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Predictors of Obstructive Airway Disease (OAD) in Post Allogenic Bone Marrow Transplant (BMT)
October 2004, Vol 126, No. 4_MeetingAbstracts Abstract: Poster Presentations | October 2004
Predictors of Obstructive Airway Disease (OAD) in Post Allogenic Bone Marrow Transplant (BMT) Mohammad Khalid, MBBS; Sarfraz Saleemi, MD; Khaliq Agha Rehan, MD; Saleh Al Dammas, MD; Mohammed Zeitouni, MD; Ayman Kharaba, MD* King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia Chest Chest. 2004;126(4_MeetingAbstracts):922S. doi:10.1378/chest.126.4_MeetingAbstracts.922S
Errata (Chest. 2005;127(1):415-416.)
Article
Abstract PURPOSE: Establish the early predictors of development of OAD and its prevalence in post BMT patients and factors influencing its prognosis. METHODS: Review of 153-post (BMT) patients, pre and post BMT pulmonary function test (PFT’s) were reviewed, post BMT period ranged from 4 months to 2 years. Patients with existing OAD excluded from the study. Impact of treatment (immunosuppressive & steroid) and presence of GVHD on development of OAD recorded. RESULTS: 3 patients excluded for pre existing OAD, 20 patients developed OAD on their first (post BMT F/U PFTs) 15 patients had − FVC, 14 − FEV, 14 − MMEF, 10 - RV, - RV/TLC 14. FVC, FEV1, MMEF & RV/TLC showed changes in all 14 patient at the same time –all 20 patient then showed a progressive worsening in their OAD. All 20 patients with declining PFT’s had GVHD which is a strong predictor of development of future OAD syndrome. 8 patients received steroids/immunosuppressive therapy but failed to show significant response. CONCLUSION: 13% patients developed OAD. An early decline in FVC, FEV, MMFF and RV/TLC are a strong predictor of future progressive OAD. Almost all patient with OAD had GVHD. A poor response to immunosuppressive therapy was noted. CLINICAL IMPLICATIONS: Early recognition and new treatment measures need to be explored for post BMT OAD. DISCLOSURE: A. Kharaba, None. Wednesday, October 27, 2004 12:30 PM - 2:00 PM
Predictors of Obstructive Airway Disease (OAD) in Post Allogenic Bone Marrow Transplant (BMT) Mohammad Khalid, MBBS; Sarfraz Saleemi, MD; Khaliq Agha Rehan, MD; Saleh Al Dammas, MD; Mohammed Zeitouni, MD; Ayman Kharaba, MD* King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia Chest Chest. 2004;126(4_MeetingAbstracts):922S. doi:10.1378/chest.126.4_MeetingAbstracts.922S
Errata (Chest. 2005;127(1):415-416.)
Article
Abstract PURPOSE: Establish the early predictors of development of OAD and its prevalence in post BMT patients and factors influencing its prognosis. METHODS: Review of 153-post (BMT) patients, pre and post BMT pulmonary function test (PFT’s) were reviewed, post BMT period ranged from 4 months to 2 years. Patients with existing OAD excluded from the study. Impact of treatment (immunosuppressive & steroid) and presence of GVHD on development of OAD recorded. RESULTS: 3 patients excluded for pre existing OAD, 20 patients developed OAD on their first (post BMT F/U PFTs) 15 patients had − FVC, 14 − FEV, 14 − MMEF, 10 - RV, - RV/TLC 14. FVC, FEV1, MMEF & RV/TLC showed changes in all 14 patient at the same time –all 20 patient then showed a progressive worsening in their OAD. All 20 patients with declining PFT’s had GVHD which is a strong predictor of development of future OAD syndrome. 8 patients received steroids/immunosuppressive therapy but failed to show significant response. CONCLUSION: 13% patients developed OAD. An early decline in FVC, FEV, MMFF and RV/TLC are a strong predictor of future progressive OAD. Almost all patient with OAD had GVHD. A poor response to immunosuppressive therapy was noted. CLINICAL IMPLICATIONS: Early recognition and new treatment measures need to be explored for post BMT OAD. DISCLOSURE: A. Kharaba, None. Wednesday, October 27, 2004 12:30 PM - 2:00 PM