- Email: [email protected]
Predictors of Advanced Fibrosis in Nonalcoholic Fatty Liver Disease, Chronic Heptitis B, Chronic Hepatitis C
MISCELLANEOUS
Table 1 LSM
CKD DM HTN Jaundice Ascites HBV HCV CAD
<7 7–12 12–21 >21 Total No
40 30 17 18 105
19 17 14 4 54
38 29 32
7 2 2
1 1 6
1 2
1 1 2
9 7 6
99
11
8
3
4
22
to diagnose asymptomatic liver involvement in advanced stage CKD population (Table 1).
CONFLICTS OF INTEREST The authors have none to declare. http://dx.doi.org/10.1016/j.jceh.2017.05.182
31 PREDICTORS OF ADVANCED FIBROSIS IN NONALCOHOLIC FATTY LIVER DISEASE, CHRONIC HEPTITIS B, CHRONIC HEPATITIS C Rajendra Gunjal ∗ , Aniruddha P. Singh, Gaurav Kapoor, N. Sandeep, Rathan Cyriac, S. Srijaya, Krishnadas Devadas
liver [P = 0.004] and coarse liver [P = 0.002], among CHB patients were older age [P = 0.048], low platelet count [P = 0.002], low serum protein [P = 0.025], USG finding of normal liver [P = 0.004] and coarse liver [P = 0.023], among CHC patients were older age [P = 0.023], increased Bilirubin [P = 0.022], increased SGOT [P = 0.001], low platelet count [P = 0.000], USG findings of normal liver [P = 0.006], fatty liver [P = 0.008] and coarse liver [P = 0.000]. On mulitivariate analysis, factors significantly associated with NAFLD were SGOT [P = 0.016] and coarse ultrasound [P = 0.017], with HBV were normal [P = 0.025] and coarse ultrasound [P = 0.000], low platelet count [P = 0.002], low protein [P = 0.009], with HCV was coarse ultrasound [P = 0.003]. Conclusion: Advanced fibrosis is more common in CHC followed by NAFLD and CHB. Factors predicting advanced fibrosis among NAFLD were SGOT and coarse ultrasound, among CHB were normal and coarse ultrasound, low platelet count, low protein, among CHC was coarse ultrasound.
CONFLICTS OF INTEREST The authors have none to declare. http://dx.doi.org/10.1016/j.jceh.2017.05.183
MISCELLANEOUS
32
Government Medical College, Thiruvananthapuram, India
E-mail address: [email protected] (R. Gunjal). Background and Aim: Transient elastography (TE) using ultrasound offers great promise in providing accurate and reliable information among Non alcoholic fatty liver disease (NAFLD), chronic Hepatitis B (CHB), chronic Hepatitis C (CHC), patients with advanced fibrosis and cirrhosis. The study was done to find out the prevalence and factors associated with advanced fibrosis among NAFLD, CHB, CHC, patients using TE. Methods: All consecutive patients with newly diagnosed NAFLD, CHB, CHC were subjected to anthropometric measurements i.e. Mid-arm circumference (MAC), Triceps skinfold thickness (TST), Waist circumference (WC) and Body Mass Index (BMI). All patients underwent TE and routine investigations like hemogram, liver function test, lipid profile and abdominal ultrasonography. Advanced fibrosis (≥F3/F4) was defined as TE value >11, >9, >9.6 kPa for NAFLD, CHB, CHC respectively. Results: This cross sectional study included 52 patients with NAFLD, 98 with CHB, 71 with CHC. Advanced fibrosis was seen in 50%, 20%, 66.2% patients with NAFLD, CHB, CHC respectively. On univariate analysis, factors significanlty associated with advanced fibrosis among NAFLD patients were older age [P = 0.008], higher BMI [P = 0.029], high SGOT [P = 0.003], USG finding of fatty S102
EXPRESSION OF PRO-INFLAMMATORY CYTOKINES IN HUMAN METABOLIC SYNDROME V. Rakotoarivelo, M. Mayhue, M.F. Langlois 1 , S. Ramanathan ∗,1 Université de Sherbrooke, Centre de Recherche Clinique, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada
E-mail address: [email protected] (S. Ramanathan). 1 Equal senior authorship. Background and Aim: Obesity is emerging as a major healthcare burden. Excess visceral adiposity is associated with insulin resistance (IR), type 2 diabetes (T2D), atherosclerosis, hypertension and fatty liver disease. Adipose tissue is considered as an endocrine organ in addition to its primary function as a depot where energy is stored in the form of triglycerides for release during starvation, exercise or infections. However, when the adipose tissue is unable to stockage the excessive nutrient influx, insulin resistance develops in a progressive manner. Insulin resistance in the liver results in dysregulated gluconeogenesis and glycogenolysis and increases circulating glucose. Insulin resistance in the muscles and adipose tissues prevents glucose uptake despite the availability © 2017, INASL
Table 1 LSM
CKD DM HTN Jaundice Ascites HBV HCV CAD
<7 7–12 12–21 >21 Total No
40 30 17 18 105
19 17 14 4 54
38 29 32
7 2 2
1 1 6
1 2
1 1 2
9 7 6
99
11
8
3
4
22
to diagnose asymptomatic liver involvement in advanced stage CKD population (Table 1).
CONFLICTS OF INTEREST The authors have none to declare. http://dx.doi.org/10.1016/j.jceh.2017.05.182
31 PREDICTORS OF ADVANCED FIBROSIS IN NONALCOHOLIC FATTY LIVER DISEASE, CHRONIC HEPTITIS B, CHRONIC HEPATITIS C Rajendra Gunjal ∗ , Aniruddha P. Singh, Gaurav Kapoor, N. Sandeep, Rathan Cyriac, S. Srijaya, Krishnadas Devadas
liver [P = 0.004] and coarse liver [P = 0.002], among CHB patients were older age [P = 0.048], low platelet count [P = 0.002], low serum protein [P = 0.025], USG finding of normal liver [P = 0.004] and coarse liver [P = 0.023], among CHC patients were older age [P = 0.023], increased Bilirubin [P = 0.022], increased SGOT [P = 0.001], low platelet count [P = 0.000], USG findings of normal liver [P = 0.006], fatty liver [P = 0.008] and coarse liver [P = 0.000]. On mulitivariate analysis, factors significantly associated with NAFLD were SGOT [P = 0.016] and coarse ultrasound [P = 0.017], with HBV were normal [P = 0.025] and coarse ultrasound [P = 0.000], low platelet count [P = 0.002], low protein [P = 0.009], with HCV was coarse ultrasound [P = 0.003]. Conclusion: Advanced fibrosis is more common in CHC followed by NAFLD and CHB. Factors predicting advanced fibrosis among NAFLD were SGOT and coarse ultrasound, among CHB were normal and coarse ultrasound, low platelet count, low protein, among CHC was coarse ultrasound.
CONFLICTS OF INTEREST The authors have none to declare. http://dx.doi.org/10.1016/j.jceh.2017.05.183
MISCELLANEOUS
32
Government Medical College, Thiruvananthapuram, India
E-mail address: [email protected] (R. Gunjal). Background and Aim: Transient elastography (TE) using ultrasound offers great promise in providing accurate and reliable information among Non alcoholic fatty liver disease (NAFLD), chronic Hepatitis B (CHB), chronic Hepatitis C (CHC), patients with advanced fibrosis and cirrhosis. The study was done to find out the prevalence and factors associated with advanced fibrosis among NAFLD, CHB, CHC, patients using TE. Methods: All consecutive patients with newly diagnosed NAFLD, CHB, CHC were subjected to anthropometric measurements i.e. Mid-arm circumference (MAC), Triceps skinfold thickness (TST), Waist circumference (WC) and Body Mass Index (BMI). All patients underwent TE and routine investigations like hemogram, liver function test, lipid profile and abdominal ultrasonography. Advanced fibrosis (≥F3/F4) was defined as TE value >11, >9, >9.6 kPa for NAFLD, CHB, CHC respectively. Results: This cross sectional study included 52 patients with NAFLD, 98 with CHB, 71 with CHC. Advanced fibrosis was seen in 50%, 20%, 66.2% patients with NAFLD, CHB, CHC respectively. On univariate analysis, factors significanlty associated with advanced fibrosis among NAFLD patients were older age [P = 0.008], higher BMI [P = 0.029], high SGOT [P = 0.003], USG finding of fatty S102
EXPRESSION OF PRO-INFLAMMATORY CYTOKINES IN HUMAN METABOLIC SYNDROME V. Rakotoarivelo, M. Mayhue, M.F. Langlois 1 , S. Ramanathan ∗,1 Université de Sherbrooke, Centre de Recherche Clinique, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada
E-mail address: [email protected] (S. Ramanathan). 1 Equal senior authorship. Background and Aim: Obesity is emerging as a major healthcare burden. Excess visceral adiposity is associated with insulin resistance (IR), type 2 diabetes (T2D), atherosclerosis, hypertension and fatty liver disease. Adipose tissue is considered as an endocrine organ in addition to its primary function as a depot where energy is stored in the form of triglycerides for release during starvation, exercise or infections. However, when the adipose tissue is unable to stockage the excessive nutrient influx, insulin resistance develops in a progressive manner. Insulin resistance in the liver results in dysregulated gluconeogenesis and glycogenolysis and increases circulating glucose. Insulin resistance in the muscles and adipose tissues prevents glucose uptake despite the availability © 2017, INASL