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Primary anetoderma: A cutaneous marker of prothrombotic states
Med Clin (Barc). 2016;147(8):e47
www.elsevier.es/medicinaclinica
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Primary anetoderma: A cutaneous marker of prothrombotic states夽 Anetodermia primaria: un marcador cutáneo de estados protrombóticos ˜ Carlos Morales-Raya ∗ , Lidia Maronas-Jiménez, Sara Burillo-Martínez, Pablo Luis Ortiz-Romero Servicio de Dermatología, Hospital Universitario Doce de Octubre, Madrid, Spain
Fig. 1. Fig. 2.
41-year-old patient whose only medical history entry was superficial thrombophlebitis in the right great saphenous vein. Patient consulted our service for flaccid, wrinkled and atrophic skin with well-defined edges, of 7 cm in diameter and a 2-year history of progressive growth (Fig. 1). A skin biopsy was performed, observing an almost total absence of elastic fibres with Van Gieson staining, compatible with anetoderma (Fig. 2). Additional tests carried out only showed a protein S deficiency, which was confirmed in a second measurement. The primary anetoderma is a rare alteration of elastic fibres closely associated with the antiphospholipid syndrome and lupus erythematosus. There have been isolated reports of association with other prothrombotic states, such as protein C and S deficiency, hyperhomocysteinemia and antithrombin iii deficiency. Therefore, a complete thrombophilia study and a lupus erythematosus screening would be appropriate after the diagnosis of primary anetoderma.
夽 Please cite this article as: Morales-Raya C, Maronas-Jiménez ˜ L, Burillo-Martínez S, Ortiz-Romero PL. Anetodermia primaria: un marcador cutáneo de estados protrombóticos. Med Clin (Barc). 2016;147:e47. ∗ Corresponding author. E-mail address: [email protected] (C. Morales-Raya). ˜ S.L.U. All rights reserved. 2387-0206/© 2016 Elsevier Espana,
www.elsevier.es/medicinaclinica
Image in medicine
Primary anetoderma: A cutaneous marker of prothrombotic states夽 Anetodermia primaria: un marcador cutáneo de estados protrombóticos ˜ Carlos Morales-Raya ∗ , Lidia Maronas-Jiménez, Sara Burillo-Martínez, Pablo Luis Ortiz-Romero Servicio de Dermatología, Hospital Universitario Doce de Octubre, Madrid, Spain
Fig. 1. Fig. 2.
41-year-old patient whose only medical history entry was superficial thrombophlebitis in the right great saphenous vein. Patient consulted our service for flaccid, wrinkled and atrophic skin with well-defined edges, of 7 cm in diameter and a 2-year history of progressive growth (Fig. 1). A skin biopsy was performed, observing an almost total absence of elastic fibres with Van Gieson staining, compatible with anetoderma (Fig. 2). Additional tests carried out only showed a protein S deficiency, which was confirmed in a second measurement. The primary anetoderma is a rare alteration of elastic fibres closely associated with the antiphospholipid syndrome and lupus erythematosus. There have been isolated reports of association with other prothrombotic states, such as protein C and S deficiency, hyperhomocysteinemia and antithrombin iii deficiency. Therefore, a complete thrombophilia study and a lupus erythematosus screening would be appropriate after the diagnosis of primary anetoderma.
夽 Please cite this article as: Morales-Raya C, Maronas-Jiménez ˜ L, Burillo-Martínez S, Ortiz-Romero PL. Anetodermia primaria: un marcador cutáneo de estados protrombóticos. Med Clin (Barc). 2016;147:e47. ∗ Corresponding author. E-mail address: [email protected] (C. Morales-Raya). ˜ S.L.U. All rights reserved. 2387-0206/© 2016 Elsevier Espana,