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PP - MALT LYMPHOMA IN LABIAL SALIVARY GLAND: A RARE MANIFESTATION OF SJOGREN´S SYNDROME
ORAL AND MAXILLOFACIAL PATHOLOGY e60 Abstracts include nuclear pleomorphism without mitotic activity, concentric calcifications, and amyloid deposits. This case is an additional example of clear cell variant of CEOT occurring in a 28-year-old male patient, presenting discomfort in the third molar right region. No clinical signs were observed. Image exams revealed a welldelimited unilocular mixed radiolucencent-radiopaque lesion with displacement of bone cortical and teeth. Incisional biopsy was performed and the microscopic examination showed a tumor consisted of proliferation of epithelial cells with eosinophilic, clear vacuolated cytoplasm interspersed with focal areas of amyloid deposition. Tumor cells were immunopositive for AE1/ AE3. Surgical excision was performed, and no tumor recurrence has been observed after three years of follow-up.
PP - CALCIFYING EPITHELIAL ODONTOGENIC TUMOR (PINDBORG TUMOR) WITHOUT CALCIFICATION: A RARE PATHOLOGICAL TYPE. LORENA CASTRO MARIANO, ANTONIO MÁRCIO TEIXEIRA MARCHIONNI, ALENA PEIXOTO MEDRADO, PATRICIA DE CASTRO VEIGA, JORGE ESQUICHE LEON, SILVIA R A REIS. ESCOLA BAHIANA DE MEDICINA E SAÚDE PÚBLICA. Calcifying epithelial odontogenic tumor (CEOT) or Pindborg tumor is a locally invasive benign lesion that originates from the remnants of dental tissue. The histopathology is characterized by the presence of polygonal epithelial cells, calcification, and deposits of amyloid-like material. However, CEOT without calcification is rare and poorly documented in literature. A 20-year-old patient visited the stomatology department with swelling in the lower one-third of her right cheek . Clinical examination revealed facial asymmetry. A panoramic radiograph showed a radiolucent, multilocular lesion involving the third molar and extending from the branch of the mandibular body to the distal portion of the lower right second molar . Histopathological diagnosis based on an incisional biopsy of the lesion confirmed CEOT; however, we were no able to rule out malignancy . Histopathological examination of the surgical specimen revealed odontogenic neoplasm made up of polygonal epithelial cells, most of them with obvious pleomorphic and intercellular bridges. Calcifications were absent, but amyloid-like material was observed. Immunohistochemical analysis revealed anti-CD 138 expression. Despite the intense cellular and nuclear pleomorphic antibody reaction , few cells expressed Ki-67. After three years of surgical treatment, there was no recurrence. Our key point of discussion is the histopathological aspects of non-calcified CEOT.
PP - MALT LYMPHOMA IN LABIAL SALIVARY GLAND: A RARE MANIFESTATION OF SJOGRENS SYNDROME. LARA MARIA ALENCAR RAMOS, TATIANE CRISTINA FERRARI, VANESSA ROCHA LIMA SHCAIRA, KARINA A, M, GRECCA PIERONI, FABIANO PINTO SAGGIORO, HILTON MARCOS ALVES RICZ, LEANDRO DORIGAN DE MACEDO. DENTISTRY AND STOMATOLOGY SERVICE, RIBEIRÃO PRETO MEDICAL SCHOOL, UNIVERSITY OF SÃO PAULO/PATHOLOGY AND LEGAL MEDICINE, RIBEIRÃO PRETO MEDICAL SCHOOL, UNIVERSITY OF SÃO PAULO. Primary Sjögren’s Syndrome (SS) is a chronic autoimmune disease that affects the exocrine glands and produces circulating antibodies. Although mucosa-associated lymphoid tissue (MALT) lymphoma may be detected in patients with SS, manifestations in
OOOO February 2017 labial salivary glands are rare. A 68-year-old woman with the diagnosis of primary SS was referred to our Dentistry and Stomatology Service, complaining of progressive thickening of lower left lip in the past four years. Previous biopsies were consistent with chronic sialadenitis with a dense mononuclear infiltrate containing lymphocytes and plasma cells. Extraoral examination revealed a fibrous aspect of lower lip and its significant asymmetry to the left. An incisional biopsy was performed, and the microscopic examination showed a dense, diffuse lymphoplasmacytic infiltration of salivary glands, with partial plasmacytic differentiation. Immunohistochemical analysis revealed diffuse positivity of neoplastic cells for CD20, bcl-2, and negativity for CD5, CD23, CD10, and cyclin D1. Areas with plasma cell differentiation were positive for CD138, lambda, and negative for kappa, consistent with extranodal marginal zone lymphoma of MALT type. Surgery was the treatment of choice, without complete remission. The patient then underwent chemotherapy with rituximab, followed by radiotherapy due to poor response to chemotherapy, with complete regression of the lesion.
PP - ORAL MUCOSAL LESIONS IN PSORIATIC PATIENTS. MARIANNE DE VASCONCELOS CARVALHO, DANIELE MELO OLIVEIRA, MARIA LUISA SOARES RIBEIRO, SILVIA CARVALHO, ANA PAULA VERAS SOBRAL. FACULDADE DE ODONTOLOGIA DE PERNAMBUCO - UNIVERSIDADE DE PERNAMBUCO, UNIVERSIDADE DE PERNAMBUCO, CAMPUS ARCOVERDE. Recent studies have shown that psoriasis can give rise to oral mucosal lesions. The aim of the present study was to analyze the association of oral mucosal lesions with psoriasis and to determine the characteristics of the association with regard to psoriasis type, family medical history, and stress level. Thirty-one patients with psoriasis were enrolled in the present study using simple nonrandom (sequential) sampling. Oral mucosal lesions were detected in five (16.1%) patients with psoriasis and were associated with the plaque type. Three patients had only fissured tongue (FT) and two patients concomitantly had FT and geographic tongue (GT). Further, stress levels were assessed in patients, and 80% of the patients were found to have a moderate (resistance) stress level. In addition, it was observed that 40% of the patients had a family medical history of psoriasis. On the basis of this study and studies found in the literature, FT and GT can be suggested as oral manifestations of psoriasis. Thus, a detailed oral examination may contribute to the early diagnosis of systemic diseases that cause buccal manifestations.
PP - INFLUENCE OF AGE, SEX, SMOKING AND DRINKING ON SURVIVAL RATES IN PATIENTS WITH PHARYNGEAL CANCER: A RETROSPECTIVE ANALYSIS. LARA MARIA ALENCAR RAMOS, ALISSON HENRIQUE TEIXEIRA, MATHEUS CORRIJO ANDRADE, HILTON MARCOS ALVES RICZ, LUCIANA ASSIRATI CASEMIRO, TATIANE CRISTINA FERRARI, LEANDO DORIGAN DE MACEDO. DENTISTRY AND STOMATOLOGY SERVICE, RIBEIRÃO PRETO MEDICAL SCHOOL, UNIVERSITY OF SÃO PAULO/SCHOOL OF DENTISTRY, UNIVERSITY OF FRANCA. The importance of age, sex, smoking and drinking habits in the incidence of pharyngeal cancer is well known. However, there is little information about their influence on the disease prognosis.
PP - CALCIFYING EPITHELIAL ODONTOGENIC TUMOR (PINDBORG TUMOR) WITHOUT CALCIFICATION: A RARE PATHOLOGICAL TYPE. LORENA CASTRO MARIANO, ANTONIO MÁRCIO TEIXEIRA MARCHIONNI, ALENA PEIXOTO MEDRADO, PATRICIA DE CASTRO VEIGA, JORGE ESQUICHE LEON, SILVIA R A REIS. ESCOLA BAHIANA DE MEDICINA E SAÚDE PÚBLICA. Calcifying epithelial odontogenic tumor (CEOT) or Pindborg tumor is a locally invasive benign lesion that originates from the remnants of dental tissue. The histopathology is characterized by the presence of polygonal epithelial cells, calcification, and deposits of amyloid-like material. However, CEOT without calcification is rare and poorly documented in literature. A 20-year-old patient visited the stomatology department with swelling in the lower one-third of her right cheek . Clinical examination revealed facial asymmetry. A panoramic radiograph showed a radiolucent, multilocular lesion involving the third molar and extending from the branch of the mandibular body to the distal portion of the lower right second molar . Histopathological diagnosis based on an incisional biopsy of the lesion confirmed CEOT; however, we were no able to rule out malignancy . Histopathological examination of the surgical specimen revealed odontogenic neoplasm made up of polygonal epithelial cells, most of them with obvious pleomorphic and intercellular bridges. Calcifications were absent, but amyloid-like material was observed. Immunohistochemical analysis revealed anti-CD 138 expression. Despite the intense cellular and nuclear pleomorphic antibody reaction , few cells expressed Ki-67. After three years of surgical treatment, there was no recurrence. Our key point of discussion is the histopathological aspects of non-calcified CEOT.
PP - MALT LYMPHOMA IN LABIAL SALIVARY GLAND: A RARE MANIFESTATION OF SJOGRENS SYNDROME. LARA MARIA ALENCAR RAMOS, TATIANE CRISTINA FERRARI, VANESSA ROCHA LIMA SHCAIRA, KARINA A, M, GRECCA PIERONI, FABIANO PINTO SAGGIORO, HILTON MARCOS ALVES RICZ, LEANDRO DORIGAN DE MACEDO. DENTISTRY AND STOMATOLOGY SERVICE, RIBEIRÃO PRETO MEDICAL SCHOOL, UNIVERSITY OF SÃO PAULO/PATHOLOGY AND LEGAL MEDICINE, RIBEIRÃO PRETO MEDICAL SCHOOL, UNIVERSITY OF SÃO PAULO. Primary Sjögren’s Syndrome (SS) is a chronic autoimmune disease that affects the exocrine glands and produces circulating antibodies. Although mucosa-associated lymphoid tissue (MALT) lymphoma may be detected in patients with SS, manifestations in
OOOO February 2017 labial salivary glands are rare. A 68-year-old woman with the diagnosis of primary SS was referred to our Dentistry and Stomatology Service, complaining of progressive thickening of lower left lip in the past four years. Previous biopsies were consistent with chronic sialadenitis with a dense mononuclear infiltrate containing lymphocytes and plasma cells. Extraoral examination revealed a fibrous aspect of lower lip and its significant asymmetry to the left. An incisional biopsy was performed, and the microscopic examination showed a dense, diffuse lymphoplasmacytic infiltration of salivary glands, with partial plasmacytic differentiation. Immunohistochemical analysis revealed diffuse positivity of neoplastic cells for CD20, bcl-2, and negativity for CD5, CD23, CD10, and cyclin D1. Areas with plasma cell differentiation were positive for CD138, lambda, and negative for kappa, consistent with extranodal marginal zone lymphoma of MALT type. Surgery was the treatment of choice, without complete remission. The patient then underwent chemotherapy with rituximab, followed by radiotherapy due to poor response to chemotherapy, with complete regression of the lesion.
PP - ORAL MUCOSAL LESIONS IN PSORIATIC PATIENTS. MARIANNE DE VASCONCELOS CARVALHO, DANIELE MELO OLIVEIRA, MARIA LUISA SOARES RIBEIRO, SILVIA CARVALHO, ANA PAULA VERAS SOBRAL. FACULDADE DE ODONTOLOGIA DE PERNAMBUCO - UNIVERSIDADE DE PERNAMBUCO, UNIVERSIDADE DE PERNAMBUCO, CAMPUS ARCOVERDE. Recent studies have shown that psoriasis can give rise to oral mucosal lesions. The aim of the present study was to analyze the association of oral mucosal lesions with psoriasis and to determine the characteristics of the association with regard to psoriasis type, family medical history, and stress level. Thirty-one patients with psoriasis were enrolled in the present study using simple nonrandom (sequential) sampling. Oral mucosal lesions were detected in five (16.1%) patients with psoriasis and were associated with the plaque type. Three patients had only fissured tongue (FT) and two patients concomitantly had FT and geographic tongue (GT). Further, stress levels were assessed in patients, and 80% of the patients were found to have a moderate (resistance) stress level. In addition, it was observed that 40% of the patients had a family medical history of psoriasis. On the basis of this study and studies found in the literature, FT and GT can be suggested as oral manifestations of psoriasis. Thus, a detailed oral examination may contribute to the early diagnosis of systemic diseases that cause buccal manifestations.
PP - INFLUENCE OF AGE, SEX, SMOKING AND DRINKING ON SURVIVAL RATES IN PATIENTS WITH PHARYNGEAL CANCER: A RETROSPECTIVE ANALYSIS. LARA MARIA ALENCAR RAMOS, ALISSON HENRIQUE TEIXEIRA, MATHEUS CORRIJO ANDRADE, HILTON MARCOS ALVES RICZ, LUCIANA ASSIRATI CASEMIRO, TATIANE CRISTINA FERRARI, LEANDO DORIGAN DE MACEDO. DENTISTRY AND STOMATOLOGY SERVICE, RIBEIRÃO PRETO MEDICAL SCHOOL, UNIVERSITY OF SÃO PAULO/SCHOOL OF DENTISTRY, UNIVERSITY OF FRANCA. The importance of age, sex, smoking and drinking habits in the incidence of pharyngeal cancer is well known. However, there is little information about their influence on the disease prognosis.