Program: Wednesday, June 6, 2001

conference.book Page 5 Wednesday, February 7, 2001 8:41 PM

IBMS/ECTS 2001 - First Joint Meeting

Wednesday, June 6, 2001

WEDNESDAY, JUNE 6, 2001 DAY-AT-A-GLANCE 08:30 - 09:30

Plenary Session 1

Auditorium

Cell Biology: Osteoclasts and Related Cytokines Speakers: Naoyuki Takahashi, Kalervo Väänänen Oral Presentations 1

Auditorium

Cell Biology: Osteoclasts and Related Cytokines 11:10 - 11:30

Coffee Break

11:30 - 12:30

Short Communications

page S6

Lunch & Poster Session 1

Bone, Cartilage and Connective Tissue Matrix Diseases of Bone Genetics Hormones and Cytokines Osteoblasts Osteoclasts Osteoporosis: Diagnosis Osteoporosis: Epidemiology Osteoporosis: Pathophysiology Osteoporosis: Treatment Vitamin D 14:00 - 15:00

Plenary Session 2

Oral Presentations 2

Coffee Break

17:30-19:30

Satellite Symposium

Concert

page S21

Auditorium

Setting the Standard for Treating Osteoporosis: Latest Research Advances with FOSAMAX sponsored by Merck Sharp and Dohme 20:00 - 21:00

page S21

Auditorium

Osteoporosis: Pathophysiology, Genetics, Epidemiology 17:00 - 17:30

page S7 S8 S10 S10 S11 S13 S14 S15 S16 S18 S21 Auditorium

Osteoporosis: Pathophysiology, Genetics, Epidemiology Speakers: Eric S. Orwoll, Huibert A. P. Pols 15:00 - 17:00

page S6

Auditorium

Bone Cell Biology 12:30 - 14:00

Wednesday

09:30 - 11.10

page S6

page S22

Auditorio Nacional

S5

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Wednesday, June 6, 2001

IBMS/ECTS 2001 - First Joint Meeting 10:18 OR5

PLENARY SESSION 1 CELL BIOLOGY: OSTEOCLASTS AND RELATED CYTOKINES Chairs: Michael A. Horton (London/UK), Alberta M. Zallone (Bari/Italy) IN2

IN3

10:30 OR6

Role of Inflammatory Cytokines in Osteoclast Differentiation and Function Naoyuki Takahashi (Tokyo/Japan) 10:42 OR7

Modulation of Osteoclast Function Kalervo Väänänen (Turku/Finland)

08:30 - 09:30

Auditorium

10:54 OR8

ORAL PRESENTATIONS 1 CELL BIOLOGY: OSTEOCLASTS AND RELATED CYTOKINES Chairs: Michael A. Horton (London/UK), Alberta M. Zallone (Bari/Italy) 09:30 - 11:10

CONNEXIN43 DEFICIENCY LEADS TO IMPAIRED OSTEOCLASTOGENESIS F. Lecanda*, F. Furlan, L. Weitzmann, S. Sheikh, R. Civitelli University of Navarra, Pamplona, SPAIN; Washington University, St. Louis, USA INTERLEUKIN-12 ALONE, AND IN SYNERGY WITH INTERLEUKIN-18, INHIBITS OSTEOCLAST FORMATION IN VITRO N. J. Horwood, J. Elliott, T. J. Martin, M. T. Gillespie* St. Vincent's Inst. Med. Res., Melbourne, Australia INTERLEUKIN-17 IS A CATABOLIC CYTOKINE FOR BONE AND CARTILAGE IN PATHOLOGICAL CONDITIONS CHARACTERIZED BY INFLAMMATION R. L. van Bezooijen*, L. van der Wee-Pals, B. Oudshoorn, S. E. Papapoulos, C. W. G. M. Löwik Leiden University Medical Center, Leiden, The Netherlands TUMOR NECROSIS FACTOR-ALPHA INDUCES OSTEOCLASTOGENESIS BY DIRECT STIMULATION OF MACROPHAGES EXPOSED TO PERMISSIVE LEVELS OF RANK LIGAND J. Lam*, S. Takeshita, J. E. Barker, O. Kanagawa, F. P. Ross, S. L. Teitelbaum Washington University School of Medicine, Saint Louis, MO, USA; The Jackson Laboratory, Bar Harbor, ME, USA

Auditorium

The abstract text of oral presentations (prefix OR) can be found in the Abstracts section, page S70 onward.

Coffee Break 11:10 - 11:30

09:30 OR1

09:42 OR2

09:54 OR3

10:06 OR4

A NOVEL OSTEOBLAST-DERIVED MOLECULE THAT INHIBITS OSTEOCLAST FORMATION H. Zhou, V. Kartsogiannis, Y. S. Hu, J. Elliott, J. M. W. Quinn, W. J. McKinstry, M. T. Gillespie*, K. W. Ng St. Vincent's Inst Med. Res. and Dept Med. Uni. Melbourne, Melbourne, Australia

SHORT COMMUNICATIONS BONE CELL BIOLOGY

CBL NEGATIVELY REGULATES SRC KINASE ACTIVITY AND VITRONECTIN RECEPTORMEDIATED CELL ADHESION A. Sanjay*, A. Houghton, E. DiDomenico, W. Horne, R. Baron Dept.of Orthopaedics, Yale University, USA

Chairs: Roland Baron (New Haven, CT/USA), Jesus González Macías (Santander/Spain), Anna Teti (L'Aquila/Italy) 11:30 - 12:30

Auditorium

The abstract text of short communications (prefix SC) can be found in the Abstracts section, page S90 onward.

INTERLEUKIN-1 REGULATES CYTOSKELETAL ORGANIZATION IN OSTEOCLASTS VIA TRAF6/CSRC COMPLEX I. N. Nakamura*, Y. Kadono, H. Takayanagi, E. Jimi, T. Miyazaki, H. Oda, K. Nakamura, S. Tanaka, G. A. Rodan, L. T. Duong Univ of Tokyo, Tokyo, Japan; Merck Res Labs, West Point, USA; Yale Univ, New Haven, USA

11:30 SC1 W

EXPRESSION AND FUNCTION OF SMALL GTPASES OF RAB FAMILY IN BONE-RESORBING OSTEOCLASTS H. B. Zhao*, O. Ettala, H. K. Väänänen Department of Anatomy, Institute of Biomedicine, University of Turku, Turku, Finland

11:35 SC2 W

S6

IDENTIFICATION OF A BISPHOSPHONATE WHICH INHIBITS FPP SYNTHASE AND IPP ISOMERASE K. Thompson*, F. P. Coxon, J. E. Dunford, F. H. Ebetino, M. J. Rogers Department of Medicine and Therapeutics, University of Aberdeen, UK; Procter & Gamble Pharmaceuticals, Cincinnati, USA IDENTIFICATION OF A PHOSPHONOCARBOXYLATE ANALOGUE OF RISEDRONATE WHICH INHIBITS GERANYLGERANYL TRANSFERASE II AND SELECTIVELY PREVENTS PRENYLATION OF RAB PROTEINS IN OSTEOCLASTS F. P. Coxon*, B. Larijani, J. E. Dunford, M. C. Seabra, F. H. Ebetino, S. P. Luckman, M. J. Rogers University of Aberdeen, UK; Imperial College London, UK; Procter & Gamble Pharmaceuticals, Cincinnati, USA

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IBMS/ECTS 2001 - First Joint Meeting 11:40 SC3 W

11:45 SC4 W

11:55 SC6 W

12:00 SC7 W

12:05 SC8 W

12:10 SC9 W

12:15 SC10 W

12:20 SC11 W

ANDROGENS AND ESTROGENS SUPPRESS RANKLINDUCED OSTEOCLAST FORMATION VIA A DIRECT ACTION ON OSTEOCLAST PRECURSORS J. W. Pike*, A. C. Bendixen, D. M. Huber, K. M. Dienger, S. Srivastava, P. Pathrose, N. K. Shevde University of Cincinnati, Cincinnati, Ohio, USA HUMAN OSTEOPROTEGERIN STIMULATES METALLOPROTEINASE ACTIVITIES OF RABBIT BONE CELLS BY THE RAS/MAPK PATHWAY A. V. Rousselle*, E. Grimaud, Y. Fortun, M. Padrines, F. Redini, D. Heymann Medicine Faculty, EE-99/01, Nantes, France

ANALYSIS OF THE MURINE MODEL OF THE SAETHRE-CHOTZEN SYNDROME SUGGESTS A FUNCTIONAL RELATIONSHIP BETWEEN TWIST AND FGFR2 V. El Ghouzzi*, R. Quillet, C. Stoetzel, A. Munnich, J. Bonaventure, F. Perrin-Schmitt INSERM U393, Hôpital Necker, Paris, France; LGMECNRS/INSERM U184, Faculté de Médecine, Strasbourg, France

All Short Communications will be displayed as posters throughout the conference. Those presented in this session will be attended during Poster Session 1 which follows.

ANTI-RESORPTIVE AND SURVIVAL ACTIONS OF SELECTIVE INTEGRIN PEPTIDOMIMETICS ON AUTHENTIC HUMAN OSTEOCLASTS P. Collin-Osdoby*, F. Anderson, L. Rothe, X. Yu, M. Nelson, Y. Huang, W. Maloney, W. Westlin, G. A. Nickols, P. Osdoby Washington Unviversity, USA; Pharmacia, USA

POSTER SESSION 1 12:30 - 14:00 The abstract text of poster presentations (prefix P) can be found in the Abstracts section, page S101 onward.

DISCOVERY AND ANALYSIS OF OSTEOBLAST RELATED GENES USING CDNA MICROARRAY A. Raouf, A. Seth* Department of Laboratory Medicine & Pathobiology, University of Toronto, Canada; CIHR group in Periodontal Physiology, University of Toronto, Canada; Laboratory of Molecular Pathology, Sunnybrook and Women's College Health Sciences Centre

Bone, Cartilage and Connective Tissue Matrix

IN VIVO EVIDENCE FOR ESTRADIOL-CONTROLLED INSULIN-LIKE GROWTH FACTOR-I AND INSULINLIKE GROWTH FACTOR BINDING PROTEIN-5 EXPRESSION IN BONE CELLS E. M. Colin, D. J. Lindenbergh-Kortleve, G. J. C. M. van den Bemd, C. J. Buurman, J. W. van Neck, S. L. S. Drop, H. A. P. Pols, J. P. T. M. van Leeuwen* Department of Internal Medicine, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Pediatrics, Erasmus Medical Center Rotterdam, The Netherlands PROTEIN KINASE C-DEPENDENT UP-REGULATION OF N-CADHERIN EXPRESSION BY PHORBOL ESTER IN HUMAN OSTEOBLASTS P. Delannoy, J. Lemonnier, E. Hay, D. Modrowski, P. J. Marie* INSERM U349, Hopital Lariboisiere, Paris, France

P1 W

THE CUT 2000 – A NEW CEMENTLESS HIP SYSTEM WITH METAPHYSICAL ANCHORAGE J. Scholz*, J. Osel Auguste-Victoria Teaching Hospital, Center for Orthopaedic Surgery, Berlin, Germany

P4 W

EXIST SEX-RELATED DIFFERENCES OF BUA AND SOS OF THE OS CALCIS IN CHILDREN AND ADOLESCENTS? B. Wuensche*, K. Wuensche, H. Faehnrich, R. Venbrocks, W. A. Kaiser Clinic of Orthopaedics, University Jena, Germany; Institute of Radiology, University Jena, Germany

P7 W

EFFECT OF DEPHOSPHORYLATION OF DENTIN PHOSPHOPHORYN ON APATITE INDUCTION T. Saito*, K. Matsuda, Y. Miyamoto, T. Uemura, M. A. Crenshaw Health Sciences, Univ. of Hokkaido, Tobetsu, Hokkaido, Japan; NAIR; JST; Univ.of North Carolina

P10 W

DETECTION AND LOCALIZATION OF OSTEOCALCIN (BGP OR BONE GLA PROTEIN) IN TELEOSTS BY IN SITU HYBRIDATION AND IMMUNOHISTOCHEMISTRY P. J. Gavaia*, C. A. Viegas, J. P. Pinto, M. C. Sarasquete, M. L. Cancela CCMar, Universidade do Algarve, Campus de Gambelas, 8000-810 Faro, Portugal; Instituto de Ciencias Marinas de Andalucía (CSIC), Polígono Río San Pedro, 11510, Puerto Real, Cádiz, Spain

P13 W

THE USE OF FLUORESCENCE ACTIVATED CELL SORTING TO ANALYSE MATRIX VESICLES FROM EPIPHYSEAL GROWTH CARTILAGE I. Schoenmakers*, B. M. Gadella, P. R. van Weeren, J. F. H. M. Brouwers, A. Barneveld, L. M. G. van Golde, C. H. A. van de Lest Department of Biochemistry, Cell Biology and Histology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands; Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, The Netherlands

ACTIVATION OF THE PROTEIN KINASE B (PKB/AKT) SIGNALLING PATHWAY IN OSTEOBLASTS BY MECHANICAL STRAIN T. S. Grewal*, R. J. Tolley, T. M. Skerry Department of Biology, University of York, York, UK C-SRC AND PKC ISOFORMS REGULATE OSTEOBLAST DIFFERENTIATION S. Migliaccio*, M. Marzia, N. Sims, A. Taranta, S. Bernardini, R. Baron, A. Teti Department of Experimental Medicine, University of L'Aquila, L'Aquila, Italy; Department of Experimental Medicine, University "La Sapienza", Rome, Italy; Department of Cell Biology and Orthopaedics, Yale University, New Haven, USA; Istituto Dermopatico dell'Immacolata, Rome, Italy

S7

Wednesday

11:50 SC5 W

Wednesday, June 6, 2001

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Wednesday, June 6, 2001 P16 W

IBMS/ECTS 2001 - First Joint Meeting

MOLECULAR EVENTS CAUSED BY CYCLIC STRETCH IN SPINAL LIGAMENT CELLS FROM PATIENTS WITH OSSIFICATION OF THE POSTERIOR LONGITUDINAL LIGAMENTS M. Tanno*, K. Furukawa, K. Ueyama, S. Harata, S. Motomura Dept. of Orthopaedic Surgery, Hirosaki University School of Medicine, Hirosaki, Japan; Dept. of Pharmacology, Hirosaki University School of Medicine, Hirosaki, Japan

P40 W

BIOMECHANICAL PROPERTIES OF FEMORAL SHAFTS IN INMATURE RATS WITH HYPOBARIAINDUCED HYPOXEMIA R. M. Alippi*, M. D. Meta, C. Bozzini, M. I. Olivera, J. L. Ferretti, C. E. Bozzini Department of Physiology, Faculty of Odontology, University of Buenos Aires, Argentina

P43 W

BMU-COUPLING IS REGULATED BY LOCAL PATTERNS OF FLUID FLOW E. H. Burger*, T. H. Smit, J. M. Huyghe ACTA - Vrije Universiteit, Amsterdam, The Netherlands; Vrije Universiteit Medical Center, Amsterdam, The Netherlands; Technical University Eindhoven, The Netherlands

P19 W

LACK OF ENDOCHONDRAL OSSIFICATION IN LONG BONES OF GROWING FROGS T. Mori-ishi*, Y. Shibata, A. Yamaguchi Department of Oral Pathology, Nagasaki university School of Dentistry, Nagasaki, Japan

P22 W

MICRODAMAGE DISTRIBUTION AND ALTERED MESSENGER RNA GENE EXPRESSION IN THE PROXIMAL FEMUR N. Fazzalari*, J. Kuliwaba, D. Findlay, M. Forwood Institute of Medical and Veterinary Science; Adelaide University; University of Queensland

P46 W

ZINC STAINING OF MATRIX METALLOPROTEINASES AND ENDONUCLEASES IN GROWTH CARTILAGE S. Gomez Dept Anatomia Patologica, Faculty of Medicine, University of Cadiz, Spain

P25 W

EFFECT OF TP508, A SYNTHETIC THROMBIN PEPTIDE, ON CBFA1, VEGF, COLLAGEN TYPE II EXPRESSION DURING FEMORAL FRACTURE HEALING H. Wang*, J. Convery, C. Fowler, J. T. Ryaby OrthoLogic

P49 W

DISTRIBUTIONS OF MRNAS FOR BMP-2 AND BMP RECEPTOR IN OSTEOARTHRITIC CARTILAGE T. Miyaji*, T. Nakase, T. Tomita, M. Kaneko, K. Takahi, A. Myoui, K. Kuriyama, M. Horiki, H. Yoshikawa Department of Orthopaedic Surgery, Osaka University Medical School, Osaka, Japan

P28 W

PENTADECAPEPTIDE BPC-157 INCREASED ACHILE TENDOM HEALING AFTER UNILATERAL TRANSECTION IN THE RAT M. Staresinic*, B. Sebecic, T. Sosa, S. Jadrijevic, L. Patrlj, D. Perovic, G. Aralica, S. Seiwerth, N. Kokic, P. Sikiric Department of Surgery, Clinical Hospital "Merkur", Zagreb, Croatia; Departments of Pathology, School of Medicine, University of Zagreb, Zagreb, Croatia; Department of Oral Surgery, School of Dental Medicine, University of Zagreb, Zagreb, Croatia; Departments of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia

P52 W

BONE MORPHOGENETIC PROTEIN EXPRESSION IN DIFFERENTIATING OSTEOBLASTS IS REGULATED BY PARATHYROID HORMONE S. Martinovic*, V. Kisic, F. Borovecki, S. Vukicevic Department of Anatomy, School of Medicine, University of Zagreb, Zagreb, Croatia

P31 W

P34 W

P37 W

Diseases of Bone

HISTOMORPHOMETRIC ANALYSIS IN ILIAC BONE OF NORMAL KOREAN INDIVIDUALS K. B. Lee*, J. H. Kim, S. J. Kim, K. M. Yang, H. Y. Lee Ajou University School of Medicine, Suwon, Korea; National Institute of Scientific Investigation, Seoul, Korea THE ALTERNATIVELY SPLICED EIIIA SEGMENT IS PREFERENTIALLY EXPOSED TO ANTIBODY RECOGNITION IN AN OSTEOARTHRITIC SYNOVIAL FLUID FIBRONECTIN FRAGMENT SPECIES J. H. Peters*, S. Carsons, K. Kalunian, M. Yoshida, F. Ko, S. McDougall, T. J. Hahn GRECC, West Los Angeles VA Medical Center, Los Angeles, CA, USA; UCLA School of Medicine, Los Angeles, CA, USA; Sacramento VA Medical Center, Mather, CA, USA; Winthrop University Hospital, Mineola, NY, USA EXPRESSION OF HEPARAN SULFATE PROTEOGLYCAN CORE PROTEINS DURING IN VITRO-DIFFERENTIATION OF OSTEOBLAST-LIKE CELLS H. Hausser*, R. Brenner Division for Biochemistry of Joint and Connective Tissue Diseases, University of Ulm, Ulm, Germany

S8

P55 W

FELINE HEAD AND NECK SQUAMOUS CELL CARCINOMA LINE: CHARACTERIZATION, PRODUCTION OF PARATHYROID HORMONERELATED PROTEIN, AND REGULATION BY TRANSFORMING GROWTH FACTOR-BETA S. H. Tannehill-Gregg, E. Ahaus, T. J. Rosol* The Ohio State University, Columbus, OH, USA

P58 W

REGULATION OF PTHrP GENE EXPRESSION: A PATTERNS OF DNA METHYLATION IN BREAST CANCER CELL LINES M. Rousière, C. Cataisson, J. Foley, J. Taboulet, Z. Bouizar* U.349, Centre Viggo Petersen, Hôpital Lariboisière, 2 rue Ambroise Paré, Paris, France.; Medical Sciences, Indiana University School of Medicine, Bloomington, IN, USA

P61 W

RECOMBINANT HUMAN RANK LIGAND (RANKL) AND MACROPHAGE COLONY-STIMULATING FACTOR (M-CSF) FAIL TO RESCUE HUMAN INFANTILE OSTEOCLAST-POOR OSTEOPETROSIS (OP) IN VITRO H. M. Massey, C. G. Steward, C. Wilson, A. Vellodi, M. A. Horton, A. M. Flanagan* Royal Free and University College London Medical School, London, UK; Royal Hospital for Sick Children, Bristol, UK; Great Ormond Street Hospital, London, UK; Bone and Mineral Centre, University College, London, UK

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Wednesday, June 6, 2001 P88 W

ANTHROPOMETRIC DIAGNOSIS OF "TRUE" OSTEOPENIA IN CAPD PATIENTS BASED ON DEXAASSESSED MUSCLE-BONE RELATIONSHIPS A. Negri*, J. L. Ferretti, G. Cointry, J. R. Zanchetta Instituto de Investigaciones Metabolicas, Buenos Aires, Argentina

P91 W

HYPERCALCEMIA AND OSTEOMALACIA COMPLICATED BY OSTEOPETROSIS CAUSED BY HIGH CONCENTRATION OF FLUORIDE AND ALUMINIUM IN CHILDREN F. C. Li The Hygieme Anti-epidemic Station of Liu Panshui City, Guizhou, 553000

P67 W

FOOT ALGO-DISTROPHIC, POST-TRAUMATIC SYNDROME: ISSUES AND POSTURE MODIFICATIONS F. M. Donelli No affiliations

P94 W

P70 W

THE CHANGES OF SERUM FGF-2 LEVELS FOLLOWING BONE MARROW TRANSPLANTATION: IMPACT ON BONE MINERAL DENSITY M. I. Kang*, W. Y. Lee, E. S. Oh, K. W. Oh, J. H. Han, B. Y. Cha, K. W. Lee, H. Y. Son, S. K. Kang, C. C. Kim The Catholic University of Korea, College of Medicine, Seoul, Korea

CHARACTERISATION AND PARTIAL PURIFICATION OF PHOSPHATE UPTAKE INHIBITORY ACTIVITY OF CONDITIONED MEDIUM FROM A SECOND ONCOGENIC OSTEOMALACIA TUMOUR CELL LINE A. E. Nelson*, M. Mirams, O. Ljunggren, E. A. Martin, R. S. Mason, B. G. Robinson Cancer Genetics, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, Australia; Physiology Department, Institute of Biomedical Research, University of Sydney, Sydney, Australia; Department of Internal Medicine, University Hospital, Uppsala, Sweden

P97 W

BONE MINERAL DENSITY (BMD), BIOCHEMICAL MARKERS AND FRACTURES IN PERITONEAL DIALYSIS (PD) PATIENTS A. L. Negri*, M. Alvarez Quiroga, M. Bravo, A. Marino, E. E. Fradinger, C. E. Bogado, J. R. Zanchetta Instituto de Investigaciones Metablicas, Buenos Aires, AR; RTC Argentina, Suc. Caballito, Buenos Aires, AR

AN OCHRONOSIS CASE ASSOCIATED WITH SPINAL CHANGES SIMILAR TO ANKYLOSING SPONDYLITIS AND HIP OSTEOPENIA Y. Sermez*, G. Fidan, N. Oruç, N. Karabulut Pamukkale University, Department of Endocrinology and Metabolism, Denizli, Turkey; Pamukkale University, Department of Radiology Department, Denizli, Turkey

P100 W

CELLULAR ORIGIN AND OSTEOLYTIC ACTIVITY OF THE UNICAMERAL BONE CYST F. Y. Lee*, G. Osgood, M. Parisien, H. M. Dick Columbia University, USA

P103 W

FIFTEEN TO SEVENTEEN YEAR FOLLOW UP OF THE UNCEMENTED SPONGIOSA METAL SURFACE (SMS) TOTAL HIP ARTHROPLASTY J. Scholz*, D. Hubalek, J. Osel, C. Höptner Auguste-Victoria Teaching Hospital, Center for Orthopaedic Surgery, Berlin, Germany

P106 W

CANDIDATE GENES FOR DEGENERATIVE JOINT DISEASE IN PIGS D. Jefferies*, J. Thompson, W. Smith, E. Seawright, C. Farquharson, C. Whitehead Bone Biology Group, Roslin Institute, Roslin, UK; SAC Veterinary Services, Penicuik, UK; SAC Veterinary Science Division, Aberdeen, UK

P109 W

AGE DEPENDENT DEMISE OF MUTATED STEM CELLS AND "NORMALIZATION" OF FIBROUS DYSPLASIA OF BONE P. Bianco*, S. A. Kuznetsov, M. Riminucci, N. Cherman, L. W. Fisher, M. T. Collins, S. Wientroub, P. G. Robey Universita "La Sapienza", Rome, Italy; CSDB, NIDCR, NIH, Bethesda, MD, USA; Universita dell'Aquila, L'Aquila, Italy; Tel Aviv Medical Center, Tel Aviv, Israel

P112 W

SEQUENCE ANALYSIS OF MEASLES VIRUS NUCLEOCAPSID TRANSCRIPTS IN PATIENTS WITH PAGET'S DISEASE S. V. Reddy, W. E. Friedrichs, G. D. Roodman* Univ TX HSC @ SA, San Antonio, TX, USA

P73 W

P76 W

P79 W

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P85 W

CIRCULATING OSTEOPROTEGERIN (OPG) IS AN UREMIC TOXIN TO CAUSE BONE AND PARATHYROID DISORDERS IN DIALYSIS PATIENTS J. J. Kazama Niigata University, Niigata, Japan; Kobe University, Kobe, Japan; National Sakura Hospital, Chiba, Japan; Tokyo Jikeikai Medical School, Tokyo, Japan; Tokai University, Kanagawa, Japan CLINICAL STUDY ABOUT THE RELATIONSHIP BETWEEN DIABETES AND OSTEOPOROSIS P. S. Li*, H. Qian, H. Jiang Department of Gerontology, 304 Hospital, Beijing 100037, China HIGH PREVALENCE AND INCIDENCE OF VERTEBRAL DEFORMITIES IN ANKYLOSING SPONDYLITIS PATIENTS WITH HYPERKYPHOSIS P. P. M. M. Geusens*, D. Vosse, D. van der Heijde, J. Vanhoof, J. Raus, S. van der Linden Department of Rheumatology, University Hospital, Maastricht, The Netherlands; Biomedical Research Institute, Limburg University Centre, Diepenbeek, Belgium EXPRESSION OF BONE INDUCING FACTORS IN RATS WITH OR WITHOUT A TIBIA FRACTURE AFTER TRAUMATIC BRAIN INJURY U. Scherbel*, J. Khurana, C. T. Born, P. Riess, W. G. DeLong University of Pennsylvania, Department of Orthopaedic Surgery; University of Cologne, Department of Surgery II; University of Pennsylvania, Department of Pathology; University of Pennsylvania, Department of Neurosurgery

S9

Wednesday

HYPOPHOSPHATEMIC HYPOPARATHYROIDISM AND RICKETS WITH CALCIUM SUPPLEMENTATION AND HYPOCALCITRIOLIC HYPERPARATHYROIDISM AND OSTEOCHONDROSIS WITH CALCIUM AND PHOSPHORUS SUPPLEMENTATION IN YOUNG DOGS I. Schoenmakers*, G. Voorhout, C. S. Carlson, J. A. Mol, D. Richardson, H. A. W. Hazewinkel Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, The Netherlands; Department of Veterinary Diagnostic Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA; Hill's Science and Technology Center, Topeka, Kansas, USA

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SEVERITY OF PAGET'S DISEASE IN THE UK: IS IT DECLINING? G. I. Al-Bahrani*, R. S. Lawson, M. C. Prescott, M. Davies, P. L. Selby Department of Nuclear Medicine, Manchester Royal Infirmary, Manchester, UK; Musculoskeletal Research Group, University of Manchester, Manchester, UK

P118 W

BISPHOSPHONATE (OLPADRONATE) RETENTION AND ITS DETERMINANTS IN PAGET'S DISEASE OF BONE S. C. L. M. Cremers*, E. Eekhoff, S. M. van Dam, J. Hartigh, N. A. T. Hamdy, P. Vermeij, S. E. Papapoulos Leiden University Medical Center, Department of Clinical Pharmacy and Toxicology; Leiden University Medical Center, Department of Endocrinology

P121 W

LOW BONE DENSITY IS ASSOCIATED WITH REDUCED LEAN SOFT TISSUE MASS IN PROSTATE CANCER PATIENTS TREATED WITH ANDROGEN ABLATION Z. Chen*, P. T. Nguyen, M. J. Maricic, F. R. Ahmann, B. L. Dalkin University of Arizona

P124 W

EFFECT OF ESTROGEN AND CALCITRIOL REPLACEMENT IN BONE MASS IN RATS WITH RENAL FAILURE IN LONG AND SHORT-TERM ESTROGEN DEPRIVATION M. Naves*, C. Díaz-Corte, C. Gómez, S. Braga, M. T. Fernández-Coto, M. Serrano, A. González, A. Rodríguez, J. B. Cannata Bone and Mineral Research Unit. Instituto Reina Sofía de Investigación, Oviedo, Spain; Biochemistry Unit, Hospital Central de Asturias, Oviedo, Spain

IBMS/ECTS 2001 - First Joint Meeting

POLYMORPHISMS IN THE ANDROGEN AND ESTROGEN RECEPTOR ALPHA GENES ARE ASSOCIATED WITH BMD IN MIDDLE-AGED FINNISH MEN T. Remes*, S. B. Väisänen, J. Huuskonen, A. Mahonen, I. M. Penttilä, P. Mäenpää, H. Kröger, R. Rauramaa Department of Biochemistry, University of Kuopio, Finland; Kuopio Research Institute of Exercise Medicine and Department of Physiology, University of Kuopio, Finland; Department of Clinical Chemistry, Kuopio University Hospital, Finland; Department of Surgery, Kuopio University Hospital, Finland; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Finland

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A LARGE CONSANGUINEOUS OSTEOPOROSIS FAMILY WITH 20 AFFECTED INDIVIDUALS P. Dincer, B. O. Yildiz*, B. Balci, M. Bayraktar Hacettepe University Faculty of Medicine Dept of Medical Biology, Ankara, Turkey; Hacettepe University Faculty of Medicine Dept of Internal Medicine Division of Endocrinology, Ankara, Turkey

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THERE IS NO ASSOCIATION BETWEEN THE POLYMORPHISM OF ESTROGEN RECEPTOR GENE AND TRANSSEXUAL MEN M. Sosa*, A. Torres, E. Salido, E. Arbelo, Y. Barrios, M. C. Navarro, P. Betancor University of Las Palmas de GC, Hospital University Insular. Bone Metabolic Unit; Investigation Unit, University of La Laguna; University of Las Palmas de Gran Canaria, Department of Nursery

COLLAGEN TYPE I ALPHA 1 SP1 POLYMORPHISM, OSTEOPOROSIS AND OSTEOARTHRITIS IN OLDER MEN AND WOMEN S. M. F. Pluijm*, H. W. van Essen, N. Bravenboer, A. G. Uitterlinden, J. H. Smit, P. Lips Institute for Research in Extramural Medicine (EMGOInstitute), Vrije Universiteit, Amsterdam, The Netherlands; Endocrinology, Academic Hospital, Vrije Universiteit, Amsterdam, The Netherlands; Department of Internal Medicine III, Erasmus University Medical School, Rotterdam, The Netherlands; Department of Sociology and Social Gerontology, Vrije Universiteit, Amsterdam, The Netherlands

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APOLIPOPROTEIN E GENOTYPE INFLUENCES BONE LOSS AND BIOCHEMICAL MARKERS OF BONE TURNOVER IN ELDERLY POSTMENOPAUSAL WOMEN J. K. Scariano*, P. J. Garry, G. Montoya, R. N. Baumgartner University of New Mexico School of Medicine, Albuquerque, New Mexico, USA

Hormones and Cytokines

Genetics P127 W

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THE EFFECT OF CALCITONIN ON HEALING OF TENDON INJURIES. FOLLOW-UP OF TENDON HEALING WITH MRI, HISTOLOGICAL EVALUATION AND MECHANICAL TESTING. EXPERIMENTAL STUDY IN RABBITS H. Petrou*, T. Karachalios, L. Khaldi, K. Kalogera, G. P. Lyritis Athens University, KAT Hospital, Kifissia, Greece; Laboratory for the Research of the Musculoskeletal Systeme

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HIGH EXTRACELLULAR GLUCOSE CONCENTRATION ENHANCES THE SENSITIVITY OF THE CALCIUM-SENSING RECEPTOR H. Kanazawa*, H. Tanaka, M. Inoue, Y. Seino Okayama University Medical School, Okayama, Japan

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INCREASED CALCIUM-SENSING RECEPTOR EXPRESSION IN CALCIUM-SUPPLEMENTED RATS WITH RENAL FAILURE B. D. Kuizon*, I. B. Salusky, D. Shoback, E. Cambay, H. Jueppner, W. G. Goodman UCLA School of Medicine, Los Angeles, USA; Endocrine Research Unit, VA Medical Center, San Francisco, USA; Endocrine Unit, Massachusetts General Hospital, Boston, USA

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MARKERS OF BONE RESORPTION IN PATIENTS WITH BREAST CANCER RECEIVING PAMIDRONATE E. Terpos*, J. Palermos, M. Vassilaki, G. Papadopoulos, G. Vaiopoulos, J. Meletis First Department of Internal Medicine, University of Athens Medical School, Laiko General Hospital, Athens, Greece; Department of Immunology, 251 General Air Force Hospital, Athens, Greece; "Hygeia" Hospital, Athens, Greece; Department of Medical Oncology, 251 General Air Force Hospital, Athens, Greece

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HISTOMORPHOMETRIC ANALYSIS OF BONE REMODELLING IN PATIENTS WITH METASTATIC BREAST CARCINOMA S. Vukmirovic Popovic*, N. R. Colterjohn, S. Lhotak, W. C. M. Duivenvoorden, G. Singh Department of Pathology and Molecular Medicine, McMaster University, Hamilton; Hamilton Health Sciences Corporation; Hamilton Regional Cancer Centre, Cancer Care Ontario; Hamilton, Ontario, Canada

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IBMS/ECTS 2001 - First Joint Meeting THE PRELIMINARY STUDY OF RELATIONSHIP BETWEEN MALIGNANT TUMOUR AND OSTEOPOROSIS M. H. Bai The Orthopaedics Institute of Lanzhou General Hospital, PLA, 730050, PR China

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PROTECTION OF NORMAL HUMAN BONE CELLS FROM APO2L/TRAIL AND CHEMOTHERAPEUTIC DRUG COMBINATION-INDUCED APOPTOSIS D. M. Findlay*, S. Bouralexis, G. J. Atkins, F. Chai, S. Hay, M. T. Clayer, A. Evdokiou Dept. of Orthopaedics and Trauma, Royal Adelaide Hospital, The University of Adelaide, Adelaide, SA, Australia; Dept. of Medicine, Dept. Orthopaedics, The Queen Elizabeth Hospital, The University of Adelaide, Woodville, SA, Australia

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BONE SIALOPROTEIN EXPRESSION IN CELL LINES OF HUMAN BREAST AND PROSTATE CANCER B. Fohr*, M. F. Young, L. W. Fisher Department of Medicine I, University of Heidelberg, Germany; Craniofacial and Skeletal Diseases Branch, NIDCR, NIH, Bethesda, MD, USA

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CLINICAL EVALUATION OF A NEW ASSAY FOR URINARY L-GALACTOSYLHYDROXYLYSINE (LGHL): A PROMISING MARKER FOR CANCER PATIENTS J. C. Dumon*, N. Kheddoumi, F. Journé, R. B. Boga, J. Mistry, J. J. Body Laboratory of Endocrinology and Breast Cancer; Diagnostic Systems Laboratories, Inc., Webster, TX 77598, USA

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COMPARATIVE STUDY OF THE SENSITIVITY OF BIOCHEMICAL MARKERS OF BONE TURNOVER IN PATIENTS WITH BONE METASTASES FROM BREAST CANCER J. C. Dumon*, B. Siwek, N. Kheddoumi, F. Journé, J. Barlé, J. J. Body Laboratory of Endocrinology and Breast Cancer Research and Clinical Chemistry INTERLEUKIN-6 EXPRESSION IN OSTEOBLASTIC CELLS IS MODULATED BY BOTH HOMOLOGOUS AND HETEROLOGOUS MECHANISMS INVOLVING PARATHYROID HORMONE-RELATED PROTEIN C. Guillen*, P. Martinez, M. E. Martinez, N. Del Valle, P. Esbrit Bone and Mineral Metabolism Lab. Fund J Díaz; Research Unit, Hosp. La Paz; Biochemistry Division, Hosp. La Paz CYTOKINES, OSTEOPROTEGERIN AND OSTEOPROTEGERIN-LIGAND IN VITRO AND HISTOMORPHOMETRIC INDICES OF BONE FORMATION IN PATIENTS WITH DIFFERENT BONE DISEASES H. Siggelkow*, T. Eidner, G. Lehmann, V. Viereck, D. Raddatz, G. Hein, M. Hüfner Dep. for Gastroenterology and Endocrinology, University Hospital of Goettingen, Germany; Dep. of Internal Medicine, Friedrich-Schiller- University, Jena, Germany; Dep. of Obstetrics and Gynecology, University Hospital of Goettingen, Germany

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INCREASED LEVELS OF THE STIMULATORY IGF BINDING PROTEIN-5 (IGFBP-5) IN EXTRACTS OF BONE MATRIX FROM OSTEOARTHRITIS AND PAGET'S DISEASE S. J. Brown*, S. Mohan, P. Magnusson, M. W. J. Davie, C. A. Sharp Charles Salt Research Centre, Oswestry, UK; Musculoskeletal Disease Center, JL Pettis VA Medical Center, Loma Linda, USA; Chester Centre for Stress Research, Chester, UK

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PTH AMELIORATES THE ACIDOSIS-INDUCED SKELETAL GROWTH INHIBITION VIA THE INSULINLIKE GROWTH FACTOR 1 (IGF1) G. Maor*, R. Goldberg, J. Green Technion, Haifa, Israel; Department of Nephrology, Rambam Medical Center, Haifa, Israel

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PERIPHERAL PTH1 RECEPTOR GENE DELIVERY IN SPONTANEOUSLY HYPERTENSIVE RATS (SHR) DOES NOT AFFECT BLOOD PRESSURE BUT INCREASES PLASMA RENIN ACTIVITY S. Fritsch, T. Massfelder, M. Grima, N. Taesch, A. Eichinger, B. Escande, M. Barthelmebs, J. J. Helwig* University Louis Pasteur Medical School, E 0015 INSERM, Strasbourg, France; University Louis Pasteur Medical School, Department of Pharmacology, Strasbourg, France

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EARLY PHASE OF CALCIPENIA-INDUCED PARATHYROID HORMONE SECRETION IS BLUNTED IN PERFUSED PARATHYROID GLANDS OF STREPTOZOTOCIN-DIABETIC RATS O. Mokuda*, R. Okazaki, Y. Sakamoto Teikyo University, Ichihara, Japan

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LONG-TERM STUDY OF FUNCTIONALLY AND VIABILITY OF RAT AND HUMAN PARATHYROID GLANDS M. Naves*, J. Menárguez, J. R. Polo, R. Jofré, J. Anguita, M. T. Fernández-Coto, J. L. Fernández-Martín, J. B. Cannata Bone and Mineral Research Unit. Instituto Reina Sofía de Investigación, Oviedo, Spain; Biochemistry Unit. Hospital Central de Asturias, Oviedo, Spain; Hospital Universitario Gregorio Marañón, Madrid, Spain

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CHARACTERISATION OF THE EFFECTS OF DEXAMETHASONE ON MOUSE BONES F. McLaughlin*, J. MacKintosh, B. Hayes, A. McLaren, P. L. Salmon, J. A. Humphreys, G. Brown, S. Farrow Cell Biology, GlaxoWellcome Medicines Research Centre, Stevenage, UK; Respiratory Systems, GlaxoWellcome Medicines Research Centre, Stevenage, UK; AEA Technology, Harwell, Didcot, Oxfordshire, UK

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ANALYSIS BY DIFFERENTIAL DISPLAY PCR OF THE MOLECULAR MECHANISM BY WHICH LEUKEMIA INHIBITORY FACTOR MEDIATES INHIBITION OF OSTEOPROGENITOR CELL DIFFERENTIATION D. Falconi*, J. Dreisziger, M. Kwok, J. E. Aubin Department of Anatomy and Cell Biology, University of Toronto, Toronto, Ontario M5S 1A8, Canada

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ANALYSIS OF 17BETA-ESTRADIOL, RALOXIFENE AND GENISTEIN STIMULATED HUMAN OSTEOBLAST CELLS USING THE GENECHIP DNA MICROARRAY TECHNOLOGY M. Heim*, J. Shantz, O. Frank, P. Fuchs, C. Riegger, P. Weber, W. Hunziker, I. Martin, I. Bendik Hoffmann-La Roche Ltd, Vitamins & Fine Chemicals Division, Department VFHF, CH-4070 Basel, Switzerland; Hoffmann-La Roche Ltd, Vitamins & Fine Chemicals Division, Department VFH, CH-4070 Basel, Switzerland; Research Division, Department of Surgery, University Hospital Basel, Switzerland

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ADRENOMEDULLIN AND ADRENOMEDULLIN RECEPTOR MRNA EXPRESSION IN OSTEOBLASTLIKE CELLS. DEXAMETHASONE EFFECT E. Diampaka, M. A. Denne, M. C. de Vernejoul, M. Cressent* U.349 Inserm Hôpital Lariboisière, Paris, France

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MICRO- AND NANOSTRUCTURE OF MINERALISED TISSUE IN MICE OVEREXPRESSING THE TRANSCRIPTION FACTOR FRA-1 P. Roschger*, W. Tesch, K. Matsuo, W. Jochum, E. F. Wagner, P. Fratzl, K. Klaushofer Ludwig Boltzmann Institute of Osteology, 4th Medical Department, Hanusch Krankenhaus and Unfallkrankenhaus Meidling, Vienna, Austria; Erich Schmid Institute of Materials Science, Austrian Academy of Sciences and University of Leoben, Leoben, Austria; Research Institute of Molecular Pathology (I.M.P.), Vienna, Austria

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CERIVASTATIN INDUCES BONE-SPECIFIC GENE EXPRESSION IN STROMAL PREADIPOCYTES W. Carley*, S. Phan Bayer Research Center, West Haven, CT, USA

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FGF2 AND FGFR-2 SIGNALING STIMULATED RUNX2 EXPRESSION H. M. Ryoo*, H. J. Kim, M. H. Park, H. I. Shin, H. J. Kim Kyungpook National University, Taegu, Korea

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LEPTIN CONTROL OF BONE METABOLISM: DIRECT OR INDIRECT ACTION? B. A. J. Evans*, C. Elford, J. W. Gregory Department of Child Health, University of Wales College of Medicine, Heath Park, Cardiff, UK

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CHARACTERIZATION OF CELL LINES DERIVED FROM PERIODONTAL LIGAMENT T. Yoshizawa*, Y. Saito, M. Ikegame, O. Ishibashi, H. Yoshie, M. Obinata, H. Kawashima Niigata University, Niigata, Japan; Tohoku University, Miyagi, Japan

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ISOLATION AND CHARACTERIZATION OF EQUINE OSTEOCALCIN B. Carstanjen*, R. Wattiez, H. Amory, O. M. Lepage, B. Remy Department of Large Animal Medicine, University of Liège, Sart-Tilman, Belgium; Service de Chimie Biologique, Université de Mons, Hainaut, Belgium; Département Hippique, Ecole Nationale Vétérinaire de Lyon, Marcy l'Etoile, France; Département de Physiologie de la Reproduction, Université de Liège, Sart-Tilman, Belgium MICROGRAVITY ACCELERATES DIFFERENTIATION, INDUCES APOPTOSIS AND STIMULATES INTERLEUKIN 6 EXPRESSION IN OSTEOBLAST-LIKE CELLS N. Rucci*, S. Migliaccio, A. Taranta, A. Teti Department of Experimental Medicine, University of L'Aquila, L'Aquila, Italy; Department of Histology and Medical Embryology, University "La Sapienza", Rome, Italy; Department of Medical Physiopathology, University "La Sapienza", Rome, Italy; Istituto Dermopatico dell'Immacolata, Rome, Italy

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ROLE OF MECHANICAL STRESS ON CULTURED SPINAL LIGAMENT CELLS DERIVED FROM PATIENTS WITH OSSIFICATION OF THE POSTERIOR LONGITUDINAL LIGAMENTS INVESTIGATED BY THE MRNA DIFFERENTIAL DISPLAY TECHNIQUE K. Iwasaki*, K. Furukawa, M. Tanno, K. Ueyama, S. Harata, S. Motomura Department of Orthopedic Surgery Hirosaki University School of Medicine, Hirosaki, Japan; Department of Pharmacology Hirosaki University School of Medicine, Hirosaki, Japan

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INTRACELLULAR PRODUCTION OF CGMP STIMULATES THE DIFFERENTIATION OF OSTEOBLASTIC CELLS H. Hagiwara*, E. Otsuka, A. Koyama, A. Inoue Tokyo Institute of Technology, Yokohama, Japan

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ROLE OF P53 AND MDM-2 IN OSTEOBLAST DIFFERENTIATION N. Chandar*, S. Bovenkerk, M. Nerney Department of Biochemistry, Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, IL, USA

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POTENTIAL OSTEOGENESIS IN A NOVEL POROUS HYDROXYAPATITE COMBINED WITH TRANSPLANTED BONE MARROW DERIVED OSTEOBLASTIC CELLS J. Dong*, H. Kojima, T. Uemura, M. Kikuchi, T. Tateishi, J. Tanaka National Institute for Advanced Interdisciplinary Research (NAIR), Tsukuba, Japan; Shanghai Medical University, Shanghai, P.R.China; CREST JST (Japan Science and Technology); National Institute for Research in Inorganic Materials (NIRIM), Tsukuba, Japan; University of Tokyo, Tokyo, Japan

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EFFECTS PRODUCED BY BONE ALLOGRAFT MATRIX ON HUMAN OSTEOBLAST PROLIFERATION AND INTERLEUKIN-6 AND PROCOLLAGEN-I SYNTHESIS L. Rodriguez de Acuña*, C. García-Moreno, C. De la Piedra, C. Vicario, S. Arlandis, L. López-Durán, M. L. Traba Fundación Jiménez Díaz, Laboratorio de Bioquímica, Madrid, Spain.; Hospital Clínico San Carlos, Traumatología y Cirugía Ortopédica, Madrid, Spain

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EFFECTS OF PERIODIC PULSED ELECTROMAGNETIC FIELD STIMULATION ON PROLIFERATION, DIFFERENTIATION AND BONELIKE MATRIX MINERALIZATION IN OSTEOBLASTS IN DIFFERENT MATURATIONAL STAGES P. Diniz*, K. Shomura, K. Soejima, G. Ito Kagoshima University Dental School, Kagoshima, Japan

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HIGH-RESOLUTION MORPHOMETRIC AND TOPOGRAPHIC ANALYSIS OF HUMAN OSTEOBLASTIC CELL ADHESION ON ORTHOPEDIC ALLOYS FUNCTIONALIZED BY ADHESIVE PEPTIDES - A QUANTITATIVE 2D AND 3D ANALYSIS A. Guignandon*, N. Boutahar, R. Bareille, Y. Usson, S. Verrier, L. Vico, C. Alexandre, J. Amédée INSERM EM9901, J Monnet University, St-Etienne, France; DyOGen, Institut A. Bonniot, Grenoble, France; U443 INSERM, Bordeaux, France

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IBMS/ECTS 2001 - First Joint Meeting CELL-MATRIX INTERFACE IN BONE A. Boyde University College London, London, UK

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ALENDRONATE INTERACTS WITH THE INHIBITORY EFFECT OF 1,25(OH)2D3 ON PTHrP EXPRESSION IN HUMAN OSTEOBLASTIC CELLS L. Gomez-Garcia*, M. Garcia-Flores, P. Sabando, A. Valin, L. Carreño, P. Esbrit, M. E. Martinez Biochemistry Division .La Paz Hospital; Rheumatology Division. Princesa Hospital; Bone and Mineral Metabolism Laboratory, Fundación Jiménez Díaz; Rheumatology Division Gregorio Marañón Hospital

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INVOLVEMENT OF INAD AND TRPC3-LIKE PROTEIN IN THE 1,25-DIHYDROXY-VITAMIN D3-INDUCEDCAPACITATIVE CATION ENTRY IN ROS 17/2.8 OSTEOBLASTIC-LIKE CELLS C. Baldi*, G. Vazquez, R. L. Boland Dept. Biologia, Bioquimica & Farmacia - Universidad Nacional del Sur, Bahia Blanca, Buenos Aires, Argentina

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ZINC MAPPING IN OSTEOBLASTS AND BONE MATRIX S. Gomez Dept Anatomia Patologica, Faculty of Medicine, University of Cadiz, Spain

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ACTIVATION OF PEROXISOME PROLIFERATORACTIVATED RECEPTOR GAMMA PATHWAY STIMULATES OSTEOBLASTIC DIFFERENTIATION OF HUMAN MESENCHYMAL STEM CELLS T. Xu*, A. Billin, D. Morris, T. Willson, L. Miller Glaxo Wellcome Research and development, Reseach Triangle park, NC, USA

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P2 RECEPTOR STIMULATION UPREGULATES EXPRESSION OF OSTEOCLAST DIFFERENTIATION FACTOR (ODF) BY HUMAN OSTEOBLASTS K. A. Buckley*, J. A. Gallagher, W. B. Bowler Human Bone Cell Research Group, Department of Human Anatomy and Cell Biology, New Medical School, Ashton Street, University of Liverpool, L69 3GE, UK

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EXPRESSION OF OSTEOCLASTOGENIC MARKERS IN INFLAMED SYNOVIAL TISSUES IN PROSTHESIS LOOSENING AND ARTHRITIS A. Sabokbar*, A. Pocock, O. Kudo, S. D. Neale, E. Schulze, L. Danks, N. A. Athanasou University of Oxford, Oxford, UK

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OSTEOCLAST SIZE CORRELATES WITH DIFFERENCES IN RESORPTIVE ACTIVITY J. N. M. Heersche*, R. Lees, M. F. Manolson, V. Sabharwal Faculty of Dentistry, University of Toronto, Toronto, Canada

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FOLLOWING OF INTRACELLULAR VESICLE TRAFFIC IN LIVING OSTEOCLASTS USING CONFOCAL MICROSCOPY J. Vaaraniemi*, H. K. Vaananen Institute of Biomedicine, Department of Anatomy, University of Turku, Finland

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ACTIVATED ENDOTHELIUM RECRUITS OSTEOCLAST PRECURSORS FROM PERIPHERAL BLOOD N. W. A. McGowan*, E. J. Walker, S. H. Ralston, M. H. Helfrich Bone Research Group, Dept. of Medicine and Therapeutics, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, UK

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P289 W THE MECHANISM OF RGD-INSULIN ANTIOSTEOCLASTIC BONE RESORPTION Y. Xue*, D. Li Department of Biochemistry, Beijing Ji Shui Tan Hospital, Beijing, P.R. China

CONNEXIN-MIMETIC PEPTIDE GAP 27 DECREASES OSTEOCLASTIC ACTIVITY J. Ilvesaro*, P. Tavi, J. Tuukkanen University of Oulu, Finland

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OSTEOCLAST DIFFERENTIATION FACTOR IS DOMINANT IN CONTROLLING THE EXTENT OF BONE RESORPTION N. Fazzalari*, J. Kuliwaba, G. Atkins, M. Forwood, D. Findlay Institute of Medical and Veterinary Science; Adelaide University; University of Queensland

THE EFFECT OF CLODRONATE METABOLISM ON THE INTRACELLULAR ATP CONCENTRATION IN RAW 264 MACROPHAGES H. Mönkkönen*, S. Niva, M. J. Rogers, J. Mönkkönen Department of Pharmaceutics, University of Kuopio, Finland; Department of Medicine and Therapeutics, University of Aberdeen, UK

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BONE RESORPTION IS DECREASED IN VITRO BY 17B ESTRADIOL AND RALOXIFENE FROM HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS M. A. Burde*, Ph Couttet, D. Saintier, M. C. de Vernejoul, M. E. Cohen-Solal INSERM U349, Paris, France

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FUNCTIONAL ROLE OF IONOTROPIC NON-NMDA RECEPTORS IN OSTEOCLAST RESORPTIVE ACTIVITY M. Mukhida*, R. Gilbert, Y-F. Chen, G. I. Anderson Dalhousie University, Halifax, Nova Scotia, Canada

EFFECTS OF THE NATURAL AND ARTIFICIAL MENSTRUAL CYCLE ON SECRETION OF BONE RESORPTIVE CYTOKINES IN WHOLE-BLOOD CULTURES B. Abrahamsen, L. Nickelsen*, V. Bonnevie, H. BeckNielsen Dept of Endocrinology, Odense Univ. Hospital, Odense, Denmark; Dept. of Medical Biology, Univ. of South Denmark, Odense, Denmark LIMITED RANKL EXPOSURE IN VITRO INDUCES OSTEOCLASTOGENESIS IN HUMAN PBMC G. C. Nicholson, C. J. Aitken, J. M. Hodge, W. R. Holloway, T. Gough, F. Collier, M. A. Kirkland, D. E. Myers* Department of Medicine, University of Melbourne, The Geelong Hospital; The Douglas Hocking Institute, The Geelong Hospital, Barwon Health

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IBMS/ECTS 2001 - First Joint Meeting

Osteoporosis: Diagnosis

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FRACTURE CASE HISTORY AT OSTEOPOROSIS, RELATION TO CURRENT RESULTS IN THE QCT AND PQCT K. Abendroth Regional Experts Group for Osteoporosis in Saxony and Thuringia, Jena, Germany

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BONE MASS ASSESSMENT BY DIGITAL X-RAY RADIOGRAMMETRY IN SPANISH POPULATION. COMPARISON WITH DUAL X-RAY ABORPTIOMETRY AND QUANTITATIVE ULTRASOUND C. Gómez*, L. Casado, J. C. Barredo, A. Iglesias, V. Valencia, M. Naves, J. L. Fernández, J. B. Díaz, J. B. Cannata Bone and Mineral Research Unit, Instituto Reina Sofía de Investigación, Hospital Central de Asturias, Oviedo, Spain; Health Centre of Vallobín; Health Centre of Ventanielles; Health Centre of Castrillón, Asturias, Spain

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INFLUENCE OF DIFFERENT DXA DEVICES ON DETECTION OF OSTEOPOROSIS IN PATIENTS SAMPLE P. Kasalicky*, J. Rosa, J. Kocian Postgraduate Medical School, Ist Med.Clin.; MEDISCAN densitometric center; Reumatologic institute

DIGITAL X-RAY RADIOGRAMMETRY ON HAND XRAYS N. Baadegaard*, R. Linde, O. Wendt, A. Rosholm Pronosco A/S, Vaedbaek, Denmark

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ELECTROALGOMETRY. DECREASE OF SKIN IMPEDANCE AS A MEASURE OF BONE AND JOINT PAIN T. Fujita*, Y. Fujii, A. Miyauchi, Y. Takagi Calcium Research Institute, Osaka, Japan; Katsuragi Hospital, Osaka, Japan; National-Hyogo Chuo Hospital, Hyogo, Japan

AGE- AND GENDER-RELATED CHANGES IN THE HUMAN SPINE AND ILIAC CREST ASSESSED BY STATIC HISTOMORPHOMETRY J. S. Thomsen*, E. N. Ebbesen, L. Mosekilde Department of Cell Biology, University of Aarhus, Aarhus, Denmark

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BONE RESORPTION IN POSTMENOPAUSAL WOMEN WITH NORMAL AND LOW BMD ASSESSED WITH BIOCHEMICAL MARKERS SPECIFIC FOR TELOPEPTIDE DERIVED DEGRADATION PRODUCTS OF COLLAGEN TYPE I J. Y. Reginster*, A. N. Taquet, C. Christiansen, E. Gamwell-Henriksen, O. Bruyere, J. Collette, S. Christgau WHO Collaborating Center for Public Health Aspects of Osteoarticular Disorders; Bone and Cartilage Metabolism Unit, University of Liège, Liège, Belgium; Center for Clinical and Basic Research, Ballerup, Denmark; Osteometer BioTech, Herlev, Denmark

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BIOCHEMICAL MARKERS IN MENOPAUSAL WOMEN J. Ferrer-Cañabate*, I. Tovar, P. Martinez Servicio AA.CC. H.U. Virgen Arrixaca

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URINARY EXCRETION OF B, CA, MG AND P IN POSTMENOPAUSAL WOMEN WITH AND WITHOUT OSTEOPOROSIS E. Arévalo González*, O. M. Alarcón, M. Mora, J. R. Vielma, L. Linares de M., G. Hernández de Avila Universidad de Los Andes, Mérida, Venezuela

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IS FRACTURE RISK RELATED TO THE RELATIVE RATES OF BONE FORMATION VERSUS RESORPTION? A PROSPECTIVE STUDY J. W. Davis, P. D. Ross*, W. Knowlton, H. Katagiri, R. D. Wasnich Hawaii Osteoporosis Center, Honolulu, HI, USA; Merck & Co., Inc., Rahway, NJ, USA; Tottori University, Yonago, Japan

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THE EFFECT OF STORAGE AND MAILING ON STABILITY OF URINARY NTX R. A. Hannon*, I. B. Catch, A. Price, R. Eastell Bone Metabolism Group, Division of Clinical Sciences (NGHT), University of Sheffield, Sheffield, UK; Clinical Chemistry, Northern General Hospital, Sheffield, UK

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YOUNG ADULT BONE MINERAL DENSITY IN CROATIA S. Cvijetic*, S. Bolanca, D. Dekanic Institute for Medical Research and Occupational Health, Ksavesrka cesta 2, Zagreb, Croatia

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BONE MINERAL DENSITY IN LUMBAR SPINE AND FEMORAL NECK IN THE FEMALE POPULATION OF MOSCOW N. V. Toroptsova*, N. V. Demin, L. I. Benevolenskaya Institute of Rheumatology, Moscow, Russia

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MENOPAUSAL AGE AND BMI INFLUENCE CORRELATION BETWEEN LUMBAR AND FEMORAL BMD M. Di Stefano*, I. Grosso, F. Navone, C. Roggia, S. Casalis, G. C. Isaia Department of Internal Medicine - University of Torino, Italy

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APPLYING A SIMPLE CLINICAL TOOL TO IDENTIFY OSTEOPOROSIS AMONG JAPANESE WOMEN S. Fujiwara*, N. Masunari, G. Suzuki, B. Sedrine, J. Y. Reginster Radiation Effects Research Foundation, Hiroshima, Japan; WHO Collaborating Center for Public Heath Aspects of Rheumatic Disorders, Liege, Belgium

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VALIDATION OF A SIMPLE CLINICAL TOOL TO IDENTIFY ASIAN WOMEN WITH OSTEOPOROSIS R. Rajatanavin*, K-S. Tsai, S-P. Chan, A. Kung, Q-R. Huang, M-I. Kang, S. B. Chionh, W. Ben Sedrine, J-Y. Reginster, The Osteoporosis Risk Assessment Tool for Asia Research Group World Health Organization Collaborating Center for Public Health Aspects of Rheumatism

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DETERMINATION OF CA ISOTOPE RATIOS IN METABOLIC STUDIES USING SECTOR FIELD INDUCTIVELY COUPLED PLASMA MASS SPECTROMETER (HR-ICP-MS) M. P. Field, M. Cifuentes, R. M. Sherrell, S. A. Shapses* Rutgers University, New Brunswick, USA

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BONE MINERAL DENSITY AND BODY COMPOSITION ASSESSMENT IN CLINICAL PRACTICE T. O. Chernova Russian Endocrinology Research Centre, Moscow

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DETERMINATION OF BONE MINERAL DENSITY OF LIMBS AND PELVIC IN NORMAL SUBJECTS OF HENAN PROVINCE Z. C. Liu*, X. H. Wang Henan Electric Hospital, Zheng Zhou 450052, China

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IBMS/ECTS 2001 - First Joint Meeting CONSIDERATIONS REGARDING SOME BIOCHEMICAL MARKERS OF BONE METABOLISM AND OF CALCIOTROPIC HORMONES IN A GROUP OF ELDERLY SUBJECTS I. Zosin*, P. Bottermann, D. Ivan, C. Crista, D. Muresan Clinic of Endocrinology, University of Medicine and Pharmacy, Timisoara, Romania; 2nd Medical Clinic, Medical Faculty of Technical University, Munich, Germany

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PREDICTION OF FRACTURE LOAD: A CHICKEN TIBIA MODEL OF IMPENDING PATHOLOGICAL FRACTURE USING ULTRASOUND DENSITOMETRY R. S. Yang*, C. H. Lin, T. H. Huang, S. J. Lin National Taiwan University, Taipei, Taiwan; National Taiwan Normal University, Taipei, Taiwan

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THE IDENTIFICATION OF FRACTURE PATIENTS AT RISK OF OSTEOPOROSIS USING ULTRASOUND AS A RISK ASSESSMENT TOOL H. J. Veevers*, I. Stewart, D. P. Montgomery, A. Doyle Blackpool Wyre & Fylde Community Health Service NHS Trust, Blackpool, UK; Blackpool Victoria Acute Trust, Blackpool, UK; Blackpool Primary Care Group, Blackpool, UK

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EUROPEAN PEDIATRIC REFERENCE DATA FOR QUANTITATIVE ULTRASOUND OF FINGER PHALANGES R. Barkmann*, W. Rohrschneider, G. Baroncelli, R. Lorenc, R. Tormo, C-C. Glüer Medizinische Physik, UKK Kiel, Germany; Pädiatrische Klinik der Universität Heidelberg, Germany; Department of Reproductive Medicine and Pediatrics, Pisa, Italy; Children's Mem. Health Institute, Warsaw, Poland; Hospital Materno-Infantil "Vall d'Hebron", Barcelona, Spain

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DIAGNOSTIC OF OSTEOPOROSIS: CUT-OFF LEVELS BASED ON CALCANEOUS ULTRASOUND WITH TWO DIFFERENT DEVICES A. Diez-Pérez*, J. Puig, M. J. Peña, L. Mellibovsky, J. Carbonell, X. Sanz, X. Nogués Hospital del Mar-UAB and URFOA-IMIM, Barcelona, Spain

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EFECTS OF THE LOW BODY MASS INDEX ON THE VERTEBRAL MINERAL DENSITY AND BONE TURNOVER IN WOMEN WITH MILD FORM OF ANOREXIA NERVOSA AND REGULAR MENSES C. Dumitrache*, D. Grigorie, C. Barbu, E. Neacsu, M. Dumitrache C. I. Parhon Institute of Endocrinology, Bucharest, Romania

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VITAMIN D STATUS IN ELDERLY WOMEN WITH HIP FRACTURE R. Nuti*, G. Martini, R. Valenti, S. Giovani, S. Salvadori, M. G. Silvestri, A. Picchi, B. Galli, A. Spinola Chair of internal Medicine, Metabolic Disease Unit, University of Siena, Italy

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BONE MINERAL DENSITY AND CONTENT IN PREMENOPAUSAL WOMEN CONSUMING A VEGAN OR OMNIVORE DIET L. Stawasz*, B. Gale, K. Parker, B. Garzelli, A. Oberbauer, M. Van Loan University of California, Davis, Davis, CA, USA; United States Department of Agriculture, Western Human Nutrition Research Center, Davis, CA, USA

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THE RELATIONSHIP OF AGE AT MENARCHE AND BONE MINERAL DENSITY L. Qin*, J. Chen, W. Zhang, H. Ma, C. Ge, Y. Xiao China-Japan Friendship Hospital, Beijing, China

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BACK PAIN AND RELATED DISABILITY BEFORE AND AFTER CLINICALLY DIAGNOSED VERTEBRAL FRACTURES M. Nevitt*, L. Palermo, D. Thompson, D. Bauer, H. Fink, K. Stone, K. Ensrud, D. Black University of California, San Francisco, USA; Merck Scientific Communications, Rahway, NJ, USA; University of Minnesota, Minneapolis, USA

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PERIPHERAL FRACTURE RATE IS REFLECTED BY BONE MINERAL DENSITY AT THE AXIAL AND PERIPHERAL SKELETON C. Horvath*, K. Bors, S. Meszaros, J. Szucs, E. Hosszu 1st Dept.Medicine, Semmelweis University, Budapest, Hungary; Ferencvaros Osteoporosis Centre, Budapest, Hungary; 2nd Dept. Pediatrics, Semmelweis University, Budapest, Hungary

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THE RESULTS OF PAMUKKALE OSTEOPOROSIS STUDY IN TURKEY Y. Sermez*, M. G. Taþkale, N. Oruç Pamukkale University, Department of Endocrinology and Metabolism, Denizli, Turkey

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PATHOGENETIC ASPECTS OF DIABETIC OSTEOPENIA IN IDDM PATIENTS A. Katushkina*, E. Kholodova, T. Mokhort Minsk Medical Institute, Belarus

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OSTEOPOROSIS AND BONE METABOLISM IN PREMENOPAUSAL PATIENTS WITH CONGENITAL HIP DYSPLASIA C. M. Bonelli*, A. Fahrleitner, D. Walter, V. Stepan, C. J. Piswanger-Sölkner, H. Dobnig, G. Leb, B. ObermayerPietsch Department Internal Medicine, Karl Franzens Universität Graz,Austria

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EPIDEMIOLOGY OF OSTEOPOROSIS IN BRASIL AND THE EFFICACY OF A UNIQUE AND NATURAL DOLOMITE IN THE TREATMENT OF THE DISEASE S. Edelstein*, H. J. R. Sanson, M. Lev-Ran, I. Otremski, A. Ornoy Weizmann Institute of Science, Rehovot, Israel; Minervale Minerios Industriais Ltda, Sao Paulo, S.P., Brasil THE SIGNIFICANCE OF SERUM UNDERCARBOXYLATED OSTEOCALCIN LEVELS IN TYPE II DIABETIC OSTEOPOROSIS T. Horiuchi*, T. Hosoi, T. Nakamura, J. Inoue, S. Mizuno, H. Orimo Tokyo Metropolitan Geriatric Center; Tokyo Metropolitan Geriatric Institute CLINICAL CHARACTERISTICS AND AETIOLOGICAL FACTORS OF PRE-MENOPAUSAL OSTEOPOROSIS P. Peris*, N. Guañabens, L. Alvarez, A. Monegal, I. Ros, M. J. Martínez de Osaba, F. Pons, J. Muñoz-Gómez Hospital Clinic, University of Barcelona, Spain

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IS ASTHMA RELATED TO INCREASED FRACTURE RISK IN PERIMENOPAUSAL WOMEN? A. K. Laatikainen*, H. P. J. Kröger, R. J. Honkanen, H. O. Tukiainen, S. V. Saarikoski Department of Respiratory Medicine, Kuopio University Hospital, Finland; Department of Surgery, Kuopio University Hospital, Finland; Research Institute of Public Health, University of Kuopio, Finland; Department of Obstetrics and Gynaecology, Kuopio University Hospital, Finland CHANGES OF GROWTH HORMONE IN PATIENTS WITH HYPERTHYROIDISM COMPLICATED BY OSTEOPOROSIS Y. L. Zhang*, S. Q. Guo Department of Endocrinology, Baoding The First Hospital, Hebei Province, Baoding 071000, China THE EFFECT OF HAND OSTEOARTHRITIS ON PERIPHERIC AND AXIAL BONE MINERAL DENSITY S. Bagis*, G. Sahin, A. Bicer, O. Bolgen Cimen, S. Ozisik, C. Erdogan Mersin University, School of Medicine, Department of Physical Medicine and Rehabilitation, Mersin, Turkey

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RELATIONSHIP BETWEEN LIPID PROFILE AND BONE MASS IN HEALTHY MALES S. Adami*, V. Braga, M. Zamboni, D. Gatti, J. Bakri Rheumatology Unit, Valeggio S/M, Italy; Geriatric Unit, Verona, Italy

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OSTEOPOROSIS IN MEN G. Resmini*, P. Ballanti, E. Bonucci, A. Rubinacci Bone Metabolic Unit, Scientific Institute H. San Raffaele, Milan, Italy; Dept. of Experimental Medicine and Pathology, "La Sapienza" University, Rome, Italy

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BALANCE AND POSTURAL MEASURES ARE ASSOCIATED WITH BONE MASS IN ELDERLY, COMMUNITY-DWELLING WOMEN C. T. Lindsey, A. R. Brownbill, E. H. Mulrenan, R. W. Bohannon, J. Z. Ilich* University of Connecticut MULTIPLE NONSPINE FRACTURES ARE ASSOCIATED WITH GREATER PHYSICAL IMPAIRMENT J. W. Davis, P. D. Ross*, J. Chandler, W. Knowlton, R. D. Wasnich Hawaii Osteoporosis Center, Honolulu, HI; Merck & Co., Inc., Rahway, NJ, USA

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BONE MARKERS PROFILE DURING ADOLESCENT PREGNANCY ON CALCIUM SUPPLEMENTATION J. A. Prada*, R. I. Sierra, R. C. Tsang, S. Guo Children's Hospital Medical Center, Cincinnati, Ohio, USA; Wright State University, Dayton, Ohio, USA

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NON-INVASIVE BONE MASS MEASUREMENTS PREDICT BONE STRENGTH IN GROWING ANIMALS M. Koo*, K. Yang, P. Begeman, M. Hammami, W. Koo Bioengineering Center, Wayne State University, Detroit, MI, USA; Department of Pediatrics, Wayne State University, Detroit, MI, USA

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INACCURACIES INHERENT IN DXA IN VIVO BONE MINERAL DENSITOMETRY MAY FLAW OSTEOPENIC/OSTEOPOROTIC INTERPRETATIONS AND MISLEAD ASSESSMENTS OF ANITRESORPTIVE THERAPY EFFECTIVENESS H. H. Bolotin School of Physics, University of Melbourne, Victoria 3010 Australia; Department of Medical Radiations Science, RMIT University, Bundoora, Victoria 3083, Australia

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THE INFLUENCE OF HIGH ENERGETIC EXTRACORPORAL SHOCK WAVES ON BONE DENSITIY IN HUMAN CALCANEUM L. Gerdesmeyer*, H. Rechl, T. Schrader, M. Weber, A. Heinzel Clinic of Orthopeadic Surgery and Sportstraumtology, Technical University of Munichand, Munich, Germany; Clinic of Nuclear Medicine, Technical University of Munich, Munich, Germany

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STRUCTURAL COMPLEXITY OF CANCELLOUS BONE: A FRACTAL ANALYSIS I. H. Parkinson*, N. L. Fazzalari Division of Tissue Pathology, Institute of Medical and Veterinary Science, South Australia; Department of Pathology, Adelaide University, South Australia

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ANABOLIC EFFECTS OF COXARTHROSIS CONFER PROTECTION AGAINST INTRA-CAPSULAR HIP FRACTURE G. R. Jordan*, N. Loveridge, J. Power, N. Rushton, J. Reeve University of Cambridge, Cambridge, UK

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EVALUATION OF BONE MASS AND BONE QUALITY IN CHILDREN WITH ASTHMA TREATED WITH ANTIINFLAMMATORY STEROIDS BY DXA AND QUS: PRELIMINARY RESULTS M. Jaworski*, K. Nowacka, R. S. Lorenc Dept. of Bioch. and Exp. Medicine, Children's Memorial Health Institute, Warsaw, Poland; Dept. of Allergology, Spec. Children's Hospital, Warsaw, Poland

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STUDY OF BONE MINERAL DENSITY IN PATIENTS WITH BRONCHIAL ASTHMA ON GLUCOCORTICOID THERAPY I. Baranova*, N. Toroptsova, K. Gadjiev, N. Demin, A. Chuchalin Pulmonology Research Institute, Moscow, Russia; Institute of Rheumatology, Moscow, Russia

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COMMUNITY USE OF ORAL GLUCOCORTICOSTEROIDS IN ICELAND AND PROPHYLACTIC TREATMENT FOR STEROIDINDUCED OSTEOPOROSIS IN DAILY CLINICAL PRACTICE U. I. Juliusson, F. V. Gudjonsson, B. Gudbjornsson* Department of Medicine, Akureyri, Iceland; Health Care Center, Akureyri, Iceland; Centre for Rheumatology Research, Reykjavik, Iceland

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NORMAL VALUES FOR QUANTITATIVE ULTRASONOMETRY AT DIFFERENT SKELETAL SITES (RADIUS, TIBIA) IN HEALTHY CAUCASIAN BOYS AGED 7-19 YEARS – INTERIM ANALYSIS OF 228 BOYS MEASURED O. Bock*, M. Berndsen, T. Biedermann, A. Oldenburg, M. Schöntube, D. Felsenberg Free University Berlin, University Hospital Benjamin Franklin, Osteoporosis Research Group, Berlin, Germany; Dept.of Rheumatology, 2nd Children's Hospital, Klinikum Buch, Berlin, Germany COMPUTED-TOMOGRAPHY BONE-DENSITY MEASUREMENTS IN NORMAL PRE- AND POSTPUBERTAL FEMALES T. N. Hangartner*, M. E. Miller BioMedical Imaging Laboratory, Wright State University, Dayton OH, USA; Department of Pediatrics, Wright State University, Dayton, OH, USA

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IBMS/ECTS 2001 - First Joint Meeting EFFECTS OF SURGERY ON BONE MINERAL DENSITY IN OBESE PATIENTS M. L. Fernandez-Soto*, E. Ferrandiz, M. Quesada, V. Luna, F. Leruite, A. Gonzalez, P. Mezquita, F. EscobarJimenez University Hospital San Cecilio, Granada, Spain

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OSTEOMALACIA IN IMMIGRANTS FROM THE MIDDLE EAST J. Feldkamp*, M. Schott, R. Fritzen, W. A. Scherbaum Dept. of Endocrinology, Heinrich-Heine-University, Duesseldorf, Germany

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THE EFFECT OF CALCIUM & VITAMIN D SUPPLEMENTATION IN INDO-ASIANS SUFFERING FROM HYPOVITAMINOSIS D WITH OR WITHOUT SECONDARY HYPERPARATHYROIDISM E. Serhan*, M. R. Holland Department of Rheumatology, New Cross Hospital, Wolverhampton, UK; Department of Cinical Chemistry, New Cross Hospital, Wolverhampton, UK

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ENERGY AND NUTRIENTS INTAKE IN A GROUP OF PSYCHOLOGICAL DISABLED PEOPLE L. Pérez Gallardo*, Y. García Pérez, J. Gil Mateo Bioquímica y Biología Molecular, Universidad de Valladolid, Spain A COMMON FACTOR RAISES BLOOD PRESSURE AND PROTECTS AGAINST FRACTURES AMONGST MIDDLE-AGED AND ELDERLY MEN G. Sigurdsson*, K. Siggeirsdottir, B. Y. Jonsson, B. Mogensen, H. Jonsson jr Department of Medicine, Landspitali, University Hospital, Reykjavik, Iceland; Icelandic Heart Association, Reykjavik, Iceland; Akranes Hospital, Akranes, Iceland; Orthopaedic Department, University Hospital, Reykjavik, Iceland CAUSES OF OSTEOPOROSIS IN MEN WITH HIP FRACTURES D. N. Edis*, B. Erbas, S. Yeung, C. Poon, P. R. Ebeling Dept Surgery, University of Melbourne, Australia; Dept General Practice and Public Health, University of Melbourne, Australia; Dept. Diabetes and Endocrinology, University of Melbourne, Royal Melbourne Hospital, Australia

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DIFFERENCES OF CALCANEAL ULTRASONOMETRY BETWEEN PHYSICAL EDUCATION AND SPORT SCHOOL STUDENTS AND MEDICAL FACULTY STUDENTS B. Durmaz*, B. Ozcaldiran Ege University Medical Faculty, Physical Therapy and Rehabilitation Department , Turkey; Ege University, Physical Education and Sport School, Turkey

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EFFECT OF STEP MASTER AND NORDIC TRACK ON BIOCHEMICAL MARKERS OF BONE METABOLISM, BONE DENSITY, FITNESS, AND STRENGTH IN PREMENOPAUSAL WOMEN M. Sinaki, J. Canvin*, P. Phillips, B. Clarke Mayo Clinic, Rochester, MN, USA

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QUANTITATIVE ULTRASOUND AND OSTEOPOROSIS RISK FACTORS: EXERCISE IS INDEPENDENT OF BONE DENSITY S. Dodin*, C. Blanchet, Y. Giguère, F. Rousseau, L. Turcot-Lemay, M. Dumont, D. Prud'homme Unité de recherche en endocrinologie de la reproduction, Pavillon St-François D'Assise, CHUQ, Québec, Canada; Laboratoire des Sciences de l'activité physique, Division Kinésiologie, Département de médecine sociale et préventive, Faculté de médecine, Université Laval, Québec, Canada; Centre Ménopause Québec, Pavillon StFrançois D'Assise, CHUQ, Québec, Canada; Unité de recherche en génétique humaine et moléculaire, Pavillon St-François D'Assise, CHUQ, Québec, Canada; Département de médecine nucléaire, Pavillon St-François D'Assise, CHUQ, Québec, Canada

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FOREARM BONE MINERAL DENSITY IN PATIENTS WITH RHEUMATOID ARTHRITIS J. Iwamoto*, T. Takeda, S. Ichimura Keio University School of Medicine, Tokyo, Japan; National Defense Medical College, Saitama, Japan

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THE BIOLOGY OF THE SOFT CALLUS IN LONG BONE FRACTURE REPAIR J. L. Ford*, B. E. Scammell, D. Robinson University of Nottingham, UK

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DIETARY PHOSPHORUS MODULATES TRABECULAR BONE MASS AND STRENGTH IN OVARIECTOMIZED RATS R. Masuyama*, M. Koshihara, S. Tanaka, T. Nakamura, M. Uehara, K. Suzuki Tokyo University of Agriculture, Tokyo, Japan; University of Occupational and Environmental Health

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DIETARY AND OTHER DETERMINANTS OF SUDDEN-ONSET POST-MENOPAUSAL BONE GAIN AND OSTEOARTHRITIS IN THE SPINE R. Abraham, J. Walton, A. Nicholls, J. Justice, B. Wardley-Smith, J. Reeve* Clinical Research Centre, Northwick Park Hospital, London, UK; Department of Medicine, University of Cambridge, Cambridge, UK

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CHANGES IN BIOCHEMICAL MARKERS OF BONE METABOLISM IN MALE PATIENTS WITH HUMAN IMMUNODEFICIENCY VIRUS INFECTION DURING POTENT ANTIRETROVIRAL THERAPY J. Teichmann*, U. Lange, G. Friese, T. Discher, J. Lohmeyer, H. Stracke, R. G. Bretzel Medizinische Klinik und Poliklinik III, Klinikum der Justus-Liebig-Universität, Giessen, Germany; Medizinische Klinik und Poliklinik II, Klinikum der Justus-Liebig-Universität, Giessen, Germany

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EFFECT OF PUBERTY, AGEING AND GENDER ON SERUM N-TERMINAL PROPEPTIDE OF TYPE I PROCOLLAGEN (PINP) AND C-TERMINAL TELOPEPTIDE OF TYPE I COLLAGEN (S-CTX) Y. M. Henry*, A. C. Eagleton, D. Fatayerji, R. Eastell University of Sheffield, UK

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EFFECTS OF LOW DOSE METHOTREXATE ON BONE MINERAL DENSITY AND BONE TURNOVER L. Ogunremi*, R. Wills, J. Barron, S. Patel Osteoporosis Unit, St George's Hospital, London, UK; Dept Clinical Chemistry, St Helier Hospital, Carshalton, Surrey, UK; Dept Rheumatology, St Helier Hospital, Carshalton, Surrey, UK

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BREAST CANCER AND OSTEOPOROSIS - A LINK BETWEEN TWO FREQUENT DISEASES OF POSTMENOPAUSAL WOMEN P. Hadji*, M. Kalder, K. Bock, U. S. Albert, G. Emons, K. D. Schulz Philipps-University of Marburg, Marburg, Germany

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INFLUENCE OF ESTROGEN RECEPTOR GENOTYPE ON BONE MINERAL DENSITY IN CHINESE HAN WOMEN Y. Xue*, D. Li Department of Biochemistry, Beijing Ji Shui Tan Hospital, Beijing, P.R. China

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CERIVASTATIN INCREASES SOME CANCELLOUS BONE FORMATION INDICES IN OVX RATS S. C. Miller*, B. M. Bowman, C. Bagi University of Utah, Salt Lake City, USA; Bayer Pharmaceutical Division, West Haven, CT, USA

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THREE-DIMENSIONAL MORPHOMETRIC ANALYSIS OF THREE DIFFERENT SKELETAL SITES IN OVARIECTOMIZED RAT MODEL OF OSTEOPOROSIS: EFFECT OF PREVENTATIVE ADMINISTRATION OF ALFACALCIDOL AND ALENDRONATE A. Nishida*, M. Ito, K. Hayashi, A. Shiraishi, S. Higashi, Y. Uchida Department of Radiology, Nagasaki University, Japan; Product Research Laboratory, Chugai Pharmaceutical Co, Ltd

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ESTABLISHMENT OF AN OSTEOPOROTIC GOAT ANIMAL MODEL W. S. Siu*, N. M. Cheung, P. P. Y. Lui, D. H. K. Chow, A. James, L. Qin, K. S. Leung Department of Orthopaedics and Traumatology, Prince of Wales Hospital, The Chinese University of Hong Kong; The Rehabilitation Engineering Center, The Hong Kong Polytechnics University; Laboratory Animal Services Center, The Chinese University of Hong Kong BOTH HIGH DIET CALCIUM AND MECHANICAL STIMULATION ARE REQUIRED TO PROTECT AGAINST OVARIECTOMY-INDUCED BONE LOSS IN THE RAT H. A. Morris*, A. J. Moore, P. D. O'Loughlin, B. Jansen, R. Larik Institute of Medical and Veterinary Science, Adelaide, South Australia, 5000

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THE EFECT OF FLUORIDE ON MINERAL FORMATION IN NOVEL HYDROGEL MATRICES OF POLY (VINYLALCOHOL) J. P. Cassella*, I. Ahmed, S. Elliott Division of Biological Sciences; Division of Environmental Sciences

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PRELIMINARY OUTCOMES OF THE FIRST 311 CONSECUTIVE KYPHOPLASTIES FOR THE FIXATION OF PAINFUL OSTEOPOROTIC VERTEBRAL COMPRESSION FRACTURES J. M. Lane, F. P. Girardi*, S. N. Khan, F. P. Cammisa, P. Philips, H. Yuan, S. Garfin, I. H. Lieberman, H. K. Parvataneni Hospital for Special Surgery, Weill Medical College of Cornell University; University of Chicago; SUNY; UCSD; Cleveland Clinic

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EFFECTS OF HMG-COA REDUCTASE INHIBITORS, STATINS, ON BONE LOSS: A PROSPECTIVE POPULATION-BASED COHORT STUDY IN EARLY POSTMENOPAUSAL WOMEN J. Sirola*, R. Honkanen, H. Kröger, J. Jurvelin, P. Mäenpää, S. Saarikoski University of Kuopio, Kuopio, Finland; Kuopio University Hospital, Department of Surgery, Kuopio, Finland; Kuopio University Hospital, Dpt Nuclear Medicine & Clinical Physiology, Kuopio, Finland; Kuopio University Hospital, Department of Obstetrics and Gynaecology, Kuopio, Finland

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MILK BASIC PROTEIN (MBP) PROMOTES BONE FORMATION AND SUPPRESSES BONE RESORPTION IN VIVO A. Itabashi*, Y. Takada, Y. Toba, Y. Matsuoka, S. Aoe, H. Kawakami, K. Nemoto, M. Kumegawa Clin Lab Med, Saitama Medical School, Saitama, Japan; Nutr Sci Lab, Snow Brand Milk Co,, Saitama, Japan; Oral Anatomy, Meikai University of Dentistry, Saitama, Japan

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ALENDRONATE TREATMENT OF PATIENTS WITH POSTMENOPAUSAL OSTEOPOROSIS AND IMPAIRED FASTING GLUCOSE M. Cokolic*, R. Hren Teaching Hospital Maribor, Maribor, Slovenia; University of Ljubljana, Ljubljana, Slovenia

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INTRAVENOUS PAMIDRONATE TREATMENT IN PATIENTS' HOMES K. R. H. Adams*, K. Turner Royal Bolton Hospital UK

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RAPID AND SUSTAINED HIP FRACTURE RISK REDUCTION WITH RISEDRONATE IN ELDERLY WOMEN WITH OSTEOPOROSIS C. Cooper*, J. Y. Reginster, M. McClung, N. L. Zorich, Z. Li University of Southampton, Southampton, UK; University of Liege, Liege, Belgium; Oregon Osteoporosis Center, Portland, OR, USA; Procter & Gamble Pharmaceuticals, Mason, OH, USA

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BONE MINERAL DENSITY CHANGES IN THE FIRST TWO YEARS FOLLOWING DISCONTINUATION OF ALENDRONATE J. D. Gay*, D. S. Ooi Ottawa Hospital Civic Campus, Ottawa, Canada

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ZOLEDRONIC ACID, A POTENT NEW BISPHOSPHONATE, REVERSES MECHANICAL HYPERALGESIA IN TWO RAT MODELS OF CHRONIC INFLAMMATORY AND NEUROPATHIC PAIN A. Fox, S. Patel, K. McNair, A. Kesingland, L. Urban, J. R. Green* Novartis Institute for Medical Sciences, London, UK; Novartis Pharma Research, Basel, Switzerland

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ONE YEAR STUDY OF ALENDRONATE EFFECTS ON VERTEBRAL MINERAL DENSITY AND BONE TURNOVER IN WOMEN WITH MILD TYPE I OSTEOGENESIS IMPERFECTA D. Grigorie*, C. Barbu, E. Neacsu, M. Dumitrache, M. Grigorie, C. Dumitrache C. I. Parhon Institute of Endocrinology, Bucharest, Romania; Ana Aslan Institute of Geriatrics and Gerontology, Bucharest, Romania

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RISEDRONATE SIGNIFICANTLY REDUCES THE RISK OF NEW VERTEBRAL FRACTURES, IN WOMEN IRRESPECTIVE OF THE NUMBER OF PREVALENT VERTEBRAL FRACTURES IN JUST ONE YEAR R. Eastell*, J. Compston, C. Roux, N. Alsayed, I. Barton University of Sheffield, Sheffield, UK; University of Cambridge, Cambridge, UK; Rene Descartes University, Paris, France; Procter & Gamble Pharmaceuticals, Geneva, Switzerland; Procter & Gamble Pharmaceuticals, Staines, UK ALENDRONATE VS. CALCITONIN: 2-YEAR TREATMENT OF OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN C. J. Rosen*, T. J. Schnitzer, M. McClung, P. D. Miller, L. Wang, L. K. Vanaman, J. Yates, M. E. Melton, J. Palmisano St. Joseph Hospital, Bangor, ME, USA; Northwestern University, Chicago, IL, USA; Oregon Osteoporosis Center, Portland, OR, USA; Colorado Center for Bone Research, Lakewood, CO, USA; Merck & Co., Inc., West Point, PA, USA

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ALENDRONATE IS MUCH MORE EFFECTIVE THAN CALCITONIN AND ALFACALCIDOL FOR PREVENTING NONVERTEBRAL FRACTURES K. Aoyagi*, M. Shiraki, M. Ito, T. Nakamura Public Health, Nagasaki University; Research Institute and Practice for Involutional Diseases; Radiology, Nagasaki University; Orthopedic Surgery, University of Occupational and Environmental Health

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RISEDRONATE REDUCES THE RISK OF NEW VERTEBRAL FRACTURES IN 1 YEAR IN POSTMENOPAUSAL WOMEN ON CORTICOSTEROID THERAPY J. P. Devogelaer*, D. Hosking, S. Wallach, D. J. Valent Louvain Catholic University, Brussels, Belgium; Nottingham City Hospital, Nottingham, UK; Hospital for Joint Diseases, New York, NY, USA; Procter & Gamble Pharmaceuticals, Geneva, Switzerland

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A ONE-YEAR RANDOMIZED TRIAL OF ETIDRONATE AND VITAMIN K IN COMBINATION WITH VITAMIN D IN POSTMENOPAUSAL PATIENTS WITH RHEUMATOID ARTHRITIS J. H. Hashimoto*, T. T. Tomita, H. O. Owaki, K. T. Tsuyama, T. O. Ochi, H. Y. Yoshikawa Dept. of Orthopedic Surg., Osaka University Medical School, Osaka, Japan; Dept. of Orthopedic Surg., Osaka Kousei-Nenkin Hospital, Osaka, Japan

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ALENDRONATE VS INTRANASAL CALCITONIN FOR TREATMENT OF OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN: 2 YEAR RESULTS R. W. Downs*, N. H. Bell, B. Walsh, M. P. Ettinger, B. Mako, M. E. Smith, L. Wang, J. Yates, M. E. Melton, J. Palmisano Medical College of Virginia, Richmond, VA, USA; University of South Carolina Research Service VMAC, Chareston, SC, USA; Brigham & Women's Hospital, Boston, MA, USA; Radient Research, Stuart, FL, USA; Merck & Co., Inc., West Point, PA, USA

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SUSTAINED FRACTURE BENEFIT WITH FIVE YEARS OF RISEDRONATE IN POSTMENOPAUSAL WOMEN D. Hosking*, O. D. Sorensen, H. Mulder, S. Adami, S. Pack, D. Wenderoth, J. Y. Reginster Nottingham City Hospital, Nottingham, UK; Hvidovre Universitetshospital, Hvidovre, Denmark; Research Center Good Clinical Practice, Rotterdam, The Netherlands; Clinicizzato di Valeggio, Valeggio, Italy; Procter & Gamble Pharmaceuticals, Staines, UK; University of Liège, Liège, Belgium

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DEXA AND PQCT CHANGES AFTER A CONTINUOUS INTRANASAL CALCITONIN TREATMENT IN WOMEN WITH POST MENOPAUSAL OSTEOPOROSIS E. Kataxaki*, G. Skarantavos, I. Koulouris, G. Trovas, G. Raptou, M. Katsiri, M. Tsipra, A. Galanos, G. P. Lyritis Laboratory for the Research of the Musculoskeletal System

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TRANSGALACTO-OLIGOSACCHARIDES STIMULATE CALCIUM ABSORPTION IN POSTMENOPAUSAL WOMEN E. G. H. M. van den Heuvel*, H. C. Schoterman, Th Muijs TNO Nutrition and Food Research, Zeist, The Netherlands; Borculo Domo Ingredients, Zwolle, The Netherlands

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SUBSTANTIAL BENEFICIAL EFFECTS OF CALCIUM SUPPLEMENTATION ON SERUM LIPIDS IN NORMAL POSTMENOPAUSAL WOMEN I. R. R. Reid*, B. Mason, A. Horne, R. Ames, J. Clearwater, F. Wu, M. C. Evans, G. Gamble University of Auckland, Auckland, New Zealand

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FERMENTED SOYBEANS MAY ACCELERATE PREMENOPAUSAL BONE GAIN AND DECELERATE POSTMENOPAUSAL BONE LOSS IN HEALTHY JAPANESE POPULATION - JPOS COHORT STUDY M. Iki*, A. Morita, Y. Ikeda, H. Aihara, A. Yura, S. Kagamimori, Y. Kagawa, T. Matsuzaki, H. Yoneshima, F. Marumo Kinki University School of Medicine, Osaka-Sayama, Japan; Toyama Medical and Pharmaceutical University, Toyama, Japan; Kagawa Nutrition University, Tokyo, Japan; Institute of Comprehensive Community Health Care, Tokyo, Japan; Kasukabe-Shuuwa Hospital, Kasukabe, Japan; Tokyo Medical and Dental University, Tokyo, Japan

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DOES HORMONE REPLACEMENT THERAPY PREVENT NON VERTEBRAL FRACTURES: A REVIEW OF RANDOMISED TRIALS AND METAANALYSIS D. J. Torgerson*, S. E. M. Bell-Syer University of York, York, UK

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DOES SMOKING INFLUENCE THE EFFICACY OF RALOXIFENE IN POSTMENOPAUSAL OSTEOPOROTIC WOMEN? RESULTS FROM THE MORE TRIAL R. D. Chapurlat*, D. C. Bauer, S. Ewing, S. R. Cummings University of California, San Francisco, USA

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DOSE-RELATED DECREASES IN BONE BIOMARKERS DUE TO NORETHINDRONE ACETATE IN POSTMENOPAUSAL WOMEN TREATED WITH ETHINYL ESTRADIOL J. A. Simon*, J. C. Gallagher, B. Drinkwater, J. P. Symons George Washington University School of Medicine, Washington, DC, USA; Creighton University Medical Center, Omaha, Nebraska, USA; Pacific Medical Center, Seattle, Washington, USA; Pfizer Global Research and Development, Ann Arbor, Michigan, USA

Wednesday

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Wednesday, June 6, 2001

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COMPARISON OF FC1271A, A NOVEL SERM, AND RALOXIFENE IN POSTMENOPAUSAL WOMEN: A 12WEEK CLINICAL PHASE II STUDY R. U. Erkkola*, M. DeGregorio, K. Halonen, Kangas, Lammintausta, Vihko, J. Heikkinen, S. Kivinen, S. Saarikoski, R. Tuimala, Vihtamäki, M. Tuppurainen, S. Voipio, O. Ylikorkala Turku University Central Hospital, FIN-20520 Turku; University of California, Davis, Sacramento, CA, USA; Hormos Medical Ltd, FIN-20520 Turku; Oulu Deaconess Institute, FIN-90100 Oulu; Kanta-Häme Central Hospital, FIN-13530 Hämeenlinna

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DEVELOPMENT OF A PREDICTIVE MODEL AND A RISK ASSESMENT INSTRUMENT TO FACILITATE DIAGNOSIS OF LOW BONE MASS IN POSTMENOPAUSAL WOMEN W. Bensedrine*, T. Chevallier, M. C. Micheletti, B. Gelas, J. Y. Reginster Department of Epidemiology and Public Health, University of Liège, Belgium; Department of Biostatistic Epidemiology and Clinical Research, University of Montpellier, France; Medical Department, Theramex Laboratory, Monaco; Georgetown University Medical Center - Washington DC, USA

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TAI CHI EXERCISE RETARDS RATE OF BONE LOSS IN POSTMENOPAUSAL WOMEN L. Qin*, K. M. Chan, S. K. Au, W. Y. Choy, M. C. Lau, J. Woo, K. M. Lee, M. A. Dambacher Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, PR China; Department of Community and Family Medicine, The Chinese University of Hong Kong, Hong Kong SAR, PR China; Department of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, PR China; LeeHysan Clinical Research Laboratory, The Chinese University of Hong Kong, Hong Kong SAR, PR China; Orthopädische Universitäsklinik Balgrist, Zürich, Switzerland

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HISTOMORPHOMETRY AND MICROSTRUCTURE OF ILIAC TRABECULAR BONE IN OSTEOPOROSIS ON INTERMITTENT SUBCUTANEOUS ADMINISTRATION OF HUMAN PTH (1-34) K. Nakatsuka*, H. Naka, H. Kawakami, K. Kitatani, T. Miki, Y. Nishizawa, H. Morii Osaka City University, Osaka, Japan; Aino Gakuin College, Ibaraki, Japan

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THE EFFECTS OF TREATMENT INTERVENTIONS ON HEALTH RELATED QUALITY OF LIFE (HRQL) IN POST-MENOPAUSAL WOMEN REGISTERED IN THE CANADIAN DATABASE OF OSTEOPOROSIS AND OSTEOPENIA (CANDOO) PATIENTS G. Ioannidis*, J. D. Adachi, A. Petrie, R. J. Sebaldt, A. Papaioannou, W. P. Olszynski, D. A. Hanley, C. H. Goldsmith McMaster University, Hamilton, Ontario, Canada; University of Saskatchewan, Saskatoon, Saskatchewan, Canada; University of Calgary, Calgary, Alberta, Canada

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REDUCTION OF PAIN AND IMPROVEMENT OF QUALITY OF LIFE IN OSTEOPOROTIC PATIENTS UNDER TREATMENT WITH INTRANASALLY ADMINISTERED SALMON CALCITONIN C. Ràfols*, I. Serra, R. DeCastellar, Acknowledgements to dr. Díez Pérez ICN Ibérica S.A., Corbera de LLobregat (Barcelona), Spain; Biométrica (CRO), Barcelona, Spain; Manager of Infectious and Medical Service, Hospital de Mar, Barcelona, Spain

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EFFECT OF ZONISAMIDE, AN ANTIEPILEPTIC AGENT, ALONE AND IN COMBINATION WITH ALFACALCIDOL ON THE CONCENTRATIONS OF VITAMIN K ANALOGUES IN THE BONE IN GROWING RATS A. Takahashi*, K. Onodera, H. Wakabayashi, T. Saito, H. Shinoda, H. Mayanagi Division of Pediatric Dentistry, Department of Lifelong Oral Health Sciences, Tohoku University Graduate School of Dentistry, Sendai, Japan; Department of Dental Pharmacology, Okayama University Dental School, Okayama, Japan; Department of Biophysical Chemistry, Niigata College of Pharmacy, Niigata, Japan; Clinic of Dentistry for the disabled, Tohoku University School of Dentistry, Sendai, Japan; Division of Pharmacology, Department of Oral Biology, Tohoku University Graduate School of Dentistry, Sendai, Japan

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ALPHACALCIDOL IN OSTEOPOROSIS PREVENTION IN POSTMENOPAUSAL WOMEN O. A. Nikitinskaya*, L. I. Benevolenskaya Institute of Rheumatology, Moscow, Russia

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COLCHICINE FOR THE PREVENTION AND TREATMENT OF OSTEOPOROSIS D. Schapira*, A. Kabala, R. Coleman Dept Rheumatology, Rambam Medical Center, Haifa, Israel; Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

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COMPLIANCE IN ANTIOSTEOPOROTIC TREATMENTS J. Blanch*, M. Coll, J. M. Pujol, M. Ciria, L. Perez-Edo, P. Benito, J. Carbonell Rheumatology Division, Hospitals Universitaris del Mar i de l'Esperança, Barcelona, Spain

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UTILITY OF MEASUREMENT OF URINARY PYRIDINOLINE AND DEOXYPYRIDINOLINE FOR MONITORING EFFECTS OF TREATMENT WITH ESTROGEN AND ALFACALCIDOL IN WOMEN WITH OSTEOPOROSIS Z. Zhan*, I. Yamanoto, R. Morita, H. Miura Xiao Xi Tian No.262 Hospital Beijing, China; Department of Radiology, Shiga University of Medical Science, Otsu 520-21, Japan.; Hikone Research Laboratories, Maruho Co. Ltd., Shiga 522-02, Japan

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ANTI-RESORPTIVE TREATMENT - A MODEL TO GAIN INSIGHT AND PREDICT LONG TERM BONE GAIN J. C. van der Linden*, J. A. N. Verhaar, H. Weinans Erasmus University Rotterdam, Rotterdam, The Netherlands

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IMPACT OF AN EDUCATIONAL PROGRAM CONSISTING OF PERIPHERAL DUAL X-RAY ABSORPTIOMETRY (PDXA) SCREENING FOLLOWED BY A LECTURE S. Levis*, P. Lassanske, N. Dgetluck University of Miami School of Medicine, GRECC/VA Medical Center, State of Florida Teaching Nursing Home at Miami Jewish Home & Hospital for the Aged, Miami, FL, USA; Elder Floridians Foundation, Tallahassee, FL, USA; Martin Memorial Health Systems, Stuart, FL, USA

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Wednesday, June 6, 2001

GP’S KNOWLEDGE OF CALCIUM AND VITAMIN D PREPARATIONS FOR FRACTURE PREVENTION: COMPARISON BETWEEN RESEARCH PARTICIPANTS AND CONTROLS R. J. Barr*, A. Stewart, B. Mcdonagh, D. M. Reid Dept. Medicine & Therapeutics, University of Aberdeen, Aberdeen, UK; Strakan Ltd, Galashiels, UK

PLENARY SESSION 2 OSTEOPOROSIS: PATHOPHYSIOLOGY, GENETICS, EPIDEMIOLOGY Chairs: Reinhard Ziegler (Heidelberg/Germany), L. Joseph Melton (Rochester, MN/USA)

Vitamin D

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HYPOVITAMINOSIS 1,25(OH)2 D3 IN PATIENTS SUFFERING FROM CHRONIC DISORDERS J. Payer*, Z. Killinger, J. Rovenský, H. Kratochvilová, P. Ondrejka 1st Department Internal Medicine, University Hospital, Comenius University, Bratislava, Slovakia; The Research Institute of Rheumatic Diseases, Piest'any, Slovakia; The Ministry of Inferior Hospital, Bratislava, Slovakia

IN5

Epidemiological Aspects of Osteoporosis in Men and Women Huibert A. P. Pols (Rotterdam/The Netherlands)

14:00 - 15:00

BONE CELL REGULATION OF VITAMIN D METABOLISM P. H. Anderson*, S. Iida, A. J. Moore, B. K. May, M. Cochran, H. A. Morris Institute of Medical and Veterinary Science, Adelaide, Australia; Department of Physiology, Adelaide University, Adelaide, Australia.; Department of Biochemistry, Adelaide University, Adelaide, Australia

VITAMIN A ANTAGONIZES CALCIUM RESPONSE TO VITAMIN D IN MAN S. Johansson*, H. Melhus Uppsala University, Uppsala, Sweden

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CALCITRIOL INCREASES BONE TURNOVER BUT NOT MINERAL DENSITY IN THE STREPTOZOTOCININDUCED DIABETIC RATS J. Del Pino-Montes*, G. E. Benito, M. P. FernándezSalazar, M. Martín, E. Martín, M. J. García-Rodriguez, M. Fernández-Puente, J. R. García-Talavera, J. J. Calvo U. Metabolismo óseo, Hospital Universitario, Salamanca, Spain; Dept. Fisiología y Farmacología, Universidad de Salamanca, Spain; S.Medicina Nuclear, Hospital Universitario, Salamanca, Spain

Auditorium

ORAL PRESENTATIONS 2 OSTEOPOROSIS: PATHOPHYSIOLOGY, GENETICS, EPIDEMIOLOGY Chairs: Reinhard Ziegler (Heidelberg/Germany), L. Joseph Melton (Rochester, MN/USA)

INFLUENCE OF DONOR AGE AND SKELETAL SITE OF ORIGIN ON VDR MRNA EXPRESSION AND PROTEIN LEVELS AND IN RESPONSE TO 1,25(OH)2D3 IN HUMAN OSTEOBLASTIC CELLS M. Garcia*, P. Martinez, I. Del Valle, L. Gomez, J. L. Castrillo, P. Esbrit, M. E. Martinez Biochemistry Division La Paz Hospital; Molecular Biological Center (CBM); Bone and Mineral Metabolism Laboratory (Fundacion Jimenez Diaz)

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Osteoporosis in Men Eric S. Orwoll (Portland, OR/USA)

15:00 - 17:00

Auditorium

The abstract text of oral presentations (prefix OR) can be found in the Abstracts section, page S70 onward. 15:00 OR9

15:12 OR10

15:24 OR11

HIGH BONE TURNOVER BUT NORMAL BONE DENSITY IN WOMEN WITH SCHIZOPHRENIA N. Bergemann, B. Auler, P. Parzer, F. Resch, C. Mundt, M. J. Seibel Department of Psychiatry, Department of Medicine, University of Heidelberg, Germany

15:36 OR12

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META-ANALYSIS OF COL1A1 SP1 POLYMORPHISM IN RELATION TO BONE MINERAL DENSITY AND OSTEOPOROTIC FRACTURE V. Mann*, S. H. Ralston University of Aberdeen, Aberdeen, UK EVIDENCE FOR A LOCUS OF A MAJOR OSTEOPOROSIS GENE IN AN ICELANDIC LINKAGE STUDY U. Styrkarsdottir*, K. Jonasson, V. D. Johannsdottir, K. H. Gudjonsdottir, H. S. Erlingsdottir, S. Oscarson, J. Gulcher, K. Stefansson, G. Sigurdsson Decode Genetics, Reykjavik, Iceland; Clinical Research Center, Reykjavik, Iceland; University Hospital, Reykjavik, Iceland GENETIC EFFECTS ON FALLS RISK MAY HELP EXPLAIN WHY FRACTURES RUN IN FAMILIES : A TWIN STUDY J. D. Wark*, K. Hill, A-M. Cassano, N. El Haber, R. MacInnis University of Melbourne, Parkville, Australia; National Ageing Research Institute, Parkville, Australia CHROMOSOMAL LOCATION OF GENES THAT CONTRIBUTE TO VERTEBRAL TRABECULAR BONE DENSITY AND MICROARCHITECTURE IN MICE M. L. Bouxsein*, T. Uchiyama, J. Mytar, W. G. Beamer, L. R. Donahue, C. J. Rosen, C. H. Turner, R. Mueller Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA; The Jackson Laboratory, Bar Harbor, ME, USA; Indiana University, Indianapolis, IN, USA

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IN4

conference.book Page 22 Wednesday, February 7, 2001 8:41 PM

Wednesday, June 6, 2001 15:48 OR13

16:00 OR14

16:12 OR15

16:24 OR16

16:36 OR17

16:48 OR18

IBMS/ECTS 2001 - First Joint Meeting

SATELLITE SYMPOSIUM

ASSOCIATION BETWEEN STATIN-USE, BONE MASS AND FRACTURE RISK IN AUSTRALIAN WOMEN: GEELONG OSTEOPOROSIS STUDY J. A. Pasco, M. A. Kotowicz*, M. J. Henry, K. M. Sanders, G. C. Nicholson The University of Melbourne, Department of Clinical and Biomedical Sciences, Barwon Health, Geelong, Victoria, Australia

SETTING THE STANDARD FOR TREATING OSTEOPOROSIS: LATEST RESEARCH ADVANCES WITH FOSAMAX sponsored by Merck Sharp and Dohme Chair: Aurelio Rapado (Madrid/Spain)

DOES A FRACTURE AT ONE SITE PREDICT LATER FRACTURES AT ANY OTHER SITE? T. P. van Staa*, H. G. M. Leufkens, C. Cooper Department of Pharmacoepidemiology and Pharmacotherapy, University of Utrecht, Sorbonnelaan 16, Utrecht, the Netherlands; Medical Research Council Environmental Epidemiology Unit, Southampton University Hospital, Southampton, UK; Procter & Gamble Pharmaceuticals, Lovett House, Lovett Road, Staines, UK

17:30 - 19:30

Auditorium

Osteoporosis: The Neglected Disease (speaker to be confirmed) The Role of Evidence Based Medicine in Treating Osteoporosis Socrates Papapoulos (Leiden/The Netherlands)

REDUCED EXPRESSION OF ENOS IN THE FRACTURED FEMORAL NECK N. Loveridge*, S. Fletcher, J. Power, J. Reeve, A. Pitsillides University of Cambridge, Cambridge, UK; Royal Veterinary College, London, UK

The Fast & Consistent Effect of FOSAMAX in Reducing Fractures David Hosking (Nottingham/UK)

VITAMIN D DEFICIENCY, SERUM IGF-1 AND MARKERS OF BONE TURNOVER PREDICT FRACTURES IN THE LONGITUDINAL AGING STUDY AMSTERDAM P. Lips*, S. M. F. Pluijm, C. Popp-Snijders, J. H. Smit Endocrinology, Academic Hospital, Vrije Universiteit, Amsterdam, The Netherlands; Institute for Research in Extramural Medicine (EMGO-Institute), Vrije Universiteit, Amsterdam, The Netherlands; Department of Sociology and Social Gerontology, Vrije Universiteit, Amsterdam, The Netherlands

FOSAMAX Once Weekly: Rationale, Study Design & Results René Rizzoli (Geneva/Switzerland) Treatment of Male Osteoporosis with FOSAMAX Eric Orwoll (Portland, OR/USA)

ISOCALORIC PROTEIN UNDERNUTRITION IS ASSOCIATED WITH ALTERATION OF SOMATOTROPIC AND GONADOTROPIC AXES RESULTING IN OSTEOPOROSIS IN MALE AND FEMALE ADULT RATS P. Ammann*, M. L. Aubert, J. P. Bonjour, S. Bourrin, R. Rizzoli Division of Bone Diseases, Department of Internal Medicine; Division of Pediatric Endocrinology and Diabetology, Department of Pediatrics, University of Geneva, Switzerland

CONCERT Orquestra Filarmonica de Madrid conducted by Maestro Enrique García Asensio

FRACTURES IN PATIENTS WITH ANOREXIA NERVOSA, BULIMIA, AND OTHER EATING DISORDERS P. Vestergaard*, C. Emborg, R. Støving, C. Hagen, L. Mosekilde, K. Brixen Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus, Denmark; Department of Psychiatric Demography, Aarhus University Hospital, Aarhus, Denmark; Department of Endocrinology, Odense University Hospital, Odense, Denmark

with the world's premier castanet player Lucero Tena Program will include works by Falla, Albeniz and Rodrigo IBMS/ECTS 2001 recognizes the generous support of this performance by Procter & Gamble Pharmaceuticals. Shuttle service from the convention center to the Auditorio Nacional will be provided by Merck Sharp and Dohme.

Coffee Break 17:00 - 17:30

20:00 - 21:00

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Auditorio Nacional