- Email: [email protected]
PP-022 Association of Coronary Atherosclerosis and Latent Chronic Kidney Disease in Turkish Population
MARCH 10e13, 2016 group of patients. However, further prospective clinical researches in larger patient populations are necessary to encourage our results.
- PP-020
P O S T E R
Conclusions: The severity of ED is an independent factor predicting the extent of CAD. The early detection of ED enables to make a cardiovascular evaluation. Therefore, taking the cardiovascular risk factors under an aggressive treatment may contribute to prevent the cardiovascular cases which may develop in the future.
The Relation between Erectile Dysfunction and Extent of Coronary Artery Disease in the Patients with Stable Coronary Artery Disease. Hikmet Hamur1, Hakan Duman2, Ercument Keskin3, Sinan Inci4, Zafer Kucuksu1, Husnu Degirmenci1, Ergun Topal1. 1 Department of Cardiology, Faculty of Medicine, Erzincan University, Erzincan, Turkey; 2Department of Cardiology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey; 3Department of Urology, Faculty of Medicine, Erzincan University, Erzincan, Turkey; 4Department of Cardiology, Aksaray State Hospital, Aksaray, Turkey.
- PP-021
Objective: Erectile dysfunction (ED) and coronary artery disease (CAD) are closely related as a result of endothelial dysfunction leading to the restriction of blood flow. ED is a potential independent risk factor of CAD. We investigated the prevalence and severity of ED, the extent of CAD and the time interval between the symptoms of ED and CAD in the stable coronary artery patients. Methods: 161 patients applied coronary angiography were divided into two groups according to SYNTAX score as group 1 (n¼81) SYNTAX score 22, and group 2 (n¼80) SYNTAX score >22. The prevalence and severity of ED was determined by using The International Index of Erectile Function (IIEF). Results: The prevalence of ED was 43.2% in group 1 and 61.3% in group 2 (P¼0.022). The score of IIEF was 23.1 (15-29) in group 1, 19.3 (6-29) in group 2; there was a significant difference (P¼0.000). In the multivariate logistic regression analysis carried out in order to determine the independent predictors on Syntax score, it was found that LDL (odds ratio: 1.032, 95% confidence interval: 1.009-1.055, P¼0.007) and IIEF score (odds ratio: 0.825, 95% confidence interval: 0.733-0.928, P¼0.001) were the independent predictors. The time between the symptoms of ED and CAD 30.1 4.8 months in group 1, and 40.5 4.3 months in group 2 (P¼0.000).
Objective: We investigated whether serum bilirubin level (a marker of heme oxygenase activity) is a predictor of trombus burden in patients with acute myocardial infarction. Methods: Patients (n ¼ 229; male 72.9%; mean age 63 13.4 years) who were admitted with ST-elevation myocardial infarction (STEMI) were enrolled. Patients were divided into 2 groups. Group 1 was defined as low thrombus burden and group 2 was defined as high thrombus burden. Results: Patients with high-thrombus burden had higher total bilirubin levels (14.36 [4.27 e 22.91] vs 7.69 [2.39 e 20.34] mmol/L, p¼<.001) and direct bilirubin levels (3.08 [2.13 e 8.38] vs 1.71 [0.51 e 6.49] mmol/L, p¼<.001). At multivariate analysis, total bilirubin (odds ratio: 1.054, 95% confidence interval: 1.031 e 1.079, p¼<.001) was the independent predictor of high thrombus burden. Conclusions: Total bilirubin level is independently associated with high thrombus burden in patients with STEMI.
A B S T R A C T S
Bilirubin Levels and Thrombus Burden in Patients with ST-elevation Myocardial Infarction. Hikmet Hamur1, Hakan Duman2, Eftal Murat Bakirci1, Zafer Kucuksu1, Selami Demirelli3, Kamuran Kalkan3, Husnu Degirmenci1. 1 Department of Cardiology, Faculty of Medicine, Erzincan University, Erzincan, Turkey; 2Department of Cardiology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey; 3Department of Cardiology, Training and Research Hospital, Erzurum, Turkey.
Figure 1. Total bilirubin levels between low and high thrombus burden groups.
- PP-022
Figure 1. The receiver-operating characteristic (ROC) curve of international index of erectile function (IIEF) score for predicting the higher Syntax score.
Association of Coronary Atherosclerosis and Latent Chronic Kidney Disease in Turkish Population. Suat Görmel1, Emre Yalçınkaya4, Mustafa Köklü2, Uygar agdas¸ Yüksel2, Barıs¸ Bugan3, Murat Çelik2, Cem Barçın2, Yalçın Gökoglan2, Kutsi Hasan Kabul2, Erol Gürsoy2, Salim Yas¸ar5, Erkan Yıldırım2. 1Beytepe Military Hospital; 2Department of Cardiology, Gulhane Military Medical Faculty, Ankara, Turkey; 3Girne Military Hospital; 4Aksaz Military Hospital; 5Etimesgut Military Hospital.
S50 The American Journal of Cardiologyâ MARCH 10e13, 2016 12th INTERNATIONAL CONGRESS OF UPDATE IN CARDIOLOGY AND CARDIOVASCULAR SURGERY ABSTRACTS / Oral
MARCH 10e13, 2016
Objective: As already known there is strong association between chronic kidney disease (CKD) and atherosclerotic coronary disease. In this study we aimed to evaluate the relationship between coronary artery disease (CAD) and renal dysfunction level (RDL) in a group of Turkish patients. Methods: 414 consecutive patients undergoing cardiac catheterization were enrolled. Angiograms were reviewed and Gensini scores were determined. Estimated glomerular filtration rate (eGFR) was calculated and classified. CKD was defined as eGFR < 60 ml/min. The results were obtained by calculating ’p’ value by ’z’ test, ’t’ test, chi-square test, as appropriate to see the difference between two groups. The results thus obtained were plotted on table, pie-chart, line chart, bar-diagram etc. as appropriate p value <0.05 was considered significant. Results: Among the 414 patients who exhibited variable degrees of CAD, 58,2% had an eGFR < 60 ml/min. We observed a steady increase in the Gensini score level as eGFR declined and a progressive reduction in renal function with the worsening of CAD extent (P < 0.05). Despite considerable inter-patient variability this correlation was quite evident. Conclusions: As a result CAD extent and RDL seems to have a gradual relationship Considering eGFR level as a risk factor may be valuable in the risk stratification of patients with coronary atherosclerosis.
- PP-023 Relationship between Exercise Testing and Variations in Hematologic Parameters. Ahmet Korkmaz1, Abdulkadir Yıldız2, Mustafa Oylumlu2, Pınar Türker1, Deniz S¸ahin1, Funda Bas¸yigit1, Özgül Uçar Elalmıs¸1, _ 1. 1Ankara Numune Egitim Ümit Güray1, Mehmet Ileri 2 Aras¸tirma Hastanesi; Dicle Üniversitesi Tıp Fakültesi Hastanesi. Background: In patients admitted to outpatient clinics with chest pain, changes in the ST segments of ECG readings are the most widely used criteria during tredmill ECG tests to determine myocardial ischaemia, despite its poor accuracy. In this study, we evaluated the benefit of hematological parameters, particularly neutrophil to lymphocyte ratio (NLR), in addition to changes in the ST segments for the detection of myocardial ischaemia with treadmill ECG testing. Methods: Total 113 patients without a history of coronary artery disease who presented with chest pain and underwent both treadmill ECG test and coronary angiography were enrolled in the study. Peripheral venous blood samples were drawn before 1 hour to exercise ECG testing. Total and differential leukocyte counts were measured. Absolute cell counts were used in the analyses. Same analyses made 15 minutes after pick exercise. Biochemical parameters were measured by standard methods and conventional coronary angiography was performed by standard
techniques and analyzed masked to identity, clinical information, exercise ECG results. In patients with stenosis 50% determined visually by the consensus of two experienced cardiologists, computer-assisted quantification of luminal diameter stenosis (QCA) was performed. Results: The NLR was significantly increased in patients with positive stress test(68 patients) and significant coronary stenosis(63 patients) compared to patients with negative stress test and insignificant coronary stenosis, respectively. The sensitivity and specificity of treadmill ECG testing in this study was 79% and 64%, respectively. The change in NLR before and after the treadmill ECG testing improved these values. A cutoff point of 0.2 for the change in NLR in addition to positive stress test had 91% sensitivity and 92% specificity (ROC area under curve:0.913, 95% CI: 0.805-1.000) in predicting significant coronary stenosis. Conclusions: Elevation of NLR during treadmill ECG testing were associated with the presence of coronary arter disease which may be an indicator of immune activation occurs during myocardial ischemia. The addition of elevation of NLR to the conventionally used criterion of changes in the ST -segments in patients with suspected myocardial ischaemia incresed the sensitivity and specificity of treadmill ECG testing for detecting myocardial ischaemia, which might reduce the need for other expensive non-invasive techniques. ROC. AUC: 0.913 (95% CI 0.805-1.000) Post-exercise NLR increase of 0.20 has a 91% sensitivity and 92% specificity for the presence of Coronary artery disease which is defined as the presence of an at least 50% stenotic lesion
- PP-024 The Comparison of mean Platelet Volumes between Non St and St Elevation Acute Coronary Syndromes. Orhan Delice1, Selami Demirelli2, Kamuran Kalkan2, Erkan Yildirim2, Mustafa Oztürk2, Emrah Ipek2. 1 Department of Emergency Medicine, Erzurum Education and Research Hospital, Erzurum, Turkey; 2Department of Cardiology, Erzurum Education and Research Hospital, Erzurum, Turkey. Objective: Platelets, as an important actor in atherothrombosis, secrete a group of substances that play some crucial role in coagulation, inflammation and thrombosis. Platelet volume is a marker of platelet activation and measured by using mean platelet volume (MPV).
The American Journal of Cardiologyâ MARCH 10e13, 2016 12th INTERNATIONAL CONGRESS OF UPDATE IN CARDIOLOGY AND CARDIOVASCULAR SURGERY ABSTRACTS / Oral
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P O S T E R A B S T R A C T S
- PP-020
P O S T E R
Conclusions: The severity of ED is an independent factor predicting the extent of CAD. The early detection of ED enables to make a cardiovascular evaluation. Therefore, taking the cardiovascular risk factors under an aggressive treatment may contribute to prevent the cardiovascular cases which may develop in the future.
The Relation between Erectile Dysfunction and Extent of Coronary Artery Disease in the Patients with Stable Coronary Artery Disease. Hikmet Hamur1, Hakan Duman2, Ercument Keskin3, Sinan Inci4, Zafer Kucuksu1, Husnu Degirmenci1, Ergun Topal1. 1 Department of Cardiology, Faculty of Medicine, Erzincan University, Erzincan, Turkey; 2Department of Cardiology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey; 3Department of Urology, Faculty of Medicine, Erzincan University, Erzincan, Turkey; 4Department of Cardiology, Aksaray State Hospital, Aksaray, Turkey.
- PP-021
Objective: Erectile dysfunction (ED) and coronary artery disease (CAD) are closely related as a result of endothelial dysfunction leading to the restriction of blood flow. ED is a potential independent risk factor of CAD. We investigated the prevalence and severity of ED, the extent of CAD and the time interval between the symptoms of ED and CAD in the stable coronary artery patients. Methods: 161 patients applied coronary angiography were divided into two groups according to SYNTAX score as group 1 (n¼81) SYNTAX score 22, and group 2 (n¼80) SYNTAX score >22. The prevalence and severity of ED was determined by using The International Index of Erectile Function (IIEF). Results: The prevalence of ED was 43.2% in group 1 and 61.3% in group 2 (P¼0.022). The score of IIEF was 23.1 (15-29) in group 1, 19.3 (6-29) in group 2; there was a significant difference (P¼0.000). In the multivariate logistic regression analysis carried out in order to determine the independent predictors on Syntax score, it was found that LDL (odds ratio: 1.032, 95% confidence interval: 1.009-1.055, P¼0.007) and IIEF score (odds ratio: 0.825, 95% confidence interval: 0.733-0.928, P¼0.001) were the independent predictors. The time between the symptoms of ED and CAD 30.1 4.8 months in group 1, and 40.5 4.3 months in group 2 (P¼0.000).
Objective: We investigated whether serum bilirubin level (a marker of heme oxygenase activity) is a predictor of trombus burden in patients with acute myocardial infarction. Methods: Patients (n ¼ 229; male 72.9%; mean age 63 13.4 years) who were admitted with ST-elevation myocardial infarction (STEMI) were enrolled. Patients were divided into 2 groups. Group 1 was defined as low thrombus burden and group 2 was defined as high thrombus burden. Results: Patients with high-thrombus burden had higher total bilirubin levels (14.36 [4.27 e 22.91] vs 7.69 [2.39 e 20.34] mmol/L, p¼<.001) and direct bilirubin levels (3.08 [2.13 e 8.38] vs 1.71 [0.51 e 6.49] mmol/L, p¼<.001). At multivariate analysis, total bilirubin (odds ratio: 1.054, 95% confidence interval: 1.031 e 1.079, p¼<.001) was the independent predictor of high thrombus burden. Conclusions: Total bilirubin level is independently associated with high thrombus burden in patients with STEMI.
A B S T R A C T S
Bilirubin Levels and Thrombus Burden in Patients with ST-elevation Myocardial Infarction. Hikmet Hamur1, Hakan Duman2, Eftal Murat Bakirci1, Zafer Kucuksu1, Selami Demirelli3, Kamuran Kalkan3, Husnu Degirmenci1. 1 Department of Cardiology, Faculty of Medicine, Erzincan University, Erzincan, Turkey; 2Department of Cardiology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey; 3Department of Cardiology, Training and Research Hospital, Erzurum, Turkey.
Figure 1. Total bilirubin levels between low and high thrombus burden groups.
- PP-022
Figure 1. The receiver-operating characteristic (ROC) curve of international index of erectile function (IIEF) score for predicting the higher Syntax score.
Association of Coronary Atherosclerosis and Latent Chronic Kidney Disease in Turkish Population. Suat Görmel1, Emre Yalçınkaya4, Mustafa Köklü2, Uygar agdas¸ Yüksel2, Barıs¸ Bugan3, Murat Çelik2, Cem Barçın2, Yalçın Gökoglan2, Kutsi Hasan Kabul2, Erol Gürsoy2, Salim Yas¸ar5, Erkan Yıldırım2. 1Beytepe Military Hospital; 2Department of Cardiology, Gulhane Military Medical Faculty, Ankara, Turkey; 3Girne Military Hospital; 4Aksaz Military Hospital; 5Etimesgut Military Hospital.
S50 The American Journal of Cardiologyâ MARCH 10e13, 2016 12th INTERNATIONAL CONGRESS OF UPDATE IN CARDIOLOGY AND CARDIOVASCULAR SURGERY ABSTRACTS / Oral
MARCH 10e13, 2016
Objective: As already known there is strong association between chronic kidney disease (CKD) and atherosclerotic coronary disease. In this study we aimed to evaluate the relationship between coronary artery disease (CAD) and renal dysfunction level (RDL) in a group of Turkish patients. Methods: 414 consecutive patients undergoing cardiac catheterization were enrolled. Angiograms were reviewed and Gensini scores were determined. Estimated glomerular filtration rate (eGFR) was calculated and classified. CKD was defined as eGFR < 60 ml/min. The results were obtained by calculating ’p’ value by ’z’ test, ’t’ test, chi-square test, as appropriate to see the difference between two groups. The results thus obtained were plotted on table, pie-chart, line chart, bar-diagram etc. as appropriate p value <0.05 was considered significant. Results: Among the 414 patients who exhibited variable degrees of CAD, 58,2% had an eGFR < 60 ml/min. We observed a steady increase in the Gensini score level as eGFR declined and a progressive reduction in renal function with the worsening of CAD extent (P < 0.05). Despite considerable inter-patient variability this correlation was quite evident. Conclusions: As a result CAD extent and RDL seems to have a gradual relationship Considering eGFR level as a risk factor may be valuable in the risk stratification of patients with coronary atherosclerosis.
- PP-023 Relationship between Exercise Testing and Variations in Hematologic Parameters. Ahmet Korkmaz1, Abdulkadir Yıldız2, Mustafa Oylumlu2, Pınar Türker1, Deniz S¸ahin1, Funda Bas¸yigit1, Özgül Uçar Elalmıs¸1, _ 1. 1Ankara Numune Egitim Ümit Güray1, Mehmet Ileri 2 Aras¸tirma Hastanesi; Dicle Üniversitesi Tıp Fakültesi Hastanesi. Background: In patients admitted to outpatient clinics with chest pain, changes in the ST segments of ECG readings are the most widely used criteria during tredmill ECG tests to determine myocardial ischaemia, despite its poor accuracy. In this study, we evaluated the benefit of hematological parameters, particularly neutrophil to lymphocyte ratio (NLR), in addition to changes in the ST segments for the detection of myocardial ischaemia with treadmill ECG testing. Methods: Total 113 patients without a history of coronary artery disease who presented with chest pain and underwent both treadmill ECG test and coronary angiography were enrolled in the study. Peripheral venous blood samples were drawn before 1 hour to exercise ECG testing. Total and differential leukocyte counts were measured. Absolute cell counts were used in the analyses. Same analyses made 15 minutes after pick exercise. Biochemical parameters were measured by standard methods and conventional coronary angiography was performed by standard
techniques and analyzed masked to identity, clinical information, exercise ECG results. In patients with stenosis 50% determined visually by the consensus of two experienced cardiologists, computer-assisted quantification of luminal diameter stenosis (QCA) was performed. Results: The NLR was significantly increased in patients with positive stress test(68 patients) and significant coronary stenosis(63 patients) compared to patients with negative stress test and insignificant coronary stenosis, respectively. The sensitivity and specificity of treadmill ECG testing in this study was 79% and 64%, respectively. The change in NLR before and after the treadmill ECG testing improved these values. A cutoff point of 0.2 for the change in NLR in addition to positive stress test had 91% sensitivity and 92% specificity (ROC area under curve:0.913, 95% CI: 0.805-1.000) in predicting significant coronary stenosis. Conclusions: Elevation of NLR during treadmill ECG testing were associated with the presence of coronary arter disease which may be an indicator of immune activation occurs during myocardial ischemia. The addition of elevation of NLR to the conventionally used criterion of changes in the ST -segments in patients with suspected myocardial ischaemia incresed the sensitivity and specificity of treadmill ECG testing for detecting myocardial ischaemia, which might reduce the need for other expensive non-invasive techniques. ROC. AUC: 0.913 (95% CI 0.805-1.000) Post-exercise NLR increase of 0.20 has a 91% sensitivity and 92% specificity for the presence of Coronary artery disease which is defined as the presence of an at least 50% stenotic lesion
- PP-024 The Comparison of mean Platelet Volumes between Non St and St Elevation Acute Coronary Syndromes. Orhan Delice1, Selami Demirelli2, Kamuran Kalkan2, Erkan Yildirim2, Mustafa Oztürk2, Emrah Ipek2. 1 Department of Emergency Medicine, Erzurum Education and Research Hospital, Erzurum, Turkey; 2Department of Cardiology, Erzurum Education and Research Hospital, Erzurum, Turkey. Objective: Platelets, as an important actor in atherothrombosis, secrete a group of substances that play some crucial role in coagulation, inflammation and thrombosis. Platelet volume is a marker of platelet activation and measured by using mean platelet volume (MPV).
The American Journal of Cardiologyâ MARCH 10e13, 2016 12th INTERNATIONAL CONGRESS OF UPDATE IN CARDIOLOGY AND CARDIOVASCULAR SURGERY ABSTRACTS / Oral
S51
P O S T E R A B S T R A C T S