methods: Data analyzed from 563 consecutive PD patients (219 women, 344 men), detailed records on medical and drug history, clinicians’ assessment, and WOQ-9 questionnaire used. Additional testing of non-motor symptoms of PD (as measured by NMS30, MADRS, HAMA, MOCA) performed by movement disorders specialists in 217 out of 563 patients (83 women, 34 men). Results: No differences between both groups found with respect to age, age at symptoms onset, laterality and clinical manifestation of the first motor symptom of PD, Hoehn and Yahr (H-Y) stage, prevalence of wearing-off symptoms. Median L-dopa equivalent dose was similar in both groups. Regarding NMS 30 results, both groups differed significantly only in the subscore evaluating sexual dysfunctions (indicated by 26% of women and 45.5% of men, p = 0.006). When selected questions from the questionnaire were taken into consideration, drooling and excessive saliva was indicated significantly more frequently in men compared to women (18.1% of women and 32.1% of men, p = 0.027) whilst women expressed sad/ depressed mood feelings significantly more frequently than men (50.6% of women and 33.6% of men, p = 0.016). Concerning other scales, no significant differences were observed between both sexes. Conclusion: We found no differences between men and women with respect to motor manifestation of PD or the prevalence of wearing off phenomena. Regarding non-motor outcomes, slight differences were identified between both sexes, including the presence of sexual dysfunction and drooling (more frequent in men), and sad/ depressed mood feelings (more frequent in women). PO24-TH-11 Prevalence and risk factors of constipation in Thai Parkinson’s disease patients S. E-la1 , S. Gonlachanvit2 , R. Bhidayasiri1 . 1 Chulalongkorn Comprehensive Movement Disorders Center, Chulalongkorn University, Bangkok, Thailand; 2 Division of Gastroenterology, Chulalongkorn University, Bangkok, Thailand Objective: To determine the prevalence and risk factors of constipation among Thai Parkinson’s disease (PD) patients. Background: Constipation is considered to be the most common manifestation of autonomic dysfunction in PD. Compared to agematched and sex-matched controls, constipation is two to four times more common in patients with PD. Methods: 200 PD patients (pts) with various Hoehn & Yahr (H&Y) stages completed the Rome III criteria constipation module. In addition to clinical data on PD, constipation characteristics and treatment response of constipation were collected. Subjects were then divided into ‘constipation’ (A) and ‘no-constipation’ (B) groups in order to identify clinical characteristics and risk factors of constipation. Results: In 200 pts, there were 103 males and 97 females. 130 pts constipated. Mean age of pts was 63.5 yrs in A and 62.7 yrs in B (p < 0.05). Duration of PD was 7.4 yrs in A and 6.1 yrs in B (p = 0.1). The frequency of constipation was 55.7% in H&Y 1, 65.6% H&Y 2, 85.1% H&Y 2.5, 69.2% H&Y 3, 70% H&Y 4, and 66.67% H&Y 5. There were no statistically significant between PD cardinal symptoms between A and B (Tremor: 82.3% vs. 81.42%, p = 0.99, Rigidity: 77.69% vs. 64.29%, p = 0.061, Bradykinesia: 92.31% vs. 90.0%, p = 0.77, Postural instability: 90.77% vs. 87.14%, p = 0.58). There was no difference on the use of antiparkinsonian medication between two groups. Pts in A reported more problems with straining, hard stool, sensation of incomplete evacuation and blockage, <2 bowel movements per week and more frequent use of laxatives. Conclusion: Constipation is a frequent disabling symptom in PD, affecting more than 50% in all stages of PD severity. No associations were identified between the increased frequency of constipation