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Practical physiological chemistry. By Philip B. Hawk, Bernard L. Oser, and William H. Summerson. The Blakiston Co., Inc. New York, 1954. 13th ed. xvi + 1439 pp. 23.5 × 16 cm. Price $12
Book Notices The Infra-Red Spectra of Complex Molecules. By L. J. BELLAMY.John Wiley & Sons, Inc.. New York, 1954. xvii 323 pp. 22.5 x 14 cm.
their suitability, precision and accuracy, cost and availability, and ease of repair and replacement of parts. Illustrations of many of the described pieces of apparatus are included. Techniques for micropreparative methods, for microsyntheses (including procedures with tracer elements), and microanalytical procedures for identification of compounds and for quantitative determination of organic compounds and their functional groups are included. The excellent presentation, the comprehensive bibliographic references, and the index make this volume a splendid addition t o this valuable series. This sixth volume also contains abbreviated cumulative author and subject indexes for volumes I to VIII inclusive.
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Price $7. The author has limited the subject-matter of this book strictly to the empirical interpretation of infrared spectra, and he has not attempted t o cover the related aspects of practical spectroscopy such as sample preparation, cell construction, quantitative analysis, instrumentation, etc. The types of linkage affecting the spectra are roughly grouped as: I. Carbon-carbon and carbon-hydrogen. 11. Carbon-oxygen and oxygen-hydrogen. 111. Carbonnitrogen and nitrogen-hydrogen. IV. Linkages involving other elements, or which are related to-inorganic structures. The author expresses measurements in terms of frequencies rather than wavelengths. Practically all of the spectra included in the text were obtained with a Perkin-Elmer 21 B double beam spectrometer equipped with a rocksalt prism. For those who use instruments with a wavelength scale. a table of reciprocals for conversion of the frequencies is appended. However, the author states that the use of the wave-number scale makes it easier t o identify overtone and combination bands and it enables direct comparisons with Raman spectra. Each chapter opens with a brief outline of the correlations to be discussed, together with a table giving the various frequency ranges; and a t the end of the chapter a series of charts is given in which the correlations are summarized in the usual line drawing form. Small groups of spectra are included at the end of each of the four divisions of the text, the divisions being based on the above-mentioned vibration-affecting linkages. Indexes of subjects and of compounds are appended. This book should be helpful to those who are interested in the rapidly growing field of infra-red spectroscopy.
Bentley’s Textbook of Phurmaceutics. 6th ed. Revised by HAROLD DAVIS,with the collaboration of M. W. PARTRIDGE, and C. L. SARCENT,with contributions by W. A Broom, H. A. Turner, and M. Turner. Bailiere, Tindall and Cox, London. xiii 1078 pp. 22.5x 14.5 cm. Price $10. The sixth edition of this textbook includes revisions based upon the latest British Pharmacopoeia (1953)and the changes in the syllabus of the examinations qualifying for pharmaceutical chemist and for registration as a pharmacist in Great Britain. The text is therefore quite comprehensive in its fields of coverage; although the extent to which the divisions in each field are presented are governed by their relative importance. Subjects such as chromatography and ion exchange are summarized and related t o pharmaceutical practices in manufacture as well as to analytical methods. Manufacturing methods and equipment are treated thoroughly. Physical and chemical methods of sterilization are discussed at length. The U. S. Food and Drug Administration statement of policy (January. 1953) on sterility of ophthalmic solutions is cited, and materials incompatible with the commonly used (in Micro and Semimicro Methods. By NICHOLAS Great Britain) bacteriostatic agents (chlorocresol CHERONIS. Interscience Publishers, Inc.. New and phenylmercuric nitrate) are listed. This edition of Bentley’s Textbook of PharmaYork, 1954. Xxiii 628 pp. 23.5 x 16.5 cm. ceutics is printed on excellent paper and includes Price $12. This is the sixth in a planned series of nine volumes many illustrations. It is well documented for furon the Technique of Organic Chemistry. This ther reference reading, and it should be available to pharmacists everywhere. text does not discuss theoretical considerations of micromethods at any length, because the basis for these procedures is identical with that of the macro- Practical Physiological Chemistry. By PHILIPB. HAWK, BERNARDL. OSER, and WILLIAMH. methods presented in the earlier volumes in the SUMMERSON. The Blakiston Co., Inc. New York, series. Where the basis for a micromethod differs 1954. 13th ed. xvi 1439 pp. 23.5 x 16 cm. from that of the macroprocedure, it is developed Price $12. more fully. Descriptions of applied microtechThis is the thirteenth edition of a widely-used niques are given in detail. This is essential for reproducible results, particularly since the number textbook with which one of the authors, P. B. Hawk, of organic chemists who have practical experience has been actively associated for i3ty years. The splendid reputation of this authoritative book will with these procedures is relatively small. The merits and limitations of the various tools be continued in its recent revision, although even the and apparatus designed t o carry out microprocedures best text must, in these days, “run a losing race with are reviewed and discussed. While only one or two the periodical literature.” In this edition the chaptypes of apparatus for a particular application are ters dealing with nucleic acids and nucleoproteins, discussed in detail, their selection was based on milk, muscular tissue, enzymes and their action. and
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02
SCIENTIFIC EDITION
January, 1955
isotopes have been exhaustively rewritten. And in all the text an endeavor has been made to include current advances in the many fields of biochemistry which are benefiting from the utilization of newer techniques and instrumentation. The student, the teacher, the investigator, and the clinician will find much information well presented and conveniently available in this book. However, the excellent index would be even better if the type were a little larger. Those who have used the earlier editions of this book will be glad to learn of the availability of a recent revision of the text, and the book should continue to be useful to workers in many fields of chemistry. No pharmacy library should be without a copy of this excellent text and reference book.
The Vitamins-Chemistry, Physiology, Pathology. Vol. 11. W . H. SEBRELL, JR.. and ROBERTS. HARRIS, Editors. Academic Press, Inc.. New York, 1954. xiii 766 pp. 9.25x 6 cm. Price $16.50. The second volume of this series of comprehensive monographs by authoritative contributors includes chapters on: Choline, Vitamin D Group, Essential Fatty Acids, Inositols, Vitamin K Group, Niacin, and Pantothenic Acid. The chapters follow a general outline which correlate the discussions by different contributors und& the headings: Chemistry, Industrial Preparation, Biochemical Systems, Specificity of Action, Biogenesis, Estimation (physical, chemical, biological, and microbiological methods), Standardization of Activity, Occurrence, Effects of Deficiency, Pharmacology, and Requirements and Factors Influencing Them. The illustrated text material is well presented with an extensive bibliography recorded on the pages which include the respective references. Author and subject indexes are appended. This series will be a necessary addition to any complete reference library on the vitamins.
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Chemical Specificity in Biological Interactions. Edited by F. R. N. GURD. Academic Press, Inc., New York, 1954. xv 4- 234 pp. 23 x 16 em. Price $6. This third volume in a series of “Memoirs” or symposia, published by the University Laboratory of Physical Chemistry Related to Medicine and Public Health, Harvard University deals with certain selected aspects of the chemical specificity underlying biological interactions. The subjects discussed by the respective authors are divided into the following chapters : Chemical Specificity in Biological Interactions (Proteins), E. J. Cohn; Effects of X-ray and Other Radiation on Proteins and Living Tissues, S. Warren; Properties of the Steroids Related to Protein Binding, R. B. Turner; Biochemical Problems of Steroid Hormones, T. F. Gallagher; Studies on the Active Principles of the Posterior Pituitary Gland, V. du Vigneaud; Influence of Ion-exchange Chromatography upon Our Concept of the Structure of Ribonucleic Acid, W. E. Cohn; Special Problems in the Formation of Metal Complexes, C. D. Coryell; Interactions of Metals with Small Molecules in Relation to Metal-Protein Complexes, J. Schubert ; Specificity of Metal Complex Formation, G. Schwarzenbach; Interaction of Proteins with Small
63
Molecules and Ions, G. Scatchard, W. L. Hughes. Jr., F. N. Gurd, and P. E. Wilcox. References are given a t the end of each chapter and author and subject indexes are appended. The value of the book as an up-to-date reference volume is evident from the list of contributors.
Hydrometers and Hydrometry. By E. R. CRANDALL. Published by the author, 10,335 Elmira, Detroit 4. iii 94 pp. 27.5 x 21.3 cm. Price $2.50. Since the seventeenth century, hydrometers have been produced in a great variety of designs for many specialized purposes, but all apply the same physical principle and are used in similar manners. Failure by the author to locate a special treatise on the subject of hydrometers and hydrometry prompted him to compile the information covered in this wellwritten, mimeographed book. The assembled material is designed to meet the need of students, teachers, and practical operators. The subject has received rather broad treatment and includes the designs of hydrometers, the physical principles involved in their use, explanations of the sources and magnitudes of error, and descriptions of many scales, both rational and arbitrary. A useful feature includes methods of converting between specific gravity and certain arbitrary scale readings of hydrometers currently in use, and those previously employed. The book also includes a list of currently used hydrometers, commercially available in the United States. Professor Crandall, of Wayne University in Detroit, deserves commendation for having brought together information on hydrometers and hydrometry, heretofore widely scattered in the scientsc literature relating to these subjects.
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Recent Progress i n Hormone Research. Vol. 10. G . PINCUS,Ed. Academic Press Inc., New York. 19.54. 511 pp. 23.5 x 16 cm. Price $9.80. This book constitutes the proceedings of the tenth annual meeting of the Laurentian Hormone Conference, which was held at Mt. Tremblant, Quebec in September, 1953. I t includes fourteen formal presentations of papers presented a t that time, each of which is followed by an abstract of the ensuing discussions. The fourteen chapters are logically arranged into six sections, covering hormone interrelationships of the nervous system, thyroid hormone physiology and biochemistry, ‘comparative endocrinology, protein hormones, the role of hormones in blood and blood-forming organs, and aspects of clinical endocrinology. The book is provided with an author index and a satisfactory subject index. It very adequately covers recent advances in hormone research. Organic Analysis. Vol. 2. Editors: JOHN MITCHELL, JR., I. M. KOLTHOFF, E. S. PROSKAUER, and A. WEISSBERGER.Interscience Publishers, 372 pp. 16 x 23.5 Inc., New York, 1954. vii cm. PriceS.50. This is the second volume of a series designed for the use of chemists in academic institutions and in industry, covering critical information on methods for the direct analysis of organic substances. It emphasizes modern trends in organic analysis toward functional group determination by chemical and instrumental techniques.
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their suitability, precision and accuracy, cost and availability, and ease of repair and replacement of parts. Illustrations of many of the described pieces of apparatus are included. Techniques for micropreparative methods, for microsyntheses (including procedures with tracer elements), and microanalytical procedures for identification of compounds and for quantitative determination of organic compounds and their functional groups are included. The excellent presentation, the comprehensive bibliographic references, and the index make this volume a splendid addition t o this valuable series. This sixth volume also contains abbreviated cumulative author and subject indexes for volumes I to VIII inclusive.
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Price $7. The author has limited the subject-matter of this book strictly to the empirical interpretation of infrared spectra, and he has not attempted t o cover the related aspects of practical spectroscopy such as sample preparation, cell construction, quantitative analysis, instrumentation, etc. The types of linkage affecting the spectra are roughly grouped as: I. Carbon-carbon and carbon-hydrogen. 11. Carbon-oxygen and oxygen-hydrogen. 111. Carbonnitrogen and nitrogen-hydrogen. IV. Linkages involving other elements, or which are related to-inorganic structures. The author expresses measurements in terms of frequencies rather than wavelengths. Practically all of the spectra included in the text were obtained with a Perkin-Elmer 21 B double beam spectrometer equipped with a rocksalt prism. For those who use instruments with a wavelength scale. a table of reciprocals for conversion of the frequencies is appended. However, the author states that the use of the wave-number scale makes it easier t o identify overtone and combination bands and it enables direct comparisons with Raman spectra. Each chapter opens with a brief outline of the correlations to be discussed, together with a table giving the various frequency ranges; and a t the end of the chapter a series of charts is given in which the correlations are summarized in the usual line drawing form. Small groups of spectra are included at the end of each of the four divisions of the text, the divisions being based on the above-mentioned vibration-affecting linkages. Indexes of subjects and of compounds are appended. This book should be helpful to those who are interested in the rapidly growing field of infra-red spectroscopy.
Bentley’s Textbook of Phurmaceutics. 6th ed. Revised by HAROLD DAVIS,with the collaboration of M. W. PARTRIDGE, and C. L. SARCENT,with contributions by W. A Broom, H. A. Turner, and M. Turner. Bailiere, Tindall and Cox, London. xiii 1078 pp. 22.5x 14.5 cm. Price $10. The sixth edition of this textbook includes revisions based upon the latest British Pharmacopoeia (1953)and the changes in the syllabus of the examinations qualifying for pharmaceutical chemist and for registration as a pharmacist in Great Britain. The text is therefore quite comprehensive in its fields of coverage; although the extent to which the divisions in each field are presented are governed by their relative importance. Subjects such as chromatography and ion exchange are summarized and related t o pharmaceutical practices in manufacture as well as to analytical methods. Manufacturing methods and equipment are treated thoroughly. Physical and chemical methods of sterilization are discussed at length. The U. S. Food and Drug Administration statement of policy (January. 1953) on sterility of ophthalmic solutions is cited, and materials incompatible with the commonly used (in Micro and Semimicro Methods. By NICHOLAS Great Britain) bacteriostatic agents (chlorocresol CHERONIS. Interscience Publishers, Inc.. New and phenylmercuric nitrate) are listed. This edition of Bentley’s Textbook of PharmaYork, 1954. Xxiii 628 pp. 23.5 x 16.5 cm. ceutics is printed on excellent paper and includes Price $12. This is the sixth in a planned series of nine volumes many illustrations. It is well documented for furon the Technique of Organic Chemistry. This ther reference reading, and it should be available to pharmacists everywhere. text does not discuss theoretical considerations of micromethods at any length, because the basis for these procedures is identical with that of the macro- Practical Physiological Chemistry. By PHILIPB. HAWK, BERNARDL. OSER, and WILLIAMH. methods presented in the earlier volumes in the SUMMERSON. The Blakiston Co., Inc. New York, series. Where the basis for a micromethod differs 1954. 13th ed. xvi 1439 pp. 23.5 x 16 cm. from that of the macroprocedure, it is developed Price $12. more fully. Descriptions of applied microtechThis is the thirteenth edition of a widely-used niques are given in detail. This is essential for reproducible results, particularly since the number textbook with which one of the authors, P. B. Hawk, of organic chemists who have practical experience has been actively associated for i3ty years. The splendid reputation of this authoritative book will with these procedures is relatively small. The merits and limitations of the various tools be continued in its recent revision, although even the and apparatus designed t o carry out microprocedures best text must, in these days, “run a losing race with are reviewed and discussed. While only one or two the periodical literature.” In this edition the chaptypes of apparatus for a particular application are ters dealing with nucleic acids and nucleoproteins, discussed in detail, their selection was based on milk, muscular tissue, enzymes and their action. and
+
+
+
02
SCIENTIFIC EDITION
January, 1955
isotopes have been exhaustively rewritten. And in all the text an endeavor has been made to include current advances in the many fields of biochemistry which are benefiting from the utilization of newer techniques and instrumentation. The student, the teacher, the investigator, and the clinician will find much information well presented and conveniently available in this book. However, the excellent index would be even better if the type were a little larger. Those who have used the earlier editions of this book will be glad to learn of the availability of a recent revision of the text, and the book should continue to be useful to workers in many fields of chemistry. No pharmacy library should be without a copy of this excellent text and reference book.
The Vitamins-Chemistry, Physiology, Pathology. Vol. 11. W . H. SEBRELL, JR.. and ROBERTS. HARRIS, Editors. Academic Press, Inc.. New York, 1954. xiii 766 pp. 9.25x 6 cm. Price $16.50. The second volume of this series of comprehensive monographs by authoritative contributors includes chapters on: Choline, Vitamin D Group, Essential Fatty Acids, Inositols, Vitamin K Group, Niacin, and Pantothenic Acid. The chapters follow a general outline which correlate the discussions by different contributors und& the headings: Chemistry, Industrial Preparation, Biochemical Systems, Specificity of Action, Biogenesis, Estimation (physical, chemical, biological, and microbiological methods), Standardization of Activity, Occurrence, Effects of Deficiency, Pharmacology, and Requirements and Factors Influencing Them. The illustrated text material is well presented with an extensive bibliography recorded on the pages which include the respective references. Author and subject indexes are appended. This series will be a necessary addition to any complete reference library on the vitamins.
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Chemical Specificity in Biological Interactions. Edited by F. R. N. GURD. Academic Press, Inc., New York, 1954. xv 4- 234 pp. 23 x 16 em. Price $6. This third volume in a series of “Memoirs” or symposia, published by the University Laboratory of Physical Chemistry Related to Medicine and Public Health, Harvard University deals with certain selected aspects of the chemical specificity underlying biological interactions. The subjects discussed by the respective authors are divided into the following chapters : Chemical Specificity in Biological Interactions (Proteins), E. J. Cohn; Effects of X-ray and Other Radiation on Proteins and Living Tissues, S. Warren; Properties of the Steroids Related to Protein Binding, R. B. Turner; Biochemical Problems of Steroid Hormones, T. F. Gallagher; Studies on the Active Principles of the Posterior Pituitary Gland, V. du Vigneaud; Influence of Ion-exchange Chromatography upon Our Concept of the Structure of Ribonucleic Acid, W. E. Cohn; Special Problems in the Formation of Metal Complexes, C. D. Coryell; Interactions of Metals with Small Molecules in Relation to Metal-Protein Complexes, J. Schubert ; Specificity of Metal Complex Formation, G. Schwarzenbach; Interaction of Proteins with Small
63
Molecules and Ions, G. Scatchard, W. L. Hughes. Jr., F. N. Gurd, and P. E. Wilcox. References are given a t the end of each chapter and author and subject indexes are appended. The value of the book as an up-to-date reference volume is evident from the list of contributors.
Hydrometers and Hydrometry. By E. R. CRANDALL. Published by the author, 10,335 Elmira, Detroit 4. iii 94 pp. 27.5 x 21.3 cm. Price $2.50. Since the seventeenth century, hydrometers have been produced in a great variety of designs for many specialized purposes, but all apply the same physical principle and are used in similar manners. Failure by the author to locate a special treatise on the subject of hydrometers and hydrometry prompted him to compile the information covered in this wellwritten, mimeographed book. The assembled material is designed to meet the need of students, teachers, and practical operators. The subject has received rather broad treatment and includes the designs of hydrometers, the physical principles involved in their use, explanations of the sources and magnitudes of error, and descriptions of many scales, both rational and arbitrary. A useful feature includes methods of converting between specific gravity and certain arbitrary scale readings of hydrometers currently in use, and those previously employed. The book also includes a list of currently used hydrometers, commercially available in the United States. Professor Crandall, of Wayne University in Detroit, deserves commendation for having brought together information on hydrometers and hydrometry, heretofore widely scattered in the scientsc literature relating to these subjects.
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Recent Progress i n Hormone Research. Vol. 10. G . PINCUS,Ed. Academic Press Inc., New York. 19.54. 511 pp. 23.5 x 16 cm. Price $9.80. This book constitutes the proceedings of the tenth annual meeting of the Laurentian Hormone Conference, which was held at Mt. Tremblant, Quebec in September, 1953. I t includes fourteen formal presentations of papers presented a t that time, each of which is followed by an abstract of the ensuing discussions. The fourteen chapters are logically arranged into six sections, covering hormone interrelationships of the nervous system, thyroid hormone physiology and biochemistry, ‘comparative endocrinology, protein hormones, the role of hormones in blood and blood-forming organs, and aspects of clinical endocrinology. The book is provided with an author index and a satisfactory subject index. It very adequately covers recent advances in hormone research. Organic Analysis. Vol. 2. Editors: JOHN MITCHELL, JR., I. M. KOLTHOFF, E. S. PROSKAUER, and A. WEISSBERGER.Interscience Publishers, 372 pp. 16 x 23.5 Inc., New York, 1954. vii cm. PriceS.50. This is the second volume of a series designed for the use of chemists in academic institutions and in industry, covering critical information on methods for the direct analysis of organic substances. It emphasizes modern trends in organic analysis toward functional group determination by chemical and instrumental techniques.
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