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Propranolol in the secondary prevention of bleeding in liver cirrhosis
THB PERSPECI'IVE OF CHRONIC STUDY OF 19 CASES,FOOLMWD L.WI1Igee*1,R.Popeae.Dept,of EGhsrest.Romania
PERSISTENT HEPATITIS KS
MORE
THAN
(CPH).A PROSPECTIVE
3 YEARS
Internal Radicii;e,Pundeni Hoopital,
rmpreemd by the recent ~ontrover~~3a from the literrcture concerning the probity of the ~leesificat*on which deliaitated heslthy carriere,CRN and chronic active heputitia (CAR),the authors fallowed for a period of more tb'an 3 years the evolution of 19 ceee8 of CPH dieSweed by liver biopsy fol-
lowing the claaeicel morphological criteria. The eex disttibution of the group ehowe a female preponderance of 68,42$,with the mean ege of 39+15 ye. The etiology is dominated by hepatitis A Virus (HAV)(47$),folloned by hopetitie B "i~e (HBV)(37$), with the pereietance of HBe Ag in serum,but,in come caeee.with convereion to anti HBa during the following period.The patients we're controlled period+.cally by chimioal end biological paremetres, and.at the end of the interval,by ltver biopsy. It wee regiatred a stationery evolution in M/19 cases,3 caees develop ping CAR, all three females and with e greater o&e. I,, the last 3 oesee i_ wee find no any new faetor of sggreeaion on the liver. In conel"sion,thay sffirm that CPR represents a stable,benign end inactive fom of hepatic portal inflammation.of viral hepatitic etiology,wbich transforms in CAR, only irl rsl: of caeee.
PROPRANOML
IN
THE SROONDARY PREV%N?ION
OF
BLEEDING IN LIVER
CIRRHOSIS L.SuLi~enm, Yi.Voiculeacu. L.LucB, Pept.of Internal Medioine, FUnden Hospital, Bucharest, Romania. -hare have mnde a comperati"e,Prospecti"e and rnndomized study of wing Propranolol in the secondary prevention of the homorrhwe ceusnd by the rypture of esophageal varice in the liver Oirrhoeis (LC). There have been studsed for two yeara two comparative ,,roupe of paticnte; 13 treated with Proprenolol (P) and 14 with placebo. T!le doee of P wee adapted eo ae to reduce the heart rate aith 25% it was 40-.20 me/day (average 73,33222,11 me/aey. The rebleedine rats was similar in botn groupe, but the cumulative supviral in the grnr;p treated with P was swnificatively longer. Without using the treatment bwith P, the relative risk of the upper digestive hemorrhage during the socondnry prevention is 2,6$. The euthore conclude that in the secondary prevention of bleeding in LO wing only P is not efficient; nevert!leless associated to endoecopic nc1erothernpy or te selective portal surgery.
, it maybe
S126
PERSISTENT HEPATITIS KS
MORE
THAN
(CPH).A PROSPECTIVE
3 YEARS
Internal Radicii;e,Pundeni Hoopital,
rmpreemd by the recent ~ontrover~~3a from the literrcture concerning the probity of the ~leesificat*on which deliaitated heslthy carriere,CRN and chronic active heputitia (CAR),the authors fallowed for a period of more tb'an 3 years the evolution of 19 ceee8 of CPH dieSweed by liver biopsy fol-
lowing the claaeicel morphological criteria. The eex disttibution of the group ehowe a female preponderance of 68,42$,with the mean ege of 39+15 ye. The etiology is dominated by hepatitis A Virus (HAV)(47$),folloned by hopetitie B "i~e (HBV)(37$), with the pereietance of HBe Ag in serum,but,in come caeee.with convereion to anti HBa during the following period.The patients we're controlled period+.cally by chimioal end biological paremetres, and.at the end of the interval,by ltver biopsy. It wee regiatred a stationery evolution in M/19 cases,3 caees develop ping CAR, all three females and with e greater o&e. I,, the last 3 oesee i_ wee find no any new faetor of sggreeaion on the liver. In conel"sion,thay sffirm that CPR represents a stable,benign end inactive fom of hepatic portal inflammation.of viral hepatitic etiology,wbich transforms in CAR, only irl rsl: of caeee.
PROPRANOML
IN
THE SROONDARY PREV%N?ION
OF
BLEEDING IN LIVER
CIRRHOSIS L.SuLi~enm, Yi.Voiculeacu. L.LucB, Pept.of Internal Medioine, FUnden Hospital, Bucharest, Romania. -hare have mnde a comperati"e,Prospecti"e and rnndomized study of wing Propranolol in the secondary prevention of the homorrhwe ceusnd by the rypture of esophageal varice in the liver Oirrhoeis (LC). There have been studsed for two yeara two comparative ,,roupe of paticnte; 13 treated with Proprenolol (P) and 14 with placebo. T!le doee of P wee adapted eo ae to reduce the heart rate aith 25% it was 40-.20 me/day (average 73,33222,11 me/aey. The rebleedine rats was similar in botn groupe, but the cumulative supviral in the grnr;p treated with P was swnificatively longer. Without using the treatment bwith P, the relative risk of the upper digestive hemorrhage during the socondnry prevention is 2,6$. The euthore conclude that in the secondary prevention of bleeding in LO wing only P is not efficient; nevert!leless associated to endoecopic nc1erothernpy or te selective portal surgery.
, it maybe
S126