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Postprandial triacylglycerol and apo lipoprotein B-48 responses to meals of varying monoun-saturated fatty acid content in young UK subjects
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Poster session abstracts / Atherosclerosis 115 (Suppl.) (1995) $45-$129 PI Nutrition
16'1 ALCOHOL CONSUMPTION AND PLASMA APOLIPOPROTEIN AND LIPOPROTEIN PROFILE E. Lecomte~. B Herbeth t, F Paille:, Y. Artur t, G, Siest ~ ICemre de M~decine Pr6ventive, URA CNRS 597, 2 Avenue du Doyen Jacques Parisot, 54501 Vandoeuvre-lbs-Nancy, France; -'Centre d'Alcoologie. CHRU. H6pital Fournier. 54000 Nancy. France The effects of alcohol consumption on plasma concentrations of apolipoproteins (apoi A-I, B and lipoprotems (kp) A-l, A I:A-II. (a). were studied in a control population of 134 supposedly healthy men who consomlned low or moderate amounts of alcohol as compared with 97 alcoholic patients without severe liver disease before and after a withdrawal treatment of 21 days Plasma concentrations of apo A-l, kp A-l and Lp A-I:A-11 were significantly higher in alcoho lies than in controls who drank low amounts of alcohol whereas apo B and Lp(a) were lower. After withdrawal, apo A-I, Lp A-I and kp A-I:A lI levels decreased whereas apo B and Lp(a) levels increased and reached concentrations comparable to those of controls, Adjustement for confounding factors (smoking status, Quetelet index and diet intakes) confirms the specific and independant effect of alcohol on apolipoprotein and lipoprotein profile: increase of antiatherngenic particles and decrease of atherogenic particles. In alcoholic patients, induction of hepatic proteins by alcohol might explain the erd~ancement of plasma levels of Lp A-I and Lp A-I:A-[I since concentrations of these particles were positively correlated to plasma aspartate an-tinotransferase activity and albumin.
POSTPRANDIAL TRIACYLGLYCEROL, RESPONSES TO MEALS OF VARYING MONOUNSATURATED FATTY ACID CONTENT IN UK AND GREEK SUBJECTS C.M. WilliamsI A. Zampelasj. K.G. Jacksont, B.J. GouldI, J. Wright ~, A. Kafatos:, M. Kapsokephalou: Nutrition Research Group, University of Surrey, Guildford, UK; 'Department of Preventive Medicine and Nutrition. University of Heraklion, Crete Postprandial responses to three test meals, of varying monounsamrated fatty acid (MUFA) content (12%, 17% and 24% dietary energy) were evaluated in 45 young males; 15 UK. 15 Greek Cretan (GC) and 15 Greek NonCretan (GNC). Subjects were matched for age, weight, exercise and fasting lipid concentrations. Habitual dietary intakes were similar for the three groups apart from significantly higher intakes of MUFA in the two Greek populations. Postprandial studies were conducted under identical conditions in two centres (UK and Crete), with test meals consumed in random order on three separate occasions over a period of two months. Total postprandial plasma triacylglycerol (TAG) responses were similar for the three groups for each of the meals, but the shape of the response curves differed, with time to peak response being significantly delayed in the UK group for all three meals (24% MUFA meal peak time responses; UK 288 (32). GNC 124 (1 I) and GC 158 (23) mins: P<0.01). Triacylglycerol rich lipoprotein (TRL} fraction triacylglycerol responses were significantly higher in UK compared with both Greek populations (24% MUFA areas under the curve; UK 401 (52), GNC 124 (13), GC 166 (27)min.nunol/l; P<0.001). Subiects habituated to a Greek diet, rich in MUFA, show an earlier and more marked rise in postprandial TAG in response to meal ingestion. The marked rise in TAG in the TRL fraction in UK compared with Greek subjects may be related to differences in the size and/or clearance of chylomicron/large VLDL panicles between the two populations.
167 POSTPRANDIAL TRIACYLGLYCEROL AND APO LIPOPROTEIN B-48 RESPONSES TO MEALS OF VARYING MONOUN SATURATED FATTY ACID CONTENT IN YOUNG UK SUBJECTS A. Zampelas, J M E Knapper, K G . Jackson, C C Culverwell, J. Vilson. BJ Gould, C M . Williams Nutritional Metabolism Research Group, Universit,, of Surrey, Guilsford. UK
PREVALENCE OF CARDIOVASCULAR RISK FACTORS IN A POPULATION WITH HYPERCALORIC DIET, ENRICHED WITH MONOUNSATURATED FATTY ACIDS (MUFA),AND RICH IN CHOLESTEROL F.J. Martin de Toro, J.F. Soto Diaz. R. Camacho Rueda, G.Gomez Martin, J. Millan Nufiez Cortes" Estudio IDRECSA, "Hospital General Universitario "Gregorio Marafion". Madrid
Attenuated postprandial lipid responses are t:hserved following consumption of meals rich in polyunsaturated fatty acids of the n-3 series, but the effects on postprandial lipaemia of substituting mo nounsaturated fatty acids iMUFA's) h)r saturated fatty acids (SFA's) are not known. Postprandial triacylglycerol ITAG). apolipoprotein B-48 and cholesterol responses of plasma, chylomicron rich lipoprotein (CRLt and chylomicron poor lipoprotein !CPL) fractions, were measured in 15 young males ti}llowing ineals nf varying MUFA contents ( 12 %, 17 ~ and 24~ of dietary energy respectively). Areas under the TAG response curves f{}r plasma, CRL and CPL fractions were identical fnr each of the three meals However in plasma and CRL fractions, a bi phasic TAG response was observed to the high MUFA nmal (24g) with TAG peaks occuring at both 18{} and 360 minutes. A similar pattern of response was observed for apolipoprorein B-48 in the CRL fraction Areas under the cholesterol time response curves were similar fnr the three meals although there was a tendency for postprandial cholesterol responses to be lower in the CRL fraction for the 24% MUFA meal iAUCs 12~ 166 !29h 17c7~ 151 t23). 24~ 91 (78) minmmol/l:NS). There was no eflect of meal MUFA content on total postprandial lipaemic response. A biphasic TAG and apo B 48 response was seen to the high MUFA meal which may be due to bi-phasic secretion of chylomicrons enriched with MUFA
A population with habits of hypercaloric diet intake and high MUFA proportion was studied to evaluate the prevalence of main cardiovascular risk factors. Study was carried out in 548 individuals (men: 278.women:270) with age between 30 and 65 years. With a weekquestionnaire was evaluated the diet that show a high caloric intake (3325 cal(day)with 49% of carbohydrates, 17% of protein, and 34% of fat (saturated fatty acids:12,5%, polyunsaturated:5.5%, and monounsaturated: 16%), cholesterol/day: 662 mg, and alcohol intake: 44 g/day, sodium: 2,9 g/day and potassium: 4,1g/day. A despite of mean levels of different metabolic factors that we have considered. we have found the following prevalence of risk factors: arterial hypertension in 6,5% of younger people (3044 years) and 22,6% in older people (45-65), smoking in 37,6%, alcohol intake higher than 10 g/day: 68,2% (higher than 200 g/day in 27,3%. Hypercholesterolemia was found in 32,5% (level: 240 mg/dl) or 68,9% (level:200 mg/dL). HDL-c lower than 35 mg/dl was present in 8,03% and LDLc higher than 150 mg/dl in 70,7%. Hyperglucemia (higher than 120 mg/dl) in 9,9%. ApoAl lower than 92 mg/dl was found in 2,5%. The 14A% of individuals show tryglicerides level higher than 200 mg/dl. In these dietetic conditions, the prevalence of some cardiovascular risk factors is higher than in general population. We conclude that high caloric intake is a more important factor than the proportion of fatty acids.
Poster session abstracts / Atherosclerosis 115 (Suppl.) (1995) $45-$129 PI Nutrition
16'1 ALCOHOL CONSUMPTION AND PLASMA APOLIPOPROTEIN AND LIPOPROTEIN PROFILE E. Lecomte~. B Herbeth t, F Paille:, Y. Artur t, G, Siest ~ ICemre de M~decine Pr6ventive, URA CNRS 597, 2 Avenue du Doyen Jacques Parisot, 54501 Vandoeuvre-lbs-Nancy, France; -'Centre d'Alcoologie. CHRU. H6pital Fournier. 54000 Nancy. France The effects of alcohol consumption on plasma concentrations of apolipoproteins (apoi A-I, B and lipoprotems (kp) A-l, A I:A-II. (a). were studied in a control population of 134 supposedly healthy men who consomlned low or moderate amounts of alcohol as compared with 97 alcoholic patients without severe liver disease before and after a withdrawal treatment of 21 days Plasma concentrations of apo A-l, kp A-l and Lp A-I:A-11 were significantly higher in alcoho lies than in controls who drank low amounts of alcohol whereas apo B and Lp(a) were lower. After withdrawal, apo A-I, Lp A-I and kp A-I:A lI levels decreased whereas apo B and Lp(a) levels increased and reached concentrations comparable to those of controls, Adjustement for confounding factors (smoking status, Quetelet index and diet intakes) confirms the specific and independant effect of alcohol on apolipoprotein and lipoprotein profile: increase of antiatherngenic particles and decrease of atherogenic particles. In alcoholic patients, induction of hepatic proteins by alcohol might explain the erd~ancement of plasma levels of Lp A-I and Lp A-I:A-[I since concentrations of these particles were positively correlated to plasma aspartate an-tinotransferase activity and albumin.
POSTPRANDIAL TRIACYLGLYCEROL, RESPONSES TO MEALS OF VARYING MONOUNSATURATED FATTY ACID CONTENT IN UK AND GREEK SUBJECTS C.M. WilliamsI A. Zampelasj. K.G. Jacksont, B.J. GouldI, J. Wright ~, A. Kafatos:, M. Kapsokephalou: Nutrition Research Group, University of Surrey, Guildford, UK; 'Department of Preventive Medicine and Nutrition. University of Heraklion, Crete Postprandial responses to three test meals, of varying monounsamrated fatty acid (MUFA) content (12%, 17% and 24% dietary energy) were evaluated in 45 young males; 15 UK. 15 Greek Cretan (GC) and 15 Greek NonCretan (GNC). Subjects were matched for age, weight, exercise and fasting lipid concentrations. Habitual dietary intakes were similar for the three groups apart from significantly higher intakes of MUFA in the two Greek populations. Postprandial studies were conducted under identical conditions in two centres (UK and Crete), with test meals consumed in random order on three separate occasions over a period of two months. Total postprandial plasma triacylglycerol (TAG) responses were similar for the three groups for each of the meals, but the shape of the response curves differed, with time to peak response being significantly delayed in the UK group for all three meals (24% MUFA meal peak time responses; UK 288 (32). GNC 124 (1 I) and GC 158 (23) mins: P<0.01). Triacylglycerol rich lipoprotein (TRL} fraction triacylglycerol responses were significantly higher in UK compared with both Greek populations (24% MUFA areas under the curve; UK 401 (52), GNC 124 (13), GC 166 (27)min.nunol/l; P<0.001). Subiects habituated to a Greek diet, rich in MUFA, show an earlier and more marked rise in postprandial TAG in response to meal ingestion. The marked rise in TAG in the TRL fraction in UK compared with Greek subjects may be related to differences in the size and/or clearance of chylomicron/large VLDL panicles between the two populations.
167 POSTPRANDIAL TRIACYLGLYCEROL AND APO LIPOPROTEIN B-48 RESPONSES TO MEALS OF VARYING MONOUN SATURATED FATTY ACID CONTENT IN YOUNG UK SUBJECTS A. Zampelas, J M E Knapper, K G . Jackson, C C Culverwell, J. Vilson. BJ Gould, C M . Williams Nutritional Metabolism Research Group, Universit,, of Surrey, Guilsford. UK
PREVALENCE OF CARDIOVASCULAR RISK FACTORS IN A POPULATION WITH HYPERCALORIC DIET, ENRICHED WITH MONOUNSATURATED FATTY ACIDS (MUFA),AND RICH IN CHOLESTEROL F.J. Martin de Toro, J.F. Soto Diaz. R. Camacho Rueda, G.Gomez Martin, J. Millan Nufiez Cortes" Estudio IDRECSA, "Hospital General Universitario "Gregorio Marafion". Madrid
Attenuated postprandial lipid responses are t:hserved following consumption of meals rich in polyunsaturated fatty acids of the n-3 series, but the effects on postprandial lipaemia of substituting mo nounsaturated fatty acids iMUFA's) h)r saturated fatty acids (SFA's) are not known. Postprandial triacylglycerol ITAG). apolipoprotein B-48 and cholesterol responses of plasma, chylomicron rich lipoprotein (CRLt and chylomicron poor lipoprotein !CPL) fractions, were measured in 15 young males ti}llowing ineals nf varying MUFA contents ( 12 %, 17 ~ and 24~ of dietary energy respectively). Areas under the TAG response curves f{}r plasma, CRL and CPL fractions were identical fnr each of the three meals However in plasma and CRL fractions, a bi phasic TAG response was observed to the high MUFA nmal (24g) with TAG peaks occuring at both 18{} and 360 minutes. A similar pattern of response was observed for apolipoprorein B-48 in the CRL fraction Areas under the cholesterol time response curves were similar fnr the three meals although there was a tendency for postprandial cholesterol responses to be lower in the CRL fraction for the 24% MUFA meal iAUCs 12~ 166 !29h 17c7~ 151 t23). 24~ 91 (78) minmmol/l:NS). There was no eflect of meal MUFA content on total postprandial lipaemic response. A biphasic TAG and apo B 48 response was seen to the high MUFA meal which may be due to bi-phasic secretion of chylomicrons enriched with MUFA
A population with habits of hypercaloric diet intake and high MUFA proportion was studied to evaluate the prevalence of main cardiovascular risk factors. Study was carried out in 548 individuals (men: 278.women:270) with age between 30 and 65 years. With a weekquestionnaire was evaluated the diet that show a high caloric intake (3325 cal(day)with 49% of carbohydrates, 17% of protein, and 34% of fat (saturated fatty acids:12,5%, polyunsaturated:5.5%, and monounsaturated: 16%), cholesterol/day: 662 mg, and alcohol intake: 44 g/day, sodium: 2,9 g/day and potassium: 4,1g/day. A despite of mean levels of different metabolic factors that we have considered. we have found the following prevalence of risk factors: arterial hypertension in 6,5% of younger people (3044 years) and 22,6% in older people (45-65), smoking in 37,6%, alcohol intake higher than 10 g/day: 68,2% (higher than 200 g/day in 27,3%. Hypercholesterolemia was found in 32,5% (level: 240 mg/dl) or 68,9% (level:200 mg/dL). HDL-c lower than 35 mg/dl was present in 8,03% and LDLc higher than 150 mg/dl in 70,7%. Hyperglucemia (higher than 120 mg/dl) in 9,9%. ApoAl lower than 92 mg/dl was found in 2,5%. The 14A% of individuals show tryglicerides level higher than 200 mg/dl. In these dietetic conditions, the prevalence of some cardiovascular risk factors is higher than in general population. We conclude that high caloric intake is a more important factor than the proportion of fatty acids.