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Polymeric reagents for immobilizing biopolymers (RC Milton, US)
• les derniers brevets deposes : morceaux choisis r6alis(~e en collaboration avec I'lnpi
AGRICtlLTUREA6 R(.: I h 'J US f R IE Productions vegetales
leurs applications dans le domaine de la regulation des teneurs en lignines des plantes (L Faye et al, FR, RU) CNRS et les inventeurs N° WO 97/45549, PCT.
> Potato plants with reduced cytosolic starch phosphorylasis and modified germination (J Kossmann et al, DE) M a x Planck-Gesellschaft zur F6rderung der Wissenchaften and the inventors N° W0 97/44471, PCT
i
The description relates to transgenic potato plants containing cells having a reduced cytosolic starch phosphorylasis activity in comparison with wild types of plant. By comparison with tubers of wild plant types, tuhers of such potato plants exhibit a drastically altered germination behaviour, restilting in an increased number of sprout ends and hence of stolones and tubers. Plants from such tubers give higher yields. > Plant immunization compositions (E Moesinger, DE) Novartis AG and the inventor N° W0 97/45018, PCT.
The present invention prorides an agent for inducing resistance against phytopathogenic microorganisnls in plants wherein the agent in an extract of biomass from non-plant-pathogenic microorganisms obtainable by the following process: a) resuspending 50g to 200g dry weight) of biomass fron nonplant-pathogenic microorganisms per liter of inorganic or organic solvent; b) stirring at room temperature for 1 to 12 hours; c) incubating; d) resuspending; e) allowing to COOl t o r o o n ] telnperature; and f} optionally filtering. > Nucleic acid molecules encoding enzymes from wheat which are involved in starch synthesis (M Block et al, DE) Hoechst Schering Agrevo GmbH and the inventors N° WO 97/45545, PCT
> S~quences d'ADN codant pour des laccases, et 42 BIOFUTUR176 • Mars1998
l.a pr~sente invention concerne toute s(3quence d'AI)N comprenant ~ titre de rdgion codante, tout ou t,artie de la sdquence nucleotidique codant pour un AP,N m codant pour une laccase, ou tout ou partie de la s6quence nucldotidique con> pl6mentaire de cette dernibre ct codant pour un A R N m antisens susceptible de s'bybridcr avec I'ARNm suslnentionnd, l:invention vise vgalement I'utilisation des seSquences susmentionn~Ses pour la mist en oeuvre de proc~dds de rdgulation de la biosynth(~se de lignines chez tes plantes.
> Souches de levure de fermentation brassicole (F Gendre et al, FR) Brasseries Kronenbourg N° 2750703. FR.
La presente invention est re{ative fi une culture pure d'une souche de Saccharomyces cerevisiae, caract6risee en ce que ladite souche possgede un ratio de croissance R, d6fini par la formule : R = (1,5 typg) + tynb (dans laquelle typg reprdsente le temps de g~)n6ration sur un milieu riche, et tvnb repr6sente le temps de gt{'n~ration sur un milieu minimum), infdrieur ou dgal h 6,5.
SANTE ¢~1) I!5!~}I :: el
~:,e!~, !i d e
> Specific inhibitors of DNA methyltransferase enzymet (M Szyf et P Bigey, CA, FR) McGill University N° WO 97/44346. PCT.
The invention provides novel mechanism-based inhibitors of DNA methyltransferase enzyme, and diagnostic and therapeutic uses for the same (...) > Novel synthetic protein
•
structural templates for the generation, screeninc and evolution of functionnal molecular surfaces (H Bruhn et al, DE)
forms PrPc and PrPsc (S Weiss et al, DE)
M e d i g e n e and the inventors N° WO 97145538, PCT.
The present invention relates to methods for the detection or isolation ot prion proteins bv use ot chaperones specifically binding to said proteins. ]'he invention further relates to a method for in vitro, diagnosis of a transmissible spongiform encephalopathy...
The present invention relates to generaly to protein molecules with novel binding or catalytic properties (...) > Interleukin-1 beta converting enzyme like apoptotic protease 7 (VM Dixit et al, US) SmithKline Beecham Corp, Human G e n o m e Sciences Inc and the inventors N° WO 97/46662, PCT
H u m a n ICE LAP-7 polypeptides and DNA (RNA) encoding such ICF I~AP-7 and a procedure for procedrag such polypeptides by recombinant techniques is dis,closed. Also disclosed are methods for utilizing such ICE I,AP-7 for the treatment of a susceptibility m viral infection, tumorogenesis and to diseases and defects m the control embryogenesis and tissue homeostasis~ and the nucleic acid sequences described above may be employed in an assay for ascertaining such susceptibilit~ (...)
> Neurotransmitters (SG Grant, RU) The University of Edinburgh and the inventor N° W0 97/46877, PCT.
The structure of an NMDA receptor signalling complex (NRSC) is elucidated, and a method disclosed for deter mining whether a candidate substance is likely to be ef fective in m~x:lifyingthe func tion of an NMDA or a non N M D A glutamate neurotransmitter receptor, the me thod comprising the step of monitoring :he effect of the, substance on the activity or signalling capacity of the NRSC, or a component thereof (..,)
> Chaperones capable of binding to prion proteins and distinguishing the iso-
EL Winnacker and the inventors N° W0 97/43649, PCI.
> Method and probes for the identification of microbial genes specifically induced during host infection (MJ Mahan et al, US) The Regents of t h e University of California and the inventors N° WO 97/4448?, PCT.
> Prion protein binding proteins and uses thereof (NR Cashman and V Dodelet, CA) McGill University N° WO 97/45746. PCJ.
in general, the invention features prkm protein binding proteins (PrPBPs) and diagnostic, therapeutic, and decontamination uses thereof. The invenlion also features fusion protein reagents for PrPBP isolation. > Polymeric reagents for immobilizing biopolymers (RC Milton, US) Beckman instruments Inc N° W0 97/46597, PCT
Reagents tor tile inmlobilization fo biopolymers, processes for their preparation and their subsequent use m the immobilized of biopolymers for analytical and diagnostic procedures art, described (...) > Transgenic animals expressing artificial epitopetagged proteins (SB Prusiner et al, US) The R e g e n t s of the University of California N° W0 97/46572, PC'[.
DNA constructs are provided of epitopes-tagged proteins or protein fragments which are conveniently purified with immunoaffinity chron~atography such as epitope-ragged prion proteins (PrPL
AGRICtlLTUREA6 R(.: I h 'J US f R IE Productions vegetales
leurs applications dans le domaine de la regulation des teneurs en lignines des plantes (L Faye et al, FR, RU) CNRS et les inventeurs N° WO 97/45549, PCT.
> Potato plants with reduced cytosolic starch phosphorylasis and modified germination (J Kossmann et al, DE) M a x Planck-Gesellschaft zur F6rderung der Wissenchaften and the inventors N° W0 97/44471, PCT
i
The description relates to transgenic potato plants containing cells having a reduced cytosolic starch phosphorylasis activity in comparison with wild types of plant. By comparison with tubers of wild plant types, tuhers of such potato plants exhibit a drastically altered germination behaviour, restilting in an increased number of sprout ends and hence of stolones and tubers. Plants from such tubers give higher yields. > Plant immunization compositions (E Moesinger, DE) Novartis AG and the inventor N° W0 97/45018, PCT.
The present invention prorides an agent for inducing resistance against phytopathogenic microorganisnls in plants wherein the agent in an extract of biomass from non-plant-pathogenic microorganisms obtainable by the following process: a) resuspending 50g to 200g dry weight) of biomass fron nonplant-pathogenic microorganisms per liter of inorganic or organic solvent; b) stirring at room temperature for 1 to 12 hours; c) incubating; d) resuspending; e) allowing to COOl t o r o o n ] telnperature; and f} optionally filtering. > Nucleic acid molecules encoding enzymes from wheat which are involved in starch synthesis (M Block et al, DE) Hoechst Schering Agrevo GmbH and the inventors N° WO 97/45545, PCT
> S~quences d'ADN codant pour des laccases, et 42 BIOFUTUR176 • Mars1998
l.a pr~sente invention concerne toute s(3quence d'AI)N comprenant ~ titre de rdgion codante, tout ou t,artie de la sdquence nucleotidique codant pour un AP,N m codant pour une laccase, ou tout ou partie de la s6quence nucldotidique con> pl6mentaire de cette dernibre ct codant pour un A R N m antisens susceptible de s'bybridcr avec I'ARNm suslnentionnd, l:invention vise vgalement I'utilisation des seSquences susmentionn~Ses pour la mist en oeuvre de proc~dds de rdgulation de la biosynth(~se de lignines chez tes plantes.
> Souches de levure de fermentation brassicole (F Gendre et al, FR) Brasseries Kronenbourg N° 2750703. FR.
La presente invention est re{ative fi une culture pure d'une souche de Saccharomyces cerevisiae, caract6risee en ce que ladite souche possgede un ratio de croissance R, d6fini par la formule : R = (1,5 typg) + tynb (dans laquelle typg reprdsente le temps de g~)n6ration sur un milieu riche, et tvnb repr6sente le temps de gt{'n~ration sur un milieu minimum), infdrieur ou dgal h 6,5.
SANTE ¢~1) I!5!~}I :: el
~:,e!~, !i d e
> Specific inhibitors of DNA methyltransferase enzymet (M Szyf et P Bigey, CA, FR) McGill University N° WO 97/44346. PCT.
The invention provides novel mechanism-based inhibitors of DNA methyltransferase enzyme, and diagnostic and therapeutic uses for the same (...) > Novel synthetic protein
•
structural templates for the generation, screeninc and evolution of functionnal molecular surfaces (H Bruhn et al, DE)
forms PrPc and PrPsc (S Weiss et al, DE)
M e d i g e n e and the inventors N° WO 97145538, PCT.
The present invention relates to methods for the detection or isolation ot prion proteins bv use ot chaperones specifically binding to said proteins. ]'he invention further relates to a method for in vitro, diagnosis of a transmissible spongiform encephalopathy...
The present invention relates to generaly to protein molecules with novel binding or catalytic properties (...) > Interleukin-1 beta converting enzyme like apoptotic protease 7 (VM Dixit et al, US) SmithKline Beecham Corp, Human G e n o m e Sciences Inc and the inventors N° WO 97/46662, PCT
H u m a n ICE LAP-7 polypeptides and DNA (RNA) encoding such ICF I~AP-7 and a procedure for procedrag such polypeptides by recombinant techniques is dis,closed. Also disclosed are methods for utilizing such ICE I,AP-7 for the treatment of a susceptibility m viral infection, tumorogenesis and to diseases and defects m the control embryogenesis and tissue homeostasis~ and the nucleic acid sequences described above may be employed in an assay for ascertaining such susceptibilit~ (...)
> Neurotransmitters (SG Grant, RU) The University of Edinburgh and the inventor N° W0 97/46877, PCT.
The structure of an NMDA receptor signalling complex (NRSC) is elucidated, and a method disclosed for deter mining whether a candidate substance is likely to be ef fective in m~x:lifyingthe func tion of an NMDA or a non N M D A glutamate neurotransmitter receptor, the me thod comprising the step of monitoring :he effect of the, substance on the activity or signalling capacity of the NRSC, or a component thereof (..,)
> Chaperones capable of binding to prion proteins and distinguishing the iso-
EL Winnacker and the inventors N° W0 97/43649, PCI.
> Method and probes for the identification of microbial genes specifically induced during host infection (MJ Mahan et al, US) The Regents of t h e University of California and the inventors N° WO 97/4448?, PCT.
> Prion protein binding proteins and uses thereof (NR Cashman and V Dodelet, CA) McGill University N° WO 97/45746. PCJ.
in general, the invention features prkm protein binding proteins (PrPBPs) and diagnostic, therapeutic, and decontamination uses thereof. The invenlion also features fusion protein reagents for PrPBP isolation. > Polymeric reagents for immobilizing biopolymers (RC Milton, US) Beckman instruments Inc N° W0 97/46597, PCT
Reagents tor tile inmlobilization fo biopolymers, processes for their preparation and their subsequent use m the immobilized of biopolymers for analytical and diagnostic procedures art, described (...) > Transgenic animals expressing artificial epitopetagged proteins (SB Prusiner et al, US) The R e g e n t s of the University of California N° W0 97/46572, PC'[.
DNA constructs are provided of epitopes-tagged proteins or protein fragments which are conveniently purified with immunoaffinity chron~atography such as epitope-ragged prion proteins (PrPL