1224 Abstracts
404 Prevalence of temporomandibular joint diseases diagnosed by magnetic resonance imagining R.F. Zanin ∗ , M.R. Volkweis, J.C.B. Wagner Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Brazil
The aim of this study was to analyze the prevalence of internal derangement of the temporomandibular joint (TMJ) diagnosed by magnetic resonance imaging (MRI). The following data was evaluated: chief complaint, gender, age, side affected, diagnosis, joint clicking, mouth opening, dental prosthesis and presence of muscle disorders. The sample comprised 59 successive patients (118 TMJs), 46 females and 13 males; ages ranged from 14 to 92 years. All patients were examined from 2002 to 2006. Anterior disc displacement with reduction was the most common disorder (60 joints); anterior disc displacement without reduction appeared in 17 joints; TNJ effusion (25 joints); open lock (1 joint); TMJ osteoarthritis (8 joints) and no pathology in 7 cases. TMJ click was present in 27 and 32 had no clicking. There were associated muscle disorders in 22 cases. Mouth opening ranged from 10 to 61 mm; 24 patients were using some kind of dental prosthesis. The following conclusions are drawn: anterior disc displacement with reduction is the most common pathological condition in patients submitted to MRI; there is a marked predominance in women; and the presence of muscle pathology associated with intracapsular pathology is more prevalent in women. Conflict of interest: None declared. doi:10.1016/j.ijom.2011.07.667
lenge because of the high incidence of recurrence. Purpose: To report 15 cases treated by either gap arthroplasty, or the articular reconstruction technique using costochondral grafts, coronoid process grafts or alloplastic condylar implants; evaluate the results of these surgeries and make a literature review. Methods: The sample was obtained from the records of the Oswaldo Cruz University Hospital (HUOC-UPE) of patients submitted to ankylosis treatment by alloplastic or autogenous graft between March 2000 and October 2006. Pre- and postoperative assessment included a thorough history and physical examination to determine the cause of ankylosis, the maximal incisal opening, etiology and type of the ankylosis, recurrence rate and presence of facial nerve paralysis. Results: The mean maximal incisal opening in the preoperative period was 8.71 + 6.97 mm and in the postoperative period it was 28.50 + 8.10 mm, the recurrence rate was 20% (n = 3), and always occurred in ankylosis type IV. Conclusion: The articular reconstruction with alloplastic or autogenous grafts, or gap arthroplasty for the treatment of ankylosis is shown to be efficient in relation to the post-operative maximal incisal opening, recurrence and articular function. Conflict of interest: None declared. doi:10.1016/j.ijom.2011.07.668
doi:10.1016/j.ijom.2011.07.669
406 Differential regulation of proteoglycan 4 by IL-1alpha and TGF-beta1 in rat condylar chondrocytes J. Cheng 1,∗ , Y. Wang 2 , Y. Wu 1 Department of Oral and Maxillofacial Surgery, Nanjing Medical University, Nanjing, China 2 Institute of Stomatology, Nanjing Medical University, Nanjing, China
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405 Surgical treatment of temporomandibular joint ankylosis: follow-up of 15 cases and literature review B.C.D.E. Vasconcelos, R.W.F. Carvalho ∗ , G.G. Porto, R.V. Bessa-Nogueira, M.M.M. Nascimento Department of Oral and Maxillofacial Surgery, University of Pernambuco, Recife, Brazil
Introduction: Ankylosis may be defined as the fusion of the articular surfaces with bony or fibrous tissue. The treatment of temporomandibular joint ankylosis poses a significant chal-
the articular chondrocytes derived from rat mandibular condyle. Methods: Articular chondrocytes were isolated from rat mandibular condyle and maintained in a monolayer culture system. After exposure to various concentrations of recombinant IL-1␣ and TGF-1 alone or in combination, the PRG4 mRNA expression and protein accumulation in the cultured condylar chondrocytes were assessed by RT-PCR and ELISA, respectively. Results: Exposure of chondrocytes to rhIL-1␣ resulted in a pronounced reduction in the expression and abundance of PRG4 in a time-dependent manner. In contrast, treatment with rhTGF-1 significantly enhanced PRG4 synthesis and secretion in a dose-and time-dependent manner. Moreover, rhTGF-1 was capable to antagonize the inhibitory effects on the PRG4 production induced by IL-1␣ pretreatment and reversed the PRG4 production in vitro. Conclusions: Condylar cartilage production of PRG4 is highly regulated by growth factors and cytokines such as IL1 and TGF-1 that relevant to mandibular condyle repair and pathogenesis of temporomandibular joint (TMJ) osteoarthritis. These results suggested that enhanced biosynthesis and secretion of PRG4 may improve the TMJ function and become a potential therapeutic strategy for TMJ osteoarthritis. Conflict of interest: None declared.
Objective: Proteoglycan 4 (PRG4) is a multifaceted cytoprotective glycoprotein that mediates the boundary lubrication of articular cartilages and maintains joint homeostasis and functions. However, the expression of PRG4 and associated regulatory mechanisms by growth factors and cytokines has not been fully clarified in the mandibular condylar cartilage. The purpose of this study was to investigate the effects of interleukin-1␣ (IL-1␣) and transforming growth factor-1 (TGF-1) on the expression and secretion of PRG4 in
407 Condilar disk plication (discopexy), with absorbable mini anchors, in advanced stages of TMJ dysfunction according to Wilkes classification in the Hus, Bogota, Colombia B.E. Mejia Florez, ˜ Almeida ∗ P.I. Bolanos Oral and Maxillofacial Surgery, Hospital Universitario de la Samaritana/Universidad Nacional de Colombia, Bogotá, Colombia
Introduction: There is high prevalence of TMJ functional impairment; these are the product of several factors that lead to joint overload and occlusal nonstability, with triggers and accelerator factors that reach irreversibly degenerated joint; being required functional surgery. Purpose: Assess the use of disc repositioning surgery with absorbable anchors, symptoms after surgery, success rate, and life quality, and to continue Prospective