Poster not available

Abstracts

Methods: Brain magnetic resonance imaging study was performed in 38 schizophrenic patients and 28 controls,and the authors measured cerebral area,anterior,middle,posterior callosal areas, vertical width,perpendicular width and maximal horizontal callosal length.The schizophreic patients were assessed by the PANSS. To correct cerebral areas, ANCOVA was used with cerebral area as covariants. And two tailed t-test,ANOVA were used to compare callosal measurements according to subgroups. Results: The schizophrenic patients,compared with controls, were significantly wider in posterior callosal area and thinner in anterior vertical width. The schizophrenic patients with prominent positive symptoms were significantly wider and thicker in middle callosal area,anterior middle vertical width than controls,and those with prominent negative symptoms were significantly thinner in posterior vertical width than those with prominent positive symptoms and wider in anterior area than controls. Early onset patients were significantly thicker in middle perpendicular area than controls. Discussion: There were various controversial findings about corpus callosal pathology of the schizophrenic patients. This study,after correction of cerebral area,revealed increased size of several parts of callosal regions,and then it suggested neurodevelopmental abnormalities. And also significant differences in callosal regions according positive and negative symptoms suggested that these reflected the heterogeneities of schizophrenia.

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phrenia patients and 28 age and gender matched healthy control subjects. Baseline and follow-up brain images were analyzed using tensor based morphometry (TBM). Voxel-wise group comparisons were performed with SPM5. Small volume correction was performed for the striatum, hippocampus and ventricles, using a FDRcorrection (p < 0.05) to control for multiple comparisons. Additionally, volumetric estimates were derived and analyzed. Effects of medication, including dose-dependent effects, and associations with psychopathology (PANSS-scores) were assessed. Results: Patients had significant striatal and hippocampal volume loss over the six months treatment period. The striatal volume loss was most pronounced with low quetiapine doses and less apparent with high doses. Conversely, hippocampal volume loss appeared more pronounced with high quetiapine doses than with low doses. Clinically, higher baseline positive symptoms were associated with more striatal and hippocampal volume loss over time. Although patients' ventricles did not change significantly, ventricular increases correlated with less improvement on negative symptoms. Discussion: Progressive regional volume loss in quetiapine-treated first-episode schizophrenia patients may be dose-dependent and clinically relevant. The mechanisms underlying progressive brain changes, specific antipsychotic compounds and clinical symptoms warrant further research. doi:10.1016/j.schres.2010.02.327

doi:10.1016/j.schres.2010.02.325

Poster 100 Poster not available

Poster 98 Poster not available doi:10.1016/j.schres.2010.02.326

Poster 99 REGIONAL BRAIN CHANGES IN INITIALLY ANTIPSYCHOTIC-NAïVE FIRST-EPISODE SCHIZOPHRENIA PATIENTS TREATED WITH QUETIAPINE: RELATION TO DOSE AND PSYCHOPATHOLOGY Bjørn H. Ebdrup1,2,3, Arnold Skimminge3, Hans Rasmussen1,2, Bodil Aggernaes1, Bob Oranje1,2, Henrik Lublin1,2, William Baaré3,4, Birte Glenthoj1,2 1 Center for Neuropsychiatric Schizophrenia Research, CNSR Glostrup, Glostrup, Denmark; 2Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, CINS Glostrup, Glostrup, Denmark; 3Danish Research Centre for Magnetic Resonance, DRCMR Hvidovre, Copenhagen, Denmark; 4Center for Integrated Molecular Brain Imaging, CIMBI Copenhagen, Copenhagen, Denmark Background: MRI studies have shown progressive brain alterations in the course of schizophrenia. Whereas first-generation antipsychotics have been associated with striatal volume increases, the effects of second-generation antipsychotics (SGA) on striatal volumes are unclear. Neuroprotective effects of SGAs have been suggested on hippocampal volumes, whereas ventricular enlargement may be associated with clinical outcome. Dose-dependent volumetric effects of individual SGAs have been scarcely investigated. In this study, we examined structural brain changes in initially antipsychotic-naïve first-episode schizophrenia patients after six months of mono-therapy with quetiapine. Methods: High-resolution 3D T1-weighted magnetic resonance imaging scans were obtained on a 3 Tesla scanner at baseline and after six months in 22 antipsychotic-naïve first-episode schizo-

doi:10.1016/j.schres.2010.02.328

Poster 101 FRONTAL CORTICAL THICKNESS IS ASSOCIATED WITH CLINICAL IMPROVEMENT OF NEGATIVE SYMPTOMS IN MALE ADOLESCENTS WITH EARLY-ONSET FIRST-EPISODE PSYCHOSIS Margarita Garcia-Amador1, Jansen Joost1,2, Santiago Reig1,2, Mara Parellada1, Dolores Moreno1, Carmen Moreno1, Maria Mayoral1,2, Montserrat Grael3, Manuel Desco2, Celso Arango1 1 Hospital Universitario Gregorio Marañón, Department of Psychiatry, and Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM) Madrid, Madrid, Spain; 2Hospital Universitario Gregorio Marañón, Department of Experimental Surgery and Medicine, and CIBERSAM Madrid, Madrid, Spain; 3Hospital Universitario Infantil Niño Jesús, Department of Psychiatry Madrid, Madrid, Spain Background: First-episode psychosis in adults and adolescents is associated with volume deficits in the frontal cortex. It is unclear if deficits in cortical thickness and/or cortical surface and/or cortical gyrification underlie the patient-control differences in cortical volume. In addition, in adult and adolescent patients with psychosis it's not evident if cortical structural brain abnormalities are related to change in clinical symptoms over time. The current study was designed to compare frontal cortical thickness, surface, and gyrification between male adolescents with early-onset firstepisode psychosis (EOP) and healthy controls. Within patients, the relationship between frontal cortical morphology and change in clinical symptoms over a two-year clinical follow up period was investigated. Methods: Baseline Magnetic Resonance Imaging (MRI) brain scans were obtained from 49 adolescent EOP patients, and 34 healthy controls. Mean age was 15 years for patients and controls, and all patients had less than six months of psychotic symptoms at study