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Preparative and process-scale liquid chromatography
Journal of Chromatography,605 (1992) 149 Elsevier Science Publishers
CHROM.
B.V., Amsterdam
24 331
Book Review Preparative
andprocess-scale liquid chromatography, edited by G. Subramanian, 1991, 286 pp., price & 55.00, US$ 94.00, ISBN o-8412-2090-5.
This book provides a general overview of the basic issues which should be considered when using chromatography on a plant scale. It would primarily be helpful for chemists, engineers and managers who have no experience or background in the field, and who need to acquire general information regarding process chromatography. For this, the book would serve them well. However, the 14-chapter book does not tell how to develop a processscale separation and is not a comprehensive source of information with which to begin the research, development or design stages of such a project. Various chapters make the reader aware of the differences between analytical and process chromatography and the differences between normal- and reversed-phase chromatography. It also gives an introduction to the different ways of operating: recycle, overloaded elution or displacement mode. Basic design and control issues such as explosion proofing, achieving gradient accuracy, detection and fraction collection are discussed in general terms with cost implications. Different column technologies are reviewed in general terms discussing technical points as well as the choices one has to make in flexibility and in the amount of operator handling, which will determine how columns are packed and unpacked. The parameters involved in choosing a stationary phase such as particle size, pore volume, surface modifier and mechanical strength of the particle are presented from different points of view. Various chapters point out how the choice of stationary phase affects the solvent choice
Ellis Horwood,
Chichester,
and has major consequences for plant design, solvent handling, safety requirements and waste disposal. Overall aspects of plant design are presented in various chapters pointing out the sources of the variables which contribute to cost. A solid introduction to continuous chromatography in a low-pressure environment is presented with examples. A brief and elementary discussion of enantioseparations is given, including an explanation of chirality, a review of the stationary phases available and some applications. The general overview introducing chromatography on the plant scale is good. The chapters are in general lacking in depth and substance. Many of the band profiles drawn in the figures are incorrect in their detail. It appears that the authors and the editors have rushed to put the book together. There are many spelling mistakes, one figure is not drawn and the affiliation of the author of one chapter is missing. There is useful and important information in this book that is waiting to be applied. However, it is the challenge for the reader to find it amongst the dilute and vague generalities, The reader must also discriminate between the important issues of how to engineer a plant which involves chromatography as an economical unit operation and not just build a bigger analytical high-performance liquid chromatograph. St. Louis, MO (USA)
Anita M. Katti
CHROM.
B.V., Amsterdam
24 331
Book Review Preparative
andprocess-scale liquid chromatography, edited by G. Subramanian, 1991, 286 pp., price & 55.00, US$ 94.00, ISBN o-8412-2090-5.
This book provides a general overview of the basic issues which should be considered when using chromatography on a plant scale. It would primarily be helpful for chemists, engineers and managers who have no experience or background in the field, and who need to acquire general information regarding process chromatography. For this, the book would serve them well. However, the 14-chapter book does not tell how to develop a processscale separation and is not a comprehensive source of information with which to begin the research, development or design stages of such a project. Various chapters make the reader aware of the differences between analytical and process chromatography and the differences between normal- and reversed-phase chromatography. It also gives an introduction to the different ways of operating: recycle, overloaded elution or displacement mode. Basic design and control issues such as explosion proofing, achieving gradient accuracy, detection and fraction collection are discussed in general terms with cost implications. Different column technologies are reviewed in general terms discussing technical points as well as the choices one has to make in flexibility and in the amount of operator handling, which will determine how columns are packed and unpacked. The parameters involved in choosing a stationary phase such as particle size, pore volume, surface modifier and mechanical strength of the particle are presented from different points of view. Various chapters point out how the choice of stationary phase affects the solvent choice
Ellis Horwood,
Chichester,
and has major consequences for plant design, solvent handling, safety requirements and waste disposal. Overall aspects of plant design are presented in various chapters pointing out the sources of the variables which contribute to cost. A solid introduction to continuous chromatography in a low-pressure environment is presented with examples. A brief and elementary discussion of enantioseparations is given, including an explanation of chirality, a review of the stationary phases available and some applications. The general overview introducing chromatography on the plant scale is good. The chapters are in general lacking in depth and substance. Many of the band profiles drawn in the figures are incorrect in their detail. It appears that the authors and the editors have rushed to put the book together. There are many spelling mistakes, one figure is not drawn and the affiliation of the author of one chapter is missing. There is useful and important information in this book that is waiting to be applied. However, it is the challenge for the reader to find it amongst the dilute and vague generalities, The reader must also discriminate between the important issues of how to engineer a plant which involves chromatography as an economical unit operation and not just build a bigger analytical high-performance liquid chromatograph. St. Louis, MO (USA)
Anita M. Katti