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Progestins in treatment of endometrial adenocarcinoma
CORRESPONDENCE Progestins endometrial To
in treatment of adenocarcinoma
down to a pH of 4.2 to 4.5 (and trichomonads cannot live below a pH of 4.9) when the progestins (or a mixture of 0.5 mg. of estradiol benzoate and 0.9 mg. of stilbestrol) are given. Very small doses of stilbestrol, 0.05 mg. daily plus 3 Thiamalt capsules (B complex plus all of the amino acids plus all the trace elements) will also produce the same normal vaginal physiology, more consistently. In many women, the use of the Trimagill alone will aid in lowering the vaginal pH to its normal physiologic range; or the range in which trichomonads cannot live. It is simpler and less costly for these women to instill this dry powder which consists of ordinary corn starch plus alum, because, if she will instill two vaginal applicators full of this powder, night and morning for 2 weeks, the identical normal vaginal physiology will result, as when the progestogens or a small dose of an estrogen with the B complex vitamins are given. We have had a way to restore normal physiology of the vagina for about 25 years. The three substances mentioned above will restore the flora, the acidity, the glycogen in the cells, and the cell height. It is the pH of the medication which is important in the treatment of vaginal infections and it appears to be so with our present-day progestins (Med. Rec. & Ann. 50: 160, 1956) (Ahi. J. OBST.&GYNEC.~~: 1292,195O).
the Editors:
In the article “Progestins in the Treatment of Patients with Endometrial Adenocarcinoma” by J. P. Smith and associates, volume 94, April, 1966, the following statement might be questioned: “. . . that adenocarcinoma of the endometrium may be amenable to control by means of sex steroids was first demonstrated by Kelly in 1951.” In 1942, I wrote on “Adenocarcinoma of Fundus Receiving Stilbestrol May Be a Cure; It Will Not Regenerate New Normal Tissue,” published in the Medical Records and Annals, May, 1942. Karl 2614-2616 Houston,
Karnaky,
M.D.
Crawford Texas 77004
Trichomonas To
John
vaginalis
therapy
the Editors:
The article of Dr. Diddle on the resistant case of Trichomonas vaginalis was of interest to me. Over the past 35 years, we have seen many excellent medications which were specific for trichomonads, at first, soon became of no or of little value for this protozoan. We now have 3 such cases, and if resistant trichomonas vaginalis keeps on developing, as it did in the past, we should soon be seeing more and more. Older medications must be replaced by newer ones which will destroy this pathogen. The only exception is therapy based on “restoration of vaginal physiology,” because in a normal vagina, no pathogen will be found. It was mentioned that the use of a progestin brought about a cure of this Flagylresistant Trichomonas vaginalis. It has been shown in our routine electronic pH recordings that it is not the progestin but the resulting “restoration of the vaginal physiology” which eradicated the pathogen. In over 500 vaginal pH recordings, it has been observed that the pH of Trichomonas which is near 5.2 is made to go
Karl
John
Karnaky,
M.D.,
F.A.C.O.G.
Obstetrical Foundation 2614-2616
and Gynecological Research and Research Institute Crawford, Houston, Texas 77004
Z-plasty transverse
for correction of congenital vaginal septum
To
the Editors:
interested in Dr. Garcia’s I was quite “Z-plasty for Correction of Congenital Transverse Vaginal Septum” in the Dec. 15, 1967, issue of the JOURNAL. I described the same technique 3 years ago in Obstetrics &? Gynecology. Like Dr. Garcia, I 272
in treatment of adenocarcinoma
down to a pH of 4.2 to 4.5 (and trichomonads cannot live below a pH of 4.9) when the progestins (or a mixture of 0.5 mg. of estradiol benzoate and 0.9 mg. of stilbestrol) are given. Very small doses of stilbestrol, 0.05 mg. daily plus 3 Thiamalt capsules (B complex plus all of the amino acids plus all the trace elements) will also produce the same normal vaginal physiology, more consistently. In many women, the use of the Trimagill alone will aid in lowering the vaginal pH to its normal physiologic range; or the range in which trichomonads cannot live. It is simpler and less costly for these women to instill this dry powder which consists of ordinary corn starch plus alum, because, if she will instill two vaginal applicators full of this powder, night and morning for 2 weeks, the identical normal vaginal physiology will result, as when the progestogens or a small dose of an estrogen with the B complex vitamins are given. We have had a way to restore normal physiology of the vagina for about 25 years. The three substances mentioned above will restore the flora, the acidity, the glycogen in the cells, and the cell height. It is the pH of the medication which is important in the treatment of vaginal infections and it appears to be so with our present-day progestins (Med. Rec. & Ann. 50: 160, 1956) (Ahi. J. OBST.&GYNEC.~~: 1292,195O).
the Editors:
In the article “Progestins in the Treatment of Patients with Endometrial Adenocarcinoma” by J. P. Smith and associates, volume 94, April, 1966, the following statement might be questioned: “. . . that adenocarcinoma of the endometrium may be amenable to control by means of sex steroids was first demonstrated by Kelly in 1951.” In 1942, I wrote on “Adenocarcinoma of Fundus Receiving Stilbestrol May Be a Cure; It Will Not Regenerate New Normal Tissue,” published in the Medical Records and Annals, May, 1942. Karl 2614-2616 Houston,
Karnaky,
M.D.
Crawford Texas 77004
Trichomonas To
John
vaginalis
therapy
the Editors:
The article of Dr. Diddle on the resistant case of Trichomonas vaginalis was of interest to me. Over the past 35 years, we have seen many excellent medications which were specific for trichomonads, at first, soon became of no or of little value for this protozoan. We now have 3 such cases, and if resistant trichomonas vaginalis keeps on developing, as it did in the past, we should soon be seeing more and more. Older medications must be replaced by newer ones which will destroy this pathogen. The only exception is therapy based on “restoration of vaginal physiology,” because in a normal vagina, no pathogen will be found. It was mentioned that the use of a progestin brought about a cure of this Flagylresistant Trichomonas vaginalis. It has been shown in our routine electronic pH recordings that it is not the progestin but the resulting “restoration of the vaginal physiology” which eradicated the pathogen. In over 500 vaginal pH recordings, it has been observed that the pH of Trichomonas which is near 5.2 is made to go
Karl
John
Karnaky,
M.D.,
F.A.C.O.G.
Obstetrical Foundation 2614-2616
and Gynecological Research and Research Institute Crawford, Houston, Texas 77004
Z-plasty transverse
for correction of congenital vaginal septum
To
the Editors:
interested in Dr. Garcia’s I was quite “Z-plasty for Correction of Congenital Transverse Vaginal Septum” in the Dec. 15, 1967, issue of the JOURNAL. I described the same technique 3 years ago in Obstetrics &? Gynecology. Like Dr. Garcia, I 272