Prostaglandin inhibition of immediate and delayed hypersensitivity in vitro: Mediation by cyclic adenosine monophosphate

PROSTAGLANDINS

Kuehl,

F.A.,

and

J.L.

its application 69:480,

Humes,

competition

receptor

studies

for this receptor an observation CAMP

possibly

Proc.

than

Nat.

receptor

Acad.

and

Sci.

USA

of A and F prostaglandins,

potencies

in stimulating

and various

constants

of 3-8

A sensitivity

ET.

applicable

that

relative

binding

E2 and

for measurement

other

organs.

nM were

of 1 pmole

obtained

makes this

of tissue concentrations

of

E prostaglandins.

L.M.,

C.S.

Henney,

and delayed

adenosine

monophosphate,

Abstract

only

dependent

by sensitized stimulate mimic

allogenic

cyclic

AMP,

of the

immediate

magnitude

inhibitory

act

controls

therapeutic

cyclic

PGE2,

levels

and

While

PGE2,

present

of the

of the

the beta

and has no activity.

immediate

reaction concentrations.

cytotoxicity

(in

and duration

while

PGFT

has no activity.

AMP

at appropriate

for a longer inhibition prostaglandins evidence

of inflammatory

believe

PGFl

cyclic

this as further

a variety

include

inhibitors

at the appropriate

catecholamine that

while

of inhibition,

lymphocyte

receptor,

duration can

levels

than do

be blocked

is blocked that

terms of the

are

which

potentially

by

in

the cyclic

responses mediated

the prostaglandins,

(AMP) or

methylxanthines,

concentration

mediated

release)

which

destruction

The most potent

first stage

AMP

leukocytes

lysis (CrST

These agents

toxin,

AMP.

and

of

IgE-

monophosphate

AMP

response.

to be maintained

involving

adenosine

cholera

magnitude

PGET

The authors

without

cyclic

of lymphocyte

in both systems,

system

leukocytes.

in the

cyclic

this increase

The authors

neither.

only

increase

catecholamines.

PGET

the

from human

In both systems agents

or inhibit

cyclic

are

inhibitors are

involves

(in terms of effective

concentration,

propranolol

reaction

of histamine

immunologic

dibutyryl

leukocyte

effect)

and cause

JULY 1972

the

response

The prostaglandins

cyclase

to generate

inhibition

by cyclic

(mouse mastocytoma)

prostaglandins,

and/or

The most potent

cell

method)

Prostaglandin mediation

1972.

mouse lymphocytes.

inhibit

The prostaglandins

of effective

49:87,

release

target

of inhibition)

increase

Allergy

immediate

Gilman

its action

Boume, in vitro:

The

cyclase

by the

H.R.

induced

reaction

catecholamines,

AMP

J.

as follows:

adenyl

(measured

and

hypersensitivity

antigenically

and the delayed

the

their

mouse ovaries

described,

immediate

and

is greater

with

in isolated

prostaglandins

Lichtenstein,

the

for a prostaglandin

in rat adipocytes, as shown by The affinity of the E prostaglandins

3H-PGET .

preparation

formation

method

is present

with

consistent

In the protocol

the

evidence

measurements,

1972.

A prostaglandin

with

Direct

to prostaglandin

by

stimulate

adenyl

of great

interest.

VOL. 2 NO.

1

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