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Pregnancy outcome in kidney allograft recipients
ELSEVIER
Pregnancy Outcome in Kidney AIIograft Recipients F. Bayle, M. Favier, J.M. Ayoubi, C. Pelloux-Gervais, P. Vialtel, and G. Bourdat HE AIM of our study was to determine the impact of a kidney graft on pregnancy. We followed 19 pregnanT cies in 13 patients from a cohort of 80 female transplant recipients, between ages 15 and 35 years, which resulted in 12 live births, 2 miscarriages, and 5 therapeutical abortions. The frequency of associated hypertension (6/19), infectious events (3/19), and intrauterine growth retardation (5/19) corresponded to previously published series. We observed four declines in graft function in the year following the pregnancy. Our results confirmed the major criteria for favorable pregnancy in these high risk patients: (1) stable graft function; (2) absence of hypertension even pharmacologically controlled; and (3) absence of underlying pathol-
0041-1345/97/$17.00 PII S0041-1345(97)00448-X 2458
ogy adversely affected by pregnancy (lupus, chronic pyelonephritis). Close nephrological and obstetrical management during pregnancy is advocated without excluding future adverse effects on renal function and long-term consequences of immunosuppressive regimen on infants after delivery.
From the Service de Nephrologie (F.B., M.F., P.V., G.B.) and Service de Gyneco-Obst6trique (J.M.A., C.P.-G.) CHU Grenoble, France. Address reprint requests to Dr D.F. Bayle, CHU Grenoble, Service de Nephrologie, BP 217, 38043 Grenoble Cedex, France.
© 1997 by Elsevier Science Inc. 655 Avenue of the Americas, New York, NY 10010
Transplantation Proceedings, 29, 2458 (1997)
Pregnancy Outcome in Kidney AIIograft Recipients F. Bayle, M. Favier, J.M. Ayoubi, C. Pelloux-Gervais, P. Vialtel, and G. Bourdat HE AIM of our study was to determine the impact of a kidney graft on pregnancy. We followed 19 pregnanT cies in 13 patients from a cohort of 80 female transplant recipients, between ages 15 and 35 years, which resulted in 12 live births, 2 miscarriages, and 5 therapeutical abortions. The frequency of associated hypertension (6/19), infectious events (3/19), and intrauterine growth retardation (5/19) corresponded to previously published series. We observed four declines in graft function in the year following the pregnancy. Our results confirmed the major criteria for favorable pregnancy in these high risk patients: (1) stable graft function; (2) absence of hypertension even pharmacologically controlled; and (3) absence of underlying pathol-
0041-1345/97/$17.00 PII S0041-1345(97)00448-X 2458
ogy adversely affected by pregnancy (lupus, chronic pyelonephritis). Close nephrological and obstetrical management during pregnancy is advocated without excluding future adverse effects on renal function and long-term consequences of immunosuppressive regimen on infants after delivery.
From the Service de Nephrologie (F.B., M.F., P.V., G.B.) and Service de Gyneco-Obst6trique (J.M.A., C.P.-G.) CHU Grenoble, France. Address reprint requests to Dr D.F. Bayle, CHU Grenoble, Service de Nephrologie, BP 217, 38043 Grenoble Cedex, France.
© 1997 by Elsevier Science Inc. 655 Avenue of the Americas, New York, NY 10010
Transplantation Proceedings, 29, 2458 (1997)