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POLYMORPHISMS ASSOCIATED WITH ORAL CLEFTS AS POSSIBLE MARKERS OF SUSCEPTIBILITY FOR BREAST CANCER AND ORAL CANCER
OOOO Volume 129, Number 1 the professional/student. As the user creates interest in the topics covered, it is expected that they seek to deepen their knowledge in the available bibliography. Conclusion: Given the great adhesion to smartphones by the general population, this tool serves as a source of research and contributes to the dissemination of specialized content, making it possible to generate faster and more accurate diagnoses.
TRENDS IN MORTALITY DUE TO ORAL AND OROPHARYNGEAL CANCERS IN URUGUAY FROM 1997 TO 2014. MARIA LAURA COSETTI, AMANDA RAMOS DA CUNHA, TAIANE SCHAEDLER PRASS, MARCO ANTONIO TREVIZANI MARTINS, VINICIUS COELHO CARRARD, FERNANDO NEVES HUGO and, MANOELA DOMINGUES MARTINS Objective: To analyze the trend of oral and oropharyngeal cancer mortality in Uruguay between 1997 and 2014 and the rates by age, sex, and departments of the country. Study Design: A time-series ecological study with secondary data. To establish an estimation of the mortality trend of the historical series, by sex, anatomic site, and age groups, linear regressions were generated by the Prais-Winsten procedure. Results: Between 1997 and 2014, there were 1696 deaths from oral cancer and oropharyngeal cancer in Uruguay. The male to female ratio was 3.23:1. Malignant neoplasm of tongue presented the highest mortality rate. The mortality rate was relatively stable (total and by sex) in all age groups studies. Means of the annual coefficients were higher for the age groups between 50 and 79 years. In women, the trend remained stable in the different departments of the country, except in Lavalleja and Maldonado where there was an increase, while in men a decrease in Artigas and Rivera was observed. Conclusion: The mortality for oral and oropharyngeal cancer in Uruguay has remained constant for the period of 1997 to 2014. Prevention strategies and early diagnosis are necessary to improve survival.
ORAL HEALTH, HEALTH-RELATED QUALITY OF LIFE, AND WORK ABILITY AMONG PATIENTS WITH CHRONIC LIVER DISEASE. LARISSA SOUZA SANTOS, FERNANDO MARTINS CARVALHO, VIVIANE ALMEIDA SARMENTO, LIANA CODES, MARIA AUXILIADORA EVANGELISTA, ALESSANDRA DE OLIVEIRA CASTRO and, LILIANE LINS Oral infections are common causes of morbidity and mortality among patients with chronic liver diseases (CLD). Objective: To evaluate health-related quality of life (HRQoL), work ability, and oral health among patients with CLD. Study Design: Cross-sectional study with 25 patients on the transplantation waiting list (group 1) and 25 patients with CLD (group 2) attended in a university hospital in Salvador, Brazil. HR-QoL and work ability were evaluated using standardized questionnaires (36-Item Short-Form Health Survey [SF-36] and Wok Ability Index [WAI], respectively). Oral health (DMFT index and periodontal disease) was evaluated using World Health Organization protocol. Mean differences were compared using t tests for independent samples. Results: The mental component summary of HR-QoL was lower in group 1 than in group 2 when WAI was low/moderate (43.3 § 9.1 vs 51.8 § 7.5, respectively; P = .003) or when
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gingivitis occurred (42.7 § 9.3 vs 50.4 § 3.6; P = .001); the physical component summary of HR-QoL was lower when periodontitis occurred (35.7 § 10.2 vs 48.8 § 6.4; P = .003). The groups presented similar DMFT index (19.1 § 8.3 vs 18.7 § 7.9; P = .86). Conclusions: Compared with patients with CLD, patients with CLD on the transplant waiting list presented lower HR-QoL because of its mental component when low work ability and gingivitis occurred; periodontitis was associated with low HR-QoL because of its physical component.
POLYMORPHISMS ASSOCIATED WITH ORAL CLEFTS AS POSSIBLE MARKERS OF SUSCEPTIBILITY FOR BREAST CANCER AND ORAL CANCER. EDIMILSON MARTINS DE FREITAS, RENATO ASSIS MACHADO, EDILMAR DE MOURA SANTOS, FELIPE RODRIGUES DE MATOS, ROSEANA DE ALMEIDA FREITAS, RICARDO D. COLETTA and, HERCILIO MARTELLI JUNIOR Objective: To evaluate the association of single nucleotide polymorphisms (SNPs) in the genes/loci IRF6, WNT3 A, GSK3 B, 8 q24, and WNT11, representing regions consistently altered in nonsyndromic oral clefts with breast and oral cancers in the Brazilian population. Study Design: We performed a case-control study with association of SNPs rs642961 (IRF6), rs708111 (WNT3 A), rs9879992 (GSK3 B), rs987525 (8 q24), and rs1533767 (WNT11) in 159 samples from breast cancer patients and 79 patients with oral squamous cell carcinoma. A total of 121 female controls (breast controls) and 130 oral cancer controls were used. Logistic regression analysis was used to adjust for confounding factors. A value of P < .05 was considered statistically significant. The study was approved by the ethics committees of the hospitals affiliated to the study. Results: Although our results have not demonstrated association between frequencies of SNP genotypes in IRF6, WNT3 A, GSK3 B, 8 q24, and WNT11 and the risk of breast and oral cancers, gene-gene interactions were associated. Conclusion: Our data revealed an association between gene-gene interactions in IRF6, WNT3 A, GSK3 B, 8 q24, and WNT11 at risk of breast cancer and oral squamous cell carcinoma in a Brazilian population. Additional experiments and large-scale independent studies in other ethnic populations are needed to confirm our results.
PREVENTION PROTOCOL FOR BISPHOSPHONATE-RELATED OSTEONECROSIS OF THE JAWS IN A PATIENT WITH HIV. NATHALIA DE ALMEIDA FREIRE, FERNANDA VIEIRA HEIMLICH, MARIA ELIZA BARBOSA RAMOS, SARAH APARECIDA ^ e ISRAEL FERREIRA ANTERO and, MONICA SIMOES Objective: To describe a preventive dental protocol for medication-related osteonecrosis of the jaw (MRONJ) in patients with HIV before and after bisphosphonate therapy. Study Design: Development of the protocol was based on literature review of articles, book chapters, and theses in the last 10 years. Results: The proposed protocol focuses on 3 groups of patients with HIV: Patients diagnosed as having osteoporosis who have not started treatment with bisphosphonates; patients at
TRENDS IN MORTALITY DUE TO ORAL AND OROPHARYNGEAL CANCERS IN URUGUAY FROM 1997 TO 2014. MARIA LAURA COSETTI, AMANDA RAMOS DA CUNHA, TAIANE SCHAEDLER PRASS, MARCO ANTONIO TREVIZANI MARTINS, VINICIUS COELHO CARRARD, FERNANDO NEVES HUGO and, MANOELA DOMINGUES MARTINS Objective: To analyze the trend of oral and oropharyngeal cancer mortality in Uruguay between 1997 and 2014 and the rates by age, sex, and departments of the country. Study Design: A time-series ecological study with secondary data. To establish an estimation of the mortality trend of the historical series, by sex, anatomic site, and age groups, linear regressions were generated by the Prais-Winsten procedure. Results: Between 1997 and 2014, there were 1696 deaths from oral cancer and oropharyngeal cancer in Uruguay. The male to female ratio was 3.23:1. Malignant neoplasm of tongue presented the highest mortality rate. The mortality rate was relatively stable (total and by sex) in all age groups studies. Means of the annual coefficients were higher for the age groups between 50 and 79 years. In women, the trend remained stable in the different departments of the country, except in Lavalleja and Maldonado where there was an increase, while in men a decrease in Artigas and Rivera was observed. Conclusion: The mortality for oral and oropharyngeal cancer in Uruguay has remained constant for the period of 1997 to 2014. Prevention strategies and early diagnosis are necessary to improve survival.
ORAL HEALTH, HEALTH-RELATED QUALITY OF LIFE, AND WORK ABILITY AMONG PATIENTS WITH CHRONIC LIVER DISEASE. LARISSA SOUZA SANTOS, FERNANDO MARTINS CARVALHO, VIVIANE ALMEIDA SARMENTO, LIANA CODES, MARIA AUXILIADORA EVANGELISTA, ALESSANDRA DE OLIVEIRA CASTRO and, LILIANE LINS Oral infections are common causes of morbidity and mortality among patients with chronic liver diseases (CLD). Objective: To evaluate health-related quality of life (HRQoL), work ability, and oral health among patients with CLD. Study Design: Cross-sectional study with 25 patients on the transplantation waiting list (group 1) and 25 patients with CLD (group 2) attended in a university hospital in Salvador, Brazil. HR-QoL and work ability were evaluated using standardized questionnaires (36-Item Short-Form Health Survey [SF-36] and Wok Ability Index [WAI], respectively). Oral health (DMFT index and periodontal disease) was evaluated using World Health Organization protocol. Mean differences were compared using t tests for independent samples. Results: The mental component summary of HR-QoL was lower in group 1 than in group 2 when WAI was low/moderate (43.3 § 9.1 vs 51.8 § 7.5, respectively; P = .003) or when
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gingivitis occurred (42.7 § 9.3 vs 50.4 § 3.6; P = .001); the physical component summary of HR-QoL was lower when periodontitis occurred (35.7 § 10.2 vs 48.8 § 6.4; P = .003). The groups presented similar DMFT index (19.1 § 8.3 vs 18.7 § 7.9; P = .86). Conclusions: Compared with patients with CLD, patients with CLD on the transplant waiting list presented lower HR-QoL because of its mental component when low work ability and gingivitis occurred; periodontitis was associated with low HR-QoL because of its physical component.
POLYMORPHISMS ASSOCIATED WITH ORAL CLEFTS AS POSSIBLE MARKERS OF SUSCEPTIBILITY FOR BREAST CANCER AND ORAL CANCER. EDIMILSON MARTINS DE FREITAS, RENATO ASSIS MACHADO, EDILMAR DE MOURA SANTOS, FELIPE RODRIGUES DE MATOS, ROSEANA DE ALMEIDA FREITAS, RICARDO D. COLETTA and, HERCILIO MARTELLI JUNIOR Objective: To evaluate the association of single nucleotide polymorphisms (SNPs) in the genes/loci IRF6, WNT3 A, GSK3 B, 8 q24, and WNT11, representing regions consistently altered in nonsyndromic oral clefts with breast and oral cancers in the Brazilian population. Study Design: We performed a case-control study with association of SNPs rs642961 (IRF6), rs708111 (WNT3 A), rs9879992 (GSK3 B), rs987525 (8 q24), and rs1533767 (WNT11) in 159 samples from breast cancer patients and 79 patients with oral squamous cell carcinoma. A total of 121 female controls (breast controls) and 130 oral cancer controls were used. Logistic regression analysis was used to adjust for confounding factors. A value of P < .05 was considered statistically significant. The study was approved by the ethics committees of the hospitals affiliated to the study. Results: Although our results have not demonstrated association between frequencies of SNP genotypes in IRF6, WNT3 A, GSK3 B, 8 q24, and WNT11 and the risk of breast and oral cancers, gene-gene interactions were associated. Conclusion: Our data revealed an association between gene-gene interactions in IRF6, WNT3 A, GSK3 B, 8 q24, and WNT11 at risk of breast cancer and oral squamous cell carcinoma in a Brazilian population. Additional experiments and large-scale independent studies in other ethnic populations are needed to confirm our results.
PREVENTION PROTOCOL FOR BISPHOSPHONATE-RELATED OSTEONECROSIS OF THE JAWS IN A PATIENT WITH HIV. NATHALIA DE ALMEIDA FREIRE, FERNANDA VIEIRA HEIMLICH, MARIA ELIZA BARBOSA RAMOS, SARAH APARECIDA ^ e ISRAEL FERREIRA ANTERO and, MONICA SIMOES Objective: To describe a preventive dental protocol for medication-related osteonecrosis of the jaw (MRONJ) in patients with HIV before and after bisphosphonate therapy. Study Design: Development of the protocol was based on literature review of articles, book chapters, and theses in the last 10 years. Results: The proposed protocol focuses on 3 groups of patients with HIV: Patients diagnosed as having osteoporosis who have not started treatment with bisphosphonates; patients at