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PP-277 Relation of ABO-Blood Groups with Angiographic Thrombus Burden in Patients with STEMI
MARCH 13e16, 2014 normal coronary arteries (p<0.001). In the multinominal logistic regression analysis, MPV was found to be an independent predictor for the presence of severe coronary artery lesions in patients undergoing coronary CTA (OR: 1.209; 95% CI 1.018-1.435, p<0.05). However, the distribution of MPV values did not differ among different types of morphology of the atherosclerotic plaque (noncalcified plaque, mixed plaque or calcified plaque) (p>0.05). Conclusion: MPV is an independent predictor of the severity of atherosclerotic lesions in patients undergoing coronary CTA, however is not associated with the morphology of coronary atherosclerostic disease.
- PP-275 Association between Serum Vitamin D Levels and Subclinical Coronary Atherosclerosis and Plaque Morphology in Young Adults. O. Celik1, F. Akin2, M. Erturk1, A. Yalcın1, M. Atasoy3, F. Akturk1, B. Ayca1, H. Psuroglu1, K.A. Celik4, N. Uslu1. 1 Department of Cardiology, Mehmet Akif Ersoy Chest and Cardiovascular Surgery Education and Research Hospital, Istanbul, Turkey; 2Department of Cardiology, Mugla Sıtkı Kocman University School of Medicine, Mugla, Turkey; 3Department of Radiology, Maltepe University School of Medicine, Istanbul, Turkey; 4Kagıthane State Hospital, Istanbul, Turkey. We investigated the link between serum vitamin D levels and subclinical coronary atherosclerosis in young adults. We measured serum 25OHD levels, high-sensitivity C-reactive protein (hs-CRP) and uric acid levels in asymptomatic patients under 45 years old without known cardiovascular disease. We analyzed the relation between serum levels of 25OHD and subclinical atherosclerosis and coronary plaque morphology. Subclinical coronary atherosclerosis was defined as the presence of any plaques on a coronary CT angiography in asymptomatic patients. Patients with subclinical atherosclerosis had significantly higher serum total cholesterol, trigliserid, hs-CRP, uric acid, hemoglobin A1c (HbA1c) and creatinine levels and lower serum 25OHD levels compared with those without subclinical atherosclerosis. There was no significant correlation with 25OHD and plaque morphology. In multivariate logistic regression analysis subclinical coronary atherosclerosis was associated hs-CRP (adjusted OR: 2.832), vitamin D (adjusted OR: 0.689), and uric acid (adjusted OR: 3.671). Serum levels of 25OHD are significantly associated with subclinical coronary atherosclerosis.
- PP-276 Effects of Statins on Hematological Parameters. A. Çolak, Y. Güray, B. Acar, S. Kuyumcu, E. Gücük, P. Dogan, B. Demirkan. Turkiye Yuksek Ihtisas Hospital, Department of Cardiology, Ankara, Turkey. Objectives: MPV has been shown to be as a predictor of platelet activation which plays an important role in pathophysiology of atherosclerosis. Elevated RDW values are shown to be associated with worse prognosii in heart failure, coronary artery disease, pulmonary hypertension and peripheral arterial disease. In our study we aim to investigate the effect of statin on hematologic parameters in stable coronary artery disease. Method: We retrospectively analysed statin naive patients who had gone coronary angiography for stable coronary artery disease between June 2012 and June 2013. MPV and RDW values, before and after statin use, are compared. Results: After a mean follow up period of 58 day (minimum 17, maximum 720), in total of 121 patient while RDW levels were significantly different before and after statin use (p¼0.001), MPV levels after treatment with statin didn’t reach an significant difference (p¼0.325). Conclusion: In conclusion treatment with statin significantly reduce the RDW levels in stable coronary artery disease which confirms the
antiinflammatory effect of statins. But decrease of RDW levels whether associated with prognosis in stable coronary artery disese or not has to established by multi center, prospective studies in large populations.
- PP-277 Relation of ABO-Blood Groups with Angiographic Thrombus Burden in Patients with STEMI. S. Topcu1, A. Kaya2, K. Kalkan1, _ Z. Lazoglu1, E.M. Bakırcı1, Z. Avs¸ar3, I.H. Tanboga1. 1 Cardiology Department, Ataturk University, Erzurum, Turkey; 2 Cardiology Department, Ordu University, Ordu, Turkey; 3Department of Family Medicine, Ataturk University, Erzurum, Turkey. Introduction: We aimed to investigate the determinants of angiographic thrombus burden in patients with ST-segment elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (pPCI). Methods: The study population consisted of 115 patients with nonanemic STEMI who underwent pPCI. Clinical, laboratory, and demographic properties of the patients were recorded. From all patients ABO blood group was determined. Angiographic coronary thrombus burden was scored based on thrombolysis in myocardial infarction (TIMI) thrombus grades. After wiring and/or small balloon dilation, patients with thrombus burden grades 4 and 5 were defined as high thrombus burden, and patients with thrombus burden¼II), baseline creatine kinase-MB fraction (CK-MB), higher peak CK-MB and more non-O blood group. In multivariate logistic regression analysis, only higher Killip class (OR: 1.12, 95% confidence interval 1.02-1.22, P <.05) and non-O blood group (OR: 1.05, 95% confidence interval 1.01-1.09, P <.05) were determined as independent predictor. Conclusion: Present study results demonstrated that high thrombus burden in patients with STEMI was associated with more non-O blood group.
Coronary Artery Disease: Clinical, Non-invasive and Invasive Evaluation (Abstract nos. PP-278 w PP-302) - PP-278 The Clinical Features, Risk Factors And Treatment Methods Of Patients with Acute Coronary Syndrome. N. Aladag1, M. Yurtdas¸1, M. Özdemir1, H. Gönüllü2, N. Babat4, G. Demir3, H. Gümrükçüoglu4. 1 Van Education and Research Hospital, Department of Cardiology, Van, Turkey; 2Yüzüncü Yıl University, Faculty of Medicine, Department of Emergency Medicine, Van, Turkey; 3Medipol University, Department _ of Cardiology, Istanbul, Turkey; 4Yüzüncü Yıl University, Faculty of Medicine, Department of Cardiology, Van, Turkey. Objective: The term acute coronary syndrome; unstable angina pectoris (USAP), non-ST segment elevation myocardial infarction
The American Journal of Cardiologyâ MARCH 13e16, 2014 10th INTERNATIONAL CONGRESS OF UPDATE IN CARDIOLOGY AND CARDIOVASCULAR SURGERY ABSTRACTS / Poster S117
P O S T E R A B S T R A C T S
- PP-275 Association between Serum Vitamin D Levels and Subclinical Coronary Atherosclerosis and Plaque Morphology in Young Adults. O. Celik1, F. Akin2, M. Erturk1, A. Yalcın1, M. Atasoy3, F. Akturk1, B. Ayca1, H. Psuroglu1, K.A. Celik4, N. Uslu1. 1 Department of Cardiology, Mehmet Akif Ersoy Chest and Cardiovascular Surgery Education and Research Hospital, Istanbul, Turkey; 2Department of Cardiology, Mugla Sıtkı Kocman University School of Medicine, Mugla, Turkey; 3Department of Radiology, Maltepe University School of Medicine, Istanbul, Turkey; 4Kagıthane State Hospital, Istanbul, Turkey. We investigated the link between serum vitamin D levels and subclinical coronary atherosclerosis in young adults. We measured serum 25OHD levels, high-sensitivity C-reactive protein (hs-CRP) and uric acid levels in asymptomatic patients under 45 years old without known cardiovascular disease. We analyzed the relation between serum levels of 25OHD and subclinical atherosclerosis and coronary plaque morphology. Subclinical coronary atherosclerosis was defined as the presence of any plaques on a coronary CT angiography in asymptomatic patients. Patients with subclinical atherosclerosis had significantly higher serum total cholesterol, trigliserid, hs-CRP, uric acid, hemoglobin A1c (HbA1c) and creatinine levels and lower serum 25OHD levels compared with those without subclinical atherosclerosis. There was no significant correlation with 25OHD and plaque morphology. In multivariate logistic regression analysis subclinical coronary atherosclerosis was associated hs-CRP (adjusted OR: 2.832), vitamin D (adjusted OR: 0.689), and uric acid (adjusted OR: 3.671). Serum levels of 25OHD are significantly associated with subclinical coronary atherosclerosis.
- PP-276 Effects of Statins on Hematological Parameters. A. Çolak, Y. Güray, B. Acar, S. Kuyumcu, E. Gücük, P. Dogan, B. Demirkan. Turkiye Yuksek Ihtisas Hospital, Department of Cardiology, Ankara, Turkey. Objectives: MPV has been shown to be as a predictor of platelet activation which plays an important role in pathophysiology of atherosclerosis. Elevated RDW values are shown to be associated with worse prognosii in heart failure, coronary artery disease, pulmonary hypertension and peripheral arterial disease. In our study we aim to investigate the effect of statin on hematologic parameters in stable coronary artery disease. Method: We retrospectively analysed statin naive patients who had gone coronary angiography for stable coronary artery disease between June 2012 and June 2013. MPV and RDW values, before and after statin use, are compared. Results: After a mean follow up period of 58 day (minimum 17, maximum 720), in total of 121 patient while RDW levels were significantly different before and after statin use (p¼0.001), MPV levels after treatment with statin didn’t reach an significant difference (p¼0.325). Conclusion: In conclusion treatment with statin significantly reduce the RDW levels in stable coronary artery disease which confirms the
antiinflammatory effect of statins. But decrease of RDW levels whether associated with prognosis in stable coronary artery disese or not has to established by multi center, prospective studies in large populations.
- PP-277 Relation of ABO-Blood Groups with Angiographic Thrombus Burden in Patients with STEMI. S. Topcu1, A. Kaya2, K. Kalkan1, _ Z. Lazoglu1, E.M. Bakırcı1, Z. Avs¸ar3, I.H. Tanboga1. 1 Cardiology Department, Ataturk University, Erzurum, Turkey; 2 Cardiology Department, Ordu University, Ordu, Turkey; 3Department of Family Medicine, Ataturk University, Erzurum, Turkey. Introduction: We aimed to investigate the determinants of angiographic thrombus burden in patients with ST-segment elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (pPCI). Methods: The study population consisted of 115 patients with nonanemic STEMI who underwent pPCI. Clinical, laboratory, and demographic properties of the patients were recorded. From all patients ABO blood group was determined. Angiographic coronary thrombus burden was scored based on thrombolysis in myocardial infarction (TIMI) thrombus grades. After wiring and/or small balloon dilation, patients with thrombus burden grades 4 and 5 were defined as high thrombus burden, and patients with thrombus burden
Coronary Artery Disease: Clinical, Non-invasive and Invasive Evaluation (Abstract nos. PP-278 w PP-302) - PP-278 The Clinical Features, Risk Factors And Treatment Methods Of Patients with Acute Coronary Syndrome. N. Aladag1, M. Yurtdas¸1, M. Özdemir1, H. Gönüllü2, N. Babat4, G. Demir3, H. Gümrükçüoglu4. 1 Van Education and Research Hospital, Department of Cardiology, Van, Turkey; 2Yüzüncü Yıl University, Faculty of Medicine, Department of Emergency Medicine, Van, Turkey; 3Medipol University, Department _ of Cardiology, Istanbul, Turkey; 4Yüzüncü Yıl University, Faculty of Medicine, Department of Cardiology, Van, Turkey. Objective: The term acute coronary syndrome; unstable angina pectoris (USAP), non-ST segment elevation myocardial infarction
The American Journal of Cardiologyâ MARCH 13e16, 2014 10th INTERNATIONAL CONGRESS OF UPDATE IN CARDIOLOGY AND CARDIOVASCULAR SURGERY ABSTRACTS / Poster S117
P O S T E R A B S T R A C T S