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Prevalence study of autism spectrum disorder in Romania
e u r o p e a n j o u r n a l o f p a e d i a t r i c n e u r o l o g y 2 1 ( 2 0 1 7 ) e 1 4 1 ee 1 4 4
2013. Normal controls were selected at out- patient clinic where they visited for vaccination. Results: Pediatric patients with epilepsy and MHD exhibited a significantly higher rate of ADHD (29.6%, and 37.5%, respectively) compare to the controls (11.9%) (P¼0.039). All groups were predominantly inattentive subtypes of ADHD. There were no significant group difference for sex and age. Conclusion: Pediatric patients with MHD and epilepsy are at significant risk for ADHD and there is a need for efficacious intervention of ADHD. Baseline testing of all MHC and epilepsy patients is necessary to check neuropsychological and academic skills over time, in order to facilitate early intervention and prevent academic failure.
http://dx.doi.org/10.1016/j.ejpn.2017.04.1289 P2-145 Self-esteem reinforcement strategies in ADHD: Comparison between hypnosis and art-therapy P. Castelnaua,b, G. Alberta,b, C. Chabbia,b, C. Gillesa,b, G. Deseille-Turlottea,b, E. Schweitzera,b, L. Thibaulta,b. aPediatric Neurology and disability unit, Reference Center for Learning disorders (CRTLA), Clocheville Children’s Hospital, Tours University Hospital, F-37000, France. bUnite Imagerie et Cerveau, Inserm U930, Tours, F-37000, France Objective: Attention-Deficit/Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder characterized by hyperactivity, impulsivity and inattention. Although diagnostic tools and therapeutics are available to identify and compensate the attention deficit, ADHD patients keep with chronic low selfesteem which alter their academic outcome and quality of life throughout lifespan. We present here some results of our research program on early self-esteem rehabilitation in ADHD based on brief therapy strategies such as medical hypnosis and modern art-therapy. Methods: 2 groups of ADHD patients (n¼8) from 6 to 12 years old were compared on a 3 months period of intervention during an open randomized study. All patients included had ADHD based on ADHD RS-IV and Conners criteria and psychometric battery tests of the sustained, selective and divided attention functions. All patients were under methylphenidate therapy. One group followed 6 hypnosis sessions and the second group followed 6 art-therapy workshops. Hypnosis used tailored metaphoric tales. Art-therapy used regular paintings and modeling techniques. Subjective questionnaires and self-esteem rating scales were submitted to both parents and subjects before and after each intervention. Results: All patients followed the sessions. From the subjective questionnaires of the parents we observed favorable changes 3 months after each of the two intervention modalities. This was not consistently confirmed from the questionnaires of the subjects whose autoevaluation sound relatively poor. Both self-esteem rating scales used in any of the 2 groups did not show significant variations. Conclusion: Subjective questionnaires suggest that modern arttherapy and medical hypnosis provide promising opportunities to improve self-esteem of ADHD children. This pilot study requires to be reproduced in a larger population and to set more adapted rating scales. Our observations suggest that the parents should be associated to the process and that self-esteem in ADHD is not only related to the stigmatization and behavioral consequences of this severe condition.
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http://dx.doi.org/10.1016/j.ejpn.2017.04.1290 P2-146 Prevalence study of autism spectrum disorder in Romania Magdalena Budisteanua,b, Florina Rada,b, Victorita Tudosiea,b, Roxana Zguraa,b, Bogdan Budisteanua,b, Sorina Mihaela Papuca,b, Andreea Tutulan-Cunitaa,b, Aurora Arghira,b, Iuliana Dobrescua,b. a Medical Genetics Laboratory, “Victor Babes” National Institute of Pathology, Bucharest, Romania. bDepartment of Pediatric Neurology, “Al. Obregia” Clinical Hospital of Psychiatry, Bucharest, Romania Objective: Over the past decades the number of children with autism spectrum disorder (ASD) has increased. Consequently, there is an increasing need for services for these patients and their families. The objective of this study is to estimate the ASD prevalence in school-aged Romanian children. This study is part of an European project about ASD aiming at evaluating the prevalence of this condition, as well as the health, economic and social burdens. Methods: A teacher nomination method (Hepburn, 2008) was used for identifying potential cases in regular schools and special education needs (SEN) schools across all country, for children aged 7-9 years. The questionnaire included questions about difficulties of children in being sociable, interacting and communicating with other children, and in thinking flexibility. The study started in February 2016 and ended in December 2016. Children denominated by the teachers were evaluated by a psychologist or child psychiatrist, with parental consent. The study had the approval of the institutional ethic committee. Results: 9135 children from 122 regular schools and 95 SEN schools were screened. 1358 were denominated by the teacher as presenting some autistic features. A diagnosis of ASD have already been established for 1295 children (1252 children from SEN schools and 43 children from regular schools). Twenty-three children were evaluated by a child psychiatrist and psychologist, a diagnosis of ASD being confirmed in 14. For the rest of 40 denominated children, the parents did not consent with the evaluation. Conclusion: 14,3% children from our cohort were diagnosed with ASD. This study will help the professionals from the field of ASD to define and design health, educational and social resources. Acknowledgement: Project SANCO/2014/C2/035 “Autism spectrum disorder across Europe (ASDEU)”.
http://dx.doi.org/10.1016/j.ejpn.2017.04.1291 P2-147 Somatosensory mismatch negativity in Dravet Syndrome M. Quintiliani, D.I. Battaglia, D. Restuccia, E. Musto, M. Perulli, I. Contaldo, M.L. Gambardella, G. Palazzese, A. Meloni, C. Dravet, E. Mercuri, F. Guzzetta. Department of Pediatric Neurology, Catholic University of the Sacred Heart, Rome, Italy Objective: In early development of patients with Dravet syndrome (DS) there is evidence of a defect in visual and verbal auditory sensorimotor integration (Battaglia et al, 2016). On the other hand, an impairment of motor coordination and postural disorders (clumsiness, crouch gait) is frequently observed, especially in older ages, so much to suggest a possible cerebellar mechanism underlying neurological and neuropsychological features in DS (Battaglia et al, 2013). To investigate also on the somatosensory citcuits, we performed a study on somatic mismatch negativity (sMMN) in 12 children with DS. Methods:
2013. Normal controls were selected at out- patient clinic where they visited for vaccination. Results: Pediatric patients with epilepsy and MHD exhibited a significantly higher rate of ADHD (29.6%, and 37.5%, respectively) compare to the controls (11.9%) (P¼0.039). All groups were predominantly inattentive subtypes of ADHD. There were no significant group difference for sex and age. Conclusion: Pediatric patients with MHD and epilepsy are at significant risk for ADHD and there is a need for efficacious intervention of ADHD. Baseline testing of all MHC and epilepsy patients is necessary to check neuropsychological and academic skills over time, in order to facilitate early intervention and prevent academic failure.
http://dx.doi.org/10.1016/j.ejpn.2017.04.1289 P2-145 Self-esteem reinforcement strategies in ADHD: Comparison between hypnosis and art-therapy P. Castelnaua,b, G. Alberta,b, C. Chabbia,b, C. Gillesa,b, G. Deseille-Turlottea,b, E. Schweitzera,b, L. Thibaulta,b. aPediatric Neurology and disability unit, Reference Center for Learning disorders (CRTLA), Clocheville Children’s Hospital, Tours University Hospital, F-37000, France. bUnite Imagerie et Cerveau, Inserm U930, Tours, F-37000, France Objective: Attention-Deficit/Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder characterized by hyperactivity, impulsivity and inattention. Although diagnostic tools and therapeutics are available to identify and compensate the attention deficit, ADHD patients keep with chronic low selfesteem which alter their academic outcome and quality of life throughout lifespan. We present here some results of our research program on early self-esteem rehabilitation in ADHD based on brief therapy strategies such as medical hypnosis and modern art-therapy. Methods: 2 groups of ADHD patients (n¼8) from 6 to 12 years old were compared on a 3 months period of intervention during an open randomized study. All patients included had ADHD based on ADHD RS-IV and Conners criteria and psychometric battery tests of the sustained, selective and divided attention functions. All patients were under methylphenidate therapy. One group followed 6 hypnosis sessions and the second group followed 6 art-therapy workshops. Hypnosis used tailored metaphoric tales. Art-therapy used regular paintings and modeling techniques. Subjective questionnaires and self-esteem rating scales were submitted to both parents and subjects before and after each intervention. Results: All patients followed the sessions. From the subjective questionnaires of the parents we observed favorable changes 3 months after each of the two intervention modalities. This was not consistently confirmed from the questionnaires of the subjects whose autoevaluation sound relatively poor. Both self-esteem rating scales used in any of the 2 groups did not show significant variations. Conclusion: Subjective questionnaires suggest that modern arttherapy and medical hypnosis provide promising opportunities to improve self-esteem of ADHD children. This pilot study requires to be reproduced in a larger population and to set more adapted rating scales. Our observations suggest that the parents should be associated to the process and that self-esteem in ADHD is not only related to the stigmatization and behavioral consequences of this severe condition.
e143
http://dx.doi.org/10.1016/j.ejpn.2017.04.1290 P2-146 Prevalence study of autism spectrum disorder in Romania Magdalena Budisteanua,b, Florina Rada,b, Victorita Tudosiea,b, Roxana Zguraa,b, Bogdan Budisteanua,b, Sorina Mihaela Papuca,b, Andreea Tutulan-Cunitaa,b, Aurora Arghira,b, Iuliana Dobrescua,b. a Medical Genetics Laboratory, “Victor Babes” National Institute of Pathology, Bucharest, Romania. bDepartment of Pediatric Neurology, “Al. Obregia” Clinical Hospital of Psychiatry, Bucharest, Romania Objective: Over the past decades the number of children with autism spectrum disorder (ASD) has increased. Consequently, there is an increasing need for services for these patients and their families. The objective of this study is to estimate the ASD prevalence in school-aged Romanian children. This study is part of an European project about ASD aiming at evaluating the prevalence of this condition, as well as the health, economic and social burdens. Methods: A teacher nomination method (Hepburn, 2008) was used for identifying potential cases in regular schools and special education needs (SEN) schools across all country, for children aged 7-9 years. The questionnaire included questions about difficulties of children in being sociable, interacting and communicating with other children, and in thinking flexibility. The study started in February 2016 and ended in December 2016. Children denominated by the teachers were evaluated by a psychologist or child psychiatrist, with parental consent. The study had the approval of the institutional ethic committee. Results: 9135 children from 122 regular schools and 95 SEN schools were screened. 1358 were denominated by the teacher as presenting some autistic features. A diagnosis of ASD have already been established for 1295 children (1252 children from SEN schools and 43 children from regular schools). Twenty-three children were evaluated by a child psychiatrist and psychologist, a diagnosis of ASD being confirmed in 14. For the rest of 40 denominated children, the parents did not consent with the evaluation. Conclusion: 14,3% children from our cohort were diagnosed with ASD. This study will help the professionals from the field of ASD to define and design health, educational and social resources. Acknowledgement: Project SANCO/2014/C2/035 “Autism spectrum disorder across Europe (ASDEU)”.
http://dx.doi.org/10.1016/j.ejpn.2017.04.1291 P2-147 Somatosensory mismatch negativity in Dravet Syndrome M. Quintiliani, D.I. Battaglia, D. Restuccia, E. Musto, M. Perulli, I. Contaldo, M.L. Gambardella, G. Palazzese, A. Meloni, C. Dravet, E. Mercuri, F. Guzzetta. Department of Pediatric Neurology, Catholic University of the Sacred Heart, Rome, Italy Objective: In early development of patients with Dravet syndrome (DS) there is evidence of a defect in visual and verbal auditory sensorimotor integration (Battaglia et al, 2016). On the other hand, an impairment of motor coordination and postural disorders (clumsiness, crouch gait) is frequently observed, especially in older ages, so much to suggest a possible cerebellar mechanism underlying neurological and neuropsychological features in DS (Battaglia et al, 2013). To investigate also on the somatosensory citcuits, we performed a study on somatic mismatch negativity (sMMN) in 12 children with DS. Methods: