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PP-168 Effects of Chronic Renal Failure on Oxidative Stress and Inflammation in Patients with Heart Failure
MARCH 10e13, 2016
- PP-168 Effects of Chronic Renal Failure on Oxidative Stress and Inflammation in Patients with Heart Failure. Zafer Isilak1, Huseyin Kozan2, Murat Yalcin1, Mehmet Dogan3, Haluk Un1, Mustafa Aparci1, Serdar Hira4, Omer Ozcan5, Ejder Kardesoglu1. 1Department of Cardiology, Gulhane Military Medical Academy, Haydarpasa Training Hospital, Istanbul, Turkey; 2Department of Cardiology, Bursa Military Hospital, Bursa, Turkey; 3 Department of Cardiology, Ankara Mevki Military Hospital, Ankara, Turkey; 4Department of Biochemisty, Tatvan Military Hospital, Bitlis, Turkey; 5Department of Biochemisty, Gulhane Military Medical Academy, Haydarpasa Training Hospital, Istanbul, Turkey. Objective: Heart failure with reduced ejection fraction (HFREF) is closely associated with high mortality and morbidity rates. HFREF is frequently associated with renal failure. Oxidative stress and inflammation are two pathological processes which have important role in the pathophysiology of HFREF. The aim of this study is to evaluate the oxidative stress and inflammation process in patients with HREF and renal failure. Methods: Forty two patients with HFREF and ischemic heart disease were included to the study. Glomerular filtration rates (GFR) were estimated by using MDRD formula. Patients were grouped according to GFR values higher or lower than 60 mL/min/1.73m2. Oxidative stress level was evaluated by malonic dialdehyde (MDA) levels and high sensitive CRP levels. Results: Patients with low GFR (n ¼ 18) had mean age and GFR values as 75.67.6 years old and 49.813.3, respectively. Patients with high GFR (n ¼ 11) had mean age and GFR as 65.912.2 years and 76.6 18.3 mL/min/1.73m2 (p <0.05). After correcting for age, there was no significant difference between groups in terms of MDA and CRP levels. Although the difference between groups was not statistically significant, mean serum level of MDA was tended to be higher in patients with low GFR (16.1 16.6 vs 17.912.3). CRP level was (2.74.8 vs 3.8 6.4) not different between study groups. Conclusion: In patients with HFREF, who had ischemic heart disease and reduced renal function, MDA was tended to be higher in subgroup with low GFR. Oxidative stress represented by MDA may contribute to HFREF in those patients. These findings should be tested in large populated study groups.
Current Issues in Preventive Cardiology (Abstract nos. PP-169 w PP-184) - PP-170 Arrhythmogenic Potential of Vitamin D Insufficiency. Ahmet Karagöz1, Aslı Vural1, Zeki Yüksel Günaydın2, Osman Bektas¸2, Abdullah Çelik3. 1Department of Cardiology, Giresun University, Giresun, Turkey; 2Department of Cardiology, Ordu University, Urdu, Turkey; 3Department of Cardiovascular Surgery, Giresun University, Giresun, Turkey. Objective: Although the reports are also present demonstrating the exact opposite, general opinion is that vitamin D has favorable effects on cardiovascular system. The association between vitamin D insufficiency and coronary artery disease, heart failure and hypertension were
well demonstrated. Nevertheless the impact of vitamin D insufficiency on arrhythmia remains unclear. Methods: Low vitamin D and control groups consisted of 74 and 80 patients respectively. Parameters of arrhythmia including QT and P wave dispersion, SDNN (standard deviation of all normal R-R intervals), SDNN-index (the mean of the standard deviation of normal 5-minute RR intervals), pNN50 (consecutive R-R intervals differ by more than 50 msec), RMSSD (root mean square of the successive differences), HF (High-frequency power) and LF (Low-frequency power) as well as the number of atrial pre-systole, atrial pair, supraventricular tachycardia, ventricular pre-systole, ventricular pair, nonsustained ventricular tachycardia, sustained ventricular tachycardia were compared between the patients with vitamin D insufficiency and controls.
Figure 1. Distribution of QT dispersion in low vitamin D and control groups. Table 2 Comparison of arrhythmia parameters between low-vitamin D and control groups Low-vitamin D group (n¼74)
Control Group (n¼80)
Max QTc 434,0017,81 432,3018,06 Min QTc 376 (343-401) 374 (341-398) QTc dispersion 61,0214,33 60,2114,17 Max p wave 111,467,83 111,217,34 P wave 45,00 (19,00-56,00) 42,00 (24,00-60,00) dispersion SDNN 136,5124,87 135,6227,15 SDNN index 54,4814,21 49,7812,72 RMSSD 30 (12-85) 26 (14-60) pNN50 9 (3-30) 8 (3-23) HF 202,80 (95,90-861,00) 191,20 (89,30-535,60) LF 481,14222,09 434,77 210,04 APS 5 (0-7863) 9 (0-8240) APS pair 0 (0-200) 0 (0-31) SVT 0 (0-29) 0 (0-3) VPS 0 (0-3780) 0 (0-7552) VPS pair 0 (0-49) 0 (0-29) Non-sustained 0 (0-0) 0 (0-2) VT Sustained VT 0 (0-5) 0 (0-0) Max HR 135,5112,41 133,0013,38 Min HR 50 (39-78) 53 (36-65) Mean HR 74,279,25 73,386,26
p 0,684 0,750 0,807 0,891 0,341 0,883 0,138 0,279 0,798 0,408 0,359 0,664 0,560 0,057 0,545 0,464 0,317 0,317 0,406 0,238 0,635
APS: Atrial pre-systole, HF: High-frequency power, LF: Low-frequency power, Max HR: Maximum heart rate, Max p wave: Maximum p wave, Max QTc: Maximum QT corrected, Mean HR: Mean heart rate, Min HR: Minimum heart rate, Min p wave: Minimum p wave, Min QTc: Minimum QT corrected, pNN50: Consecutive R-R intervals differ by more than 50 msec, RMSSD: Root mean square of the successive differences, SDNN: Standard deviation of all normal R-R intervals, SVT: Supraventricular tachycardia, VPS: Ventricular pre-systole, VT: Ventricular tachycardia
The American Journal of Cardiologyâ MARCH 10e13, 2016 12th INTERNATIONAL CONGRESS OF UPDATE IN CARDIOLOGY AND CARDIOVASCULAR SURGERY ABSTRACTS / Poster S101
P O S T E R A B S T R A C T S
- PP-168 Effects of Chronic Renal Failure on Oxidative Stress and Inflammation in Patients with Heart Failure. Zafer Isilak1, Huseyin Kozan2, Murat Yalcin1, Mehmet Dogan3, Haluk Un1, Mustafa Aparci1, Serdar Hira4, Omer Ozcan5, Ejder Kardesoglu1. 1Department of Cardiology, Gulhane Military Medical Academy, Haydarpasa Training Hospital, Istanbul, Turkey; 2Department of Cardiology, Bursa Military Hospital, Bursa, Turkey; 3 Department of Cardiology, Ankara Mevki Military Hospital, Ankara, Turkey; 4Department of Biochemisty, Tatvan Military Hospital, Bitlis, Turkey; 5Department of Biochemisty, Gulhane Military Medical Academy, Haydarpasa Training Hospital, Istanbul, Turkey. Objective: Heart failure with reduced ejection fraction (HFREF) is closely associated with high mortality and morbidity rates. HFREF is frequently associated with renal failure. Oxidative stress and inflammation are two pathological processes which have important role in the pathophysiology of HFREF. The aim of this study is to evaluate the oxidative stress and inflammation process in patients with HREF and renal failure. Methods: Forty two patients with HFREF and ischemic heart disease were included to the study. Glomerular filtration rates (GFR) were estimated by using MDRD formula. Patients were grouped according to GFR values higher or lower than 60 mL/min/1.73m2. Oxidative stress level was evaluated by malonic dialdehyde (MDA) levels and high sensitive CRP levels. Results: Patients with low GFR (n ¼ 18) had mean age and GFR values as 75.67.6 years old and 49.813.3, respectively. Patients with high GFR (n ¼ 11) had mean age and GFR as 65.912.2 years and 76.6 18.3 mL/min/1.73m2 (p <0.05). After correcting for age, there was no significant difference between groups in terms of MDA and CRP levels. Although the difference between groups was not statistically significant, mean serum level of MDA was tended to be higher in patients with low GFR (16.1 16.6 vs 17.912.3). CRP level was (2.74.8 vs 3.8 6.4) not different between study groups. Conclusion: In patients with HFREF, who had ischemic heart disease and reduced renal function, MDA was tended to be higher in subgroup with low GFR. Oxidative stress represented by MDA may contribute to HFREF in those patients. These findings should be tested in large populated study groups.
Current Issues in Preventive Cardiology (Abstract nos. PP-169 w PP-184) - PP-170 Arrhythmogenic Potential of Vitamin D Insufficiency. Ahmet Karagöz1, Aslı Vural1, Zeki Yüksel Günaydın2, Osman Bektas¸2, Abdullah Çelik3. 1Department of Cardiology, Giresun University, Giresun, Turkey; 2Department of Cardiology, Ordu University, Urdu, Turkey; 3Department of Cardiovascular Surgery, Giresun University, Giresun, Turkey. Objective: Although the reports are also present demonstrating the exact opposite, general opinion is that vitamin D has favorable effects on cardiovascular system. The association between vitamin D insufficiency and coronary artery disease, heart failure and hypertension were
well demonstrated. Nevertheless the impact of vitamin D insufficiency on arrhythmia remains unclear. Methods: Low vitamin D and control groups consisted of 74 and 80 patients respectively. Parameters of arrhythmia including QT and P wave dispersion, SDNN (standard deviation of all normal R-R intervals), SDNN-index (the mean of the standard deviation of normal 5-minute RR intervals), pNN50 (consecutive R-R intervals differ by more than 50 msec), RMSSD (root mean square of the successive differences), HF (High-frequency power) and LF (Low-frequency power) as well as the number of atrial pre-systole, atrial pair, supraventricular tachycardia, ventricular pre-systole, ventricular pair, nonsustained ventricular tachycardia, sustained ventricular tachycardia were compared between the patients with vitamin D insufficiency and controls.
Figure 1. Distribution of QT dispersion in low vitamin D and control groups. Table 2 Comparison of arrhythmia parameters between low-vitamin D and control groups Low-vitamin D group (n¼74)
Control Group (n¼80)
Max QTc 434,0017,81 432,3018,06 Min QTc 376 (343-401) 374 (341-398) QTc dispersion 61,0214,33 60,2114,17 Max p wave 111,467,83 111,217,34 P wave 45,00 (19,00-56,00) 42,00 (24,00-60,00) dispersion SDNN 136,5124,87 135,6227,15 SDNN index 54,4814,21 49,7812,72 RMSSD 30 (12-85) 26 (14-60) pNN50 9 (3-30) 8 (3-23) HF 202,80 (95,90-861,00) 191,20 (89,30-535,60) LF 481,14222,09 434,77 210,04 APS 5 (0-7863) 9 (0-8240) APS pair 0 (0-200) 0 (0-31) SVT 0 (0-29) 0 (0-3) VPS 0 (0-3780) 0 (0-7552) VPS pair 0 (0-49) 0 (0-29) Non-sustained 0 (0-0) 0 (0-2) VT Sustained VT 0 (0-5) 0 (0-0) Max HR 135,5112,41 133,0013,38 Min HR 50 (39-78) 53 (36-65) Mean HR 74,279,25 73,386,26
p 0,684 0,750 0,807 0,891 0,341 0,883 0,138 0,279 0,798 0,408 0,359 0,664 0,560 0,057 0,545 0,464 0,317 0,317 0,406 0,238 0,635
APS: Atrial pre-systole, HF: High-frequency power, LF: Low-frequency power, Max HR: Maximum heart rate, Max p wave: Maximum p wave, Max QTc: Maximum QT corrected, Mean HR: Mean heart rate, Min HR: Minimum heart rate, Min p wave: Minimum p wave, Min QTc: Minimum QT corrected, pNN50: Consecutive R-R intervals differ by more than 50 msec, RMSSD: Root mean square of the successive differences, SDNN: Standard deviation of all normal R-R intervals, SVT: Supraventricular tachycardia, VPS: Ventricular pre-systole, VT: Ventricular tachycardia
The American Journal of Cardiologyâ MARCH 10e13, 2016 12th INTERNATIONAL CONGRESS OF UPDATE IN CARDIOLOGY AND CARDIOVASCULAR SURGERY ABSTRACTS / Poster S101
P O S T E R A B S T R A C T S