PP147-SUN PRE-CACHEXIA AND CACHEXIA IN SURGICAL CANCER PATIENTS

PP147-SUN PRE-CACHEXIA AND CACHEXIA IN SURGICAL CANCER PATIENTS

84 Poster presentations PP146-SUN OPINION OF BREAST CANCER PATIENTS CANDIDATES FOR CHEMOTHERAPY ON THE NUTRITION CANCER RELATIONSHIPS 1 1 2 PP147...

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Poster presentations

PP146-SUN OPINION OF BREAST CANCER PATIENTS CANDIDATES FOR CHEMOTHERAPY ON THE NUTRITION CANCER RELATIONSHIPS 1

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PP147-SUN PRE-CACHEXIA AND CACHEXIA IN SURGICAL CANCER PATIENTS 2

M. Touillaud , A.-S. Kempf-L´ epine , A. Bajard , T. Gargi , J. Carretier1 , A.-M. Foucaut1,3 , S. Berthouze-Aranda3 , O. Tr´ edan4 , B. Fervers1 , P. Bachmann5 . 1 Cancer, Environment and Nutrition Unit, 2 Department of Public Health, L´ eon B´ erard Cancer Centre, Lyon, 3 Centre for Research and Innovation on Sport (CRIS) EA647, UCB Lyon 1, Villeurbanne, 4 Department of Medical Oncology, 5 Department of Nutrition-DISSPO, L´ eon B´ erard Cancer Centre, Lyon, France Rationale: Recommendations on cancer risk associated with nutritional factors were released in recent years in France. The purpose of our study was to assess awareness and knowledge about nutrition and cancer in French breast cancer patients. Methods: In 2009 2011, patients diagnosed with localized breast cancer and candidates for adjuvant chemotherapy (CT) were enrolled into a prospective cohort in a comprehensive cancer centre. During initial consultation with a dietician, a questionnaire was administered on patients’ views about risk factors usually involved in cancer onset, progression or recurrence. Level of information (very, moderately, little or not at all informed) and alcohol and tobacco consumption were collected. Descriptive results were expressed as % or mean±sd. Results: In the 272 women of the cohort (age 54±11 yrs), 148 (54%) had at least a high school diploma. A majority (57%) of patients said they were little or not informed on the nutrition-cancer relationships, 44% moderately and 6% very informed; obese patients were not informed twice more often than lean patients. Fruits and vegetables had no effect on risk for 13% of patients. Cancer risk would increase with alcohol (83%), meat (69%), salty foods (54%), dairy products (12%), dietary supplements (16%), overweight/obesity (78%), menopausal hormone therapy (61%), oral contraceptives (45%), stress (83%) and mainly food contaminants (93%). Regular physical activity (83%) and breast-feeding (48%) would reduce cancer risk. Among patients, 125 (46%) consumed alcohol weekly, including 35 (13%) daily; 34 (13%) were current and 74 (27%) former smokers. Conclusion: This study shows a lack of awareness and knowledge in more than half of breast cancer patients starting adjuvant CT on nutritional risk factors of cancer. Efforts are needed to improve information level, particularly as nutritional factors are associated with breast cancer prognosis. Disclosure of Interest: None Declared.

S. Lucia1 , G. Vuolo2 , R. Verzaro3 , C. Ramaccini1 , A. Molfino1 , F. Rossi Fanelli1 , A. Laviano1 , M. Muscaritoli1 . 1 Department of Clinical Medicine, Sapienza University of Rome, Rome, 2 Department of Surgery and Bioengineering, St. Maria delle Scotte Hospital, Siena, 3 Department of General Surgery, Vannini Hospital, Rome, Italy Rationale: Cachexia is a complex metabolic condition negatively affecting morbidity and mortality. Recent definitions and classifications of cancer pre-cachexia and cachexia point to early detection and to timely appropriate preventative and therapeutic interventions. The present study aimed at evaluating the prevalence of pre-cachexia and cachexia in cancer patients as well as at studying the relation between anthropometric measures and body composition. Methods: Immediately before operation, thirty-six consecutive surgical cancer patients (21 M, 15 F) were assessed for weight loss, anorexia and serum biochemistry. Based on the recent classifications of pre-cachexia (Muscaritoli et al) and cachexia (Fearon et al), patients were classified into pre-cachectic (P), cachectic (C) or no pre-cachectic/cachectic (NoP-NoC). In 19 patients, body composition (with bioimpedance spectroscopy, BIS, BCM Fresenius) and handgrip muscle strength (HGS, JAMAR Dynamometer) were also assessed. Statistical analysis was performed using ANOVA, two-way Dunnett post-hoc analysis, Kruskal Wallis test, Spearman test. Results: According to the available criteria, pre-cachexia was present in 6 patients (16.7%), cancer cachexia in 13 patients (36.1%), while 17 (47.2%) patients did not match the criteria for either pre-cachexia or cachexia. Body mass index (BMI) was decreased in C vs NoP-NoC (p = 0.01). In the subset of 19 patients, 4 (21%) were P, 7 (37%) were C, 8 (42%) were NoP-NoC. Fat-free mass (FFM) was decreased in C vs P and NoP-NoC (p = 0.009 and p = 0.035, respectively). HGS negatively correlated with CRP (r = 0.478, p = 0.039), while HGS increased with FFM (r = 0.577, p = 0.01). Conclusion: The study suggests that pre-cachexia and cachexia are present in >50% of pre-surgery cancer patients. Pre-cachexia and cachexia are associated with decreased FFM and functional impairment and might predict surgical outcome. Preoperative screening for precachexia and cachexia should be considered in cancer patients. Disclosure of Interest: None Declared.