PP095-SUN COMPUTED TOMOGRAPHY AND BIOELECTRICAL IMPEDANCE: RELEVANCE FOR BODY COMPOSITION ASSESSMENT IN ONCOLOGY

S58 determined by using ELISA. The proliferation of TE-1 cells, which were derived from the esophageal squamous cancer cell, treated with EPA was determined by premix WST-1 cell proliferation assay system kit. TE-1 cells treated with EPA were stained with Hoechst 33342 and Propidium iodide to observe apoptosis. To prove these reactions were through activation of Nuclear factor-kappa B (NF-kB), immunohistochemical staining of NF-kB in TE-1 cells was investigated Results: IL-6 which was produced by TE-1 cells was significantly increased by LPS stimulation and the effect was completely controlled by EPA treatment even in the addition of 100 mg/ml LPS. The proliferations of TE-1 cells were inhibited by the treatment treat with EPA. The IC50 was 260mM EPA. EPA treatment inhibited NF-kB activation and that induced apoptosis in TE-1 cells Conclusion: EPA inhibited IL-6 production from cancer cells by control of NF-kB activation. That resulted in the induction of apoptosis in TE-1 cells. These effects of EPA might contribute to improve the outcome of cancer surgery Disclosure of Interest: None Declared

PP095-SUN COMPUTED TOMOGRAPHY AND BIOELECTRICAL IMPEDANCE: RELEVANCE FOR BODY COMPOSITION ASSESSMENT IN ONCOLOGY P. Ravasco1 , A.I. Almeida1 , C. Ferreira1 , M. Camilo1 , N. Johns2 , K. Fearon2 , I. Monteiro Grillo3 . 1 Unit of Nutrition & Metabolism, Institute Molecular Medicine & Laboratory of Nutrition, Faculty of Medicine of the University of Lisbon, Lisboa, Portugal; 2 University of Edimburgh, University of Edimburgh, Edimburgh, United Kingdom; 3 Radiotherapy Department, University Hospital of Santa Maria, Lisboa, Portugal Rationale: Body composition assessment in cancer has gained major interest. This longitudinal study aimed to characterize body composition in cancer by Computed Tomography(CT) & Bioelectrical Impedance Analysis(BIA) & explore potential associations between body composition/phase angle(PA) & cancer histology & stage. Methods: We included 71(42M:29F) pts with solid tumours at various stages. Parameters: %body fat (%FM) & PA assessed by tetrapolar multifrequency BIA (Biodynamics 450® , Seattle, USA), muscle mass(MM) assessed also by CT scans (n = 35); %FM & PA were compared with age/sex reference values: % intervals & percentiles, respectively. Toxicity was assessed by the Common Toxicity Criteria from Eastern Cooperative Oncology Group. Results: Excessive %FM was prevalent (69%), as well as sarcopenia (49%); both occurred concomitantly in 29% of pts. PA < 5th percentile was found in 11 pts; of those, 55% had excessive FM & 83% had sarcopenia. The prevalence of stage III/IV & moderately/poorly differentiated cancers was similar in normal FM/MM as it was in high FM/sarcopenia. In what concerns PA, 90% & 86% pts with PA < 5th percentile had cancers of stages III/IV & moderate/low differentiation, respectively, vs 60% & 63% pts with PA >5th percentile, which had advanced & aggressive cancers, respectively. Treatment toxicity was more frequent & severe in sarcopenic pts (90%, p < 0.05). Conclusion: Sarcopenia was masked by excessive adiposity, leading to under-diagnosed sarcopenic obesity. BIA deter-

Poster presentations mined excessive adiposity and phase angle, the latter assuming a prognostic value. CT scans were accurate in identifying sarcopenia that was associated with greater treatment toxicity; this is an indirect indicator of poorer treatment efficacy. These results corroborate the clinical relevance of body composition assessment in oncology and do support the importance of maintaining an adequate body composition throughout cancer treatments. Disclosure of Interest: None Declared

PP096-SUN PHYSICAL ACTIVITY AND FUNCTIONAL PERFORMANCE IN PATIENTS WITH CANCER-RELATED FATIGUE C. Korn1 , N. Stob¨ aus1 , S. Daum1 , K. Norman1 . 1 Department of Gastroenterology, Infectiology and Rheumatology (Section Nutritional Medicine), Charit´ e University Medicine, Berlin, Germany Rationale: Cancer-related fatigue plays an important role in the impairment of wellbeing of patients. This study investigates the association between fatigue and physical activity level as well as functional performance. Methods: Fatigue was evaluated by the Brief Fatigue Inventory (BFI) and the short version of the International Physical Activity Questionnaire (IPAQ) was used to determine physical activity level. Functional status was measured employing Digimax Dynamometer for knee extension strength. Furthermore general health status and physical performance was evaluated by Karnofsky performance status (KPS). Data are given as median [min-max]. Results: 53 patients (31 women) under chemotherapy with a median age of 65 years [26 79 years] were recruited. 47.2% of patients had mild fatigue, 47.2% moderate and 5.7% severe fatigue. 64.3% of patients with moderate or severe fatigue (BFI-Score >4) had low physical activity level whereas only 28% of patients with mild fatigue had low physical activity level (p = 0.008). Knee extension strength decreased significantly from 20 kg [8 39.5 kg] for mild fatigue to 17.5 kg [2.5 26.0 kg] for moderate/severe fatigue; p = 0.014. KPS was higher in mild fatigue (80% [60 90%]) compared to patients with moderate/severe fatigue (70% [40 90%]; p = 0.002). KPS also increased with higher physical activity level (high activity level: 85% [70 90%]; moderate: 80% [60 90%]; low: 70% [40 90%], p = 0.020). Conclusion: The cancer-related fatigue is a major problem for patients during chemotherapy with impact on physical activity and functional performance. Disclosure of Interest: None Declared

PP097-SUN MALNUTRITION AND CLINICAL OUTCOMES IN CANCER PATIENTS: RESULTS FROM A POINT PREVALENCE STUDY IN AUSTRALIA K. Marshall1 , J. Loeliger1 , L. Nolte2 . 1 Nutrition, Peter MacCallum Cancer Centre, 2 Department of Health, Melbourne, Australia Rationale: Malnutrition is an important supportive care need for people with cancer. The Patient Generated Subjective Global Assessment (PG-SGA) is a validated tool to determine malnutrition in cancer patients.