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PP-282. Anti-annexin V antibodies in SLE patients
Abstracts
S129
Conclusions
Aim
We point out that, inspite of the advances in intensive care units, morbidity is still a serious problem for preterm infants. These infants with high risk must be followed for late complications.
The diagnostic significance of anti-annexin V antibodies (a-A5) has been studied by many authors but remains controversial. The clinical importance of these antibodies is unclear. The aim of our study was to investigate the levels of IgG and IgM a-A5 in patients with systemic lupus erythematosus (SLE) with and without antiphospholipid syndrome (APS).
doi:10.1016/j.earlhumdev.2010.09.336
Materials and methods PP-281. Relationship between serum visfatin, adiponectin and insulin sensitivity markers in neonates after birth Cihan Meral, Ferhat Cekmez, Ozgur Pirgon Department of Pediatrics, Gata Medical Faculty, Turkey
We investigated the serum levels of IgG and IgM a-A5 in 36 patients with SLE (33 female, 3 male, aged 10–54 years, 20 with APS and 16 without APS) and in 38 healthy volunteers (19 female, 19 male, aged 17–45 years), using ELISA method.
Aim
Results
Adiponectin and visfatin appear to play a crucial role in birthweight and insulin resistance, it is of interest to investigate these metabolic parameters in small for gestational age (SGA), apropriate for gestational age (AGA) and large for gestational age (LGA) newborns and their mothers.
High levels of IgG and/or IgM a-A5 were found in 23% of SLE patients and in none of the controls. The mean concentrations of IgG and IgM in SLE patients was significantly elevated, but there is no difference between SLE patients with or without APS. The main clinical manifestations are pulmonary embolism, spontaneous abortions, deep venous thrombosis.
Materials and methods
Conclusions
Sixty parturients who gave birth consecutively to 20 term singleton infants who were AGA, 20 term singleton infants who were SGA and 20 term singleton infants who were LGA were included.
We found positive a-A5 in a part of patients with SLE with and without APS and probably their diagnostic significance is limited.
Results Mean visfatin levels were found significantly higher in SGA (p < 0.001) and LGA (p < 0.001) and adiponectin levels were found significantly lower in SGA group (p < 0.001) than AGA group. SGA and LGA group had higher concentrations of insulin, HOMA-IR, total cholesterol in comparison to the AGA group. LGA group had higher visfatin, glucose and HOMA-IR (p < 0.001, p < 0.001 and p: 0.002; respectively) in comparison to the SGA group. According to correlation of visfatin to the other parameters, visfatin was negatively correlated with height in SGA groups (r: −0.49, p: 0.02), according to correlation of adiponectin to the other parameters, adiponectin was negatively correlated with insulin and HOMA-IR (r: −0.49, p: 0.02 and r: −0.549, p: 0.012) in SGA group. Conclusions Based on the findings of this study, it is too difficult to explain relation between birthweight and these adipocytokines, but findings of high insulin levels, high HOMA-IR, high visfatin and low adiponectin levels in LGA and SGA neonates showed that these adipocytokines can be used as a good marker for searching metabolic syndrome in two groups.
doi:10.1016/j.earlhumdev.2010.09.337
PP-282. Anti-annexin V antibodies in SLE patients Marta Balevaa, Jivka Karagiozovab, Krasimir Nikolovc, Milena Nikolovaa a University Hospital Alexandrovska, Sofia, Bulgaria b University Hospital Maichin Dom, Sofia, Bulgaria c University Hospital St. Anna, Varna, Bulgaria
doi:10.1016/j.earlhumdev.2010.09.338
PP-283. Two cases of congenital portosystemic venous shunts in neonates Petja Fistera, Anton Kenigb, Damjana Kljucevsekb, Mojca Tomazicb, Matjaz Homanc, Jernej Breceljc, Darja Paro Panjana a Department of Neonatology, University Children's Hospital, Slovenia b Pediatric Radiology Unit, University Children's Hospital, Slovenia c Department of Gastroenterology, University Children's Hospital, Slovenia Aim Congenital porto-systemic venous shunts (CPSVS) are rare vascular malformations, reported to occur in 1 out of 30,000 births. They can be classified as extrahepatic or intrahepatic. Congenital intrahepatic porto-systemic venous shunts can close spontaneously in infancy, but more often remain patent. Affected individuals are at risk of developing complications such as: hepatic encephalopathy, intrahepatic tumor, hepatopulmonary syndrome, pulmonary artery hypertension and heart failure. Symptomatic infants may present with signs of cholestasis or elevated plasma ammonia. Additional congenital anomalies may be associated with any type of CPSVS. Case presentation In case 1, a term neonate was sent to further evaluation because of venous malformation on the right leg. US-Doppler showed no portal vein with enlarged flow through the hepatic artery. There were no USDoppler signs of portal hypertension. Spleen was of normal size. MRA of splenoportal system revealed absence of portal vein, most probably mesenteric vein communicating with iliac vein. There was no communication between mesenteric vessels and the liver. He had elevated gamma-glutamyl transpeptidase, bile acids, alkaline phosphatase and plasma ammonia. We diagnosed Abernethy type IA syndrome. In case 2,
S129
Conclusions
Aim
We point out that, inspite of the advances in intensive care units, morbidity is still a serious problem for preterm infants. These infants with high risk must be followed for late complications.
The diagnostic significance of anti-annexin V antibodies (a-A5) has been studied by many authors but remains controversial. The clinical importance of these antibodies is unclear. The aim of our study was to investigate the levels of IgG and IgM a-A5 in patients with systemic lupus erythematosus (SLE) with and without antiphospholipid syndrome (APS).
doi:10.1016/j.earlhumdev.2010.09.336
Materials and methods PP-281. Relationship between serum visfatin, adiponectin and insulin sensitivity markers in neonates after birth Cihan Meral, Ferhat Cekmez, Ozgur Pirgon Department of Pediatrics, Gata Medical Faculty, Turkey
We investigated the serum levels of IgG and IgM a-A5 in 36 patients with SLE (33 female, 3 male, aged 10–54 years, 20 with APS and 16 without APS) and in 38 healthy volunteers (19 female, 19 male, aged 17–45 years), using ELISA method.
Aim
Results
Adiponectin and visfatin appear to play a crucial role in birthweight and insulin resistance, it is of interest to investigate these metabolic parameters in small for gestational age (SGA), apropriate for gestational age (AGA) and large for gestational age (LGA) newborns and their mothers.
High levels of IgG and/or IgM a-A5 were found in 23% of SLE patients and in none of the controls. The mean concentrations of IgG and IgM in SLE patients was significantly elevated, but there is no difference between SLE patients with or without APS. The main clinical manifestations are pulmonary embolism, spontaneous abortions, deep venous thrombosis.
Materials and methods
Conclusions
Sixty parturients who gave birth consecutively to 20 term singleton infants who were AGA, 20 term singleton infants who were SGA and 20 term singleton infants who were LGA were included.
We found positive a-A5 in a part of patients with SLE with and without APS and probably their diagnostic significance is limited.
Results Mean visfatin levels were found significantly higher in SGA (p < 0.001) and LGA (p < 0.001) and adiponectin levels were found significantly lower in SGA group (p < 0.001) than AGA group. SGA and LGA group had higher concentrations of insulin, HOMA-IR, total cholesterol in comparison to the AGA group. LGA group had higher visfatin, glucose and HOMA-IR (p < 0.001, p < 0.001 and p: 0.002; respectively) in comparison to the SGA group. According to correlation of visfatin to the other parameters, visfatin was negatively correlated with height in SGA groups (r: −0.49, p: 0.02), according to correlation of adiponectin to the other parameters, adiponectin was negatively correlated with insulin and HOMA-IR (r: −0.49, p: 0.02 and r: −0.549, p: 0.012) in SGA group. Conclusions Based on the findings of this study, it is too difficult to explain relation between birthweight and these adipocytokines, but findings of high insulin levels, high HOMA-IR, high visfatin and low adiponectin levels in LGA and SGA neonates showed that these adipocytokines can be used as a good marker for searching metabolic syndrome in two groups.
doi:10.1016/j.earlhumdev.2010.09.337
PP-282. Anti-annexin V antibodies in SLE patients Marta Balevaa, Jivka Karagiozovab, Krasimir Nikolovc, Milena Nikolovaa a University Hospital Alexandrovska, Sofia, Bulgaria b University Hospital Maichin Dom, Sofia, Bulgaria c University Hospital St. Anna, Varna, Bulgaria
doi:10.1016/j.earlhumdev.2010.09.338
PP-283. Two cases of congenital portosystemic venous shunts in neonates Petja Fistera, Anton Kenigb, Damjana Kljucevsekb, Mojca Tomazicb, Matjaz Homanc, Jernej Breceljc, Darja Paro Panjana a Department of Neonatology, University Children's Hospital, Slovenia b Pediatric Radiology Unit, University Children's Hospital, Slovenia c Department of Gastroenterology, University Children's Hospital, Slovenia Aim Congenital porto-systemic venous shunts (CPSVS) are rare vascular malformations, reported to occur in 1 out of 30,000 births. They can be classified as extrahepatic or intrahepatic. Congenital intrahepatic porto-systemic venous shunts can close spontaneously in infancy, but more often remain patent. Affected individuals are at risk of developing complications such as: hepatic encephalopathy, intrahepatic tumor, hepatopulmonary syndrome, pulmonary artery hypertension and heart failure. Symptomatic infants may present with signs of cholestasis or elevated plasma ammonia. Additional congenital anomalies may be associated with any type of CPSVS. Case presentation In case 1, a term neonate was sent to further evaluation because of venous malformation on the right leg. US-Doppler showed no portal vein with enlarged flow through the hepatic artery. There were no USDoppler signs of portal hypertension. Spleen was of normal size. MRA of splenoportal system revealed absence of portal vein, most probably mesenteric vein communicating with iliac vein. There was no communication between mesenteric vessels and the liver. He had elevated gamma-glutamyl transpeptidase, bile acids, alkaline phosphatase and plasma ammonia. We diagnosed Abernethy type IA syndrome. In case 2,