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Propranolol efficacy in adolescent essential hypertension
42
ABSTRACTS:
HIGH
BLOOD
PRESSURE
CONTROL
A-19 DIFFICULTIES IN SCREENING AND RECRUITING FREE HYPERTENSIVE TREATMENT PROGRAM David M. Berkson, Erich Brueschke, Jeanine Turner,
LOW INCOME
Heart Disease Control Officer, Murray C. Brown, Ghanim Kassir, Betty Allen, and Evelyn Stokes
COMMUNITY
RESIDENTS
INTO
A
Chicago Department of Health; Diane Mikes, Barbara Jalowiec,
As part of an ongoing totally free program to detect and treat all hypertensives in a low income black Chicago copunity, 2,417 (28.6%) of 8,461 persons screened during 1976 had blood pressure = 90 mm Hg and were invited back for a second blood pressure measurement. Only 1,045 (43%) elected to have the second determination performed by the screening team and the free program. Of 3,926 persons having repeat determinations in 1976, 2,135 (54.3%) had normal blood pressures. Of 1,791 invited for full evaluation and free treatment, only 960 (54%) elected to take advantage of this program while 814 (45%) elected other facilities for evaluation and treatment and 17 (1%) refused followup. In a three month period, Community Health Assistants made 615 separate home visits to 416 patients who had failed to show up for their second blood pressure determination, yet only 43 persons (0.72%) returned for the rescreening blood pressure. During the same period telephone calls and letters to 1,296 patients for the same purpose resulted in 55 persons (1.62%) reporting for repeat determinations. Although a high degree of success, greater than 80%, has been achieved in control of blood pressure of those entered into the treatment program,efforts at recruitment are disappointing. Further analysis of these problems will be presented.
A-20 PROPRANOLOL Pierre Montreal,
EFFICACY
IN ADOLESCENT
Biron, Department of Montreal, Canada:
ESSENTIAL
HYPERTENSION
Pharmacology, Faculty of Jean-Guy Mongeau, H8pital
Medicine, Ste-Justine,
A single-blind, crossover 8-month clinical trial of propranolol carried out in 10 adolescents with essential hypertension to cy of beta-blockade in this type of hypertension. Each blood from
treatment pressure 90 to 240
period lasted 4 months, and pulse measurements. mg daily.
University Montreal. versus determine
patients were seen at 2-week Maintenance dose of propranolol
of
placebo was the effica-
intervalsfor ranged
The mean systolic pressure was 144.5 after placebo, 120.00 mm Hg after propranolol, the difference of 24.5 being significant (p< 0.005) by paired t-test. The mean diastolic was 85.0 under placebo and 75.5 under propranolol, the difference of 9.5 mm Hg being significant (p < 0.05). Heart rate dropped from 82.8 per minute under placebo to 68 after propranolol, a significant (p< 0.001) difference of 14.8 b/ min. Side effects bradycardia therapy. Antihypertensive value under p< 0.05). It is concluded beta-blockade.
were minor and included and a transient Raynaud's
placebo Plasma
response for renin
that
was directly the diastolic, was unrelated
adolescents
with
transient fatigue phenomenon, none
after strenuous exercise, requiring cessation of
related (r = 0.93, and for the systolic to the response. essential
hypertension
p<
0.01) also (r
to the E 0.71,
respond
well
initial
to
ABSTRACTS:
HIGH
BLOOD
PRESSURE
CONTROL
A-19 DIFFICULTIES IN SCREENING AND RECRUITING FREE HYPERTENSIVE TREATMENT PROGRAM David M. Berkson, Erich Brueschke, Jeanine Turner,
LOW INCOME
Heart Disease Control Officer, Murray C. Brown, Ghanim Kassir, Betty Allen, and Evelyn Stokes
COMMUNITY
RESIDENTS
INTO
A
Chicago Department of Health; Diane Mikes, Barbara Jalowiec,
As part of an ongoing totally free program to detect and treat all hypertensives in a low income black Chicago copunity, 2,417 (28.6%) of 8,461 persons screened during 1976 had blood pressure = 90 mm Hg and were invited back for a second blood pressure measurement. Only 1,045 (43%) elected to have the second determination performed by the screening team and the free program. Of 3,926 persons having repeat determinations in 1976, 2,135 (54.3%) had normal blood pressures. Of 1,791 invited for full evaluation and free treatment, only 960 (54%) elected to take advantage of this program while 814 (45%) elected other facilities for evaluation and treatment and 17 (1%) refused followup. In a three month period, Community Health Assistants made 615 separate home visits to 416 patients who had failed to show up for their second blood pressure determination, yet only 43 persons (0.72%) returned for the rescreening blood pressure. During the same period telephone calls and letters to 1,296 patients for the same purpose resulted in 55 persons (1.62%) reporting for repeat determinations. Although a high degree of success, greater than 80%, has been achieved in control of blood pressure of those entered into the treatment program,efforts at recruitment are disappointing. Further analysis of these problems will be presented.
A-20 PROPRANOLOL Pierre Montreal,
EFFICACY
IN ADOLESCENT
Biron, Department of Montreal, Canada:
ESSENTIAL
HYPERTENSION
Pharmacology, Faculty of Jean-Guy Mongeau, H8pital
Medicine, Ste-Justine,
A single-blind, crossover 8-month clinical trial of propranolol carried out in 10 adolescents with essential hypertension to cy of beta-blockade in this type of hypertension. Each blood from
treatment pressure 90 to 240
period lasted 4 months, and pulse measurements. mg daily.
University Montreal. versus determine
patients were seen at 2-week Maintenance dose of propranolol
of
placebo was the effica-
intervalsfor ranged
The mean systolic pressure was 144.5 after placebo, 120.00 mm Hg after propranolol, the difference of 24.5 being significant (p< 0.005) by paired t-test. The mean diastolic was 85.0 under placebo and 75.5 under propranolol, the difference of 9.5 mm Hg being significant (p < 0.05). Heart rate dropped from 82.8 per minute under placebo to 68 after propranolol, a significant (p< 0.001) difference of 14.8 b/ min. Side effects bradycardia therapy. Antihypertensive value under p< 0.05). It is concluded beta-blockade.
were minor and included and a transient Raynaud's
placebo Plasma
response for renin
that
was directly the diastolic, was unrelated
adolescents
with
transient fatigue phenomenon, none
after strenuous exercise, requiring cessation of
related (r = 0.93, and for the systolic to the response. essential
hypertension
p<
0.01) also (r
to the E 0.71,
respond
well
initial
to