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Primary prevention program on atherosclerosis and cardiovascular disease in youth
Thursday June 29, 2000: Poster Abstracts P: W31 Prevention of CVD
284 ]
ThP61 :W31 J Screening and registration program for patients with familial hypercholesterolemia in Spain _R. Alonso ] , P. Mozas 2, S. Castillo 2 , G. Reyes 2, J. Puzo 3 , M. Pocovi 2 , P. Mata I . On behalf of The Spanish Group of FH; 1Lipid Unit, Fundaci6n
JimEnez Dfaz, Madrid; 2Departamento de Bioqufmica, Biologfa Molecular y Celular, Universidad de Zaragoza; 3Hospital San Jorge, Huesca, Spain
Results: After treatment with vitamins tHcy decreased to the levels in reference ranges in all the cases. Neither negative clinical or EEG symptom occurred in these patients. Our findings indicate that treatment with a single vitamin may negatively influence the status of other vitamins. Conclusions: Antiepileptic drug treatment may increase plasma concentrations of homocysteine. Vitamin therapy in patients on AED with hyperhomocysteinemia decreases total homocysteine levels to reference ranges.
Background: Familial hypercholesterolemia (FH) is an autosomal disorder caused by defects in the low-density-lipoprotein receptor (LDLr) gene. Patients with FH have an increased risk for premature coronary artery disease (CAD). Objective: Prevention of CAD by early identification and treatment of patients with FH. Methods: l) The Spanish Familial Hypereholesterolemia Foundation coordinates active case-finding by a toll-free telephone helpline and a mail questionnaire. 2) Identified patients are referred to one of the 35 National Lipid Clinic Network Centers. 3) Lipid analysis and DNA-diagnosis are performed in a Central Laboratory. 4) Optimal treatment is initiated and patients are registered for a long-term follow-up. Results: Up to december 1999, 1224 contacts to the belpline were recorded. Of theses, 954 were interactive calls and 270 were requests for the questionaire. Three hundred and seventy five people were clinically and biochemically diagnosticated with FH. Of these, 22% were shown to be positive for one of the 37 FH known causes for LDLr mutation present in Spain. Only 48% of these patients received some form of lipid-lowering therapy previously. Conversely, after referral, 95% adheres to a statin therapy. Conclusion: 1) Toll-free telephone helpline is very effective to identify FH patients. 2) Referral to a Lipid Clinic, early diagnosis and initiation of optimal therapy may reduce cardiovascular morbility and mortality. 1
ThP62:W31 ] Comparison of simvastatin and guar gum in the treatment hyperlipidemic patients with diabetes mellitus II type K. Yafasov 1, G. Shamukhitdinova2 . 1Institute Endocrinology; 2Hospital
MinEnergo, Tashkent, Uzbekistan Diabetes mellitus II type is characterized by the increased risk CHD mortality. For reduce cardiovascular risk, it's necessary to treat the patients with hypolipidemic drugs. We investigate the effect of simvastatin and guar gum was in diabetic patients with hyperlipidemia (basal level TC 7.78 mmol/l, TG 2.94 mmol/1). Twenty patients have been treated with simvastatin 10 mg once a day, and sixteen patients was treated by guar gum 5 g three times daily. After 4 week treatment simvastatin decreased TC by 17%, LDL-C by 21%, TG by 13%, and increased HDL-C by 6%. In the guar gum group TC, LDL-C, TG decreased by 14%, 7%, 21%, and HDL-C increased by 3%. Fasting blood sugar was reduced by guar gum (P < 0.001), and didn't changed by simvastatin. Glycated hemoglobin remained similar to the basal level in both group. Two patients stopped the treatment by guar gum because of gastrointestinal side effects. Conclusion: 1) Simvastatin and guar gum are effective in reducing atherogenic lipids in diabetic patients with dyslipidemia. 2) Guar gum appears to be an effective hypoglycemic agent, and demonstrated better hypotriglyceridemic efficacy than simvastatin. 3) Simvastatin was more effective in lowering TC, LDL-C and increasing antiatherogenic HDL-C, and better tolerated than guar gum. l
ThP63:W31 I Vitamin supplementation in epileptic patients with
i ThP64:W31 ] Fat, cholesterol and fatty acids intake in the diet as a
factor of atherosclerosis treat among people at advanced age A. Kits, J. Bertrandt, A. Tutaj. Military Institute of Hygiene and Epidemiology, 4 Kozielska St., 01-163 Warsaw, Poland
Objective: The aim of the work was estimation intake of fat, cholesterol (Ch) and fatty acids (FA) in the diet and cholesterol, triglyceride (Tg), high density lipoproteins (HDL) fraction in the blood serum of people aged 60-90, living in the pensioner house for few years. Methods: Using software "FOOD" contents of Ch and FA were calculated and fat content was estimated analytically. In serum m/a elements were estimated in 26 pensioners. Results: It was stated that average fat content in 40 analytical examined daily food rations was 133.1 =t= 24.9 g and covered 30.4% of daily energy value. Moreover meals delivered 524.6 -I- 121.7 mg of Ch, 56.2 =1= 10.1 g of saturated, 57.0 -I- 14.1 g monounsaturated and 31.5 :t= 12.8 g of polyunsaturated fatty acids. Ratio of polyunsaturated to saturated fatty acids P: S was in average 0.59. Analysed daily food rations contained in an average 29.4 -4- 13.0 linoleic acid, 2.2 =1=0.35 g ~-Iinolenic acid and 0.259 4- 0.17 g arachidonic acid. Mean Ch level in the examined blood serum was follows: 236.2 4- 66.1 mg/dl. Tg content in the blood serum was in an average 147.9 -4- 61.3 mg/dl. There was a significant difference in the HDL level in the women's blood serum of 70.0 -4- 13.9 mg/dl but among men 49.4 -4- 12.3 mg/dl. Conclusion: Performed examinations showed necessity to implement proper food ration planning, with cholesterol content not exceeding 300 mg and bigger contribution of vegetable fat containing polyunsaturated fatty acids, as a atherosclerosis prophylactic factor. 1
ThP65:W31 ] Primary prevention program on cardiovascular disease in youth
atherosderosis
and
M. Wosik-Erenbek, A. Sierakowska-Fijalek, K. Siniewicz. M. Medical
University of Lodz, Lodz, Poland Objective: To study the influence of the primary prevention program in some anthropometric parameters in school girls and boys. Methods: Our primary prevention program based on regular physical activity, health education, and life style modification was performed on 70 school teenagers. We have used some anthropometric indices and compared them before and after the prevention program implementation. Examined parameters included body mass (m), height (h), skinfolds, waist and hip circumferences. Using these parameters we calculated: the body mass index (BMI), ponderal index (PI), waist/hip ratio (WHR), body fat percentage (BF%) (according to the Siri's formula), subscapular/triceps skin folds ratio (Ss/TR), and biceps + triceps/suprailiac + subscapular skinfolds ratio (BT/SSsR). Results: Based on our primary prevention program we found positive changes in the body fat distribution, heart health knowledge, and health self-monitoring in the investigated subjects. Conclusions: It is beneficial to use our school-based primary prevention program as a part of regular educational programs. In addition, its implementation is very easy.
hyperhomocysteinemia J. Dvorakova 1 , M. Kolinnva2 , J. H yanek 1 , L. Taborsky 1 . 1 Dept. Clin.
Hospital Homolka; LDept. Clin. Neurology, 1st Medical Faculty Prague, Czech Republic Objective: Hyperhomocysteinemia is a risk factor of atheroscterosis and homocysteine is an experimental convulsant. Patients suffering from different types of epilepsy with hyperhomocysteinemia were treated with vitamins. Methods: From a group of 85 patients on long-term antiepileptic treatment we selected 18 patients with hyperhomocysteinemia/total plasma homocysteine (tHcy) > 16 umol/1/, confirmed by the positive L-methionine loading test. We started the vitamin mono - or combination therapy according to the vitamin levels. The daily doses were 1 to 5 mg folic acid, 5 to 10 mg vitamin B6 and 0.3 mg vitamin Bl2 per week, duration from 9 to 18 months.
I ThP66:W31 I Comparison of two systems for LDL-apheresis: Immunoadsorption and hole blood perfusion S. Pokrovsky, I. Adamova, O. Afanasieva, H. Borberg I . Cardiology Research
Center, Moscow, Russia; 1German Haemapheresis Centre, Cologne, Germany Extracorporeal LDL elimination called LDL apheresis for the treatment of FH patients have been successfully used since 1981 year. Currently several systems for LDL apheresis are available: immunoadsorption, chemaadsorption by dextran sulfate, beparin-induced extracorporeal LDL precipitation all this systems was designed for the plasmatherapy and requires step at plasmaseparation, couple years ago new system - Direct Adsorption of Lipids (DALI) for whole blood perfusion have been developed. We performd comparison
Xlhh International Symposium on Atherosclerosis, Stockholm, Sweden, June 25-29, 2000
284 ]
ThP61 :W31 J Screening and registration program for patients with familial hypercholesterolemia in Spain _R. Alonso ] , P. Mozas 2, S. Castillo 2 , G. Reyes 2, J. Puzo 3 , M. Pocovi 2 , P. Mata I . On behalf of The Spanish Group of FH; 1Lipid Unit, Fundaci6n
JimEnez Dfaz, Madrid; 2Departamento de Bioqufmica, Biologfa Molecular y Celular, Universidad de Zaragoza; 3Hospital San Jorge, Huesca, Spain
Results: After treatment with vitamins tHcy decreased to the levels in reference ranges in all the cases. Neither negative clinical or EEG symptom occurred in these patients. Our findings indicate that treatment with a single vitamin may negatively influence the status of other vitamins. Conclusions: Antiepileptic drug treatment may increase plasma concentrations of homocysteine. Vitamin therapy in patients on AED with hyperhomocysteinemia decreases total homocysteine levels to reference ranges.
Background: Familial hypercholesterolemia (FH) is an autosomal disorder caused by defects in the low-density-lipoprotein receptor (LDLr) gene. Patients with FH have an increased risk for premature coronary artery disease (CAD). Objective: Prevention of CAD by early identification and treatment of patients with FH. Methods: l) The Spanish Familial Hypereholesterolemia Foundation coordinates active case-finding by a toll-free telephone helpline and a mail questionnaire. 2) Identified patients are referred to one of the 35 National Lipid Clinic Network Centers. 3) Lipid analysis and DNA-diagnosis are performed in a Central Laboratory. 4) Optimal treatment is initiated and patients are registered for a long-term follow-up. Results: Up to december 1999, 1224 contacts to the belpline were recorded. Of theses, 954 were interactive calls and 270 were requests for the questionaire. Three hundred and seventy five people were clinically and biochemically diagnosticated with FH. Of these, 22% were shown to be positive for one of the 37 FH known causes for LDLr mutation present in Spain. Only 48% of these patients received some form of lipid-lowering therapy previously. Conversely, after referral, 95% adheres to a statin therapy. Conclusion: 1) Toll-free telephone helpline is very effective to identify FH patients. 2) Referral to a Lipid Clinic, early diagnosis and initiation of optimal therapy may reduce cardiovascular morbility and mortality. 1
ThP62:W31 ] Comparison of simvastatin and guar gum in the treatment hyperlipidemic patients with diabetes mellitus II type K. Yafasov 1, G. Shamukhitdinova2 . 1Institute Endocrinology; 2Hospital
MinEnergo, Tashkent, Uzbekistan Diabetes mellitus II type is characterized by the increased risk CHD mortality. For reduce cardiovascular risk, it's necessary to treat the patients with hypolipidemic drugs. We investigate the effect of simvastatin and guar gum was in diabetic patients with hyperlipidemia (basal level TC 7.78 mmol/l, TG 2.94 mmol/1). Twenty patients have been treated with simvastatin 10 mg once a day, and sixteen patients was treated by guar gum 5 g three times daily. After 4 week treatment simvastatin decreased TC by 17%, LDL-C by 21%, TG by 13%, and increased HDL-C by 6%. In the guar gum group TC, LDL-C, TG decreased by 14%, 7%, 21%, and HDL-C increased by 3%. Fasting blood sugar was reduced by guar gum (P < 0.001), and didn't changed by simvastatin. Glycated hemoglobin remained similar to the basal level in both group. Two patients stopped the treatment by guar gum because of gastrointestinal side effects. Conclusion: 1) Simvastatin and guar gum are effective in reducing atherogenic lipids in diabetic patients with dyslipidemia. 2) Guar gum appears to be an effective hypoglycemic agent, and demonstrated better hypotriglyceridemic efficacy than simvastatin. 3) Simvastatin was more effective in lowering TC, LDL-C and increasing antiatherogenic HDL-C, and better tolerated than guar gum. l
ThP63:W31 I Vitamin supplementation in epileptic patients with
i ThP64:W31 ] Fat, cholesterol and fatty acids intake in the diet as a
factor of atherosclerosis treat among people at advanced age A. Kits, J. Bertrandt, A. Tutaj. Military Institute of Hygiene and Epidemiology, 4 Kozielska St., 01-163 Warsaw, Poland
Objective: The aim of the work was estimation intake of fat, cholesterol (Ch) and fatty acids (FA) in the diet and cholesterol, triglyceride (Tg), high density lipoproteins (HDL) fraction in the blood serum of people aged 60-90, living in the pensioner house for few years. Methods: Using software "FOOD" contents of Ch and FA were calculated and fat content was estimated analytically. In serum m/a elements were estimated in 26 pensioners. Results: It was stated that average fat content in 40 analytical examined daily food rations was 133.1 =t= 24.9 g and covered 30.4% of daily energy value. Moreover meals delivered 524.6 -I- 121.7 mg of Ch, 56.2 =1= 10.1 g of saturated, 57.0 -I- 14.1 g monounsaturated and 31.5 :t= 12.8 g of polyunsaturated fatty acids. Ratio of polyunsaturated to saturated fatty acids P: S was in average 0.59. Analysed daily food rations contained in an average 29.4 -4- 13.0 linoleic acid, 2.2 =1=0.35 g ~-Iinolenic acid and 0.259 4- 0.17 g arachidonic acid. Mean Ch level in the examined blood serum was follows: 236.2 4- 66.1 mg/dl. Tg content in the blood serum was in an average 147.9 -4- 61.3 mg/dl. There was a significant difference in the HDL level in the women's blood serum of 70.0 -4- 13.9 mg/dl but among men 49.4 -4- 12.3 mg/dl. Conclusion: Performed examinations showed necessity to implement proper food ration planning, with cholesterol content not exceeding 300 mg and bigger contribution of vegetable fat containing polyunsaturated fatty acids, as a atherosclerosis prophylactic factor. 1
ThP65:W31 ] Primary prevention program on cardiovascular disease in youth
atherosderosis
and
M. Wosik-Erenbek, A. Sierakowska-Fijalek, K. Siniewicz. M. Medical
University of Lodz, Lodz, Poland Objective: To study the influence of the primary prevention program in some anthropometric parameters in school girls and boys. Methods: Our primary prevention program based on regular physical activity, health education, and life style modification was performed on 70 school teenagers. We have used some anthropometric indices and compared them before and after the prevention program implementation. Examined parameters included body mass (m), height (h), skinfolds, waist and hip circumferences. Using these parameters we calculated: the body mass index (BMI), ponderal index (PI), waist/hip ratio (WHR), body fat percentage (BF%) (according to the Siri's formula), subscapular/triceps skin folds ratio (Ss/TR), and biceps + triceps/suprailiac + subscapular skinfolds ratio (BT/SSsR). Results: Based on our primary prevention program we found positive changes in the body fat distribution, heart health knowledge, and health self-monitoring in the investigated subjects. Conclusions: It is beneficial to use our school-based primary prevention program as a part of regular educational programs. In addition, its implementation is very easy.
hyperhomocysteinemia J. Dvorakova 1 , M. Kolinnva2 , J. H yanek 1 , L. Taborsky 1 . 1 Dept. Clin.
Hospital Homolka; LDept. Clin. Neurology, 1st Medical Faculty Prague, Czech Republic Objective: Hyperhomocysteinemia is a risk factor of atheroscterosis and homocysteine is an experimental convulsant. Patients suffering from different types of epilepsy with hyperhomocysteinemia were treated with vitamins. Methods: From a group of 85 patients on long-term antiepileptic treatment we selected 18 patients with hyperhomocysteinemia/total plasma homocysteine (tHcy) > 16 umol/1/, confirmed by the positive L-methionine loading test. We started the vitamin mono - or combination therapy according to the vitamin levels. The daily doses were 1 to 5 mg folic acid, 5 to 10 mg vitamin B6 and 0.3 mg vitamin Bl2 per week, duration from 9 to 18 months.
I ThP66:W31 I Comparison of two systems for LDL-apheresis: Immunoadsorption and hole blood perfusion S. Pokrovsky, I. Adamova, O. Afanasieva, H. Borberg I . Cardiology Research
Center, Moscow, Russia; 1German Haemapheresis Centre, Cologne, Germany Extracorporeal LDL elimination called LDL apheresis for the treatment of FH patients have been successfully used since 1981 year. Currently several systems for LDL apheresis are available: immunoadsorption, chemaadsorption by dextran sulfate, beparin-induced extracorporeal LDL precipitation all this systems was designed for the plasmatherapy and requires step at plasmaseparation, couple years ago new system - Direct Adsorption of Lipids (DALI) for whole blood perfusion have been developed. We performd comparison
Xlhh International Symposium on Atherosclerosis, Stockholm, Sweden, June 25-29, 2000