Preliminary Evaluation of the Safety and Efficacy of in Clinical

Diffuse Lung Disease SESSION TITLE: Diffuse Lung Disease: Interstitial Lung Disease SESSION TYPE: Original Investigation Poster PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

Preliminary Evaluation of the Safety and Efficacy of in Clinical Li Shen Huiping Li* Fen Zhang Yang Hu Qiuhong Li; and Yiliang Su Shanghai Pulmonary Hospital, Shanghai, China PURPOSE: We apply the in normal healthy people and patients with idiopathic pulmonary fibrosis and study the effectiveness and safety in clinical. METHODS: We study 20 cases of normal healthy people (10 male and 10 female), exercise three motions of VRI data (QLD, MEF, EVP), record the changes of vital signs before and after exercise. 19 cases of stable patients with idiopathic pulmonary fibrosis (9control,10exercise) was studied for 3 months. Pulmonary function, VRI data and vital signs were recorded to preliminary evaluate its safety and effectiveness.

DIFFUSE LUNG DISEASE

RESULTS: The three motions of were decomposited into six motions and were measured by VRI QLD value (%). It is concluded that when whole lung motion with deep breath, QLD average of both lower lung was obviously higher, unilateral lung was higher, bilateral lung was higher than that of quiet breathing. After one times exercise, heart rate of normal persons had a significant change from the previous, no significant changes in pulse oxygen saturation. After one minute rest, there was no significant difference in heart rate from previous data, no serious arrhythmia accured during exercise. We followed 19 cases of IPF (10 cases of exercise group, 9 cases of control group) without acute aggravating for 3 months. The FVC of lung function were measured and reveal that exercise training group were increased than before exercise, QLD visible image contrast before and after exercise, the SGRQ scores after exercise had obvious drop and had significance difference between before and after exercise (p¼0.017), 6MWT walking distance of exercise group were increased, DLCO falling slower in exercise group than control group. Breathing exercise during exercise had lead to cough, chest tightness could be tolerated. CONCLUSIONS: is safe for both healthy persons and patients with idiopathic pulmonary fibrosis. Three motions can improve part of lung capacity. When it was applied to the rehabilitation exercise for patients with IPF, it can delay the decline of vital capacity, improve the quality of life of patients. CLINICAL IMPLICATIONS: may play an important role in pulmonary rehabilitation of interstitial lung disease patients. DISCLOSURE: The following authors have nothing to disclose: Li Shen, Huiping Li, Fen Zhang, Yang Hu, Qiuhong Li, Yiliang Su No Product/Research Disclosure Information DOI:

http://dx.doi.org/10.1016/j.chest.2016.02.225

Copyright ª 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

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