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PREVALENCE OF FUNGAL INFECTIONS AND THE ORAL HEALTH OF HOSPITALIZED PATIENTS IN A DERMATOLOGY SERVICE
OOOO Volume 129, Number 1 Objective: To perform an oral vascular anomalies (OVAs) retrospective analysis in a Brazilian population, in order to investigate its frequency distribution, demographic peculiarities and clinical-pathology characteristics. Study Design: Data about the sex, age, race, clinical characteristics, location, and histopathologic diagnosis were extracted from cases recorded as OVAs in a reference center in the period between 1970 and 2016. Then, a database was created for analysis in the SPSS 20.0 system, in which they were submitted to a descriptive analysis. Results: A total of 14,560 records were analyzed, of which 597 cases were histologically confirmed as OVA, indicating a 4.1% incidence. The lesions were grouped as the following: pyogenic granuloma (n = 454), hemangioma of childhood (n = 57), vascular malformation (n = 37), lymphangioma (n = 20), hemangiolymphangioma (n = 10), vascular thrombus (n = 7), hemangioendothelioma (n = 5), Kaposi sarcoma (n = 5), angiofibroma (n = 1), and hemangioendotheliosarcoma (n = 1). The patients’ sociodemographic profile was predominantly women (64.2%) and white people (48.2%), with a greater occurrence between the second and fourth decades of life. The majority was located in the gingiva or alveolar ridge (42.9%), presenting a red color (50.9%), sessile implantation (42%), soft consistency (44.5%), nodular appearance (38.3%), nonhemorrhagic (42.9%), and asymptomatic (32.8%). Conclusions: These lesions particularities knowledge is important for a correct diagnosis and adequate treatment decision.
LOW-LEVEL LASER THERAPY APPLICATION FOR ANALGESIA OF ODYNOPHAGIA CAUSED BY HEAD AND NECK RADIOTHERAPY. GUILHERME HENRIQUE RIBEIRO, GABRIELA PASQUALIN GHIDINI, AIRA BONFIM SANTOS, LUZ LISBOA, CLAUDIA ^S MARIAH TIEMI MITUUTI, INE BEATRIZ DA SILVA RATH and, LILIANE JANETE GRANDO Head and neck radiotherapy causes many side effects, including hypopharyngeal mucositis (HPM), which makes feeding and swallowing difficult. Low-level laser therapy (LLLT) to treat oral mucositis is already consolidated in the literature. However, there are no reports of laser application in hypopharyngeal region. This study aimed to identify the best anatomic area of cervical region of corpses to propose an extraoral LLLT protocol for treating HPM, as well as to evaluate odynophagia in patients treated at a universitary hospital, in southern Brazil. An anatomic study in corpses was performed selecting the best extraoral site to apply LLLT for treating HPM. Furthermore, statements about extraoral LLLT were reported by patients complaining of odynophagia. The carotid trigone showed to be the best site to perform LLLT. Laser protocol to treat HPM consisted of infrared, 4 J, 100 mW, 4 points along the anterior margin of sternocleidomastoid muscle. All patients related comfort and odynophagia relief after LLLT. This proposed extraoral LLLT protocol presented promising results.
ENAMEL RENAL SYNDROME: A NOVEL HOMOZYGOUS FAM20A FOUNDER MUTATION IN 5 NEW BRAZILIAN FAMILIES. ANA TEREZINHA MARQUES MESQUITA, MAURICIO ROCHA DOURADO, CASSIO ROBERTO ROCHA DOS SANTOS, ESMERALDA MARIA DA
ABSTRACTS
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SILVEIRA, RAFAELA NOGUEIRA MOREIRA GONCALVES, ¸ ROBERT KLETA and, RICARDO DELLA COLETTA Objective: To investigate mutations in FAM20A of 11 unreported patients with ERS from 5 different Brazilian families. Study Design: Clinical examination, imaging, renal ultrasonography, laboratory tests and DNA sequencing were performed in 11 patients with ERS. Results: The patients’ ages ranged from 6 to 25 years old, and the presence of hypoplastic amelogenesis imperfecta, microdontia, spaced teeth, intrapulpal calcification, impacted posterior teeth with hyperplastic pericoronal follicle, gingival fibromatosis, ectopic calcifications on gingival and pericoronal tissues, and nephrocalcinosis were common findings to all patients. Only 4 patients showed abnormal results in laboratory tests (vitamin D, parathyroid hormone, phosphate, calcium). Intellectual disability and renal cysts were present in 2 patients each. Biallelic loss of function mutations in FAM20A gene, characterized by 1 base pair deletion in exon 11 (c.1447 delG) and resulting in a premature stop codon at p.GLU483 LYSfsX24 were detected in all patients strongly suggesting a founder effect. Conclusions: Our results reinforce the distinct orofacial features of ERS, which are the clue for kidney examination and genetic testing. Here we report the largest series of patients with ERS of the same population, and describe, for the first time, a founder mutation for FAM20A gene. FAPEMIG, FAPESP, CAPES.
HISTOPATHOLOGIC REVIEW OF MALIGNANT SALIVARY GLAND TUMORS. KATYA PULIDO DIAZ, MARIANA MARTINEZ CALLEJA, JORGE RODARTE CORRO, VICTOR RAMON DE ALBA RAMIREZ, DANIEL CARDOSO PEREZ, GABRIELA ANAYA SAAVEDRA and, ROGERIO DE OLIVEIRA GONDAK Objective: To describe the epidemiologic and histopathologic features of surgical specimens from patients with malignant salivary gland tumors. Study Design: In this retrospective study, we evaluated and reclassified 34 cases of a general hospital, between January 2005 and January 2018. Results: In this period, malignant salivary gland tumors were more common among females (56%) and parotid gland (67.6%) as the most affected site, followed by minor salivary glands (23.5%). The mean age was 43 years. Adenoid cystic carcinoma was the most common malignant salivary gland tumor (29%), followed by mucoepidermoid carcinoma (24%). There were 3 cases reclassified as secretory carcinoma and 1 case as adenocarcinoma not otherwise specified, according to the World Health Organization Classification of Head and Neck Tumors of 2017. Conclusions: This study is relevant to obtain epidemiologic data of malignant salivary gland tumors due to few reports from our country.
PREVALENCE OF FUNGAL INFECTIONS AND THE ORAL HEALTH OF HOSPITALIZED PATIENTS IN A DERMATOLOGY SERVICE. ANA MARIA HOYOS CADAVID, MARCELLO MENTA SIMONSEN NICO, LIGIA MARIA QUITERIO, VIVIANE MAZO FAVERO GIMENES and, SILVIA VANESSA LOURENCO ¸
ABSTRACTS
e170
Objective: To identify the prevalence of fungal infections and evaluate the oral health of patients admitted in a dermatology service. Study Design: Clinical examination and direct mycologic and fungal culture (CHROMagar / Thermotolerance) were performed in patients admitted to a dermatology service between July and December 2017. Results: Ninety-three patients were evaluated and their age ranged from 1 to 83 years old; 50.5% needed dental or oral care at the time of hospitalization, the most common diseases being mucositis (36.5%), rampant caries (18.8%) and periodontal abscesses (5.7%) and the majority of dermatologic pathologies: pemphigus vulgaris (16%), erythroderma (7.5%), and leprosy (6.4%). Candidiasis was present in 23.6% cases (100% Candida albicans), with female to male ratio of 1.5:1, 41% wore dental prosthesis and 47% exhibited mucosal injury. Conclusions: This study demonstrated that the percentage of patients with dental/oral care needs in a hospital service is high and that the performance of dentist in the hospital environment is essential for the promotion, protection, and recovery of hospitalized patients’ health, reducing the risk of infection caused by opportunistic pathogens and improving the quality of life of these patients.
INTRAVASCULAR PAPILLARY ENDOTHELIAL HYPERPLASIA: A SYSTEMATIC REVIEW. KAIO HEIDE SAMPAIO NOBREGA, LAUREN FRENZEL SCHUCH, ANA PAULA NEUTZLING GOMES, SANDRA BEATRIZ CHAVES TARQUINIO and, ANA CAROLINA UCHOA VASCONCELOS Objectives: The aim of this study was to integrate the available data published on intravascular papillary endothelial hyperplasia (IPEH) into a comprehensive analysis of their clinic, radiographic, and imaginologic features, treatment, and recurrence. Methods: An electronic search was undertaken in April 2018 in 3 databases, including cases reports and cases series of IPEH. Eligibility criteria included publications having enough clinical, radiologic, and histopathologic information to confirm a definite diagnosis of the lesion. Results: Thirty studies were included in the systematic review with 86 cases of IPEH. The mean age was 46 years— with a predilection for females (55%). Asymptomatic (88%) lesions on the lower lip (39%), with a clinical presentation of firm nodular lesion, bluish, or reddish coloration and mean size of 1.6 cm were the most observed. When intraosseous, the radiographic features were multilocular radiolucent area. Of informed cases, treatment chosen was excisional biopsy (96%) and no recurrence was observed. The diagnostic hypothesis most prevalent was hemangioma, in 27 cases (31%). Conclusions: The features presented in this study are more similar to than different from those reported in the literature.
EPIDEMIOLOGIC EVALUATION OF ORAL LESIONS BIOPSIED IN STOMATOLOGY SERVICE IN POPULATION OF 7 CITIES. ERASMO BERNARDO MARINHO, FILIPE DIAS CHRISPIM, ANIBAL ARAUJO PINTO, PAULO GOBERLANIO DE BARROS SILVA and, FABRICIO BITU SOUSA
OOOO January 2020 Objective: Dental specialty centers (DSC) in Brazil are secondary care units associated with the public health system that offer care directed to the specialty of stomatology, among other areas. The present study aimed to evaluate epidemiologic data of lesions biopsied in DSC responsible for clinical care in 7 cities in its state. Study Design: This is a retrospective, observational, quantitative study. Information related to age, sex, anatomic location of the lesion, diagnostic hypothesis, type of biopsy, and histopathologic conclusion were collected from the health unit’s database with the aid of a data collection instrument. Biopsy procedures performed between the period from May 10, 2013, to April 5, 2018, were considered. Absolute frequency and chisquare test were used for statistical analysis. Results: One hundred ninety-four biopsy procedures were performed in 187 patients. The age ranged from 5 to 87 years. Male sex was represented by 66 individuals (35.2%), while female sex was represented by 120 individuals (64.1%). Conclusions: Clinical care in the area of stomatology offered to population of 7 cities by the CEO presents fundamental importance in the diagnosis and treatment of oral cavity lesions.
ASSOCIATION BETWEEN PERIAPICAL LESIONS AND SINUS MAXILLARY ALTERATIONS USING CONE BEAM COMPUTED TOMOGRAPHY. PRISCILA QUINTINO CHABOT, ^ TANIA MARA PIMENTA AMARAL, LOLIZA LUIZ FIGUEIREDO HOURI CHALUB and, CLAUDIA BORGES BRASILEIRO Objective: The aim of this study was to evaluate the relationship between periapical lesion (PL) and maxillary sinus alterations (MSA) using cone beam computed tomography (CBCT). Study Design: CBCT images of a dental radiology service were seen from January 2013 to December 2017 by a single previously calibrated examiner. PL was recorded when at least 1 posterior tooth presented radiolucency around the root apex indicating bone destruction. MSA observed were presence of mucous retention cyst, sinus polyp, antrolith, and mucosal thickening above 3 mm. Data were analyzed with descriptive statistics and chi-square test in SPSS 21.0. Results: A total of 865 maxillary sinuses of 560 patients (63% females; mean age in years § SD, 48.9 § 16.8), were included in the study. It was found at least 1 type of MSA in 62% of the maxillary sinuses and the most common alteration was mucosal thickening above 3 mm (34%). PL was observed in 52% posterior region of the maxilla and in these areas the proportion of present MSA (67%) was significantly higher (P < .01) than proportion of absent MSA (33%). Considering MSA separately, only the relation between PL and antrolith had statistical significance (P < .01). Conclusions: The presence of PL showed association with several MSA.
CALCIFICATION OF THE STYLOHYOID LIGAMENT: A RETROSPECTIVE STUDY OF THE YEAR 2017. UARLEI NOGUEIRA PORTO, KELI CRISTINA LIMA VIEIRA, FLAVIA CRISTINA ROSAS DE CARVALHO and, ORLANDO IZOLANI NETO
LOW-LEVEL LASER THERAPY APPLICATION FOR ANALGESIA OF ODYNOPHAGIA CAUSED BY HEAD AND NECK RADIOTHERAPY. GUILHERME HENRIQUE RIBEIRO, GABRIELA PASQUALIN GHIDINI, AIRA BONFIM SANTOS, LUZ LISBOA, CLAUDIA ^S MARIAH TIEMI MITUUTI, INE BEATRIZ DA SILVA RATH and, LILIANE JANETE GRANDO Head and neck radiotherapy causes many side effects, including hypopharyngeal mucositis (HPM), which makes feeding and swallowing difficult. Low-level laser therapy (LLLT) to treat oral mucositis is already consolidated in the literature. However, there are no reports of laser application in hypopharyngeal region. This study aimed to identify the best anatomic area of cervical region of corpses to propose an extraoral LLLT protocol for treating HPM, as well as to evaluate odynophagia in patients treated at a universitary hospital, in southern Brazil. An anatomic study in corpses was performed selecting the best extraoral site to apply LLLT for treating HPM. Furthermore, statements about extraoral LLLT were reported by patients complaining of odynophagia. The carotid trigone showed to be the best site to perform LLLT. Laser protocol to treat HPM consisted of infrared, 4 J, 100 mW, 4 points along the anterior margin of sternocleidomastoid muscle. All patients related comfort and odynophagia relief after LLLT. This proposed extraoral LLLT protocol presented promising results.
ENAMEL RENAL SYNDROME: A NOVEL HOMOZYGOUS FAM20A FOUNDER MUTATION IN 5 NEW BRAZILIAN FAMILIES. ANA TEREZINHA MARQUES MESQUITA, MAURICIO ROCHA DOURADO, CASSIO ROBERTO ROCHA DOS SANTOS, ESMERALDA MARIA DA
ABSTRACTS
e169
SILVEIRA, RAFAELA NOGUEIRA MOREIRA GONCALVES, ¸ ROBERT KLETA and, RICARDO DELLA COLETTA Objective: To investigate mutations in FAM20A of 11 unreported patients with ERS from 5 different Brazilian families. Study Design: Clinical examination, imaging, renal ultrasonography, laboratory tests and DNA sequencing were performed in 11 patients with ERS. Results: The patients’ ages ranged from 6 to 25 years old, and the presence of hypoplastic amelogenesis imperfecta, microdontia, spaced teeth, intrapulpal calcification, impacted posterior teeth with hyperplastic pericoronal follicle, gingival fibromatosis, ectopic calcifications on gingival and pericoronal tissues, and nephrocalcinosis were common findings to all patients. Only 4 patients showed abnormal results in laboratory tests (vitamin D, parathyroid hormone, phosphate, calcium). Intellectual disability and renal cysts were present in 2 patients each. Biallelic loss of function mutations in FAM20A gene, characterized by 1 base pair deletion in exon 11 (c.1447 delG) and resulting in a premature stop codon at p.GLU483 LYSfsX24 were detected in all patients strongly suggesting a founder effect. Conclusions: Our results reinforce the distinct orofacial features of ERS, which are the clue for kidney examination and genetic testing. Here we report the largest series of patients with ERS of the same population, and describe, for the first time, a founder mutation for FAM20A gene. FAPEMIG, FAPESP, CAPES.
HISTOPATHOLOGIC REVIEW OF MALIGNANT SALIVARY GLAND TUMORS. KATYA PULIDO DIAZ, MARIANA MARTINEZ CALLEJA, JORGE RODARTE CORRO, VICTOR RAMON DE ALBA RAMIREZ, DANIEL CARDOSO PEREZ, GABRIELA ANAYA SAAVEDRA and, ROGERIO DE OLIVEIRA GONDAK Objective: To describe the epidemiologic and histopathologic features of surgical specimens from patients with malignant salivary gland tumors. Study Design: In this retrospective study, we evaluated and reclassified 34 cases of a general hospital, between January 2005 and January 2018. Results: In this period, malignant salivary gland tumors were more common among females (56%) and parotid gland (67.6%) as the most affected site, followed by minor salivary glands (23.5%). The mean age was 43 years. Adenoid cystic carcinoma was the most common malignant salivary gland tumor (29%), followed by mucoepidermoid carcinoma (24%). There were 3 cases reclassified as secretory carcinoma and 1 case as adenocarcinoma not otherwise specified, according to the World Health Organization Classification of Head and Neck Tumors of 2017. Conclusions: This study is relevant to obtain epidemiologic data of malignant salivary gland tumors due to few reports from our country.
PREVALENCE OF FUNGAL INFECTIONS AND THE ORAL HEALTH OF HOSPITALIZED PATIENTS IN A DERMATOLOGY SERVICE. ANA MARIA HOYOS CADAVID, MARCELLO MENTA SIMONSEN NICO, LIGIA MARIA QUITERIO, VIVIANE MAZO FAVERO GIMENES and, SILVIA VANESSA LOURENCO ¸
ABSTRACTS
e170
Objective: To identify the prevalence of fungal infections and evaluate the oral health of patients admitted in a dermatology service. Study Design: Clinical examination and direct mycologic and fungal culture (CHROMagar / Thermotolerance) were performed in patients admitted to a dermatology service between July and December 2017. Results: Ninety-three patients were evaluated and their age ranged from 1 to 83 years old; 50.5% needed dental or oral care at the time of hospitalization, the most common diseases being mucositis (36.5%), rampant caries (18.8%) and periodontal abscesses (5.7%) and the majority of dermatologic pathologies: pemphigus vulgaris (16%), erythroderma (7.5%), and leprosy (6.4%). Candidiasis was present in 23.6% cases (100% Candida albicans), with female to male ratio of 1.5:1, 41% wore dental prosthesis and 47% exhibited mucosal injury. Conclusions: This study demonstrated that the percentage of patients with dental/oral care needs in a hospital service is high and that the performance of dentist in the hospital environment is essential for the promotion, protection, and recovery of hospitalized patients’ health, reducing the risk of infection caused by opportunistic pathogens and improving the quality of life of these patients.
INTRAVASCULAR PAPILLARY ENDOTHELIAL HYPERPLASIA: A SYSTEMATIC REVIEW. KAIO HEIDE SAMPAIO NOBREGA, LAUREN FRENZEL SCHUCH, ANA PAULA NEUTZLING GOMES, SANDRA BEATRIZ CHAVES TARQUINIO and, ANA CAROLINA UCHOA VASCONCELOS Objectives: The aim of this study was to integrate the available data published on intravascular papillary endothelial hyperplasia (IPEH) into a comprehensive analysis of their clinic, radiographic, and imaginologic features, treatment, and recurrence. Methods: An electronic search was undertaken in April 2018 in 3 databases, including cases reports and cases series of IPEH. Eligibility criteria included publications having enough clinical, radiologic, and histopathologic information to confirm a definite diagnosis of the lesion. Results: Thirty studies were included in the systematic review with 86 cases of IPEH. The mean age was 46 years— with a predilection for females (55%). Asymptomatic (88%) lesions on the lower lip (39%), with a clinical presentation of firm nodular lesion, bluish, or reddish coloration and mean size of 1.6 cm were the most observed. When intraosseous, the radiographic features were multilocular radiolucent area. Of informed cases, treatment chosen was excisional biopsy (96%) and no recurrence was observed. The diagnostic hypothesis most prevalent was hemangioma, in 27 cases (31%). Conclusions: The features presented in this study are more similar to than different from those reported in the literature.
EPIDEMIOLOGIC EVALUATION OF ORAL LESIONS BIOPSIED IN STOMATOLOGY SERVICE IN POPULATION OF 7 CITIES. ERASMO BERNARDO MARINHO, FILIPE DIAS CHRISPIM, ANIBAL ARAUJO PINTO, PAULO GOBERLANIO DE BARROS SILVA and, FABRICIO BITU SOUSA
OOOO January 2020 Objective: Dental specialty centers (DSC) in Brazil are secondary care units associated with the public health system that offer care directed to the specialty of stomatology, among other areas. The present study aimed to evaluate epidemiologic data of lesions biopsied in DSC responsible for clinical care in 7 cities in its state. Study Design: This is a retrospective, observational, quantitative study. Information related to age, sex, anatomic location of the lesion, diagnostic hypothesis, type of biopsy, and histopathologic conclusion were collected from the health unit’s database with the aid of a data collection instrument. Biopsy procedures performed between the period from May 10, 2013, to April 5, 2018, were considered. Absolute frequency and chisquare test were used for statistical analysis. Results: One hundred ninety-four biopsy procedures were performed in 187 patients. The age ranged from 5 to 87 years. Male sex was represented by 66 individuals (35.2%), while female sex was represented by 120 individuals (64.1%). Conclusions: Clinical care in the area of stomatology offered to population of 7 cities by the CEO presents fundamental importance in the diagnosis and treatment of oral cavity lesions.
ASSOCIATION BETWEEN PERIAPICAL LESIONS AND SINUS MAXILLARY ALTERATIONS USING CONE BEAM COMPUTED TOMOGRAPHY. PRISCILA QUINTINO CHABOT, ^ TANIA MARA PIMENTA AMARAL, LOLIZA LUIZ FIGUEIREDO HOURI CHALUB and, CLAUDIA BORGES BRASILEIRO Objective: The aim of this study was to evaluate the relationship between periapical lesion (PL) and maxillary sinus alterations (MSA) using cone beam computed tomography (CBCT). Study Design: CBCT images of a dental radiology service were seen from January 2013 to December 2017 by a single previously calibrated examiner. PL was recorded when at least 1 posterior tooth presented radiolucency around the root apex indicating bone destruction. MSA observed were presence of mucous retention cyst, sinus polyp, antrolith, and mucosal thickening above 3 mm. Data were analyzed with descriptive statistics and chi-square test in SPSS 21.0. Results: A total of 865 maxillary sinuses of 560 patients (63% females; mean age in years § SD, 48.9 § 16.8), were included in the study. It was found at least 1 type of MSA in 62% of the maxillary sinuses and the most common alteration was mucosal thickening above 3 mm (34%). PL was observed in 52% posterior region of the maxilla and in these areas the proportion of present MSA (67%) was significantly higher (P < .01) than proportion of absent MSA (33%). Considering MSA separately, only the relation between PL and antrolith had statistical significance (P < .01). Conclusions: The presence of PL showed association with several MSA.
CALCIFICATION OF THE STYLOHYOID LIGAMENT: A RETROSPECTIVE STUDY OF THE YEAR 2017. UARLEI NOGUEIRA PORTO, KELI CRISTINA LIMA VIEIRA, FLAVIA CRISTINA ROSAS DE CARVALHO and, ORLANDO IZOLANI NETO