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Prevention of sodium lauryl sulfate irritant contact dermatitis by pro-Q® aerosol foam skin protectant
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ABSTRACTS
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ENHANCEMENT OF THE STRATUM CORNEUM BARRIER: THE EFFECT OF MOISTURIZER TREATMENT Ludger Kolbe, Tracy Stoudemayer, Klaus-Peter Wrttern, and Albert M. Kligman, Paul Gerson Unna Research Center, Beiersdorf AG, Hamburg, Germany, SK I.N. Inc., Conshohocken. PA, Department of Dermatology, University of Pennsylvania, Phrladelphia, PA Moisturizers are frequently used to improve the appearance of the skin. The beneficial effects of emollients are well known, but lithe is known about the mechanrsms by which they work. We studred the effect of moisturizers on the barrier functron of the skin and the susceptrbrlity to irrrtants after treatment Normal forearm skin and xerotrc legs have been treated with moisturizers for four or six week periods The barrier properties have been analyzed before and afler treatment. A sodium hydroxide erosion assay was performed to study the integrity of the horny layer. The time to develop erosions was significantly higher afler treatment. Wheal formation after application of DMSO was determrned with Laser Doppler Imaging (LDI). DMSO Induced whealing and erythema was srgniticantly decreased after treatment Transepidermal water loss (TWL) was not significantly changed on normal forearm skrn. However, on dry legs the TWL decreased after treatment SLS patches were applied for 24 hours to induce barrier disruption. After treatment test reactions were significantly reduced. Moisturizers are thought to act by increasing the amount of water within the stratum corneum and have no long-lasting effects However our studies provide evidence, that moisturizers help to sustain a healthy horny layer, assist to repair an imparred stratum corneum barrier and prevent the development of irritant dermatrtrs
THE NATIONAL OCCUPATIONAL RESEARCH AGENDA REPORT FROM THE ALLERGIC AND IRRITANT DERMATITIS TEAM Lushnrak Boris D (NIOSH, Crncinnatr) and the NORA AID Team In 1996 the National Institute for OccupatIonal Safety and Health (NIOSH) introduced the Natronal Occupatronal Research Agenda (NORA) as a first step rn an ongoing effort to target and coordrnate occupational safety and health research Allergrc and lmtani Dermatitrs (AID) was rdentrfred as one of 21 prrorlty research areas and a NORA AID Team was formed rn 1997 The NORA AID team rncludes 14 members from academra Industry, labor, and the Federal government, and Includes experts rn clrnrcal dermatology and allergy, mdustrial hygiene exposure assessment, eprdemiology, Immunology, toxrcology and personal protective clothing The Team mrssron IS to develop a broad-based, active and lasting group whose Interest IS rn catalyzrng research rn AID Its rmmedrate task was to develop a list of research pr~ontres rn AID. lmplementatron optrons, and potentral partners rn research The proposed research prlorrtres will be presented These include pnorrtres rn the followrng categorres 1) Basic Bromedrcal Sciences, 2) Cl~mcal / Eprdemrology / Surverllance. and 3) Intervention / Prevention / Exposure and Risk Assessment. The AID Team seeks feedback from the contact dermatrtrs communrty on these research oriontIes
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PREVENTION OF SODIUM LAURYL SULFATE IRRITANT CONTACT DERMATITIS BY PRO-Q@ AEROSOL FOAM SKIN PROTECTANT Sean E. Patterson, Ph.D., Ferndale Laboratories Inc., Ferndale, Michigan, Judith V Williams, M.D., The Milton S. Hershey Medical Center, Hershey, Pennsylvania, James G. Marks. Jr.. M.D., The Milton S. Hershey Medical Center, Hershey, Pennsylvania Objectives: To assess the safety and efficacy of an aerosol skin protectant to block or modify the irritant or sensitizing effects of lauryl sulfate or urushiol. Design. Randomized, single-blind, controlled study design. Participants: Twenty healthy volunteers with a history of sensitivity to urushiol Intervention: Application of an aerosol skin protectant 15 minutes prior to occlusive application of sensitizers Outcome Measure. Visual assessment of irritation. Results: Significant protection from sodium laury sulfate irritancy but not urushiol allergenicity. Conclusion: The aerosol skin protectant gave significant protection from the irrrtancy of 10% sodium lauryl sulfate. Allergic responses to urushiol in alcohol were not modified. however.
CLINICAL REACTIONS AND CYTOKINE RELEASE AFTER SYSTEMIC PROVOCATION IN PATIENTS WITH CONTACT ALLERGY TO GOLD AND NICKEL Halvor Mdller’, Kjell Ohlsson’, Carrna Linde?, Bert Bjorkner’. Magnus Bruze’ Departments of Dermatology’ and Surgical Pathophysrology2, Malmo Unrverslty Hospital, Malmo, Sweden Patients with a contact allergy to gold, when grven an rntramuscular injectron of gold sodium thromalate, show clrnlcal flare up reactions as well as a release in blood of several cytokines (Am J Contact Derm 1998, 9 15-22) In the present controlled study patrents wrth gold or mckel allergy were systemrcally challenged with one of the two contact allergens or placebo. Clrnrcal flare up reactions implied reactrvatron of previous eczematous dermatrtis as well as transrent rashes and fever Plasma Tumor necrosis factor alfa, Soluble tumor necrosis factor receptor antagonist, and receptor 1, Interleukln-1 Neutrophrl gelatinase associated lrpocalrn Increased srgnrfrcantly rn gold palrents recerving gold Plasma Soluble tumor necrosrs factor receptor 1 also Increased In nickel patients receiving nickel No cytokine release was observed in crosswrse or placebo provocations Conclusion. The release of plasma cytokines is not a toxic phenomenon but correlated to the specific flare up in contact allergy
ABSTRACTS
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ENHANCEMENT OF THE STRATUM CORNEUM BARRIER: THE EFFECT OF MOISTURIZER TREATMENT Ludger Kolbe, Tracy Stoudemayer, Klaus-Peter Wrttern, and Albert M. Kligman, Paul Gerson Unna Research Center, Beiersdorf AG, Hamburg, Germany, SK I.N. Inc., Conshohocken. PA, Department of Dermatology, University of Pennsylvania, Phrladelphia, PA Moisturizers are frequently used to improve the appearance of the skin. The beneficial effects of emollients are well known, but lithe is known about the mechanrsms by which they work. We studred the effect of moisturizers on the barrier functron of the skin and the susceptrbrlity to irrrtants after treatment Normal forearm skin and xerotrc legs have been treated with moisturizers for four or six week periods The barrier properties have been analyzed before and afler treatment. A sodium hydroxide erosion assay was performed to study the integrity of the horny layer. The time to develop erosions was significantly higher afler treatment. Wheal formation after application of DMSO was determrned with Laser Doppler Imaging (LDI). DMSO Induced whealing and erythema was srgniticantly decreased after treatment Transepidermal water loss (TWL) was not significantly changed on normal forearm skrn. However, on dry legs the TWL decreased after treatment SLS patches were applied for 24 hours to induce barrier disruption. After treatment test reactions were significantly reduced. Moisturizers are thought to act by increasing the amount of water within the stratum corneum and have no long-lasting effects However our studies provide evidence, that moisturizers help to sustain a healthy horny layer, assist to repair an imparred stratum corneum barrier and prevent the development of irritant dermatrtrs
THE NATIONAL OCCUPATIONAL RESEARCH AGENDA REPORT FROM THE ALLERGIC AND IRRITANT DERMATITIS TEAM Lushnrak Boris D (NIOSH, Crncinnatr) and the NORA AID Team In 1996 the National Institute for OccupatIonal Safety and Health (NIOSH) introduced the Natronal Occupatronal Research Agenda (NORA) as a first step rn an ongoing effort to target and coordrnate occupational safety and health research Allergrc and lmtani Dermatitrs (AID) was rdentrfred as one of 21 prrorlty research areas and a NORA AID Team was formed rn 1997 The NORA AID team rncludes 14 members from academra Industry, labor, and the Federal government, and Includes experts rn clrnrcal dermatology and allergy, mdustrial hygiene exposure assessment, eprdemiology, Immunology, toxrcology and personal protective clothing The Team mrssron IS to develop a broad-based, active and lasting group whose Interest IS rn catalyzrng research rn AID Its rmmedrate task was to develop a list of research pr~ontres rn AID. lmplementatron optrons, and potentral partners rn research The proposed research prlorrtres will be presented These include pnorrtres rn the followrng categorres 1) Basic Bromedrcal Sciences, 2) Cl~mcal / Eprdemrology / Surverllance. and 3) Intervention / Prevention / Exposure and Risk Assessment. The AID Team seeks feedback from the contact dermatrtrs communrty on these research oriontIes
25
26
PREVENTION OF SODIUM LAURYL SULFATE IRRITANT CONTACT DERMATITIS BY PRO-Q@ AEROSOL FOAM SKIN PROTECTANT Sean E. Patterson, Ph.D., Ferndale Laboratories Inc., Ferndale, Michigan, Judith V Williams, M.D., The Milton S. Hershey Medical Center, Hershey, Pennsylvania, James G. Marks. Jr.. M.D., The Milton S. Hershey Medical Center, Hershey, Pennsylvania Objectives: To assess the safety and efficacy of an aerosol skin protectant to block or modify the irritant or sensitizing effects of lauryl sulfate or urushiol. Design. Randomized, single-blind, controlled study design. Participants: Twenty healthy volunteers with a history of sensitivity to urushiol Intervention: Application of an aerosol skin protectant 15 minutes prior to occlusive application of sensitizers Outcome Measure. Visual assessment of irritation. Results: Significant protection from sodium laury sulfate irritancy but not urushiol allergenicity. Conclusion: The aerosol skin protectant gave significant protection from the irrrtancy of 10% sodium lauryl sulfate. Allergic responses to urushiol in alcohol were not modified. however.
CLINICAL REACTIONS AND CYTOKINE RELEASE AFTER SYSTEMIC PROVOCATION IN PATIENTS WITH CONTACT ALLERGY TO GOLD AND NICKEL Halvor Mdller’, Kjell Ohlsson’, Carrna Linde?, Bert Bjorkner’. Magnus Bruze’ Departments of Dermatology’ and Surgical Pathophysrology2, Malmo Unrverslty Hospital, Malmo, Sweden Patients with a contact allergy to gold, when grven an rntramuscular injectron of gold sodium thromalate, show clrnlcal flare up reactions as well as a release in blood of several cytokines (Am J Contact Derm 1998, 9 15-22) In the present controlled study patrents wrth gold or mckel allergy were systemrcally challenged with one of the two contact allergens or placebo. Clrnrcal flare up reactions implied reactrvatron of previous eczematous dermatrtis as well as transrent rashes and fever Plasma Tumor necrosis factor alfa, Soluble tumor necrosis factor receptor antagonist, and receptor 1, Interleukln-1 Neutrophrl gelatinase associated lrpocalrn Increased srgnrfrcantly rn gold palrents recerving gold Plasma Soluble tumor necrosrs factor receptor 1 also Increased In nickel patients receiving nickel No cytokine release was observed in crosswrse or placebo provocations Conclusion. The release of plasma cytokines is not a toxic phenomenon but correlated to the specific flare up in contact allergy