- Email: [email protected]
Polygraphic study during sleep in the Lennox syndrome
s37
A transference phenomenon to the hippocampus may be an explanation , but the time for establishment of generalization was much shorter than that for the induction by electrical stimIn addition, at this ulation reported by Sato. stage the amygdala was not established as the primary focus of secondary generalization. The results suggest that the nature of the chemically induced focus is different from that induced by electrical stimulation. Further discussion will compare KA and electrically induced foci. B-5.05 POLYGRAPHIC STUDY DURING SLEEP IN THE Y. Iwakawa, T. Niwa, M. Ogiso, LENNOX SYNDROME. T. Dan, S. Hosaka, M. Toyoda, H. Segawa and Y. Nomura (Tokyo, Japan) In order to clarify the relationship between the brain-stem functions and the prognosis of Lennox syndrome, all-night sleep polygraphs were performed. Eight patients aged from 5 to 17 years were divided into two groups according to their prognosis: group 1 showed relatively good prognosis and group 2 were intractable. Polygraphic recording consisted of EEG, EOG and surface EMG. Body movement was classified in two types: gross movement (GM, diffuse electrical discharge on surface EMG) and twitch movement (TM, localized discharge). 1) In contrast to normal subjects and group I, in whom GM and TM were prominent in stage 1 and REM, group 2 showed an abnormal distribution of body movements, especially in TM. 2) In one case of group 2, seizures as well as TM were partially improved by administration of L-dopa. The abnormal distribution of TM in arouo 2 mav reflect abnormalitv of the dopaminergic system in this group,-since TM is thought to depend on that system. The clinical and polygraphic improvement in a patient of group 2 caused by the administration of L-dopa would also indicate the contribution of the dopaminergic system to the prognosis of the Lennox syndrome. D-20.06 ASYMMETRY OF AEP PHRENICS WITH PERSISTENT TIONS. K. Hiramatsu, S. O.Saitoh, Y. Saitoh and Japan)
PATTERNS IN SCHIZOAUDITORY HALLUCINANiwa, T. Kameyama, K. Itoh (Bunkyo,
To investiqate the abnormal verbal behavior in schizophrenics physiologically, auditory evoked potentials (AEPs) elicited bv tone bursts (1 kc/ set, 150 m&c, 76 dB, l/2 se;) were examined in' 6 schizophrenics with persistent auditory hallucinations. EEGs were recorded at T3, T4 and Cz monopolarly. In 5 patients the NlOO peak of the AEP derived from T3 showed a characteristic double-peaked pattern, while that from T4 remained single-peakeo. The mean latencies of each sub-component of the double-peaked NlOO
were 81, llC!, 138 msec (first negative peak, positive peak and second negative peak respecSince the mean NlOO latency of the tively). AEP from T4 was 107 msec, the AEPs displayed phase reversal between T3 and T4 in these paThe distribution of the double-peaked tients. NlOO was localized near T3. Visual stimuli failed to show similar asvmmetrv of VEP patterns in the relevant region. ?he hailucinatibns of these patients were neither dialogic nor systematic, but rather fragmentary. Results of further experiments will be reported in which stimulus conditions were changed in terms of stimulus intensity, stimulus duration and interstimulus interval to ascertain more precise characteristics of the AEPs in these patients. B-17.03 EVOKED EMG TEST FOR PROG1!OSTIC DIAGNOSIS OF PATIENTS WITH PERIPHERAL FACIAL NERVE PALSY. I. Satoh (Kurume, Japan) When an evoked EMG test is applied to a perioheral facial nerve oalsv. the electrical stimulation must be given on"the distal side of the nerve lesion. Therefore, threshold and latency are not so available. The authors found that the number of spikes in an evoked wave induced by a bipolar concentric needle electrode show the degree of the nerve lesion more than other factors in evoked EMG. At this congress, criteria for prognosis of patients with peripheral facial nerve palsy are presented. Also an animal experiment using facial nerve of rabbits is shown in order to clarify the relation between the degree of the nerve lesion and the number of spikes. B-18.04 EMGRESPONSESTORAPID PULLPERTURBATIONAPPLIEDBY ADC TORQUEMOTOR IN MAN. H. Yokochi (Tokyo, Japan) A.Strupplerand F.Velho (Munich,W.Germany) The EMG responses in brachialis to a sudden rapid pull applied by a torque motor were studied innormai subjects. They consisted of three comoonents. Rl. R2 and R3. with mean latencies of 23, 50 and 82 msec respectively. In the first series of experiment, the perturbing torque was constant and the steady state load before the perturbation was changed stepwise (0 - 6.8 Nm). In the second series, the torque was changed stepwise (0.8 - 4.5 Nm), while the steady load was maintained at the same level with a constant torque. In both series, the instruction was given to the subject to maintain a same steady position despite the perturbation ("resist") or not to fix but to allow passive displacement of the forearm ("let go"). For quantitative analysis, the digital integration of the rectified averaged EMG of the period from 50 msec prior to perturbation to the start of Rl, and that of each component were measured. The integrals of Rl, the monosynaptic spinal reflex, and of R2, the so-called long-loop reflex, increased stepwise on exponential curves with
A transference phenomenon to the hippocampus may be an explanation , but the time for establishment of generalization was much shorter than that for the induction by electrical stimIn addition, at this ulation reported by Sato. stage the amygdala was not established as the primary focus of secondary generalization. The results suggest that the nature of the chemically induced focus is different from that induced by electrical stimulation. Further discussion will compare KA and electrically induced foci. B-5.05 POLYGRAPHIC STUDY DURING SLEEP IN THE Y. Iwakawa, T. Niwa, M. Ogiso, LENNOX SYNDROME. T. Dan, S. Hosaka, M. Toyoda, H. Segawa and Y. Nomura (Tokyo, Japan) In order to clarify the relationship between the brain-stem functions and the prognosis of Lennox syndrome, all-night sleep polygraphs were performed. Eight patients aged from 5 to 17 years were divided into two groups according to their prognosis: group 1 showed relatively good prognosis and group 2 were intractable. Polygraphic recording consisted of EEG, EOG and surface EMG. Body movement was classified in two types: gross movement (GM, diffuse electrical discharge on surface EMG) and twitch movement (TM, localized discharge). 1) In contrast to normal subjects and group I, in whom GM and TM were prominent in stage 1 and REM, group 2 showed an abnormal distribution of body movements, especially in TM. 2) In one case of group 2, seizures as well as TM were partially improved by administration of L-dopa. The abnormal distribution of TM in arouo 2 mav reflect abnormalitv of the dopaminergic system in this group,-since TM is thought to depend on that system. The clinical and polygraphic improvement in a patient of group 2 caused by the administration of L-dopa would also indicate the contribution of the dopaminergic system to the prognosis of the Lennox syndrome. D-20.06 ASYMMETRY OF AEP PHRENICS WITH PERSISTENT TIONS. K. Hiramatsu, S. O.Saitoh, Y. Saitoh and Japan)
PATTERNS IN SCHIZOAUDITORY HALLUCINANiwa, T. Kameyama, K. Itoh (Bunkyo,
To investiqate the abnormal verbal behavior in schizophrenics physiologically, auditory evoked potentials (AEPs) elicited bv tone bursts (1 kc/ set, 150 m&c, 76 dB, l/2 se;) were examined in' 6 schizophrenics with persistent auditory hallucinations. EEGs were recorded at T3, T4 and Cz monopolarly. In 5 patients the NlOO peak of the AEP derived from T3 showed a characteristic double-peaked pattern, while that from T4 remained single-peakeo. The mean latencies of each sub-component of the double-peaked NlOO
were 81, llC!, 138 msec (first negative peak, positive peak and second negative peak respecSince the mean NlOO latency of the tively). AEP from T4 was 107 msec, the AEPs displayed phase reversal between T3 and T4 in these paThe distribution of the double-peaked tients. NlOO was localized near T3. Visual stimuli failed to show similar asvmmetrv of VEP patterns in the relevant region. ?he hailucinatibns of these patients were neither dialogic nor systematic, but rather fragmentary. Results of further experiments will be reported in which stimulus conditions were changed in terms of stimulus intensity, stimulus duration and interstimulus interval to ascertain more precise characteristics of the AEPs in these patients. B-17.03 EVOKED EMG TEST FOR PROG1!OSTIC DIAGNOSIS OF PATIENTS WITH PERIPHERAL FACIAL NERVE PALSY. I. Satoh (Kurume, Japan) When an evoked EMG test is applied to a perioheral facial nerve oalsv. the electrical stimulation must be given on"the distal side of the nerve lesion. Therefore, threshold and latency are not so available. The authors found that the number of spikes in an evoked wave induced by a bipolar concentric needle electrode show the degree of the nerve lesion more than other factors in evoked EMG. At this congress, criteria for prognosis of patients with peripheral facial nerve palsy are presented. Also an animal experiment using facial nerve of rabbits is shown in order to clarify the relation between the degree of the nerve lesion and the number of spikes. B-18.04 EMGRESPONSESTORAPID PULLPERTURBATIONAPPLIEDBY ADC TORQUEMOTOR IN MAN. H. Yokochi (Tokyo, Japan) A.Strupplerand F.Velho (Munich,W.Germany) The EMG responses in brachialis to a sudden rapid pull applied by a torque motor were studied innormai subjects. They consisted of three comoonents. Rl. R2 and R3. with mean latencies of 23, 50 and 82 msec respectively. In the first series of experiment, the perturbing torque was constant and the steady state load before the perturbation was changed stepwise (0 - 6.8 Nm). In the second series, the torque was changed stepwise (0.8 - 4.5 Nm), while the steady load was maintained at the same level with a constant torque. In both series, the instruction was given to the subject to maintain a same steady position despite the perturbation ("resist") or not to fix but to allow passive displacement of the forearm ("let go"). For quantitative analysis, the digital integration of the rectified averaged EMG of the period from 50 msec prior to perturbation to the start of Rl, and that of each component were measured. The integrals of Rl, the monosynaptic spinal reflex, and of R2, the so-called long-loop reflex, increased stepwise on exponential curves with