PROTECTIVE EFFECT OF PHTALIDES FROM APIUM GRAVEOLENS IN ACRYLAMIDE INTOXICATION

Abstracts from 10th Congress of the European Federation of Internal Medicine/European Journal of Internal Medicine 22S (2011) S1–S112 valve, microorganism and ICU income. Output variables were 30 days mortality. Results: Results were shown in Table 1. The variables discriminated by each algorithm in Table 2. Table1 Feature Selection Classification

Class recall Alive Dead Class precision Alive Dead Accuracy

Classification with all features

SVM

ID3

Naïve Bayes

SVM

ID3

Naïve Bayes

94.12% 12.50%

84.62% 33.33%

92.31% 33.33%

80.85% 0.00%

84.62% 11.11%

91.67% 12.50%

82.05% 33.33% 79%

84.62% 33.33% 79.50%

85.71% 50.00% 82%

97.44% 0.00% 79%

80.49% 14.29% 78%

82.50% 25.00% 71%

Table 2

Features selected

Features rejected

SVM

ID3

Naïve Bayes

Sex ICU Septic shock Complications Appropriate treatment Catheter Sepsis Diagnostic Tool Previous valve Infected valve Age Valve type Change time Clinical time Organism

Age ICU Complications Appropriate treatment Change time Previous valve Valve type Clinical time Organism

Sex ICU Septic shock Complications Appropriate treatment Change time Previous valve Valve type Infected valve Organism Age Catheter Sepsis Diagnostic Tool Clinical time

Sex Septic shock Catheter Sepsis Diagnostic Tool Infected valve

Conclusions: These features are able to predict the mortality risk with a reasonable degree of accuracy using a relatively quite small amount of samples and agree with de mortality medical literature results. Also, has been able to identify and discard the most uninteresting features for this analysis.

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PROTECTIVE EFFECT OF PHTALIDES FROM APIUM GRAVEOLENS IN ACRYLAMIDE INTOXICATION Anca Irina Prisa Ûcaru1, Ca Ûlin Vasile Andrit¸oiu2, Cornelia Prisa Ûcaru3, Nicolae Hurduc1. 1Department of Natural and Synthetic Polymers, Faculty of Chemical Engineering and Environmental Protection, “Gheorghe Asachi” Technical University, Iaüi, Romania; 2Department of Physical Chemistry, Faculty of Chemical Engineering and Environmental Protection, „Gheorghe Asachi” Technical University, Iaüi, Romania; 3Department of Sciences, Faculty of Horticulture, University of Agricultural Sciences and Veterinary Medicine Iaüi Background: The high levels of acrylamide in alimentary products and the exposure risk of consumers demand the necessity of finding means of reducing its toxicity. The present experiment evaluates the protective effects of phytopreparations from Apium graveolens in laboratory animals with acrylamide induced hepatotoxicity. Methods: Hepatic lesion was induced by daily administration of 25 Pg acrylamide/kg body weight by gavage, for 11 weeks. Protection was achieved with extractive solutions from Apii folium, Apii radix and Apii semen. Results: Administration of phytotherapeutic extracts to laboratory animals with acrylamide induced hepatopathy determines, when compared to the group that received acrylamide without protection, the following modifications regarding: I) cytolysis parameters: decrease of aspartate aminotransferase for Apii folium (39.53 ± 4.22 versus 35.89 ± 3.45), for Apii radix (39.53 ± 4.22 versus 33.53 ± 4.35), for Apii semen (39.53 ± 4.22 versus 35.89 ± 2.88); decrease of alanine aminotransferase for Apii folium (34.85±4.09 versus 30.01±1.4), for Apii radix (34.85 ± 4.09 versus 30.31 ± 3.15), for Apii semen (34.85 ± 4.09 versus 25.95 ± 3.16); II) proteosynthesis parameters: increase of total proteins: for Apii folium (7.21 ± 0.75 versus 7.75 ± 0.59), for Apii radix (7.21 ± 0.75 versus 7.70 ± 0.73), for Apii semen (7.21 ± 0.75 versus 8.07 ± 0.41). Parameters revealing oxidative stress (catalase, superoxide dismutase and glutathion peroxidase) were also evaluated. Conclusions: Administration of extracts from Apium graveolens reflect the improvement of cytolysis, proteosynthetic and oxidative stress parameters. The most significant protective effect is obtained for the Apii semen extract.

POSTPARTUM FOLLOW-UP OF PREGNANT WOMEN POSITIVELY SCREENED FOR THYROID DISORDERS: THE NEED FOR A BETTER CARE Eliska Potlukova1, Jan Jiskra1, Zdenek Telicka1, Jana Bartakova1, Drahomira Springer2, Zdenka Limanova1. 1Third Department of Medicine, General University Hospital, Prague, Czech Republic; 2Institute of Clinical Biochemistry and Laboratory Diagnostics, General University Hospital Prague, Czech Republic Background: About 11% of women are positive for antibodies against thyroperoxidase (TPOAb). The utility of screening for TPOAb in early pregnancy remains controversial. The aim of our study was to examine the thyroid function in initially euthyroid TPOAb+ women two years after delivery. Methods: We invited 822 women screened positive for thyroid disorders in the 9th-12th gestational week for follow-up. This included measurement of thyroid-stimulating hormone (TSH), free thyroxine (FT4) and filling of a detailed questionnaire. Results: Two hundred and thirty-seven (28.8%) of invited women joined the study, with the median time after delivery of 21 months. One hundred and thirteen women were TPOAb+ and euthyroid in pregnancy. At follow-up, 38 (33.6 %) of these women had TSH outside of normal range: 13 (11.5%) had TSH<0.37 mU/l, 18 (15.9%) had TSH between 4 and 10 mU/l; and 7 (6.2%) had TSH>10 mU/l. Thirty-four percent of women who were never treated for thyropathy developed thyroid dysfunction at follow-up. Similarly, 32% of women who were treated for thyroid disease in pregnancy had TSH outside of normal range at follow-up. Based on data in personal/family history, 57.8% of women were at high-risk for autoimmune thyroid diseases. Conclusion: One third of TPOAb+ women euthyroid in early pregnancy have TSH outside of the normal range at nearly two years after delivery. The follow-up and treatment of these women is insufficient. These data support the implementation of universal screening for autoimmune thyroid diseases in pregnancy. Acknowledgement: Supported by the Grant of The Czech Health Ministry IGA 10662-3.

STREPTOCOCCUS CONSTELLATUS AS CAUSATIVE AGENT OF THORACIC INFECTIONS Rubén Puerta Louro, Laura González Vázquez, Francisco Fernández Fernández, Susana Araujo Fernández, Hector Enríquez Gómez, Luis Novoa Lamazares, Alejandra Arca Blanco, Javier De La Fuente Aguado. Department of Internal Medicine. POVISA. Vigo. Spain. Background: Streptococcus constellatus (member of S. anginosus group) form part of the normal flora of the mouth, gastrointestinal tract, and genitourinary tract and are often associated with purulent infections. Most patients had evident predisposing conditions. Streptococcus constellatus may be aspirated and can cause a variety of thoracic infections. These include pneumonia, lung abscess, empyema, and mediastinitis. Risk factors include male gender, alcoholism, cancer, and cystic fibrosis. We report two cases. The first, 71 years old male with pancreatic cancer and endoscopic stent was used to drain the biliary tree five weeks ago, that consulted in the emergency room for cough y fever of 2 days of evolution. A right lung abscess was diagnosed. The bacteriological culture of the effusion disclosed the presence of Streptococcus constellatus. The second, 42 years old male that consulted in the emergency room for productive cough and fever of 2 days of evolution. A pneumonia and left empyema was diagnosed. The bacteriological culture of the effusion disclosed the presence of Streptococcus constellatus and Peptostreptococcus magnus. The patients were treated with a percutaneous thoracic drainage pleural and antimicrobial therapy with amoxicillin and clavulanate potassium. They were discharged and asymptomatic with resolution radiologic after five weeks of follow up. Conclusion: We present two cases, one with cancer but other is inmunocompetent, without risk factors. Thoracic infections have significant morbidity and mortality and treatment requires drainage abscess and antimicrobial therapy. Two cases presents good evolution.