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PP334 BODY MASS INDEX CLASSIFICATION COMPARED WITH BIOELECTRICAL IMPEDANCE VECTORIAL ANALYSIS IN PATIENTS WITH RHEUMATOID ARTHRITIS
154
Poster presentations
function was evaluated by handgrip strength (Jamar® Handgrip Strength) and the highest of three measurements was used in the analyses. Ultra-sensitive CRP was measured by immunoturbidimetry. After a pairwise correlation, a multiple linear regression was performed to identify if malnutrition, CRP and PA were independent determinants of handgrip strength after adjustment for other variables. Results: Sixty patients with gastrointestinal and lung cancer were studied. Sixty percent were male, and the mean age was 62.3±11.7 years old. The highest significant correlation was found between HS and sex (r = 0.59) and current weight (r = 0.57). After controlling for sex, age and height, only PG-SGA score and phase angle were considered significant determinants factors for HGS (Adj R2 = 0.69). Conclusion: CRP was not considered a significant factor to determine HS. Nutritional status evaluated by PG-SGA score and PA remained as important determinants of HS even after adjustments for other biological variables.
Conclusion: According our findings, 78.6% of RA patients would be misclassified as normal weight based on traditional BMI cut-offs. RA patients with normal or even high BMI have a significantly lower muscle component. Evaluation of body composition as well as UWL is essential.
Disclosure of Interest: None declared
Rationale: Malnutrition and disease-related catabolism are consequences of end-stage renal disease (ESRD) that may result in altered body composition. Bioimpedance spectroscopy (BIS) is a non-invasive method of body composition that has the potential to provide reliable estimates of fat-free mass (FFM) in ESRD patients. Methods: In sixteen ESRD patients on hemodialysis (HD) therapy (mean body mass index 27.2 kg/m2 ; age: 42 years), 12 undialysed (UD) ESRD patients scheduled for transplant (28.8 kg/m2 ; 48 years) and 23 healthy control subjects (26.6 kg/m2 ; age: 46 years) FFM measured by BIS (ImpediMed SFB7) was compared to FFM measured by dual-energy x-ray absorptiometry (DXA) (GE Lunar Prodigy). Measurements were taken at one time point prior to a HD treatment modality intervention. Statistical analyses included: Student’s paired t-tests, oneway analysis of variance, correlation coefficient, BlandAltman plots and multiple linear regression. Results: Comparisons of body composition by each method were similar across subject groups. The methods were highly correlated for FFM in all subject groups (r = 0.87, P < 0.001). The mean difference between methods (DXA-BIS) for FFM did not differ in HD patients (0.94±5.33 kg), UD patients ( 1.89±6.42 kg) or control subjects ( 1.10±4.17 kg). Based on individual comparisons 39.3 percent of ESRD patients had BIS estimates of FFM that were greater than 10 percent of the reference (DXA) value. There were wide limits of agreement between methods in HD patients (11.6 to 9.72 kg) and UD patients (10.95 to 14.73 kg). Conclusion: Although BIS and DXA were highly correlated andBIS estimates of FFM in the ESRD patient groups were not different from DXA at the group mean level, they were highly variable at the individual level. From these data it cannot be recommended that BIS be used to evaluate FFM in ESRD patients.
PP334 BODY MASS INDEX CLASSIFICATION COMPARED WITH BIOELECTRICAL IMPEDANCE VECTORIAL ANALYSIS IN PATIENTS WITH RHEUMATOID ARTHRITIS L. Castillo-Martinez1 , A. Orea-Tejeda1 , R. S´ anchez1 , 1 1 anchez , J.A. Pineda1 , E. Colín-Ramirez , A. S´ O. Carrasco1 , A. Navarro1 . 1 Cardiology, INCMNSZ, Mexico, Mexico Rationale: Bioelectrical Impedance Vector Analysis (BIVA) has been recognized as a new approach to evaluate body composition without making any assumption on hydration state of the subjects. There is little documentation of body composition in rheumatoid arthritis (RA), where inflammation associated with the illness can also lead to unintentional weight loss (UWL) and reduced muscle mass, that can be evaluate by BIVA. Methods: We study 44 females with RA (mean age 65±12 years). Body mass index (BMI) was divided in: <18.5, low weight; 18.5 to 25, normal and >25 overweight or obese. Unintentional weight loss was defined as lost >5% in one year from habitual weight. Whole-body bioelectrical impedance was assessed with tetra-polar equipment (RJL Systems Quantum X). For BIVA evaluation resistance and reactance normalized by height were plotted on the gender specific 50%, 75%, and 95% tolerance ellipses calculated from a Mexican reference healthy population as a resistance-reactance graph (RXc graph). Patients were classified as muscle depleted if they fell out the right half of the normal reference 75% tolerance ellipses. Chi square test was used to obtain difference between the three groups of BMI. Results: Three patients (6.8%) had low weight, 14 (31.8%) had normal weight and 27 (61.4%) were overweight or obese. Patients with muscle depletion were 32 (72.7%) and UWL 13 (33.3%). Muscle depletion was presented in: all patients with low weight, normal weight 78.6% and 66.7% of overweight patients. UWL was more frequent in low weight group (66.7%), 50% in normal weight and 20.8% in overweight or obese group.
Disclosure of Interest: None declared
PP335 COMPARISON OF BIOIMPEDANCE SPECTROSCOPY AND DUAL-ENERGY X-RAY ABSORPTIOMETRY FOR ASSESSMENT OF FAT-FREE MASS IN END STAGE RENAL DISEASE C.P. Earthman1 , S.M. Vine1 , M. Kuskowski2 , P. Painter3 . 1 Food Science and Nutrition, University of Minnesota, Twin Cities, MN, 2 Geriatric Research, Education and Clinical Center, Minneapolis Veterans Affairs Medical Center, Minneapolis, 3 School of Nursing, University of Minnesota, Twin Cities, MN, United States
Disclosure of Interest: C. Earthman: None declared, S. Vine: None declared, M. Kuskowski: None declared, P. Painter Grant/Research Support from: NIH/NINR 008286
Poster presentations
function was evaluated by handgrip strength (Jamar® Handgrip Strength) and the highest of three measurements was used in the analyses. Ultra-sensitive CRP was measured by immunoturbidimetry. After a pairwise correlation, a multiple linear regression was performed to identify if malnutrition, CRP and PA were independent determinants of handgrip strength after adjustment for other variables. Results: Sixty patients with gastrointestinal and lung cancer were studied. Sixty percent were male, and the mean age was 62.3±11.7 years old. The highest significant correlation was found between HS and sex (r = 0.59) and current weight (r = 0.57). After controlling for sex, age and height, only PG-SGA score and phase angle were considered significant determinants factors for HGS (Adj R2 = 0.69). Conclusion: CRP was not considered a significant factor to determine HS. Nutritional status evaluated by PG-SGA score and PA remained as important determinants of HS even after adjustments for other biological variables.
Conclusion: According our findings, 78.6% of RA patients would be misclassified as normal weight based on traditional BMI cut-offs. RA patients with normal or even high BMI have a significantly lower muscle component. Evaluation of body composition as well as UWL is essential.
Disclosure of Interest: None declared
Rationale: Malnutrition and disease-related catabolism are consequences of end-stage renal disease (ESRD) that may result in altered body composition. Bioimpedance spectroscopy (BIS) is a non-invasive method of body composition that has the potential to provide reliable estimates of fat-free mass (FFM) in ESRD patients. Methods: In sixteen ESRD patients on hemodialysis (HD) therapy (mean body mass index 27.2 kg/m2 ; age: 42 years), 12 undialysed (UD) ESRD patients scheduled for transplant (28.8 kg/m2 ; 48 years) and 23 healthy control subjects (26.6 kg/m2 ; age: 46 years) FFM measured by BIS (ImpediMed SFB7) was compared to FFM measured by dual-energy x-ray absorptiometry (DXA) (GE Lunar Prodigy). Measurements were taken at one time point prior to a HD treatment modality intervention. Statistical analyses included: Student’s paired t-tests, oneway analysis of variance, correlation coefficient, BlandAltman plots and multiple linear regression. Results: Comparisons of body composition by each method were similar across subject groups. The methods were highly correlated for FFM in all subject groups (r = 0.87, P < 0.001). The mean difference between methods (DXA-BIS) for FFM did not differ in HD patients (0.94±5.33 kg), UD patients ( 1.89±6.42 kg) or control subjects ( 1.10±4.17 kg). Based on individual comparisons 39.3 percent of ESRD patients had BIS estimates of FFM that were greater than 10 percent of the reference (DXA) value. There were wide limits of agreement between methods in HD patients (11.6 to 9.72 kg) and UD patients (10.95 to 14.73 kg). Conclusion: Although BIS and DXA were highly correlated andBIS estimates of FFM in the ESRD patient groups were not different from DXA at the group mean level, they were highly variable at the individual level. From these data it cannot be recommended that BIS be used to evaluate FFM in ESRD patients.
PP334 BODY MASS INDEX CLASSIFICATION COMPARED WITH BIOELECTRICAL IMPEDANCE VECTORIAL ANALYSIS IN PATIENTS WITH RHEUMATOID ARTHRITIS L. Castillo-Martinez1 , A. Orea-Tejeda1 , R. S´ anchez1 , 1 1 anchez , J.A. Pineda1 , E. Colín-Ramirez , A. S´ O. Carrasco1 , A. Navarro1 . 1 Cardiology, INCMNSZ, Mexico, Mexico Rationale: Bioelectrical Impedance Vector Analysis (BIVA) has been recognized as a new approach to evaluate body composition without making any assumption on hydration state of the subjects. There is little documentation of body composition in rheumatoid arthritis (RA), where inflammation associated with the illness can also lead to unintentional weight loss (UWL) and reduced muscle mass, that can be evaluate by BIVA. Methods: We study 44 females with RA (mean age 65±12 years). Body mass index (BMI) was divided in: <18.5, low weight; 18.5 to 25, normal and >25 overweight or obese. Unintentional weight loss was defined as lost >5% in one year from habitual weight. Whole-body bioelectrical impedance was assessed with tetra-polar equipment (RJL Systems Quantum X). For BIVA evaluation resistance and reactance normalized by height were plotted on the gender specific 50%, 75%, and 95% tolerance ellipses calculated from a Mexican reference healthy population as a resistance-reactance graph (RXc graph). Patients were classified as muscle depleted if they fell out the right half of the normal reference 75% tolerance ellipses. Chi square test was used to obtain difference between the three groups of BMI. Results: Three patients (6.8%) had low weight, 14 (31.8%) had normal weight and 27 (61.4%) were overweight or obese. Patients with muscle depletion were 32 (72.7%) and UWL 13 (33.3%). Muscle depletion was presented in: all patients with low weight, normal weight 78.6% and 66.7% of overweight patients. UWL was more frequent in low weight group (66.7%), 50% in normal weight and 20.8% in overweight or obese group.
Disclosure of Interest: None declared
PP335 COMPARISON OF BIOIMPEDANCE SPECTROSCOPY AND DUAL-ENERGY X-RAY ABSORPTIOMETRY FOR ASSESSMENT OF FAT-FREE MASS IN END STAGE RENAL DISEASE C.P. Earthman1 , S.M. Vine1 , M. Kuskowski2 , P. Painter3 . 1 Food Science and Nutrition, University of Minnesota, Twin Cities, MN, 2 Geriatric Research, Education and Clinical Center, Minneapolis Veterans Affairs Medical Center, Minneapolis, 3 School of Nursing, University of Minnesota, Twin Cities, MN, United States
Disclosure of Interest: C. Earthman: None declared, S. Vine: None declared, M. Kuskowski: None declared, P. Painter Grant/Research Support from: NIH/NINR 008286