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PP127-MON PARENTERAL NUTRITION IS ASSOCIATED WITH CENTRAL VENOUS CATHETER-RELATED BLOODSTREAM INFECTION IN COLORECTAL CANCER PATIENTS RECEIVING POSTOPERATIVE CHEMOTHERAPY
188 non-routine dressing change (NR-DC). The purpose of this study is to compare the time interval from insertion until development of CVC-RBSI between patients who received NR-DC (Group 1) and patients who received R-DC (Group 2). Methods: Between March 2006 and July 2008, patients who underwent CVC were randomly divided into Groups 1 and 2. Comparative study between the two groups was performed by reference to the incidences of CVC-RBSI from the prospectively obtained database. Results: One hundred eighty-nine patients underwent 530 CVC insertions. Group 1 had 254 CVCs and Group 2 had 276 CVCs. There were no significant inter-group differences in patient background factors, except for sex. In addition, Group 1 had a shorter duration of catheter insertion than Group 2. Nevertheless, Group 1 had not only a significantly shorter period from insertion until the development of CVC-RBSI but also a higher frequency of fever than Group 2. Conclusion: The results of our comparison between NR-DC and R-DC indicate that R-DC can reduce the incidence of CVC-RBSI in patients undergoing CVC insertions. References Adal KA, Farr BM. Central venous catheter-related infections: a review. Nutrition 1996; 12: 208 213. Bacuzzi A, Cecchin A, Del Bosco A, Cantone G, Cuffai S. Recommendations and reports about central venous catheterrelated infection. Surg Infect 2006; 7: 65 67. Disclosure of Interest: None Declared.
PP127-MON PARENTERAL NUTRITION IS ASSOCIATED WITH CENTRAL VENOUS CATHETER-RELATED BLOODSTREAM INFECTION IN COLORECTAL CANCER PATIENTS RECEIVING POSTOPERATIVE CHEMOTHERAPY M. Ishizuka1 , H. Nagata1 , K. Takagi1 , K. Kubota1 . 1 Department of Gastroenterological Surgery, Dokkyo Medical University, Mibu, Japan Rationale: To clarify the risk factors for central venous catheter-related bloodstream infection (CVC-RBSI) in patients receiving chemotherapy after surgery for colorectal cancer (CRC). Methods: CVC-RBSI was evaluated retrospectively from a database of patients who had received postoperative chemotherapy using CVC. Results: One hundred nine patients received 542 CVCs for a total of 5558 catheter-days. There were no significant differences in background between the patients who had CVC-RBSI and those who did not, except for the term of insertion (P = 0.0028) and administration of parenteral nutrition (PN) (P < 0.0001). Moreover, univariate analyses using factors including type of catheter, sex, age, troubles with insertion, types of disinfectant, types of catheter, length of inserted catheter, period of insertion, and administration of PN revealed that administration of PN (odds ratio, 12.74; 95% CI, 2.489 62.26; P = 0.0023) was risk factors for CVC-RBSI. Conclusion: PN is associated with CVC-RBSI in CRC patients receiving postoperative chemotherapy.
Poster presentations References Dissanaike S, Shelton M, Warner K, et al.: The risk for bloodstream infections is associated with increased parenteral caloric intake in patients receiving parenteral nutrition. Crit Care 2007. Tacconelli E, Tumbarello M, Pittiruti M, et al.: Central venous catheter-related sepsis in a cohort of 366 hospitalised patients. Eur J Clin Microbiol Infect Dis 1997; 16: 203 209. Disclosure of Interest: None Declared.
PP128-MON NUTRITIONAL STATUS OF PATIENTS SUBJECTED TO HEMATOPOIETIC STEM CELL TRANSPLANTATION INTERIM REPORT J. Krawczyk1 , G.W. Basak1 , K. Hałaburda1 , T. Korta2 , L. Kraj1,3 , A. ´ Swieboda-Sadlej1 , W.W. Je˛drzejczak1 . 1 Department of Hematology, Oncology and Internal Diseases, 2 2nd Clinic of Anesthesiology and Intensive Care, 3 Department of Biochemistry, Medical University of Warsaw, Warsaw, Poland Rationale: Hematopoietic stem cell transplantation (HSCT) is an aggressive method of treatment which significantly affects patients’ homeostasis, including the nutritional status. The aim of the work was to evaluate the nutritional status of patients before the intensive preparatory treatment (conditioning) and within the first two weeks following the procedure. Methods: The prospective study included consecutive patients with hematological malignancies subjected to HSCT (62 autologous, 38 allogeneic) in a single transplantation centre. The assessment of the nutritional status was made using the Nutritional Risk Screening 2002 (NRS), Subjective Global Assessment (SGA), anthropometric and biochemical parameters. For statistical analyses, the Wilcoxon test was used. Results: Before conditioning the median result of NRS was 3 points and the most frequent of SGA result was A (88%). The median body weight was 78 kg, BMI 26 kg/m2 , concentration of total protein (TP) 6.8 g/dl, albumin (A) 4.2 g/dl, transferrin (Tr) 228 mg/dl. The frequency of overweight and obesity were 42% and 25%, respectively. On the day +7 following HSCT the median result of NRS was 4 points; on the SGA results A and B were noted in 62% and 31%, respectively. The median body weight was 75 kg, BMI 25 kg/m2 . We observed a significant decrease in concentration of TP (5.8 g/dl), A (3.6 g/dl), Tr (165 mg/dl) p < 0.001. On the day +14, the biochemical parameters were even lower: TP 5.5 g/dl, A 3.2 g/dl, Tr 144 mg/dl, p < 0.001. These values did not significantly differ between patients after allogeneic or autologous HSCT. Conclusion: Before conditioning, the majority of patients did not display undernutrition features, while overweight and obesity were frequent. During treatment, the nutritional status deteriorated. The patients subjected to HSCT required regular nutritional status assessment. Disclosure of Interest: None Declared.
PP127-MON PARENTERAL NUTRITION IS ASSOCIATED WITH CENTRAL VENOUS CATHETER-RELATED BLOODSTREAM INFECTION IN COLORECTAL CANCER PATIENTS RECEIVING POSTOPERATIVE CHEMOTHERAPY M. Ishizuka1 , H. Nagata1 , K. Takagi1 , K. Kubota1 . 1 Department of Gastroenterological Surgery, Dokkyo Medical University, Mibu, Japan Rationale: To clarify the risk factors for central venous catheter-related bloodstream infection (CVC-RBSI) in patients receiving chemotherapy after surgery for colorectal cancer (CRC). Methods: CVC-RBSI was evaluated retrospectively from a database of patients who had received postoperative chemotherapy using CVC. Results: One hundred nine patients received 542 CVCs for a total of 5558 catheter-days. There were no significant differences in background between the patients who had CVC-RBSI and those who did not, except for the term of insertion (P = 0.0028) and administration of parenteral nutrition (PN) (P < 0.0001). Moreover, univariate analyses using factors including type of catheter, sex, age, troubles with insertion, types of disinfectant, types of catheter, length of inserted catheter, period of insertion, and administration of PN revealed that administration of PN (odds ratio, 12.74; 95% CI, 2.489 62.26; P = 0.0023) was risk factors for CVC-RBSI. Conclusion: PN is associated with CVC-RBSI in CRC patients receiving postoperative chemotherapy.
Poster presentations References Dissanaike S, Shelton M, Warner K, et al.: The risk for bloodstream infections is associated with increased parenteral caloric intake in patients receiving parenteral nutrition. Crit Care 2007. Tacconelli E, Tumbarello M, Pittiruti M, et al.: Central venous catheter-related sepsis in a cohort of 366 hospitalised patients. Eur J Clin Microbiol Infect Dis 1997; 16: 203 209. Disclosure of Interest: None Declared.
PP128-MON NUTRITIONAL STATUS OF PATIENTS SUBJECTED TO HEMATOPOIETIC STEM CELL TRANSPLANTATION INTERIM REPORT J. Krawczyk1 , G.W. Basak1 , K. Hałaburda1 , T. Korta2 , L. Kraj1,3 , A. ´ Swieboda-Sadlej1 , W.W. Je˛drzejczak1 . 1 Department of Hematology, Oncology and Internal Diseases, 2 2nd Clinic of Anesthesiology and Intensive Care, 3 Department of Biochemistry, Medical University of Warsaw, Warsaw, Poland Rationale: Hematopoietic stem cell transplantation (HSCT) is an aggressive method of treatment which significantly affects patients’ homeostasis, including the nutritional status. The aim of the work was to evaluate the nutritional status of patients before the intensive preparatory treatment (conditioning) and within the first two weeks following the procedure. Methods: The prospective study included consecutive patients with hematological malignancies subjected to HSCT (62 autologous, 38 allogeneic) in a single transplantation centre. The assessment of the nutritional status was made using the Nutritional Risk Screening 2002 (NRS), Subjective Global Assessment (SGA), anthropometric and biochemical parameters. For statistical analyses, the Wilcoxon test was used. Results: Before conditioning the median result of NRS was 3 points and the most frequent of SGA result was A (88%). The median body weight was 78 kg, BMI 26 kg/m2 , concentration of total protein (TP) 6.8 g/dl, albumin (A) 4.2 g/dl, transferrin (Tr) 228 mg/dl. The frequency of overweight and obesity were 42% and 25%, respectively. On the day +7 following HSCT the median result of NRS was 4 points; on the SGA results A and B were noted in 62% and 31%, respectively. The median body weight was 75 kg, BMI 25 kg/m2 . We observed a significant decrease in concentration of TP (5.8 g/dl), A (3.6 g/dl), Tr (165 mg/dl) p < 0.001. On the day +14, the biochemical parameters were even lower: TP 5.5 g/dl, A 3.2 g/dl, Tr 144 mg/dl, p < 0.001. These values did not significantly differ between patients after allogeneic or autologous HSCT. Conclusion: Before conditioning, the majority of patients did not display undernutrition features, while overweight and obesity were frequent. During treatment, the nutritional status deteriorated. The patients subjected to HSCT required regular nutritional status assessment. Disclosure of Interest: None Declared.