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Prospective study of effectiveness of platelet rich plasma in the treatment of early osteoarthritis of knee
j o u r n a l o f c l i n i c a l o r t h o p a e d i c s a n d t r a u m a 6 ( 2 0 1 5 ) 5 8 e6 0
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Conference Proceedings - Annual conference of Delhi Orthopaedic Association, Year 2014, at Maulana Azad Medical College, Delhi, 1st & 2nd November 2014 Basic orthopaedics AB1. Quantitative measurement of intra-compartmental pressure of the leg in acute traumatic injury: As a routine trend A. Yadav, V. Anand, J. Sikdar, R. Singh, V. Sidhu, R. Sharma MMIMSR, Ambala, India Background: Experience and literature regarding complications of Lower Extremity Compartment Syndrome led us to hypothesize that delayed diagnosis and limb loss are potentially preventable events. Clinical examination do play role, but quantification of compartment pressure reading serves as confirmation and determines the need of surgical intervention and provides the only objective data in case of conflict. Methods: We performed a prospective study of all cases of closed tibial fractures over a 3 year period (Jan 09 to June 2012) presenting to our trauma center. Variables reviewed included intracompartmental pressure readings and location of the fracture, development of subsequent compartment syndrome requiring fasciotomy. Patients were divided in to 1) Group A-proximal tibial fracture. 2) Group B- diaphyseal fracture. 3) Group C- pilon fracture. Values of the injured and uninjured leg were taken and the data analysed using spss version 22. Results: 168 (41 female, 127 male) cases were analysed. Mean pressure readings of the fractured limb were higher in group A compared to the other groups. The mean difference in pressure values between the injured and uninjured limb recorded were of 15.1 mm Hg (group A), 13.8 mmHg (group B), 13.3 mm Hg (group C). Patients who eventually underwent fasciotomy were 5(10.8%) in Group A, 8(10.3%), in Group B and 3(6.8%) in Group C had initial baseline pressure difference of 18.5 mm Hg. Conclusion: These data underscore the importance of routine recording of initial intra-compartmental pressure and relation of difference in compartmental pressure between injured and uninjured limb to eventual development of compartment syndrome requiring fasciotomy.
AB2. Prospective study of effectiveness of platelet rich plasma in the treatment of early osteoarthritis of knee S. Sharma1,2, V.K. Gautam1,2, L. Maini1,2 1 Maulana Azad Medical College, India; 2Lok Nayak Hospital, India
Background: In this study, we prospectively sought to determine the therapeutic effect of intra articular Platelet Rich Plasma (PRP) in osteoarthritis (OA) of knee in early stages by injecting single shot autologous PRP and following patients for a period of 6 months assessing their improvement in Pain, function, stiffness through WOMAC score Materials and method: A total of 15 patients with Osteoarthritis knee were selected on basis of predefined inclusion and exclusion criteria after informed consent. PRP was prepared from 20 ml of patients blood in Acid Citrate Dextrose vials and were centrifuged at 3500 Rpm using in-house centrifugation machine. Patients were injected with PRP in affected knee in OT environment under aseptic precautions. The subjects were advised to follow up every month for 6months for assessment through WOMAC score. Results: The analysis revealed that a significant and continuous improvement in all parameters of WOMAC score was observed in the patients injected with PRP and showed dramatic improvement during first month with continued to improve till 3months followed by some recurrence or worsening till 6 months but it never reverted to pre injection level. Conclusion: The result of our study supports the effectiveness of PRP injection for relieving pain and improving knee function in OA knee. Improvement in symptoms was noted by 1month after PRP injection which continued to improve over next two months followed by some recurrence or worsening till 6 months but never reached the pre injection level.
AB3. Efficacy of single dose preoperative versus pre- and postoperative injectable cefazolin in surgeries around hip joint N. Bhatnagar, S. Sural, S. Arora, S.K. Prakash, A. Dhal Maulana Azad Medical College, India Background: Injectable cefazolin is commonly used for surgical prophylaxis in orthopaedic patients. The duration of antibiotic therapy has long been a topic of debate among orthopaedic surgeons in Indian sub-continent and majority of the time prolonged antibiotics are administered post-operatively. Materials and methods: We enrolled 104 consecutive patients undergoing elective surgery (with instrumentation) around the hip joint during 2012 to 2013. They were randomized into two groups A and B. Group A (53 patients) received a single dose of
Available online at www.sciencedirect.com
ScienceDirect journal homepage: www.elsevier.com/locate/jcot
Conference Proceedings - Annual conference of Delhi Orthopaedic Association, Year 2014, at Maulana Azad Medical College, Delhi, 1st & 2nd November 2014 Basic orthopaedics AB1. Quantitative measurement of intra-compartmental pressure of the leg in acute traumatic injury: As a routine trend A. Yadav, V. Anand, J. Sikdar, R. Singh, V. Sidhu, R. Sharma MMIMSR, Ambala, India Background: Experience and literature regarding complications of Lower Extremity Compartment Syndrome led us to hypothesize that delayed diagnosis and limb loss are potentially preventable events. Clinical examination do play role, but quantification of compartment pressure reading serves as confirmation and determines the need of surgical intervention and provides the only objective data in case of conflict. Methods: We performed a prospective study of all cases of closed tibial fractures over a 3 year period (Jan 09 to June 2012) presenting to our trauma center. Variables reviewed included intracompartmental pressure readings and location of the fracture, development of subsequent compartment syndrome requiring fasciotomy. Patients were divided in to 1) Group A-proximal tibial fracture. 2) Group B- diaphyseal fracture. 3) Group C- pilon fracture. Values of the injured and uninjured leg were taken and the data analysed using spss version 22. Results: 168 (41 female, 127 male) cases were analysed. Mean pressure readings of the fractured limb were higher in group A compared to the other groups. The mean difference in pressure values between the injured and uninjured limb recorded were of 15.1 mm Hg (group A), 13.8 mmHg (group B), 13.3 mm Hg (group C). Patients who eventually underwent fasciotomy were 5(10.8%) in Group A, 8(10.3%), in Group B and 3(6.8%) in Group C had initial baseline pressure difference of 18.5 mm Hg. Conclusion: These data underscore the importance of routine recording of initial intra-compartmental pressure and relation of difference in compartmental pressure between injured and uninjured limb to eventual development of compartment syndrome requiring fasciotomy.
AB2. Prospective study of effectiveness of platelet rich plasma in the treatment of early osteoarthritis of knee S. Sharma1,2, V.K. Gautam1,2, L. Maini1,2 1 Maulana Azad Medical College, India; 2Lok Nayak Hospital, India
Background: In this study, we prospectively sought to determine the therapeutic effect of intra articular Platelet Rich Plasma (PRP) in osteoarthritis (OA) of knee in early stages by injecting single shot autologous PRP and following patients for a period of 6 months assessing their improvement in Pain, function, stiffness through WOMAC score Materials and method: A total of 15 patients with Osteoarthritis knee were selected on basis of predefined inclusion and exclusion criteria after informed consent. PRP was prepared from 20 ml of patients blood in Acid Citrate Dextrose vials and were centrifuged at 3500 Rpm using in-house centrifugation machine. Patients were injected with PRP in affected knee in OT environment under aseptic precautions. The subjects were advised to follow up every month for 6months for assessment through WOMAC score. Results: The analysis revealed that a significant and continuous improvement in all parameters of WOMAC score was observed in the patients injected with PRP and showed dramatic improvement during first month with continued to improve till 3months followed by some recurrence or worsening till 6 months but it never reverted to pre injection level. Conclusion: The result of our study supports the effectiveness of PRP injection for relieving pain and improving knee function in OA knee. Improvement in symptoms was noted by 1month after PRP injection which continued to improve over next two months followed by some recurrence or worsening till 6 months but never reached the pre injection level.
AB3. Efficacy of single dose preoperative versus pre- and postoperative injectable cefazolin in surgeries around hip joint N. Bhatnagar, S. Sural, S. Arora, S.K. Prakash, A. Dhal Maulana Azad Medical College, India Background: Injectable cefazolin is commonly used for surgical prophylaxis in orthopaedic patients. The duration of antibiotic therapy has long been a topic of debate among orthopaedic surgeons in Indian sub-continent and majority of the time prolonged antibiotics are administered post-operatively. Materials and methods: We enrolled 104 consecutive patients undergoing elective surgery (with instrumentation) around the hip joint during 2012 to 2013. They were randomized into two groups A and B. Group A (53 patients) received a single dose of