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PPET: A software tool for kinetic and parametric analyses of dynamic PET studies
T62
Poster Presentations / NeuroImage 31 (2006) T44 – T186
Poster Presentation No.: 019
PPET: A software tool for kinetic and parametric analyses of dynamic PET studies Ronald Boellaard, M. Yaqub, M. Lubberink, A. Lammertsma VU University Medical Center, Department of Nuclear Medicine and PET Research, Amsterdam, The Netherlands
Introduction: Analysis of dynamic PET studies includes pharmacokinetic modeling of regional time – activity curves (TAC) and/or application of parametric methods at the voxel level. A software tool was developed to facilitate kinetic modeling and parametric processing of dynamic PET studies. A short description of this program, called PPET (Parametric imaging of PET studies), is presented here. Methods: PPET consists of three main modules all included within one GUI: (1) GIFT (General Input Function Tool), (2) PPP (Parametric Processing of PET data), and (3) CAT (Compartmental Analysis of TAC). Image data are accepted in 4D ANALYZE format, while other (non-imaging) data are accepted as flat (ascii) files. GIFT can be used to convert a measured (on-line) arterial whole blood input curve into a delay and metabolite-corrected plasma input function. This conversion involves on-line calibration, corrections for plasma to whole blood ratios, metabolite fractions and delay. For each step, the user can choose from a variety of fit or correction functions and results are displayed instantaneously. PPP is a parametric processing tool, which includes parametric methods such as Logan plot, reference Logan, Patlak, reference Patlak, various versions of Ichise multi-linearizations, RPM, spectral analysis, SUV and a CBF basis function method including additional corrections for dispersion and delay. Settings, such as thresholds, can be selected from a tracer-specific predefined list or set by the user interactively. PPP also includes several utilities, such as rebinning, smoothing, generation of masks and partial volume correction methods. Moreover, a tool for generating simulated noisy 4D images, which can be used for parametric method evaluations, is included. Finally, CAT can be used for pharmacokinetic modeling of TAC. It includes common PET pharmacokinetic models, such as 1-tissue, and reversible and irreversible 2-tissue compartment models, together with simplified and full reference tissue models, all with and without blood volume fraction (optional). For fitting, all parameters can be fixed or a constraint can be applied. Pharmacokinetic parameters, Akaike information criterion numbers, and graphics are saved in a user-defined output file for further analysis. The entire program can be run under the IDL virtual machine, which allows distribution of the package without the need for an (IDL) license. The program will be released around winter 2006/2007 and will be available free of charge (but licensed) for research groups/purposes only. Conclusion: PPET is a free and convenient software package developed for pharmacokinetic analysis and parametric processing of PET brain studies. All modules of the program were validated against existing stand-alone programs. doi:10.1016/j.neuroimage.2006.04.053
Poster Presentations / NeuroImage 31 (2006) T44 – T186
Poster Presentation No.: 019
PPET: A software tool for kinetic and parametric analyses of dynamic PET studies Ronald Boellaard, M. Yaqub, M. Lubberink, A. Lammertsma VU University Medical Center, Department of Nuclear Medicine and PET Research, Amsterdam, The Netherlands
Introduction: Analysis of dynamic PET studies includes pharmacokinetic modeling of regional time – activity curves (TAC) and/or application of parametric methods at the voxel level. A software tool was developed to facilitate kinetic modeling and parametric processing of dynamic PET studies. A short description of this program, called PPET (Parametric imaging of PET studies), is presented here. Methods: PPET consists of three main modules all included within one GUI: (1) GIFT (General Input Function Tool), (2) PPP (Parametric Processing of PET data), and (3) CAT (Compartmental Analysis of TAC). Image data are accepted in 4D ANALYZE format, while other (non-imaging) data are accepted as flat (ascii) files. GIFT can be used to convert a measured (on-line) arterial whole blood input curve into a delay and metabolite-corrected plasma input function. This conversion involves on-line calibration, corrections for plasma to whole blood ratios, metabolite fractions and delay. For each step, the user can choose from a variety of fit or correction functions and results are displayed instantaneously. PPP is a parametric processing tool, which includes parametric methods such as Logan plot, reference Logan, Patlak, reference Patlak, various versions of Ichise multi-linearizations, RPM, spectral analysis, SUV and a CBF basis function method including additional corrections for dispersion and delay. Settings, such as thresholds, can be selected from a tracer-specific predefined list or set by the user interactively. PPP also includes several utilities, such as rebinning, smoothing, generation of masks and partial volume correction methods. Moreover, a tool for generating simulated noisy 4D images, which can be used for parametric method evaluations, is included. Finally, CAT can be used for pharmacokinetic modeling of TAC. It includes common PET pharmacokinetic models, such as 1-tissue, and reversible and irreversible 2-tissue compartment models, together with simplified and full reference tissue models, all with and without blood volume fraction (optional). For fitting, all parameters can be fixed or a constraint can be applied. Pharmacokinetic parameters, Akaike information criterion numbers, and graphics are saved in a user-defined output file for further analysis. The entire program can be run under the IDL virtual machine, which allows distribution of the package without the need for an (IDL) license. The program will be released around winter 2006/2007 and will be available free of charge (but licensed) for research groups/purposes only. Conclusion: PPET is a free and convenient software package developed for pharmacokinetic analysis and parametric processing of PET brain studies. All modules of the program were validated against existing stand-alone programs. doi:10.1016/j.neuroimage.2006.04.053