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PP-208: SURGICAL APPROACH FOR ANOMALOUS ORIGIN OF THE LEFT CORONARY ARTERY ARISING FROM RIGHT PULMONARY ARTERY; A CASE REPORT
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Posters / International Journal of Cardiology 147S2 (2011) S131–S175
that were not readily detectable in the original sample indicating the power of enrichment. This consistent and high resolved analysis of pericardial effusions allowed us to compare samples obtained from different patients indicating the potential use of pericardial effusions for clinincal diagnosis of cardiovascular diseases. Conclusions: Proteins which can be analyzed with proteomics display tumor load and response to treatment. These proteins can be used for diognosis, treatment modalities and prognostic analysis. In the literature there are very few studies for proteomics analysis of pericardial effusions. Advance in proteomics analyses is apperant but present studies do not produce novel, specific biomarkers. Developments increase in proteomics field and data analyse programs are improved. PP-208 SURGICAL APPROACH FOR ANOMALOUS ORIGIN OF THE LEFT CORONARY ARTERY ARISING FROM RIGHT PULMONARY ARTERY; A CASE REPORT A. Icli1 , M. Erdinc2 , O. Karahan3 , H. Mutlu4 , H. Kahraman1 . 1 Department of Cardiology, Buyuksehir Belediye Hosptial, Konya, Turkey; 2 Department of Cardiovascular Surgery, Buyuksehir Belediye Hosptial, Konya, Turkey; 3 Department of Cardiovascular Surgery, Medical School of Cumhuriyet University, Sivas, Turkey; 4 Department of Internal Medicine, St. Peter‘s Hospital, Albany, Newyork, USA Objective: The left coronary artery arising from the pulmonary artery is a rare congenital anomaly. It causes dramatic clinical features in childhood. However, it can be shows silent progression with the development of collateral circulation such as our case. Based on a review of the literature, we report a 44-year-old female case without any other previous history of hospitalization. Methods: The patient was admitted to our clinic with complaint of recently occurred chest pain and effort dyspnea. In her electrocardiogram persistent atrial fibrillation and left bundle brunch block was detected. Because of this angiography was applied to the case. Angiography revealed the anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA). Results: Osteal reimplantation was applied with Kang Procedure which is based on extending of left coronary artery with pulmonary artery wall and pulmonary artery patching with pericardia, in surgical approach. Patient had an uneventful postoperative period.
Figure 1. Multislice computer tomography with three-dimensional reconstruction of ALCAPA.
Figure 2. A Bolus of radio-opaque is injected into the right coronary artery, it fills the left coronary artery branches from collaterals, then reaches to main pulmonary artery through the ALCAPA. Conclusions: To sum up, congenital coronary artery anomalies may not have the early signs. They must determine, before the irreversible changes occurred. The ALCAPA’s prognosis is very poor, but it has been changed by the development of appropriate cardiac surgical approaches. For example in our case; although advanced age and severe cardiac failure, osteal correction surgery with Kang Procedure was applied successfully. This procedure is easily applicable and it is good technique for provide the anatomical position and intraoperative bleeding control. PP-209 PARAOXONASE 1 ENZYME ACTIVITY IN METABOLIC SYNDROME PATIENTS WITHOUT CORONARY ARTERY DISEASE E. Yucel, A. Aydinlar, A. Aydin Kaderli, T. Senturk, S. Gunay, B. Ozdemir, I. Baran, S. Gullulu. Department of Cardiology, Uludag University, Bursa, Turkey Objective: The metabolic syndrome (MS) involving lots of atherosclerotic risk factors together is a disease of increased oxidative stress and cardiovascular mortality. Paraoxonase 1 (PON1) which is synthesized in the liver and carried on high density lipoprotein cholesterol (HDL-C) in plasma shows protective effect against atherosclerosis via preventing oxidation of low density lipoprotein cholesterol (LDL-C). The purpose of this study is to compare PON1 enzyme activity in MS patients without coronary artery disease (CAD) and healty controls. Methods: A total of 50 patients were performed coronary angiography were included in this study. Patients were separated to 2 groups. 30 patients with MS and without CAD was classified as group 1 (MS+ CAD-) and 20 patients with neither MS nor CAD (control group, MS- CAD-) was classified as group 2. Groups were compared according to their PON1 acitivity. Results: Paraoxonase 1 enzyme activity was lower in MS+ CADgroup than in controls (p = 0.004). Conclusions: This study has shown that PON1 enzyme activity which is antioxidant and protective against atherosclerosis is decreased in patients with MS without CAD compared to controls.
Posters / International Journal of Cardiology 147S2 (2011) S131–S175
that were not readily detectable in the original sample indicating the power of enrichment. This consistent and high resolved analysis of pericardial effusions allowed us to compare samples obtained from different patients indicating the potential use of pericardial effusions for clinincal diagnosis of cardiovascular diseases. Conclusions: Proteins which can be analyzed with proteomics display tumor load and response to treatment. These proteins can be used for diognosis, treatment modalities and prognostic analysis. In the literature there are very few studies for proteomics analysis of pericardial effusions. Advance in proteomics analyses is apperant but present studies do not produce novel, specific biomarkers. Developments increase in proteomics field and data analyse programs are improved. PP-208 SURGICAL APPROACH FOR ANOMALOUS ORIGIN OF THE LEFT CORONARY ARTERY ARISING FROM RIGHT PULMONARY ARTERY; A CASE REPORT A. Icli1 , M. Erdinc2 , O. Karahan3 , H. Mutlu4 , H. Kahraman1 . 1 Department of Cardiology, Buyuksehir Belediye Hosptial, Konya, Turkey; 2 Department of Cardiovascular Surgery, Buyuksehir Belediye Hosptial, Konya, Turkey; 3 Department of Cardiovascular Surgery, Medical School of Cumhuriyet University, Sivas, Turkey; 4 Department of Internal Medicine, St. Peter‘s Hospital, Albany, Newyork, USA Objective: The left coronary artery arising from the pulmonary artery is a rare congenital anomaly. It causes dramatic clinical features in childhood. However, it can be shows silent progression with the development of collateral circulation such as our case. Based on a review of the literature, we report a 44-year-old female case without any other previous history of hospitalization. Methods: The patient was admitted to our clinic with complaint of recently occurred chest pain and effort dyspnea. In her electrocardiogram persistent atrial fibrillation and left bundle brunch block was detected. Because of this angiography was applied to the case. Angiography revealed the anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA). Results: Osteal reimplantation was applied with Kang Procedure which is based on extending of left coronary artery with pulmonary artery wall and pulmonary artery patching with pericardia, in surgical approach. Patient had an uneventful postoperative period.
Figure 1. Multislice computer tomography with three-dimensional reconstruction of ALCAPA.
Figure 2. A Bolus of radio-opaque is injected into the right coronary artery, it fills the left coronary artery branches from collaterals, then reaches to main pulmonary artery through the ALCAPA. Conclusions: To sum up, congenital coronary artery anomalies may not have the early signs. They must determine, before the irreversible changes occurred. The ALCAPA’s prognosis is very poor, but it has been changed by the development of appropriate cardiac surgical approaches. For example in our case; although advanced age and severe cardiac failure, osteal correction surgery with Kang Procedure was applied successfully. This procedure is easily applicable and it is good technique for provide the anatomical position and intraoperative bleeding control. PP-209 PARAOXONASE 1 ENZYME ACTIVITY IN METABOLIC SYNDROME PATIENTS WITHOUT CORONARY ARTERY DISEASE E. Yucel, A. Aydinlar, A. Aydin Kaderli, T. Senturk, S. Gunay, B. Ozdemir, I. Baran, S. Gullulu. Department of Cardiology, Uludag University, Bursa, Turkey Objective: The metabolic syndrome (MS) involving lots of atherosclerotic risk factors together is a disease of increased oxidative stress and cardiovascular mortality. Paraoxonase 1 (PON1) which is synthesized in the liver and carried on high density lipoprotein cholesterol (HDL-C) in plasma shows protective effect against atherosclerosis via preventing oxidation of low density lipoprotein cholesterol (LDL-C). The purpose of this study is to compare PON1 enzyme activity in MS patients without coronary artery disease (CAD) and healty controls. Methods: A total of 50 patients were performed coronary angiography were included in this study. Patients were separated to 2 groups. 30 patients with MS and without CAD was classified as group 1 (MS+ CAD-) and 20 patients with neither MS nor CAD (control group, MS- CAD-) was classified as group 2. Groups were compared according to their PON1 acitivity. Results: Paraoxonase 1 enzyme activity was lower in MS+ CADgroup than in controls (p = 0.004). Conclusions: This study has shown that PON1 enzyme activity which is antioxidant and protective against atherosclerosis is decreased in patients with MS without CAD compared to controls.