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Polydioxanone knotless thread lifting
1105
1422
Polydioxanone knotless thread lifting Hwa Jung Ryu, MD, PhD, Department of Dermatology, College of Medicine Korea University, Seoul, South Korea; Hee Won Jang, MD, Department of Dermatology, College of Medicine Korea University, Seoul, South Korea; Sang Jun Lee, MD, PhD, Arumdaun Nara Dermatologic Clinic, Seoul, South Korea; Won Seok Lee, MD, Gold Plastic Surgery, Seoul, South Korea; Dong Hye Suh, MD, PhD, Arumdaun Nara Dermatologic Clinic, Seoul, South Korea
The efficacy and safety of injection with PP-501-A-lidocaine in correction of nasolabial fold: A multicenter, randomized, patient and evaluator blinded, matched pairs, active controlled design clinical study Hoon Kang, MD, PhD, Department of Dermatology, St Paul’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea; Won Joon Choi, MD, Department of Dermatology, St Paul’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea; Jung Eun Kim, MD, PhD, Department of Dermatology, St Paul’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea; Hye Won Kim, MD, Department of Dermatology, Gangnam Sacred Heart Hospital, Seoul, Korea; Moon Beom Kim, MD, Department of Dermatology, Pusan National University Hospital, Pusan, South Korea Background: The use of injectable hyaluronic acidebased gel is well established in aesthetic facial procedures especially on nasolabial fold (NLF). Objective: To compare dermal filler efficacy, and safety of PP-501-A-lidocaine with Restylane Lidocaine when administered to the NLF.
Background: As average life span increases, demand has risen for procedures to help maintain a youthful appearance. Thread lifting is a minimally invasive technique for facial rejuvenation. Various devices for thread lifting using polydioxanone are popular in aesthetic plastic surgery and dermatology clinics in Korea, but there have been a few studies regarding its use. This study describes polydioxanone thread and techniques adopted to counteract the descent and laxity of the face. Methods: A retrospective chart review was conducted over a 24-month period. A total of 31 thread lifting procedures were performed under local anesthesia. The physicians marked the areas of thread insertion in seated patients preoperatively to determine the appropriate vector of the thread. Bidirectional cog threads were used in the procedure for the flabby skin of the nasolabial folds and the jaw line. Threads were inserted in the correction direction of the vector of the subcutaneous layer of the sagging skin. The procedure was done on the marionette line using two twin threads inserted lateral to the marionette line, parallel to the margin of the chin. Results: In most patients (87%), the results obtained were considered satisfactory. Consensus ratings by two physicians found that objective outcomes were divided among ‘‘excellent,’’ ‘‘good,’’ ‘‘fair,’’ and ‘‘poor.’’ Texture-wise, the outcome ratings were 13 as excellent (41.9%), 9 as good (29.0%), 8 as fair (25.8%), and 1 as poor (3.2%). Lifting-wise, ratings were 11 as excellent (35.5%), 6 as good (19.4%), 5 as fair (16.1%), and 9 as poor (29.0%). The incidence of complications was low and not serious. Conclusions: Facial rejuvenation using polydioxanone thread is a safe and effective procedure associated with only minor complications when performed on patients with modest face sagging, fine wrinkles, and marked facial pores. Commercial support: None identified.
Methods: Sixty-six subjects seeking correction of NLFs, with moderate or severe wrinkle severity, were recruited for this multicenter, randomized, patient and evaluator-blinded, matched pairs, active-controlled design clinical study. PP-501-Alidocaine and Restylane LidocaineÒ was injected into the deep layer of the dermis and/or subcutis, of the NLF. First validity evaluation was average Wrinkle Severity Rating Scale (WSRS) by independent assessors on the 24 week. Second validity evaluation variable including the Global Aesthetic Improvement Scale (GAIS), the WSRS, and adverse event reporting for 8, 16, 24 weeks between two groups were done. Results: The mean improvement in the WSRS from baseline was 1.57 6 0.62 for the PP-501-A-lidocaine and 1.50 6 0.60 for the Restylane Lidocaine at week 24. The average value on 8th week after final application is 1.57 6 0.68 and 1.55 6 0.63 in parts subject to PP-501-A-lidocaine and Restylane Lidocaine and 1.55 6 0.65 and 1.55 6 0.63 on the week 16. Both improvement and duration of treatment effect were similar between two groups. GAIS data rated by treating investigator and study subjects showed no statistically significant difference. Both fillers were welltolerated and adverse reactions were mild and transient in most cases. Conclusions: PP-501-A-lidocaine showed an equivalent efficacy and safety observed after 6 months of follow-up compared to Restylane Lidocaine. Commercial support: None identified.
900 Postoperative use of a TCA chemical peel to treat residual AK and improve scar cosmesis David Pate, MD, Texas Tech Univeristy Health Science Center, Lubbock, TX, United States; Jordan Jamerson, Texas Tech Univeristy Health Science Center, Lubbock, TX, United States; Ashley Sturgeon, MD, Texas Tech Univeristy Health Science Center, Lubbock, TX, United States; Ikue Shimizu, MD, Texas Tech Univeristy Health Science Center, Lubbock, TX, United States A 71-year-old female with a history of numerous nonmelanoma skin cancers and actinic keratoses (AK) presented with lesions on her left fourth finger and right forehead. Biopsies demonstrated squamous cell carcinoma (SCC) with involved margins and SCC in situ, respectively. Mohs micrographic surgery was performed on both. Residual focal AKs were seen in the margins of both lesions and subsequent treatment with a 35% trichloroacetic acid (TCA) chemical peel was performed to the affected areas of the scars. Subsequent follow-up demonstrated improved scar appearance in the TCA-treated regions compared to untreated areas, with no clinically apparent AKs. We recommend considering a TCA chemical peel postoperatively for treatment of residual AKs in excision margins or in surgical site background due to the additional benefit of improved scar cosmesis without significant patient time commitment or inflammation. Commercial support: None identified.
AB258
J AM ACAD DERMATOL
MAY 2015
1422
Polydioxanone knotless thread lifting Hwa Jung Ryu, MD, PhD, Department of Dermatology, College of Medicine Korea University, Seoul, South Korea; Hee Won Jang, MD, Department of Dermatology, College of Medicine Korea University, Seoul, South Korea; Sang Jun Lee, MD, PhD, Arumdaun Nara Dermatologic Clinic, Seoul, South Korea; Won Seok Lee, MD, Gold Plastic Surgery, Seoul, South Korea; Dong Hye Suh, MD, PhD, Arumdaun Nara Dermatologic Clinic, Seoul, South Korea
The efficacy and safety of injection with PP-501-A-lidocaine in correction of nasolabial fold: A multicenter, randomized, patient and evaluator blinded, matched pairs, active controlled design clinical study Hoon Kang, MD, PhD, Department of Dermatology, St Paul’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea; Won Joon Choi, MD, Department of Dermatology, St Paul’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea; Jung Eun Kim, MD, PhD, Department of Dermatology, St Paul’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea; Hye Won Kim, MD, Department of Dermatology, Gangnam Sacred Heart Hospital, Seoul, Korea; Moon Beom Kim, MD, Department of Dermatology, Pusan National University Hospital, Pusan, South Korea Background: The use of injectable hyaluronic acidebased gel is well established in aesthetic facial procedures especially on nasolabial fold (NLF). Objective: To compare dermal filler efficacy, and safety of PP-501-A-lidocaine with Restylane Lidocaine when administered to the NLF.
Background: As average life span increases, demand has risen for procedures to help maintain a youthful appearance. Thread lifting is a minimally invasive technique for facial rejuvenation. Various devices for thread lifting using polydioxanone are popular in aesthetic plastic surgery and dermatology clinics in Korea, but there have been a few studies regarding its use. This study describes polydioxanone thread and techniques adopted to counteract the descent and laxity of the face. Methods: A retrospective chart review was conducted over a 24-month period. A total of 31 thread lifting procedures were performed under local anesthesia. The physicians marked the areas of thread insertion in seated patients preoperatively to determine the appropriate vector of the thread. Bidirectional cog threads were used in the procedure for the flabby skin of the nasolabial folds and the jaw line. Threads were inserted in the correction direction of the vector of the subcutaneous layer of the sagging skin. The procedure was done on the marionette line using two twin threads inserted lateral to the marionette line, parallel to the margin of the chin. Results: In most patients (87%), the results obtained were considered satisfactory. Consensus ratings by two physicians found that objective outcomes were divided among ‘‘excellent,’’ ‘‘good,’’ ‘‘fair,’’ and ‘‘poor.’’ Texture-wise, the outcome ratings were 13 as excellent (41.9%), 9 as good (29.0%), 8 as fair (25.8%), and 1 as poor (3.2%). Lifting-wise, ratings were 11 as excellent (35.5%), 6 as good (19.4%), 5 as fair (16.1%), and 9 as poor (29.0%). The incidence of complications was low and not serious. Conclusions: Facial rejuvenation using polydioxanone thread is a safe and effective procedure associated with only minor complications when performed on patients with modest face sagging, fine wrinkles, and marked facial pores. Commercial support: None identified.
Methods: Sixty-six subjects seeking correction of NLFs, with moderate or severe wrinkle severity, were recruited for this multicenter, randomized, patient and evaluator-blinded, matched pairs, active-controlled design clinical study. PP-501-Alidocaine and Restylane LidocaineÒ was injected into the deep layer of the dermis and/or subcutis, of the NLF. First validity evaluation was average Wrinkle Severity Rating Scale (WSRS) by independent assessors on the 24 week. Second validity evaluation variable including the Global Aesthetic Improvement Scale (GAIS), the WSRS, and adverse event reporting for 8, 16, 24 weeks between two groups were done. Results: The mean improvement in the WSRS from baseline was 1.57 6 0.62 for the PP-501-A-lidocaine and 1.50 6 0.60 for the Restylane Lidocaine at week 24. The average value on 8th week after final application is 1.57 6 0.68 and 1.55 6 0.63 in parts subject to PP-501-A-lidocaine and Restylane Lidocaine and 1.55 6 0.65 and 1.55 6 0.63 on the week 16. Both improvement and duration of treatment effect were similar between two groups. GAIS data rated by treating investigator and study subjects showed no statistically significant difference. Both fillers were welltolerated and adverse reactions were mild and transient in most cases. Conclusions: PP-501-A-lidocaine showed an equivalent efficacy and safety observed after 6 months of follow-up compared to Restylane Lidocaine. Commercial support: None identified.
900 Postoperative use of a TCA chemical peel to treat residual AK and improve scar cosmesis David Pate, MD, Texas Tech Univeristy Health Science Center, Lubbock, TX, United States; Jordan Jamerson, Texas Tech Univeristy Health Science Center, Lubbock, TX, United States; Ashley Sturgeon, MD, Texas Tech Univeristy Health Science Center, Lubbock, TX, United States; Ikue Shimizu, MD, Texas Tech Univeristy Health Science Center, Lubbock, TX, United States A 71-year-old female with a history of numerous nonmelanoma skin cancers and actinic keratoses (AK) presented with lesions on her left fourth finger and right forehead. Biopsies demonstrated squamous cell carcinoma (SCC) with involved margins and SCC in situ, respectively. Mohs micrographic surgery was performed on both. Residual focal AKs were seen in the margins of both lesions and subsequent treatment with a 35% trichloroacetic acid (TCA) chemical peel was performed to the affected areas of the scars. Subsequent follow-up demonstrated improved scar appearance in the TCA-treated regions compared to untreated areas, with no clinically apparent AKs. We recommend considering a TCA chemical peel postoperatively for treatment of residual AKs in excision margins or in surgical site background due to the additional benefit of improved scar cosmesis without significant patient time commitment or inflammation. Commercial support: None identified.
AB258
J AM ACAD DERMATOL
MAY 2015