- Email: [email protected]
Progress in medicinal chemistry
464 14-17 October The Membrane
1990 Conference
Information: W Shoemaker, pensburg PA 17257 USA, 7174235633 22-24 janvier 1991 Congres de chromatographies critique
Boston (USA) on Technology/Planning Filterex, RD 1 Box 507, ShipPhone 717 423 6218, or Fax
ENCPB, Paris (France) en phases liquide et super-
OrganisC par la division “Chimie Analytique” de la SociCt6 franCaise de Chimie, avec le contours du GAMS.
Information: SFC, C Iarmarelli, 250, rue Saint-Jacques, 75005 Paris, Ttl: (1) 43 25 20 78, TClCcopie: (1) 40 46 83 80 23-28 June 1991 XVIIth International
Congress
Berlin of Chemotherapy
(Germany)
Associated with 17th International Conmess of Chemotheraw is the 3rd Biennial Conference on Chemotherapy of Infect&& Diseases and Malienancies (BICON). Information: Secretariat ~ 17th international Congress of Chemotherapy, c/o Congress Organization, Futuramed Verlag Gmbh, PO Box 70 06 40, D-8000 Munich 70, Phone 089/78 90 46, Telefax 089/7 85 59 29
Recent books Comprehensive Medicinal Chemistry, edited by C Hansch, PG Sammes and JB Taylor - Pergamon Press, Oxford, UK, 1990,5494 + cii pages in six volumes, U$$ 1995, & 1145 This major work describes all the aspects of Medicinal Chemistry: about 250 contributors have been enlisted. Each of the six volumes deals with a specific theme. Volume 1 (PD Kennewell, ed) describes the General Principles of Medicinal Chemistry: Historical Perspective; Targets of Biologically Active Molecules; Bioactive Materials and Socioeconomic Factors of Drug Development. Volume 2 (PG Sammes, ed) deals with Enzymes and other Molecular Targets: Enzymes; Agents Acting on Oxygenases, Electron Transport Systems and Pyridoxal Dependent Systems; Agents Acting on Metabolic Processes; Agents Acting on Hydrolases and Peptidases; Agents Acting on Cell Walls and Agents Acting on Nucleic Acids. Volume 3 (JC Emmett, ed) describes in detail Membranes and Receptors: Membranes, Membrane Receptors and Second Messenger Pathways; Neurotransmitter and Autocoid Receptors; Peptidergic Receptors; Drugs Acting on Ion Channels and Membranes; Lymphokines and Cytokines and Intracellular Receptors. Volume 4 (CA Ramsden, ed) covers Quantitative Drug Design: Introduction to Drug Design and Molecular Modelling; Quantitative Description of Physicochemical Properties of Drug Molecules; Quantitative Description of Biological Activity and Drug Transport; Molecular Graphics and Drug Design; Quantitative Structure-Activity Relationships; Pattern Recognition and other Statistical Methods for Drug Design. Volume 5 (JB Taylor, ed) deals with Biopharmaceutics: Principles of Pharmacokinetics and Metabolism; Analytical Metbodology and Chemistry and Pharmacy in Drug Development. Volume 6 (CJ Drayton, ed) contains a Cumulative Subject Index and a Drug Compendium containing information on about 5500 compounds. According to the editors “The aim of Comprehensive Medicinal Chemistry is to present the subject, the modem role of which is the understanding of structure-activity relationships and drug design from the mechanistic viewpoint, as a field in its own right, integrating with its central chemistry all the necessary ancillary disciplines”. S N I Jacques et Demontrond
/ ZI Thise -
The authors undoubtly achieved their end and this series will become an indispensable tool for medicinal chemists as well as for organic chemists, biochemists, pharmacologists and of course students. Immunology: Clinical, Fundamental and Therapeutic Aspects, edited by P Ram, MC Harris, P Tyle. VCH, Weinheim, New York, Basel, Cambridge, 1990, XII, 364 p, DM 154.00, f. 59.00 The book discusses the clinical, fundamental, and therapeutic effects of immunology. The book begins with the fundamentals of immunology and proceeds to explore the subject at increasing levels of detail. The first section delves into the present “state-of-the-art” knowledge of the immune system and immunoglobulins, and its devel
in Medicinal Chemistry, volume 27, edited by and GB West - Elsevier, Amsterdam, 1990, 400 p, Dfl320.00
Eight reviews are presented here, some of which deal with classes of compounds, namely, pyridazine derivatives, with broad-spectrum pharmacological activity, the 1-benzazepines (especially in relation to hypertension), antibacterial fluoroquinolones, having, like the benzazepines, enzyme inhibition as a modus operandi, and antagonists of PAF, recognized as having a crucial role in many disorders. Additionally, the importance and dangers of mercury and nickel compbunds, especially those forming in the skin. are surveved. The deleterious effect of light on ‘irugs is de& with a$ a topic of considerable concern. Mast cells have a pivotal role as sentinels of inflammatory response, and their regulation by peptides is of current interest. The control of emesis is investigated particularly in relation to cancer chemotherapy. BesanGon / DCpBt lCga1 juin 1990 no 11256
1990 Conference
Information: W Shoemaker, pensburg PA 17257 USA, 7174235633 22-24 janvier 1991 Congres de chromatographies critique
Boston (USA) on Technology/Planning Filterex, RD 1 Box 507, ShipPhone 717 423 6218, or Fax
ENCPB, Paris (France) en phases liquide et super-
OrganisC par la division “Chimie Analytique” de la SociCt6 franCaise de Chimie, avec le contours du GAMS.
Information: SFC, C Iarmarelli, 250, rue Saint-Jacques, 75005 Paris, Ttl: (1) 43 25 20 78, TClCcopie: (1) 40 46 83 80 23-28 June 1991 XVIIth International
Congress
Berlin of Chemotherapy
(Germany)
Associated with 17th International Conmess of Chemotheraw is the 3rd Biennial Conference on Chemotherapy of Infect&& Diseases and Malienancies (BICON). Information: Secretariat ~ 17th international Congress of Chemotherapy, c/o Congress Organization, Futuramed Verlag Gmbh, PO Box 70 06 40, D-8000 Munich 70, Phone 089/78 90 46, Telefax 089/7 85 59 29
Recent books Comprehensive Medicinal Chemistry, edited by C Hansch, PG Sammes and JB Taylor - Pergamon Press, Oxford, UK, 1990,5494 + cii pages in six volumes, U$$ 1995, & 1145 This major work describes all the aspects of Medicinal Chemistry: about 250 contributors have been enlisted. Each of the six volumes deals with a specific theme. Volume 1 (PD Kennewell, ed) describes the General Principles of Medicinal Chemistry: Historical Perspective; Targets of Biologically Active Molecules; Bioactive Materials and Socioeconomic Factors of Drug Development. Volume 2 (PG Sammes, ed) deals with Enzymes and other Molecular Targets: Enzymes; Agents Acting on Oxygenases, Electron Transport Systems and Pyridoxal Dependent Systems; Agents Acting on Metabolic Processes; Agents Acting on Hydrolases and Peptidases; Agents Acting on Cell Walls and Agents Acting on Nucleic Acids. Volume 3 (JC Emmett, ed) describes in detail Membranes and Receptors: Membranes, Membrane Receptors and Second Messenger Pathways; Neurotransmitter and Autocoid Receptors; Peptidergic Receptors; Drugs Acting on Ion Channels and Membranes; Lymphokines and Cytokines and Intracellular Receptors. Volume 4 (CA Ramsden, ed) covers Quantitative Drug Design: Introduction to Drug Design and Molecular Modelling; Quantitative Description of Physicochemical Properties of Drug Molecules; Quantitative Description of Biological Activity and Drug Transport; Molecular Graphics and Drug Design; Quantitative Structure-Activity Relationships; Pattern Recognition and other Statistical Methods for Drug Design. Volume 5 (JB Taylor, ed) deals with Biopharmaceutics: Principles of Pharmacokinetics and Metabolism; Analytical Metbodology and Chemistry and Pharmacy in Drug Development. Volume 6 (CJ Drayton, ed) contains a Cumulative Subject Index and a Drug Compendium containing information on about 5500 compounds. According to the editors “The aim of Comprehensive Medicinal Chemistry is to present the subject, the modem role of which is the understanding of structure-activity relationships and drug design from the mechanistic viewpoint, as a field in its own right, integrating with its central chemistry all the necessary ancillary disciplines”. S N I Jacques et Demontrond
/ ZI Thise -
The authors undoubtly achieved their end and this series will become an indispensable tool for medicinal chemists as well as for organic chemists, biochemists, pharmacologists and of course students. Immunology: Clinical, Fundamental and Therapeutic Aspects, edited by P Ram, MC Harris, P Tyle. VCH, Weinheim, New York, Basel, Cambridge, 1990, XII, 364 p, DM 154.00, f. 59.00 The book discusses the clinical, fundamental, and therapeutic effects of immunology. The book begins with the fundamentals of immunology and proceeds to explore the subject at increasing levels of detail. The first section delves into the present “state-of-the-art” knowledge of the immune system and immunoglobulins, and its devel
in Medicinal Chemistry, volume 27, edited by and GB West - Elsevier, Amsterdam, 1990, 400 p, Dfl320.00
Eight reviews are presented here, some of which deal with classes of compounds, namely, pyridazine derivatives, with broad-spectrum pharmacological activity, the 1-benzazepines (especially in relation to hypertension), antibacterial fluoroquinolones, having, like the benzazepines, enzyme inhibition as a modus operandi, and antagonists of PAF, recognized as having a crucial role in many disorders. Additionally, the importance and dangers of mercury and nickel compbunds, especially those forming in the skin. are surveved. The deleterious effect of light on ‘irugs is de& with a$ a topic of considerable concern. Mast cells have a pivotal role as sentinels of inflammatory response, and their regulation by peptides is of current interest. The control of emesis is investigated particularly in relation to cancer chemotherapy. BesanGon / DCpBt lCga1 juin 1990 no 11256