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Proceedings of the international conference on the peaceful uses of atomic energy; vol. 10, radioactive isotopes and nuclear radiations in medicine, and vol. 11, biological effects of radiation
Rook Reviews OF THE IN’I‘EKNr!TlO~AL CONFEKEXCE OS THE I’E.\CEFl~L USES OF ATOMIC ENERGY; VOL. 10, KADIOACTIVE ISOTOPES riN1) NI’CLEXR RADIATIONS IN MEDICINE, AND VOL. 11, BIOLOGIC.\L EFFECTS OF K.LSDIA’I‘ION; Editorial Board, Robert A. Charpie, Donald J. Dewar, XndrC Finkelstein, John Gaunt, Jacob _A. Goedkoop, Elwyn 0. Hughes, Leonard F. Lamerton, =\leksandar MilojeviC, Clifford Mosbacher, C&ar A. Sastre, and Brian E. Iirquhart. Pp. ix plus 544 (\‘ol. 10) and ix plus 402 (\:ol. 11); Sew York, 1956, (-nited Nations. Price $8.00 per \-olume.
I’KOCEEDINGS
These volumes include all of the papers submitted to the Geneva Conferellre on the Peaceful loses of .\tomic Energy, held in Geneva, Switzerland, from .4ug. 8 to 20, 1955, in the tields of medicine and radiobiology. The pertinent verbatim records of the Conference are also included. Of the two volumes, volume 10 will probably hold the greater interest for the medical reader. Including as it does a series of papers in which are described some of the more significant work of many of the leading authorities in the field of radioisotope medicine throughout the world, Volume 10 gives an excellent cross section of the clinical and associated experimental applications of radioisotopes in medical science. The volume is divided into four sections: Isotopes in Medicine and Biology; Radioisotopes in Therapy; Radioisotopes in the Diagnosis and Study of Disease (Clinical Applications); and Radioisotopes in the Diagnosis and Study of Disease (Experimental Applications). In all four sections, most of the papers were written by workers living within There is, ho\\-ever, good representation of the work the United States and the United Kingdom. of investigators in many other parts of the world, including Russia. The first section of Volume 10 is devoted to a series of four papers by \Varren of the I*nited States, McFarlane of the United Kingdom, Nakaidzumi of Japan, and Coursaget of France. These papers discuss, in a general way, the historical background of radioisotopes in each of the respective countries. The papers therefore serve as a background for the remaining papers given at the Geneva Conference. The second section of Volume 10 preseuts, in a series of twenty-seven papers, a review of the \vork which has been done with radioisotopes in the field of radiation therapy. The scope of these papers ranges from descriptions of kilocurie teletherapy and multimegavolt radiation sources for the external application of ionizing radiation to descriptions of the internal use of radioisotopes in the treatment of principally malignant disease. In the latter category, several excellent papers appear on the subjects of the usefulness of radioactive colloids (Gold-198, Chromic Phosphate (P-32), Yttrium-go, and Lutetium-177) in the treatment of pleural and peritoneal effusions in malignant disease; the usefulness of radiophosphorus in the treatment of polycythemia vera; and the usefulness of radioiodine in the treatment of thyroid disease. :\lso included in this section is a number of sophisticated papers describing the neutron therapy of boron activated neoplasms of the brain, the irradiation hypophysectomy of individuals with 340-Me\- protons and 190-Me\. deuterons. The third section of Volume 10, Radioisotopes in the Diagnosis and Study of Disease (Clinical Applications), is to this reviewer the most interesting portion of the volume. In it are included thirty-four papers, many of which are classical works describing the techniques, indications, and contraindications for a wide variety of radioisotopes in the study and diagnosis of clinical problems. Several papers discuss the problems concerned with the application of radioiodine in the diagnosis of thyroid disease. Another group of excellent manuscripts devotes attention to the problems of hematology which are amenable to study and solution by radioisotopic means. Brownell and Sweet describe their ingenious technique for the localization of intracranial and other lesions b)
656 positron-emitting receive extensive
isotopes. application
The high resolution ~~~fortled by this method indicates that it \vill almost certainly in man!. medical diagnostic problems of the future.
In the fourth section of Volume 10 are included twenty additional papers concerned with the use of radioisotopes in the diagnosis and study of disease. I’nlike the third section, howe\.cr, most of these papers are devoted to experimental problems in medicine rather than to clinical application. .As might be expected, these papers rover a wide variety of experimental problems. including the use of radiosodium and radiopotassium in electrolyte metabolism, the use of tritiumc.ontaining water in the same application, the use of radioisotopes in the study of tuberculosis, vitamin pathogenesis, muscle biochemistr)., protein biosynthesis, and the modes of cancer inThree papers are also devoted to the IISC of radioisotopes in the study of public health duction. problems. Biological Volume 11 is divided into four sectiolls, with several of these further subdivided: effects of Radiation; Modes of Radiation Injury and Radiation Hazards; Mechanism of Radiation The first section Injury (Protection and Recovery); and Genetic Effects (Human Implications). is a review of a rapidly-accumulating literature on the subject of the biologic effects of radiatioll. The papers appearing in this section should be quite useful to workers in this field, since many of them contain extensive bibliographies. This is particularly true of some of the foreign manuscripts. The second section, on the modes of radiation injur). and radiation hazards, is divided into Here, fourteen three subsections, the first of which is concerned principally with radiation injur).. papers present extensive data on the early and late effects of radiation injury, injury due to radioactive fall-out, modes of acute radiation death, the effect of radiation dosage on the lifespan of The second the exposed individual, and the effects of chronic low intensity radiation exposure. subsection is devoted to the rarcinogenesis and metabolism of bone-seeking isotopes and the final subdivision to a series of four papers on the effects of radiation on the reproductive system and on the fetus. The third section of yolume 11 is devoted to a series of papers discussing the protection and recovery of biologic tissues and systems from radiation injur).. ;\s in the previous sections in this volume, and in Volume 10, the papers are accompanied by extensive bibliographies on the subject and give the reader an excellent background of information from which added study ma!. he projected. The final section of Volume 11 is devoted radiation exposure. Although these papers do highly controversial subject, they provide both a superb discussion of the problems of genetic
to a series of four papers on the genetic etfects of not resolve the many problems concerned \vith this the radiation worker and the physician alike with change induced by radiation.
III this book review, it is not possible to do more than outline a few wealth of information and data presented at the International Congress .jtomic Energy, in Geneva in 195.5. For the radiation worker, whether he or medicine, these \-olumes are required reading. ;Uthough they are in books in the lield of nuclear medicine, their breadth of coverage and their should prove invaluable to the ph>+ian tvho has onI?- cursor!. contact radioisotones.
of the high spots of the of the Peaceful Uses of be in the field of biolog!. no sense a pair of textextensive bibliographies from time to time with
Russell
H. Morgan,
X1.D.
SOCIO-ECONOMIC CONDITIONS .ANDTVBERCULOSIS PREV=\LENCE IN NE\\‘YORK New York Tuberculosis and Health AssociaCITY, 1949-1951. By Anthony M. Lowell. tion, 1956. pp. 127. -Abstracts available only on request to the New York Tuberculosis and Health .%ssoriation, Inc., 386 Fourth .4ve., New York 16, N. Y. This well-documented study describes intensively illustrations, Health Area maps, and other statistical ~3llosis prevalence in Neu- York Cit!..”
in 42 pages of text and 85 pages of charts, ronditionq and tnberdata “so&-economic
I’KOCEEDINGS
These volumes include all of the papers submitted to the Geneva Conferellre on the Peaceful loses of .\tomic Energy, held in Geneva, Switzerland, from .4ug. 8 to 20, 1955, in the tields of medicine and radiobiology. The pertinent verbatim records of the Conference are also included. Of the two volumes, volume 10 will probably hold the greater interest for the medical reader. Including as it does a series of papers in which are described some of the more significant work of many of the leading authorities in the field of radioisotope medicine throughout the world, Volume 10 gives an excellent cross section of the clinical and associated experimental applications of radioisotopes in medical science. The volume is divided into four sections: Isotopes in Medicine and Biology; Radioisotopes in Therapy; Radioisotopes in the Diagnosis and Study of Disease (Clinical Applications); and Radioisotopes in the Diagnosis and Study of Disease (Experimental Applications). In all four sections, most of the papers were written by workers living within There is, ho\\-ever, good representation of the work the United States and the United Kingdom. of investigators in many other parts of the world, including Russia. The first section of Volume 10 is devoted to a series of four papers by \Varren of the I*nited States, McFarlane of the United Kingdom, Nakaidzumi of Japan, and Coursaget of France. These papers discuss, in a general way, the historical background of radioisotopes in each of the respective countries. The papers therefore serve as a background for the remaining papers given at the Geneva Conference. The second section of Volume 10 preseuts, in a series of twenty-seven papers, a review of the \vork which has been done with radioisotopes in the field of radiation therapy. The scope of these papers ranges from descriptions of kilocurie teletherapy and multimegavolt radiation sources for the external application of ionizing radiation to descriptions of the internal use of radioisotopes in the treatment of principally malignant disease. In the latter category, several excellent papers appear on the subjects of the usefulness of radioactive colloids (Gold-198, Chromic Phosphate (P-32), Yttrium-go, and Lutetium-177) in the treatment of pleural and peritoneal effusions in malignant disease; the usefulness of radiophosphorus in the treatment of polycythemia vera; and the usefulness of radioiodine in the treatment of thyroid disease. :\lso included in this section is a number of sophisticated papers describing the neutron therapy of boron activated neoplasms of the brain, the irradiation hypophysectomy of individuals with 340-Me\- protons and 190-Me\. deuterons. The third section of Volume 10, Radioisotopes in the Diagnosis and Study of Disease (Clinical Applications), is to this reviewer the most interesting portion of the volume. In it are included thirty-four papers, many of which are classical works describing the techniques, indications, and contraindications for a wide variety of radioisotopes in the study and diagnosis of clinical problems. Several papers discuss the problems concerned with the application of radioiodine in the diagnosis of thyroid disease. Another group of excellent manuscripts devotes attention to the problems of hematology which are amenable to study and solution by radioisotopic means. Brownell and Sweet describe their ingenious technique for the localization of intracranial and other lesions b)
656 positron-emitting receive extensive
isotopes. application
The high resolution ~~~fortled by this method indicates that it \vill almost certainly in man!. medical diagnostic problems of the future.
In the fourth section of Volume 10 are included twenty additional papers concerned with the use of radioisotopes in the diagnosis and study of disease. I’nlike the third section, howe\.cr, most of these papers are devoted to experimental problems in medicine rather than to clinical application. .As might be expected, these papers rover a wide variety of experimental problems. including the use of radiosodium and radiopotassium in electrolyte metabolism, the use of tritiumc.ontaining water in the same application, the use of radioisotopes in the study of tuberculosis, vitamin pathogenesis, muscle biochemistr)., protein biosynthesis, and the modes of cancer inThree papers are also devoted to the IISC of radioisotopes in the study of public health duction. problems. Biological Volume 11 is divided into four sectiolls, with several of these further subdivided: effects of Radiation; Modes of Radiation Injury and Radiation Hazards; Mechanism of Radiation The first section Injury (Protection and Recovery); and Genetic Effects (Human Implications). is a review of a rapidly-accumulating literature on the subject of the biologic effects of radiatioll. The papers appearing in this section should be quite useful to workers in this field, since many of them contain extensive bibliographies. This is particularly true of some of the foreign manuscripts. The second section, on the modes of radiation injur). and radiation hazards, is divided into Here, fourteen three subsections, the first of which is concerned principally with radiation injur).. papers present extensive data on the early and late effects of radiation injury, injury due to radioactive fall-out, modes of acute radiation death, the effect of radiation dosage on the lifespan of The second the exposed individual, and the effects of chronic low intensity radiation exposure. subsection is devoted to the rarcinogenesis and metabolism of bone-seeking isotopes and the final subdivision to a series of four papers on the effects of radiation on the reproductive system and on the fetus. The third section of yolume 11 is devoted to a series of papers discussing the protection and recovery of biologic tissues and systems from radiation injur).. ;\s in the previous sections in this volume, and in Volume 10, the papers are accompanied by extensive bibliographies on the subject and give the reader an excellent background of information from which added study ma!. he projected. The final section of Volume 11 is devoted radiation exposure. Although these papers do highly controversial subject, they provide both a superb discussion of the problems of genetic
to a series of four papers on the genetic etfects of not resolve the many problems concerned \vith this the radiation worker and the physician alike with change induced by radiation.
III this book review, it is not possible to do more than outline a few wealth of information and data presented at the International Congress .jtomic Energy, in Geneva in 195.5. For the radiation worker, whether he or medicine, these \-olumes are required reading. ;Uthough they are in books in the lield of nuclear medicine, their breadth of coverage and their should prove invaluable to the ph>+ian tvho has onI?- cursor!. contact radioisotones.
of the high spots of the of the Peaceful Uses of be in the field of biolog!. no sense a pair of textextensive bibliographies from time to time with
Russell
H. Morgan,
X1.D.
SOCIO-ECONOMIC CONDITIONS .ANDTVBERCULOSIS PREV=\LENCE IN NE\\‘YORK New York Tuberculosis and Health AssociaCITY, 1949-1951. By Anthony M. Lowell. tion, 1956. pp. 127. -Abstracts available only on request to the New York Tuberculosis and Health .%ssoriation, Inc., 386 Fourth .4ve., New York 16, N. Y. This well-documented study describes intensively illustrations, Health Area maps, and other statistical ~3llosis prevalence in Neu- York Cit!..”
in 42 pages of text and 85 pages of charts, ronditionq and tnberdata “so&-economic