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PP076. Gender differences in fetal growth and fetal-placental ratio in preeclamptic and normal pregnancies
Poster Presentations / Pregnancy Hypertension: An International Journal of Women’s Cardiovascular Health 3 (2013) 67–99
and 7 severe late-onset PE (SL) pregnancies were collected at regular intervals between week 12 and birth. ESM-1 was measured by ELISA. Results: (see figure) Between GA week 24 and birth, ESM1 concentrations were significantly increased in both early and late preeclampsia compared to controls (Mann Whitney, p < 0.05). Surprisingly, the concentration of ESM-1 also differed between the three groups at weeks 12 and 16. The ESM-1 concentration of healthy pregnancies (mean ± SEM:1857 ± 861 pg/ml) and those that developed severe late-onset PE (1298 ± 371 pg/ml) are comparable, but in those pregnancies that develop severe early-onset PE, the concentration (410 ± 355 pg/ml) is significantly lower as compared with healthy pregnancies. Conclusions: ESM-1 concentrations are increased during early and late severe preeclampsia, which may be due to endothelial cell activation in these conditions. Interestingly, since ESM-1 is decreased at 12–16 weeks in patients that later on develop early onset severe PE, it might be a prognostic marker which can determine the risk of women to develop severe early-onset PE already as early as 12 to 16 weeks of gestation. doi:10.1016/j.preghy.2013.04.102
PP078. The influence of maternal position on gestational hemodynamics Tomsin Kathleen, Oben Jolien, Staelens Anneleen, Molenberghs Geert, Mesens Tinne, Peeters Louis, Gyselaers Wilfried Introduction: Cardiovascular profiling is useful for gestational hemodynamic studies. Conflicting results of cardiac output evolution from third trimester pregnancy to term are frequently reported.1 Objectives: To stress the effect of maternal position in the assessment of maternal cardiac and arterial parameters during normal pregnancy. Methods: Impedance cardiography measurements were executed during 16 normal pregnancies using a standard protocol with known reproducibility. Gestational evolution of stroke volume, cardiac output, cardiac cycle time intervals, aortic flow parameters and total peripheral vascular resistance was measured in supine, standing and sitting
95
positions. SAS procedure MIXED for linear mixed models was used for each parameter separately. Results: Evolution of stroke volume and cardiac output in supine position differed from standing (p < 0.01) and sitting positions (p < 0.05). Next to this, pre-ejection period, left ventricular ejection time index, systolic time ratio and total peripheral vascular resistance also showed a different evolution between supine and standing positions (p < 0.05); no differences were observed between standing and sitting positions (p P 0.19). Conclusion: Next to the frequently reported cardiac output, gestational evolutions of other pre-load dependent parameters are influenced by maternal position. This study shows the importance of a standardized protocol for the measurement of cardiovascular parameters in pregnancy. doi:10.1016/j.preghy.2013.04.103
PP079. Ovarian reserve and function is preserved following severe preeclampsia Vårtun Åse, Aune Berit, Flo Kari, Acharya Ganesh Introduction: Preeclampsia is a multi-organ disorder that predominantly affects renal, cardiovascular, and endocrine systems with long-term consequences for the women’s health. As advanced age and history of subfertility increase the risk of developing preeclampsia, reduced ovarian reserve may be associated with preeclampsia. However, long-term effect of preeclampsia on the ovarian function and reserve is not known. We hypothesized that the ovarian reserve and function are reduced in women with a previous history of severe preeclampsia. Objective: To compare the plasma levels of markers of ovarian function (FSH, LH, SHBG, testosterone) and reserve (anti-Müllerian hormone, AMH) in women who previously had preeclampsia with their matched controls. Method: Twenty women who had severe preeclampsia (PE group) requiring delivery before 36 weeks of gestation and 20 controls were matched for age, parity, height and weight were included in the study. Women were not breast-feeding, they were having regular menstrual periods and were not using any hormonal contraception. Fasting blood samples were taken during the follicular phase. Plasma was separated and frozen at 70 degrees until
and 7 severe late-onset PE (SL) pregnancies were collected at regular intervals between week 12 and birth. ESM-1 was measured by ELISA. Results: (see figure) Between GA week 24 and birth, ESM1 concentrations were significantly increased in both early and late preeclampsia compared to controls (Mann Whitney, p < 0.05). Surprisingly, the concentration of ESM-1 also differed between the three groups at weeks 12 and 16. The ESM-1 concentration of healthy pregnancies (mean ± SEM:1857 ± 861 pg/ml) and those that developed severe late-onset PE (1298 ± 371 pg/ml) are comparable, but in those pregnancies that develop severe early-onset PE, the concentration (410 ± 355 pg/ml) is significantly lower as compared with healthy pregnancies. Conclusions: ESM-1 concentrations are increased during early and late severe preeclampsia, which may be due to endothelial cell activation in these conditions. Interestingly, since ESM-1 is decreased at 12–16 weeks in patients that later on develop early onset severe PE, it might be a prognostic marker which can determine the risk of women to develop severe early-onset PE already as early as 12 to 16 weeks of gestation. doi:10.1016/j.preghy.2013.04.102
PP078. The influence of maternal position on gestational hemodynamics Tomsin Kathleen, Oben Jolien, Staelens Anneleen, Molenberghs Geert, Mesens Tinne, Peeters Louis, Gyselaers Wilfried Introduction: Cardiovascular profiling is useful for gestational hemodynamic studies. Conflicting results of cardiac output evolution from third trimester pregnancy to term are frequently reported.1 Objectives: To stress the effect of maternal position in the assessment of maternal cardiac and arterial parameters during normal pregnancy. Methods: Impedance cardiography measurements were executed during 16 normal pregnancies using a standard protocol with known reproducibility. Gestational evolution of stroke volume, cardiac output, cardiac cycle time intervals, aortic flow parameters and total peripheral vascular resistance was measured in supine, standing and sitting
95
positions. SAS procedure MIXED for linear mixed models was used for each parameter separately. Results: Evolution of stroke volume and cardiac output in supine position differed from standing (p < 0.01) and sitting positions (p < 0.05). Next to this, pre-ejection period, left ventricular ejection time index, systolic time ratio and total peripheral vascular resistance also showed a different evolution between supine and standing positions (p < 0.05); no differences were observed between standing and sitting positions (p P 0.19). Conclusion: Next to the frequently reported cardiac output, gestational evolutions of other pre-load dependent parameters are influenced by maternal position. This study shows the importance of a standardized protocol for the measurement of cardiovascular parameters in pregnancy. doi:10.1016/j.preghy.2013.04.103
PP079. Ovarian reserve and function is preserved following severe preeclampsia Vårtun Åse, Aune Berit, Flo Kari, Acharya Ganesh Introduction: Preeclampsia is a multi-organ disorder that predominantly affects renal, cardiovascular, and endocrine systems with long-term consequences for the women’s health. As advanced age and history of subfertility increase the risk of developing preeclampsia, reduced ovarian reserve may be associated with preeclampsia. However, long-term effect of preeclampsia on the ovarian function and reserve is not known. We hypothesized that the ovarian reserve and function are reduced in women with a previous history of severe preeclampsia. Objective: To compare the plasma levels of markers of ovarian function (FSH, LH, SHBG, testosterone) and reserve (anti-Müllerian hormone, AMH) in women who previously had preeclampsia with their matched controls. Method: Twenty women who had severe preeclampsia (PE group) requiring delivery before 36 weeks of gestation and 20 controls were matched for age, parity, height and weight were included in the study. Women were not breast-feeding, they were having regular menstrual periods and were not using any hormonal contraception. Fasting blood samples were taken during the follicular phase. Plasma was separated and frozen at 70 degrees until