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PO29-FR-14 Quality of life evaluation in patients with migraine at headache clinic in King Chulalongkorn Memorial Hospital
S316
19th World Congress of Neurology, Poster Abstracts / Journal of the Neurological Sciences 285 S1 (2009) S155–S339
PO29-FR-14 Quality of life evaluation in patients with migraine at headache clinic in King Chulalongkorn Memorial Hospital P. Vorasayan, K. Phanthumchinda, T. Asawavichianjinda. Department of Medicine, Chulalongkorn University, Bangkok, Thailand Introduction: Migraine is a common neurological problem. The clinical features of migraine are recurrent unilateral headache with moderate to severe intensity. During headache, the patient often has nausea, vomiting, photophobia and/or phonophobia. Migraines adversely affect quality of life of the patient and is associated with disability. Objective: To evaluate and compare quality of life of migraine patients at Headache Clinic in King Chulalongkorn Memorial Hospital after treatment for 8 weeks. Method: New twelve migraine patients at Headache Clinic, diagnosed with migraine without aura, typical aura with migraine headache and chronic migraine according to IHS criteria, were recruited. Demographic data, frequency, duration and severity of headache, as well as headache characteristics and Migraine-Specific Quality of Life (MSQ) Version 2.1 (Thai Version) during each visit at 0, 4 and 8 weeks follow-up were collected. Analysis was performed by SPSS version 11.5. Result: Frequency and duration of headache significantly decreased after attending the Headache Clinic for 8 weeks. (p = 0.02 and 0.04 relatively). The quality of life also significantly increased from baseline at 8 weeks follow-up. (p < 0.001). The score of MSQ had a good relationship to the frequency of headache (p = 0.02), but not to duration and severity of headache. Conclusion: Migraine patients, treated and followed up at Headache Clinic, had clinical and quality-of-life improvement after 8-week follow-up. Quality of life evaluation correlates well with clinical indicators. PO29-FR-15 Clinical profile of chronic daily headache: study from a tertiary care referral centre D. Joshi, N. Kumar, S.P. Patidar. Neurology, I.M.S. B.H.U., Varanasi, India Purpose: Chronic daily headache (CDH) represents a range of disorders characterized by the occurrence of long-duration headache of 15 or more days per month. CDH may be primary or secondary to an underlying cause. CDH is associated with a significant disability and has an impact on quality of life. We present the clinical profile of CDH patients from a tertiary care referral centre in India. Material and method: All patient with clinical features of CDH attending neurology out patient department and or admitted in the neurology wards from January 2008 to March 2009 were enrolled. Patient were subjected to a detailed clinical and neurological examination. Relevant biochemical investigation were carried out. Neuroimaging (CT scan or MRI) was done in all. A total of 626 patient were included. Patients were classified into various headache subtypes using the ICHD-2 criteria. Results: A total of 626 patients were enrolled, out of which 606 were primary headache and 20 were secondary headache types. Male: Female ratio was 1:1.9. Age of presentation ranged from 16 to 65 years and duration of illness varied from 1 to 20 years. Overall patients were younger and the disease duration was less in the NDPH group. Out of 626 patient 374 had chronic migraine, 222 had CTTH and 10 patients were diagnosed as having NDPH. History of medication abuse was present in 75% of migraineurs and in 60% of CTTH group. Conclusion: Thus chronic migraine and CTTH comprised the majority of CDH patients while NDPH was the least common. A high percentage of patients had history of medication abuse in both the migraine and CTTH, more so in the former.
PO29-FR-16 Prevalence of cluster headache in the Republic of Georgia A. Dzagnidze1 , Z. Katsarava2 , M. Kukava1 , E. Mirvelashvili3 , M. Djibuti3 , M. Janelidze1 , R. Jensen4 , L.J. Stovner5 , T.J. Steiner6 . 1 Neurology, Tbilisi State Medical University Clinic, Tbilisi, Georgia; 2 Neurology, University of Essen, Essen, Germany; 3 School of Public Health, Tbilisi State Medical University, Tbilisi, Georgia; 4 Danish Headache Centre, Glostrup University, Copenhagen, Denmark; 5 Norwegian National Headache Centre, Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway; 6 Division of Neuroscience and Mental Health, Imperial College London, London, United Kingdom Purpose: Cluster headache (CH) is a strictly unilateral, severe or very severe retro-orbital or temporal headache lasting 15–180 min and accompanied by ipsilateral cranial autonomic symptoms and a sense of restlessness or agitation. It is methodologically challenging to measure its prevalence in general population samples. No data from the eastern European or post-Soviet countries are available yet. We present a study of the general-population prevalence of cluster headache in the Republic of Georgia and discuss the advantages and challenges of different methodological approaches. Method: In a community-based survey, specially trained medical residents visited 500 adjacent households in the capital city, Tbilisi, and 300 households in the eastern rural area of Kakheti. They interviewed all (n = 1145) biologically unrelated adult occupants using a previously validated questionnaire. The household responses rates were 92% in Tbilisi and 100% in Kakheti. The survey identified 32 persons with possible cluster headache, who were then personally interviewed by one of two headacheexperienced neurologists. Cluster headache was confirmed in one subject. Results: The prevalence of cluster headache was therefore estimated to be 87/100,000 (95% confidence interval <258/100,000). We used a conservative approach, which has an obvious advantage of high-quality data collection, but is very demanding of manpower and time. The main limitation of the study was that the population sample was too small to allow an accurate estimate of a rare disorder like CH. Conclusion: This is the first study to provide data on the prevalence of CH in an eastern European country. The methodology assured high quality of data collection. Ideally, it should have been three to four times as large to have sufficient statistical power. PO29-FR-17 Abstract withdrawn PO29-FR-18 Intracranial pachymeningitis associated with Sweet’s syndrome S. Setthawatcharawanich1 , N. Preejawai1 , K. Kayasut2 . 1 Department of Medicine, Prince of Songkla University, Songkhla, Thailand; 2 Department of Pathology, Prince of Songkla University, Songkhla, Thailand Although multiple organs involvement is a characteristic feature of Sweet’s syndrome, neurological involvement (neuro-Sweet disease) is rare. It commonly involves brain parenchyma which produces many symptoms such as alteration of consciousness, weakness, epilepsy, memory disturbance, involuntary movement as well as headache. Meningeal involvement has been found to be one-fourth of neuro-Sweet disease, but meningeal thickness is very rare. We herein present a case of Intracranial pachymeningitis in a 45-yearold woman presented with headache and acute dermopathy.
19th World Congress of Neurology, Poster Abstracts / Journal of the Neurological Sciences 285 S1 (2009) S155–S339
PO29-FR-14 Quality of life evaluation in patients with migraine at headache clinic in King Chulalongkorn Memorial Hospital P. Vorasayan, K. Phanthumchinda, T. Asawavichianjinda. Department of Medicine, Chulalongkorn University, Bangkok, Thailand Introduction: Migraine is a common neurological problem. The clinical features of migraine are recurrent unilateral headache with moderate to severe intensity. During headache, the patient often has nausea, vomiting, photophobia and/or phonophobia. Migraines adversely affect quality of life of the patient and is associated with disability. Objective: To evaluate and compare quality of life of migraine patients at Headache Clinic in King Chulalongkorn Memorial Hospital after treatment for 8 weeks. Method: New twelve migraine patients at Headache Clinic, diagnosed with migraine without aura, typical aura with migraine headache and chronic migraine according to IHS criteria, were recruited. Demographic data, frequency, duration and severity of headache, as well as headache characteristics and Migraine-Specific Quality of Life (MSQ) Version 2.1 (Thai Version) during each visit at 0, 4 and 8 weeks follow-up were collected. Analysis was performed by SPSS version 11.5. Result: Frequency and duration of headache significantly decreased after attending the Headache Clinic for 8 weeks. (p = 0.02 and 0.04 relatively). The quality of life also significantly increased from baseline at 8 weeks follow-up. (p < 0.001). The score of MSQ had a good relationship to the frequency of headache (p = 0.02), but not to duration and severity of headache. Conclusion: Migraine patients, treated and followed up at Headache Clinic, had clinical and quality-of-life improvement after 8-week follow-up. Quality of life evaluation correlates well with clinical indicators. PO29-FR-15 Clinical profile of chronic daily headache: study from a tertiary care referral centre D. Joshi, N. Kumar, S.P. Patidar. Neurology, I.M.S. B.H.U., Varanasi, India Purpose: Chronic daily headache (CDH) represents a range of disorders characterized by the occurrence of long-duration headache of 15 or more days per month. CDH may be primary or secondary to an underlying cause. CDH is associated with a significant disability and has an impact on quality of life. We present the clinical profile of CDH patients from a tertiary care referral centre in India. Material and method: All patient with clinical features of CDH attending neurology out patient department and or admitted in the neurology wards from January 2008 to March 2009 were enrolled. Patient were subjected to a detailed clinical and neurological examination. Relevant biochemical investigation were carried out. Neuroimaging (CT scan or MRI) was done in all. A total of 626 patient were included. Patients were classified into various headache subtypes using the ICHD-2 criteria. Results: A total of 626 patients were enrolled, out of which 606 were primary headache and 20 were secondary headache types. Male: Female ratio was 1:1.9. Age of presentation ranged from 16 to 65 years and duration of illness varied from 1 to 20 years. Overall patients were younger and the disease duration was less in the NDPH group. Out of 626 patient 374 had chronic migraine, 222 had CTTH and 10 patients were diagnosed as having NDPH. History of medication abuse was present in 75% of migraineurs and in 60% of CTTH group. Conclusion: Thus chronic migraine and CTTH comprised the majority of CDH patients while NDPH was the least common. A high percentage of patients had history of medication abuse in both the migraine and CTTH, more so in the former.
PO29-FR-16 Prevalence of cluster headache in the Republic of Georgia A. Dzagnidze1 , Z. Katsarava2 , M. Kukava1 , E. Mirvelashvili3 , M. Djibuti3 , M. Janelidze1 , R. Jensen4 , L.J. Stovner5 , T.J. Steiner6 . 1 Neurology, Tbilisi State Medical University Clinic, Tbilisi, Georgia; 2 Neurology, University of Essen, Essen, Germany; 3 School of Public Health, Tbilisi State Medical University, Tbilisi, Georgia; 4 Danish Headache Centre, Glostrup University, Copenhagen, Denmark; 5 Norwegian National Headache Centre, Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway; 6 Division of Neuroscience and Mental Health, Imperial College London, London, United Kingdom Purpose: Cluster headache (CH) is a strictly unilateral, severe or very severe retro-orbital or temporal headache lasting 15–180 min and accompanied by ipsilateral cranial autonomic symptoms and a sense of restlessness or agitation. It is methodologically challenging to measure its prevalence in general population samples. No data from the eastern European or post-Soviet countries are available yet. We present a study of the general-population prevalence of cluster headache in the Republic of Georgia and discuss the advantages and challenges of different methodological approaches. Method: In a community-based survey, specially trained medical residents visited 500 adjacent households in the capital city, Tbilisi, and 300 households in the eastern rural area of Kakheti. They interviewed all (n = 1145) biologically unrelated adult occupants using a previously validated questionnaire. The household responses rates were 92% in Tbilisi and 100% in Kakheti. The survey identified 32 persons with possible cluster headache, who were then personally interviewed by one of two headacheexperienced neurologists. Cluster headache was confirmed in one subject. Results: The prevalence of cluster headache was therefore estimated to be 87/100,000 (95% confidence interval <258/100,000). We used a conservative approach, which has an obvious advantage of high-quality data collection, but is very demanding of manpower and time. The main limitation of the study was that the population sample was too small to allow an accurate estimate of a rare disorder like CH. Conclusion: This is the first study to provide data on the prevalence of CH in an eastern European country. The methodology assured high quality of data collection. Ideally, it should have been three to four times as large to have sufficient statistical power. PO29-FR-17 Abstract withdrawn PO29-FR-18 Intracranial pachymeningitis associated with Sweet’s syndrome S. Setthawatcharawanich1 , N. Preejawai1 , K. Kayasut2 . 1 Department of Medicine, Prince of Songkla University, Songkhla, Thailand; 2 Department of Pathology, Prince of Songkla University, Songkhla, Thailand Although multiple organs involvement is a characteristic feature of Sweet’s syndrome, neurological involvement (neuro-Sweet disease) is rare. It commonly involves brain parenchyma which produces many symptoms such as alteration of consciousness, weakness, epilepsy, memory disturbance, involuntary movement as well as headache. Meningeal involvement has been found to be one-fourth of neuro-Sweet disease, but meningeal thickness is very rare. We herein present a case of Intracranial pachymeningitis in a 45-yearold woman presented with headache and acute dermopathy.