- Email: [email protected]
Poster 15 - Clinical Performance of an Investigational Multi-Purpose Disinfecting Solution in Soft Lens Wearers with Subjective Discomfort
Following Purevision" Toric wear, 85.0% and 83.7% of patients preferred the vision provided by PureVision Toric lens at the follow-up visits (p < 0.05). For overall comfort, 73.2% and 70.3% of patients preferred the PureVision" Toric lenses (p < 0.05). Conclusion: The Purevision@Toric contact lenses offers a unique stabilizing geometry and advanced optics that can provide improved visual outcomes for patients with "low"amounts of astigmatism. The improved vision benefits do not appear to come at the expense of comfort. As practitioners consider the cost of patient dropout due to poor visual outcomes, they should consider the benefits of fitting advanced toric lenses on patients with low amounts of astigmatism.
POSTER 14 Spherical Aberration Changes with Three Silicone-Hydrogel Contact Lenses William Reindel, O.D., M.S., Caroline O'Brien, B.Optom., Michelle Lagana, 0.D., and Ian Cox, B.Optom., Ph.D. Bausch & Lomb, Inc., 1400 North Goodman Street, Rochester, New York 14609 Background: Because spherical aberration can reduce the retinal image quality of the eye when it is present in sufficient magnitude, some manufacturers report use of aspheric surfaces to reduce these aberrations. The purpose of this evaluation was to compare the change in spherical aberration for -1.00 D and -5.00 D lenses for three silicone-hydrogel lenses. Method: W o groups of 20 subjects were dilated to achieve a minimum of 6-mm pupils. Baseline spherical aberration readings were recorded using a Zywave" aberrometer. For one group, -1.00 D and -5.00 D PureVisionm and Night&Dap lenses were inserted in one eye in random order. The spherical aberration measurement of the contact lens and eye was repeated. For the cohort, -1.00 D and -5.00 D PureVisionmand Acuvue Advance" lenses were evaluated using the same protocol. Results: The amount of positive spherical aberration increased an average 0.131 microns from baseline for the -1.00 D Night&Day@lens and did not change significantly from baseline for the -5.00 D Night&Dap lens. From baseline, the amount of positive spherical aberration was reduced an average of 0.128 microns and 0.155 microns for the -1.00 D and -5.00 D Purevision" lenses, respectively. The amount of positive spherical aberration did not change significantly from baseline for the -1.00 D Acuvue Advance" lens, and was reduced an " average of 0.146 microns for the -5.00 D lens. For this comparison, the amount of positive spherical aberration was reduced an average of 0.129 microns and 0.145 microns for the -1.00 D and -5.00 D PureVision lenses, respectively. Conclusion: The Bausch & Lomb Purevision@contact lenses consistently reduced the amount of positive spherical aberration of the contact lensleye system for both -1.00 D and -5.00 D lenses. Of the remaining silicone-hydrogel lenses, only the -5.00 D Acuvue AdvanceTM lens significantly reduced the amount of positive spherical aberration of the contact lensleye system.
POSTER 15 Clinical Performance of an Investigational Multi-Purpose Disinfecting Solution in Soft Lens Wearers with Subjective Discomfort Renee Garofalo, 0 .D., Jerry Stein, Ph.D., Susan Potts, Dina Amin, M.S., Claudia Blalock, M.B.A., Tolgar Bayraktaroglu, M.S., and Ralph Stone, Ph.D. Alcon Research, Ltd., 6201 South Freeway, Fort Worth, Texas 76134-2099 Background: Despite improvements in contact lens materials and solutions, many soft lens wearers continue to experience lens discomfort, particularly as the wearing day progresses. This discomfort can result in decreased wear time, increased use of rewetting drops, and permanent discontinuation of lens wear. Purpose: This study evaluated the safety and efficacy of a new, investigational multi-purpose disinfecting solution (MPDS),designed to provide superior lens conditioning and wettability. Methods: Three-hundred sixty-two subjects wearing Group IV soft lenses and who reported end-of-day discomfort or reduced wear time were enrolled at 19 sites for this 28-day, double-masked, parallel, concurrently controlled study. Subjects were randomized to Regimen 1 (Test MPDS, Alcon Labs., Inc.) or to Regimen 2 (ReNum MultiPlus MPS, B&L, Inc.). Subjects were dispensed a new pair of their current lens brand to wear for the duration of the study and were evaluated on Days 0, 14, and 28. Results: Subjective ratings of ocular comfort, dryness, scratchiness, and burning on 100-point visual analog scales were significantly different in favor of Regimen 1 ( p d 0.04). Significant differences were noted in favor of Regimen 1 on all twelve Likert questionnaire responses (e.g., "This solution gives my lenses longlasting comfort" [Day 14, p = 0.05; Day 28, p = 0.0011; "My vision is clear at the end of the day when I use this solution" [Day 14, p = 0.02; Day 28, p < 0.0011). Lens deposit and total lens surface evaluation scores were statistically superior for Regimen 1, as compared to Regimen 2 (p d 0.02; p d 0.03). Conclusion: A new, investigational MPDS, designed for superior lens conditioning and wettability, was shown to be safe and effective, and was consistently rated superior to a currently marketed MPS in terms of regimen comfort and satisfaction. The solution may be particularly beneficial for patients with end-of-day lens discomfort and at risk of discontinuation of lens wear.
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VOLUME 76lNUMBER 6IIUNE 2005
OPTOMETRY
POSTER 14 Spherical Aberration Changes with Three Silicone-Hydrogel Contact Lenses William Reindel, O.D., M.S., Caroline O'Brien, B.Optom., Michelle Lagana, 0.D., and Ian Cox, B.Optom., Ph.D. Bausch & Lomb, Inc., 1400 North Goodman Street, Rochester, New York 14609 Background: Because spherical aberration can reduce the retinal image quality of the eye when it is present in sufficient magnitude, some manufacturers report use of aspheric surfaces to reduce these aberrations. The purpose of this evaluation was to compare the change in spherical aberration for -1.00 D and -5.00 D lenses for three silicone-hydrogel lenses. Method: W o groups of 20 subjects were dilated to achieve a minimum of 6-mm pupils. Baseline spherical aberration readings were recorded using a Zywave" aberrometer. For one group, -1.00 D and -5.00 D PureVisionm and Night&Dap lenses were inserted in one eye in random order. The spherical aberration measurement of the contact lens and eye was repeated. For the cohort, -1.00 D and -5.00 D PureVisionmand Acuvue Advance" lenses were evaluated using the same protocol. Results: The amount of positive spherical aberration increased an average 0.131 microns from baseline for the -1.00 D Night&Day@lens and did not change significantly from baseline for the -5.00 D Night&Dap lens. From baseline, the amount of positive spherical aberration was reduced an average of 0.128 microns and 0.155 microns for the -1.00 D and -5.00 D Purevision" lenses, respectively. The amount of positive spherical aberration did not change significantly from baseline for the -1.00 D Acuvue Advance" lens, and was reduced an " average of 0.146 microns for the -5.00 D lens. For this comparison, the amount of positive spherical aberration was reduced an average of 0.129 microns and 0.145 microns for the -1.00 D and -5.00 D PureVision lenses, respectively. Conclusion: The Bausch & Lomb Purevision@contact lenses consistently reduced the amount of positive spherical aberration of the contact lensleye system for both -1.00 D and -5.00 D lenses. Of the remaining silicone-hydrogel lenses, only the -5.00 D Acuvue AdvanceTM lens significantly reduced the amount of positive spherical aberration of the contact lensleye system.
POSTER 15 Clinical Performance of an Investigational Multi-Purpose Disinfecting Solution in Soft Lens Wearers with Subjective Discomfort Renee Garofalo, 0 .D., Jerry Stein, Ph.D., Susan Potts, Dina Amin, M.S., Claudia Blalock, M.B.A., Tolgar Bayraktaroglu, M.S., and Ralph Stone, Ph.D. Alcon Research, Ltd., 6201 South Freeway, Fort Worth, Texas 76134-2099 Background: Despite improvements in contact lens materials and solutions, many soft lens wearers continue to experience lens discomfort, particularly as the wearing day progresses. This discomfort can result in decreased wear time, increased use of rewetting drops, and permanent discontinuation of lens wear. Purpose: This study evaluated the safety and efficacy of a new, investigational multi-purpose disinfecting solution (MPDS),designed to provide superior lens conditioning and wettability. Methods: Three-hundred sixty-two subjects wearing Group IV soft lenses and who reported end-of-day discomfort or reduced wear time were enrolled at 19 sites for this 28-day, double-masked, parallel, concurrently controlled study. Subjects were randomized to Regimen 1 (Test MPDS, Alcon Labs., Inc.) or to Regimen 2 (ReNum MultiPlus MPS, B&L, Inc.). Subjects were dispensed a new pair of their current lens brand to wear for the duration of the study and were evaluated on Days 0, 14, and 28. Results: Subjective ratings of ocular comfort, dryness, scratchiness, and burning on 100-point visual analog scales were significantly different in favor of Regimen 1 ( p d 0.04). Significant differences were noted in favor of Regimen 1 on all twelve Likert questionnaire responses (e.g., "This solution gives my lenses longlasting comfort" [Day 14, p = 0.05; Day 28, p = 0.0011; "My vision is clear at the end of the day when I use this solution" [Day 14, p = 0.02; Day 28, p < 0.0011). Lens deposit and total lens surface evaluation scores were statistically superior for Regimen 1, as compared to Regimen 2 (p d 0.02; p d 0.03). Conclusion: A new, investigational MPDS, designed for superior lens conditioning and wettability, was shown to be safe and effective, and was consistently rated superior to a currently marketed MPS in terms of regimen comfort and satisfaction. The solution may be particularly beneficial for patients with end-of-day lens discomfort and at risk of discontinuation of lens wear.
369
VOLUME 76lNUMBER 6IIUNE 2005
OPTOMETRY