- Email: [email protected]
Progress In Psychiatric Genetics In China
Abstracts of the XXIV World Congress of Psychiatric Genetics (WCPG) 2016 cognitive performance and educational attainment; significantly negative rg with BMI, obesity, hip circumference, fasting glucose, fasting insulin, and coronary artery disease; and significantly positive rg with various HDL measures. LDSC results encourage further exploration of metabolic aspects of AN. GWAS of AN may have reached its inflection point with our first significant association. We will report up to the minute progress on the GWAS and pathway and network analyses. 2017 will witness a substantial infusion of new cases (+ 16,000) from the Anorexia Nervosa Genetics Initiative (ANGI), Charlotte’s Helix, and incoming samples from around the world currently queued for genotyping.
Disclosure Shire - Grant recipient, Self Ironshore - Consultant, Self Pfizer - Consultant, Spouse http://dx.doi.org/10.1016/j.euroneuro.2016.09.381
Concurrent Symposia Session 2 PROGRESS IN PSYCHIATRIC GENETICS IN CHINA
Margit Burmeister (Chair)1, Chunyu Liu (Co-chair)2, Thomas G. Schulze (Discussant)3 University of Michigan University of Illinois at Chicago 3 University of Munich 1
2
Overall Abstract The purpose of this symposium is to highlight recent progress in psychiatric genetics in Chinese samples, complementing findings largely from Caucasian samples. We will stress commonalities and differences between existing studies and Chinese studies. Weihua Yue from Peking University reports on a multi-site GWAS of schizophrenia with 410,000 samples. 13 SNPs were selected for replication in another 10,000 samples. 4 SNPs in 3 regions out of 13 survived after confirmation in the replication sample, 9/13 SNPs were in the same direction, and 7/13 SNPs were both po0.05 and in the same direction. One SNP in 2p16.1 is near a region on 2p16.3 implicated previously (2011) in schizophrenia in a different Han Chinese sample, while two hits, on 10q24.32 and 6p22.1 appear to be novel. Polygenic Risk scores from Caucasian schizophrenia GWAS only moderately predicted case-control status in Chinese (R2 of 1.5-5.7 %). Yin Yao from NIMH integrated functional magnetic resonance imaging (fMRI) and brain-gene ResNet (BGR) data to
S361
identify functional pathways associated with SCZ phenotypes. Automated Anatomical Labeling based brain connectivity analysis on fMRI data and Gene Set and Subnetwork Enrichment Analyses identified 4 SCZ candidate brain regions (Po1e-5) using fMRI data alone, which were replicated in the BGR data. These 4 SCZ candidate brain regions were related to 26 SCZ candidate genes, which were enriched in 62 genetic SCZ candidate pathways (Pvalueo1e-4), including those related to brain functional development (Poo1e-5), and implicating 7 genes, SNAP25, APP, MAPT, APOE, NTRK2, GRM5, and BDNF as top candidates. Gang Chen from Nanjing University of Chinese Medicine will report on a GWAS of alcohol dependence symptom count (ADSC) in sample of 3838 European and African Americans from the “Study of Addiction: Genetics and Environment”. Using a mixed linear approach, 20 SNPs showed significant (permutation testing) association with ADSC after accounting for ethnicity, co-morbidities, and including additive as well as dominance and epistasis in the model. Association with the previously known ADH1C gene was confirmed, as well as several other known and new genes. The detected SNPs explain 20% of the variance, half of which is accounted for by dominance and epistatic interactions, suggesting such networks are important in the genetic architecture of alcoholism. Margit Burmeister will report on implementing in China Srijan Sen’s “medical intern health study”. Medical graduates are recruited after matching in now 55 hospitals in the US. Baseline surveys include personality, stress level, other psychological tests and the PHQ9 depression score. Depression increases from 4% of incoming Medical graduates to 26% during internship. Perceived stress, work hour and medical errors are associated with increased PHQ9 scores. Most residents do not seek care for their depression symptoms, out of fear of reprisal. In China, a formal residency program has recently been introduced in several cities. Interviews with residents documented similar concerns as in the US. Our pilot data (N =75, 75% participation) in 2015 in Peking Union Medical College demonstrate a similar increase of depression scores from 4% to 22%, suggesting that work-stress induced depression may be modeled similarly in China as in the US, where a GWAS of the first 7500 interns will soon become available.
Disclosure Nothing to disclose. http://dx.doi.org/10.1016/j.euroneuro.2016.09.382
Disclosure Shire - Grant recipient, Self Ironshore - Consultant, Self Pfizer - Consultant, Spouse http://dx.doi.org/10.1016/j.euroneuro.2016.09.381
Concurrent Symposia Session 2 PROGRESS IN PSYCHIATRIC GENETICS IN CHINA
Margit Burmeister (Chair)1, Chunyu Liu (Co-chair)2, Thomas G. Schulze (Discussant)3 University of Michigan University of Illinois at Chicago 3 University of Munich 1
2
Overall Abstract The purpose of this symposium is to highlight recent progress in psychiatric genetics in Chinese samples, complementing findings largely from Caucasian samples. We will stress commonalities and differences between existing studies and Chinese studies. Weihua Yue from Peking University reports on a multi-site GWAS of schizophrenia with 410,000 samples. 13 SNPs were selected for replication in another 10,000 samples. 4 SNPs in 3 regions out of 13 survived after confirmation in the replication sample, 9/13 SNPs were in the same direction, and 7/13 SNPs were both po0.05 and in the same direction. One SNP in 2p16.1 is near a region on 2p16.3 implicated previously (2011) in schizophrenia in a different Han Chinese sample, while two hits, on 10q24.32 and 6p22.1 appear to be novel. Polygenic Risk scores from Caucasian schizophrenia GWAS only moderately predicted case-control status in Chinese (R2 of 1.5-5.7 %). Yin Yao from NIMH integrated functional magnetic resonance imaging (fMRI) and brain-gene ResNet (BGR) data to
S361
identify functional pathways associated with SCZ phenotypes. Automated Anatomical Labeling based brain connectivity analysis on fMRI data and Gene Set and Subnetwork Enrichment Analyses identified 4 SCZ candidate brain regions (Po1e-5) using fMRI data alone, which were replicated in the BGR data. These 4 SCZ candidate brain regions were related to 26 SCZ candidate genes, which were enriched in 62 genetic SCZ candidate pathways (Pvalueo1e-4), including those related to brain functional development (Poo1e-5), and implicating 7 genes, SNAP25, APP, MAPT, APOE, NTRK2, GRM5, and BDNF as top candidates. Gang Chen from Nanjing University of Chinese Medicine will report on a GWAS of alcohol dependence symptom count (ADSC) in sample of 3838 European and African Americans from the “Study of Addiction: Genetics and Environment”. Using a mixed linear approach, 20 SNPs showed significant (permutation testing) association with ADSC after accounting for ethnicity, co-morbidities, and including additive as well as dominance and epistasis in the model. Association with the previously known ADH1C gene was confirmed, as well as several other known and new genes. The detected SNPs explain 20% of the variance, half of which is accounted for by dominance and epistatic interactions, suggesting such networks are important in the genetic architecture of alcoholism. Margit Burmeister will report on implementing in China Srijan Sen’s “medical intern health study”. Medical graduates are recruited after matching in now 55 hospitals in the US. Baseline surveys include personality, stress level, other psychological tests and the PHQ9 depression score. Depression increases from 4% of incoming Medical graduates to 26% during internship. Perceived stress, work hour and medical errors are associated with increased PHQ9 scores. Most residents do not seek care for their depression symptoms, out of fear of reprisal. In China, a formal residency program has recently been introduced in several cities. Interviews with residents documented similar concerns as in the US. Our pilot data (N =75, 75% participation) in 2015 in Peking Union Medical College demonstrate a similar increase of depression scores from 4% to 22%, suggesting that work-stress induced depression may be modeled similarly in China as in the US, where a GWAS of the first 7500 interns will soon become available.
Disclosure Nothing to disclose. http://dx.doi.org/10.1016/j.euroneuro.2016.09.382