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PP097-MON: Effect of Arginine-Rich Enteral Nutrition after Pancreaticoduodenectomy
S166 52% and 38% of the patients, respectively, would like that the exercise program takes place 2 3 times per week and outside in the countryside. As part of a program, 64% of the patients indicated that they would be interested in strength or endurance training. Few patients reported to prefer games and wellness, i.e. yoga or football. Conclusion: The present data show the importance of nutrition and exercise in patients with metastatic cancer. Based on the evaluated preferences a suitable nutrition and exercise program can be established. Disclosure of Interest: None Declared.
PP097-MON EFFECT OF ARGININE-RICH ENTERAL NUTRITION AFTER PANCREATICODUODENECTOMY M. Ogiku1 , Y. Ikematsu1 , T. Ogasawara2 , Y. Okamoto3 . 1 Digestive Surgery, 2 Respiratory Medicine, 3 Nutrition management office, Hamamatsu Medical Center, Hamamatsu, Japan Rationale: Early enteral nutrition improves the postoperative course after GI tract surgery. Also arginine is known to accelerate wound healing. But the effect of enteral nutrition with arginine-rich formula on the course after pancreaticoduodenectomy (PD) is not well known. Methods: 65 consecutive patients, who underwent standard PD or pylorus-preserving PD (PpPD) at our institute between January 2005 and December 2013, were analyzed retrospectively. Twenty-eight received enteral nutrition with argininerich agents (Arginade® , Nestle Health Science, Japan; Arg group) and 37 received enteral nutrition with standard agents (control group). We investigated the length of hospital stay, time to start oral intake, the incidence of pancreatic fistula, serum albumin level and diarrhea. Results: There were no difference in the length of hospital stay, time to start oral intake, the incidences of pancreatic fistula and the incidences of diarrhea between the Arg and control group. However, the recovery of serum albumin level at discharge compared to postoperative day 7 was significantly improved in the Arg group (D 0.6 vs. 0.3, P = 0.04). Conclusion: Arginine-rich enteral nutrition have therapeutic potential to increase nutritional biomarker especially serum albumin after PD. Disclosure of Interest: None Declared.
PP098-MON PERSONALISED NUTRITIONAL SUPPORT IN CANCER PATIENTS WITH BOWEL RESECTION C. Komives1 , C. Fejer1 , M. Varga1 , I. Biro1 , A. Molnar2 , L. Topa1 , P. Sahin1 . 1 St. Imre Hospital, 2 School of PhD. Studies of Semmelweis University, Pathological Sciences, Health science research, Budapest, Hungary Rationale: Sarkopenia in malignancies deteriorated by chemotherapy, increases the side affects of the therapy, decreases its efficiency and therefore worsens survival rate. Therefore avoiding sarkopenia is very important. Methods: Description of personalised nutritional support of 3 cancer patients (A: poorly differentiated neuroendocrine carcinoma of the small intestine pT3NxM0; B: colon adenocarcinoma pT3pN2M2; C: desmoid tumor of the pelvis, after
Poster presentations the surgery: short bowel syndrome [SBS] type I with 100 cm jejunum and jejunostoma) who underwent bowel resection surgery (A: SBS type II with 70 cm jejunum and coecum without rectosigma; B: subtotal colectomy and perianal fistulas; C: total proctocolectomy with ileoanal pouch) for different reasons (A: stricturing Crohn’s disease localized in the small intestine; B: stricturing Crohn’s disease localized in the colon; C: familial adenomatous polyposis). The malignant disease, the resection surgery and the chemotherapy jointly made the nutrition therapy more complex and difficult for our patients. To determine the body composition we used bioelectrical impedance analysis (Inbody720). Results: Malnutrition (body mass index [kg/m2 ], A: 15.6 19.4; B: 17.7 18.9; C: 14.7 17.5) and sarkopenia (sceletal muscle mass [kg], A: 16.9 15.8 19.3; B: 23.8 24.8; C: 26.9 32.8) experienced at the beginning of nutrition support improved in all cases in spite of the chemotherapy, usually with loss of body fat mass (A: 17 21.8%; B: 27.2 21.7%; C: 9.1 <5%). We successively optimized the enteral diet and oral nutritional support of our patients. A and C patients have been receiving long term home parenteral nutrition too. Conclusion: With personalised nutritional therapy the development of sarkopenia can be delayed, life expectancy of patients can be improved, quality of life can be maintained. Disclosure of Interest: None Declared.
PP099-MON PESTICIDES AND CANCER: PROBLEM OF THE CENTURY M. Mokhtari1 , F. Mouhouche1 . 1 Zoology, High National School of Agronomy, Algiers, Algeria Rationale: Population growth put the agricultural under increasing pressure to produce more without worrying about the risks caused by overproduction and the use of pesticides. The change of lifestyle causes the appearance of phenomena of cancer. Without preventive action, the prevalence of cancer will continue to increase. The intervention must reach the major environmental factors in the onset of cancer. Methods: A survey study was carried out in Algiers city to identify factors associated to pesticides risk, and put the focus on the prevalence of cancer in Algeria. Results: In Algeria, cancer exponentially thrust. The prevalence of this disease is doubled. Studies continue to show the links between pesticides and cancer. Algeria is a major consumer of pesticides: 30,000 tonnes are “applied to land” each year. But cancer kills 40,000 people each year in Algeria. In 2011, the physico-chemical laboratory of the Algerian Centre of quality control and packaging (CACQE) received 7,675 food samples. 2419 samples are declared non-compliant or 32% of the total. Consumers are constantly exposed to many thousands of chemical components through the water and food. The health consequences of exposure are massive and worrisome. Conclusion: The intense and inappropriate use of pesticides contributes to the increasing of cancer in our country. These substances are often also endocrine disruptors. For further epidemiological studies should be conducted to explain the link and mechanisms between pesticides and the development of cancers. Disclosure of Interest: None Declared.
PP097-MON EFFECT OF ARGININE-RICH ENTERAL NUTRITION AFTER PANCREATICODUODENECTOMY M. Ogiku1 , Y. Ikematsu1 , T. Ogasawara2 , Y. Okamoto3 . 1 Digestive Surgery, 2 Respiratory Medicine, 3 Nutrition management office, Hamamatsu Medical Center, Hamamatsu, Japan Rationale: Early enteral nutrition improves the postoperative course after GI tract surgery. Also arginine is known to accelerate wound healing. But the effect of enteral nutrition with arginine-rich formula on the course after pancreaticoduodenectomy (PD) is not well known. Methods: 65 consecutive patients, who underwent standard PD or pylorus-preserving PD (PpPD) at our institute between January 2005 and December 2013, were analyzed retrospectively. Twenty-eight received enteral nutrition with argininerich agents (Arginade® , Nestle Health Science, Japan; Arg group) and 37 received enteral nutrition with standard agents (control group). We investigated the length of hospital stay, time to start oral intake, the incidence of pancreatic fistula, serum albumin level and diarrhea. Results: There were no difference in the length of hospital stay, time to start oral intake, the incidences of pancreatic fistula and the incidences of diarrhea between the Arg and control group. However, the recovery of serum albumin level at discharge compared to postoperative day 7 was significantly improved in the Arg group (D 0.6 vs. 0.3, P = 0.04). Conclusion: Arginine-rich enteral nutrition have therapeutic potential to increase nutritional biomarker especially serum albumin after PD. Disclosure of Interest: None Declared.
PP098-MON PERSONALISED NUTRITIONAL SUPPORT IN CANCER PATIENTS WITH BOWEL RESECTION C. Komives1 , C. Fejer1 , M. Varga1 , I. Biro1 , A. Molnar2 , L. Topa1 , P. Sahin1 . 1 St. Imre Hospital, 2 School of PhD. Studies of Semmelweis University, Pathological Sciences, Health science research, Budapest, Hungary Rationale: Sarkopenia in malignancies deteriorated by chemotherapy, increases the side affects of the therapy, decreases its efficiency and therefore worsens survival rate. Therefore avoiding sarkopenia is very important. Methods: Description of personalised nutritional support of 3 cancer patients (A: poorly differentiated neuroendocrine carcinoma of the small intestine pT3NxM0; B: colon adenocarcinoma pT3pN2M2; C: desmoid tumor of the pelvis, after
Poster presentations the surgery: short bowel syndrome [SBS] type I with 100 cm jejunum and jejunostoma) who underwent bowel resection surgery (A: SBS type II with 70 cm jejunum and coecum without rectosigma; B: subtotal colectomy and perianal fistulas; C: total proctocolectomy with ileoanal pouch) for different reasons (A: stricturing Crohn’s disease localized in the small intestine; B: stricturing Crohn’s disease localized in the colon; C: familial adenomatous polyposis). The malignant disease, the resection surgery and the chemotherapy jointly made the nutrition therapy more complex and difficult for our patients. To determine the body composition we used bioelectrical impedance analysis (Inbody720). Results: Malnutrition (body mass index [kg/m2 ], A: 15.6 19.4; B: 17.7 18.9; C: 14.7 17.5) and sarkopenia (sceletal muscle mass [kg], A: 16.9 15.8 19.3; B: 23.8 24.8; C: 26.9 32.8) experienced at the beginning of nutrition support improved in all cases in spite of the chemotherapy, usually with loss of body fat mass (A: 17 21.8%; B: 27.2 21.7%; C: 9.1 <5%). We successively optimized the enteral diet and oral nutritional support of our patients. A and C patients have been receiving long term home parenteral nutrition too. Conclusion: With personalised nutritional therapy the development of sarkopenia can be delayed, life expectancy of patients can be improved, quality of life can be maintained. Disclosure of Interest: None Declared.
PP099-MON PESTICIDES AND CANCER: PROBLEM OF THE CENTURY M. Mokhtari1 , F. Mouhouche1 . 1 Zoology, High National School of Agronomy, Algiers, Algeria Rationale: Population growth put the agricultural under increasing pressure to produce more without worrying about the risks caused by overproduction and the use of pesticides. The change of lifestyle causes the appearance of phenomena of cancer. Without preventive action, the prevalence of cancer will continue to increase. The intervention must reach the major environmental factors in the onset of cancer. Methods: A survey study was carried out in Algiers city to identify factors associated to pesticides risk, and put the focus on the prevalence of cancer in Algeria. Results: In Algeria, cancer exponentially thrust. The prevalence of this disease is doubled. Studies continue to show the links between pesticides and cancer. Algeria is a major consumer of pesticides: 30,000 tonnes are “applied to land” each year. But cancer kills 40,000 people each year in Algeria. In 2011, the physico-chemical laboratory of the Algerian Centre of quality control and packaging (CACQE) received 7,675 food samples. 2419 samples are declared non-compliant or 32% of the total. Consumers are constantly exposed to many thousands of chemical components through the water and food. The health consequences of exposure are massive and worrisome. Conclusion: The intense and inappropriate use of pesticides contributes to the increasing of cancer in our country. These substances are often also endocrine disruptors. For further epidemiological studies should be conducted to explain the link and mechanisms between pesticides and the development of cancers. Disclosure of Interest: None Declared.