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PP - EFFECTS OF PHOTODYNAMIC THERAPY MEDIATED BY NANOEMULSION CONTAINING CHLORO-ALUMINUM PHTHALOCYANINE
ORAL AND MAXILLOFACIAL PATHOLOGY e64 Abstracts located in the lip vermilion, soft palate, hard palate, gingival tissues inserted in the upper and lower arches, floor of the mouth, lower tongue, and belly trine region retromolar; all present for approximately 2 months. Faced with this situation, the diagnosis hypothesis was pemphigus vulgaris. The patient was sent to the dermatologist who confirmed the hypothesis by clinical examination and direct immunofluorescence. The patient was hospitalized with profound anemia and was submitted to a new treatment for pemphigus vulgaris. Despite the improvement of mucosal lesions, other multiple lesions in the scalp, abdomen, chest and breasts were observed. Currently, the patient is waiting to undergo routine dental treatment.
PP - A CASE SERIES OF CALCIFYING CYST ODONTOGENIC TUMOR DIAGNOSED IN 4 YEARS IN A ORAL DIAGNOSIS CENTER. VANESSA JULIANA GOMES CARVALHO, JULIANE PIRÁGINE ARAUJO, THAIS GIMENEZ MINIELLO, WELLINGTON HIDEAKI YANAGUIZAWA, CELSO AUGUSTO LEMOS, CARINA DOMANESCHI. SCHOOL OF DENTISTRY, UNIVERSITY OF SÃO PAULO. Calcifying cystic odontogenic tumor is a rare lesion of unknown origin. It represents 2% of all odontogenic cysts and tumors. Clinically, it is presented as a painless swelling of slow growth, affecting the jaws equally, with predominance in the anterior region. It affects young adults of both genders, with average age of 33 years. Radiographically, it may be presented as uni- or multi-locular radiolucent area, and might contain irregular radiopaque areas. Some studies report that these lesions could be related to non-erupted teeth, with root resorption not commonly observed. This study addresses seven patients treated between 2010 and 2014, with average age of 29.9 years, 57% men, 70% Caucasian. In all cases, the intraosseous images showed a unilocular radiolucent circumscribed lesion; scattered radiopaque focuses were found in 71% of the cases. The lesions were associated with impacted teeth in 42% of the cases investigated. Swelling and pain were the clinical features more commonly observed. The most affected region was the mandible in the canine region, and in one case, the posterior region of the mandible presented root resorption in three teeth. All cases were treated with enucleation with no recurrence.
PP - GRANULAR CELL TUMOR: AN UNCOMMON LESION IN TWO ORAL ANATOMIC SITES - A CASE REPORT. LUCIANA CASTRO NÓBREGA, MARIANNA SAMPAIO SERPA, HUGO COSTA NETO, PATRÍCIA TEIXEIRA DE OLIVEIRA, ÉRICKA JANINE DANTAS DA SILVEIRA, ANA MIRYAM COSTA DE MEDEIROS. FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE. Granular cell tumor (GCT) is an uncommon benign neoplasm that represents approximately 0.5% of all soft tissue tumors. Its occurrence is rare in children and is usually a solitary lesion that involves especially the tongue. However, multiple lesions can occur in up to 25% of the cases and frequently affect intradermal or subcutaneous tissue, with few cases being reported in the oral cavity. This report aims to describe an uncommon case of multiple oral GCT in a young patient. A 12-year-old female patient presented two asymptomatic lesions with nodular aspect, sessile implantation and firm consistence located in the dorsal surface and lateral border of the tongue. Surgical excision of lesions was performed. Histologically, both lesions were composed
OOOO February 2017 of polygonal cells with large and granular cytoplasm with indistinct margins, presenting small, ovoid and picnotic nuclei. Immunohistochemical analysis of both lesions revealed strong positivity of tumor cells for S-100 protein and periodic acidSchiff (PAS) was performed to further characterize this cell population. Thus, the diagnosis of GCT was established. GCT is an uncommon lesion with few cases being reported in more than one oral site. It is important to know their clinical and histopathological characteristics so that they are correctly diagnosed, treated and followed.
PP - EFFECTS OF PHOTODYNAMIC THERAPY MEDIATED BY NANOEMULSION CONTAINING CHLORO-ALUMINUM PHTHALOCYANINE. LUCIANA CASTRO NÓBREGA, MAIARA DE MORAES, ROSEANE CARVALHO DE VASCONCELOS, JOÃO PAULO FIGUEIRÓ LONGO, RICARDO BENTES DE AZEVEDO, ANTÔNIO DE LISBOA LOPES COSTA. FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE. The aim of the present work was to evaluate the effects of local application of nanoemulsion chloro-aluminum phthalocyanine (AlClFc) with a specific type of light on human gingiva and analyze by means of immunohistochemistry the expression of VEGF in a split-mouth model. Eight healthy volunteers with clinical indication for extraction were included in the study. Seven days before the extraction, 40ml of nanoemulsion containing AlClPc 5mM was injected into gingival tissue followed by irradiation with diode laser (660nm, 7J/cm2). Tissue specimens were removed seven days after PDT and divided into two groups for histological and immunohistochemical analysis. Patients were monitored at days 0, 7, 14 and 30 to assess adverse effects of the therapy. Areas of edema, vascular congestion, and intense vascularization were viewed in gingival samples that received PDT. Dystrophic calcification was observed in the subepithelial region of the test group. VEGF showed moderate to strong immunostaining in specimens from the test group. The therapy was well tolerated by all patients. Taken together, the results showed that the protocol used in this study mediated by nanoemulsion containing AlClPc is safe for clinical application in gingival tissue and suggests that VEGF is increased after PDT application.
PP - PRIMARY MANIFESTATION OF ERYTHEMATOSUS LUPUS. ALESSANDRA DUTRA DA SILVA, FERNANDO BORBA DE ARAÚJO, VIVIANE PALMEIRA DA SILVA, PANTELIS VARVAKI RADOS, FERNANDA VISIOLI, MANOEL SANT’ANA FILHO, MÁRCIA GAIGER DE OLIVEIRA. FEDERAL UNIVERSITY OF RIO GRANDE DO SUL. Lupus erythematosus is a chronic autoimmune disorder characterized by the production of autoantibodies directed against nuclear and cytoplasmic antigens. This disease can cause oral lesions manifesting as white striae and erythematous atrophic areas, as well as erosions and ulcerations. These signs are sometimes misdiagnosed as other oral diseases, such as lichen planus. This report describes the case of a 23-year-old woman, leukoderma, who presented with painful erosive lesions on the gingiva, hard palate, and skin. The lesions had been diagnosed previously as erosive lichen planus. The patient also reported xerophthalmia and xerostomia, suggesting Sjogrens syndrome. She was referred to a rheumatologist, and the results of
PP - A CASE SERIES OF CALCIFYING CYST ODONTOGENIC TUMOR DIAGNOSED IN 4 YEARS IN A ORAL DIAGNOSIS CENTER. VANESSA JULIANA GOMES CARVALHO, JULIANE PIRÁGINE ARAUJO, THAIS GIMENEZ MINIELLO, WELLINGTON HIDEAKI YANAGUIZAWA, CELSO AUGUSTO LEMOS, CARINA DOMANESCHI. SCHOOL OF DENTISTRY, UNIVERSITY OF SÃO PAULO. Calcifying cystic odontogenic tumor is a rare lesion of unknown origin. It represents 2% of all odontogenic cysts and tumors. Clinically, it is presented as a painless swelling of slow growth, affecting the jaws equally, with predominance in the anterior region. It affects young adults of both genders, with average age of 33 years. Radiographically, it may be presented as uni- or multi-locular radiolucent area, and might contain irregular radiopaque areas. Some studies report that these lesions could be related to non-erupted teeth, with root resorption not commonly observed. This study addresses seven patients treated between 2010 and 2014, with average age of 29.9 years, 57% men, 70% Caucasian. In all cases, the intraosseous images showed a unilocular radiolucent circumscribed lesion; scattered radiopaque focuses were found in 71% of the cases. The lesions were associated with impacted teeth in 42% of the cases investigated. Swelling and pain were the clinical features more commonly observed. The most affected region was the mandible in the canine region, and in one case, the posterior region of the mandible presented root resorption in three teeth. All cases were treated with enucleation with no recurrence.
PP - GRANULAR CELL TUMOR: AN UNCOMMON LESION IN TWO ORAL ANATOMIC SITES - A CASE REPORT. LUCIANA CASTRO NÓBREGA, MARIANNA SAMPAIO SERPA, HUGO COSTA NETO, PATRÍCIA TEIXEIRA DE OLIVEIRA, ÉRICKA JANINE DANTAS DA SILVEIRA, ANA MIRYAM COSTA DE MEDEIROS. FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE. Granular cell tumor (GCT) is an uncommon benign neoplasm that represents approximately 0.5% of all soft tissue tumors. Its occurrence is rare in children and is usually a solitary lesion that involves especially the tongue. However, multiple lesions can occur in up to 25% of the cases and frequently affect intradermal or subcutaneous tissue, with few cases being reported in the oral cavity. This report aims to describe an uncommon case of multiple oral GCT in a young patient. A 12-year-old female patient presented two asymptomatic lesions with nodular aspect, sessile implantation and firm consistence located in the dorsal surface and lateral border of the tongue. Surgical excision of lesions was performed. Histologically, both lesions were composed
OOOO February 2017 of polygonal cells with large and granular cytoplasm with indistinct margins, presenting small, ovoid and picnotic nuclei. Immunohistochemical analysis of both lesions revealed strong positivity of tumor cells for S-100 protein and periodic acidSchiff (PAS) was performed to further characterize this cell population. Thus, the diagnosis of GCT was established. GCT is an uncommon lesion with few cases being reported in more than one oral site. It is important to know their clinical and histopathological characteristics so that they are correctly diagnosed, treated and followed.
PP - EFFECTS OF PHOTODYNAMIC THERAPY MEDIATED BY NANOEMULSION CONTAINING CHLORO-ALUMINUM PHTHALOCYANINE. LUCIANA CASTRO NÓBREGA, MAIARA DE MORAES, ROSEANE CARVALHO DE VASCONCELOS, JOÃO PAULO FIGUEIRÓ LONGO, RICARDO BENTES DE AZEVEDO, ANTÔNIO DE LISBOA LOPES COSTA. FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE. The aim of the present work was to evaluate the effects of local application of nanoemulsion chloro-aluminum phthalocyanine (AlClFc) with a specific type of light on human gingiva and analyze by means of immunohistochemistry the expression of VEGF in a split-mouth model. Eight healthy volunteers with clinical indication for extraction were included in the study. Seven days before the extraction, 40ml of nanoemulsion containing AlClPc 5mM was injected into gingival tissue followed by irradiation with diode laser (660nm, 7J/cm2). Tissue specimens were removed seven days after PDT and divided into two groups for histological and immunohistochemical analysis. Patients were monitored at days 0, 7, 14 and 30 to assess adverse effects of the therapy. Areas of edema, vascular congestion, and intense vascularization were viewed in gingival samples that received PDT. Dystrophic calcification was observed in the subepithelial region of the test group. VEGF showed moderate to strong immunostaining in specimens from the test group. The therapy was well tolerated by all patients. Taken together, the results showed that the protocol used in this study mediated by nanoemulsion containing AlClPc is safe for clinical application in gingival tissue and suggests that VEGF is increased after PDT application.
PP - PRIMARY MANIFESTATION OF ERYTHEMATOSUS LUPUS. ALESSANDRA DUTRA DA SILVA, FERNANDO BORBA DE ARAÚJO, VIVIANE PALMEIRA DA SILVA, PANTELIS VARVAKI RADOS, FERNANDA VISIOLI, MANOEL SANT’ANA FILHO, MÁRCIA GAIGER DE OLIVEIRA. FEDERAL UNIVERSITY OF RIO GRANDE DO SUL. Lupus erythematosus is a chronic autoimmune disorder characterized by the production of autoantibodies directed against nuclear and cytoplasmic antigens. This disease can cause oral lesions manifesting as white striae and erythematous atrophic areas, as well as erosions and ulcerations. These signs are sometimes misdiagnosed as other oral diseases, such as lichen planus. This report describes the case of a 23-year-old woman, leukoderma, who presented with painful erosive lesions on the gingiva, hard palate, and skin. The lesions had been diagnosed previously as erosive lichen planus. The patient also reported xerophthalmia and xerostomia, suggesting Sjogrens syndrome. She was referred to a rheumatologist, and the results of