- Email: [email protected]
Asc of Gallbladder
Annals of Oncology 25 (Supplement 5): v44–v74, 2014 doi:10.1093/annonc/mdu435.78
Oral Session (Oral presentations categorized by each organ) O2
9
3
Li Xiong1, Jane Yu2, Xiongying Miao1, Yu Wen1, Kuijie Liu1, Fusheng Wang2, Zhulin Yang1, Yang Sun2 1 Second Xiangya Hospital 2 Dana-Farber Cancer Institute, Brigham and Women’s Hospital, Harvard University
abstracts
Background: Squamous cell/adenosquamous carcinomas (SC/ASC) are rare and little is known about the differences in clinical, pathological and biological characteristics between them.
© The Author 2014. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: [email protected].
Downloaded from https://academic.oup.com/annonc/article-abstract/25/suppl_5/v62/2240313 by guest on 26 October 2019
PROTHYMOSIN AND PARATHYMOSIN α ARE PROGNOSTIC MARKERS IN SC/ASC OF GALLBLADDER
Methods: Prothymosin and parathymosin α expression were examined in 46 SC/ASC and 80 AC samples using EnVision immunohistochemistry and analyzed their correlations with clinicopathological characteristics. Results: Prothymosin and parathymosin α positive expression in SC/ASCs and ACs with mass maximal diameter ≤ 3cm, TNM staging I/II, no lymphnode metastasis, no adjacent invasion and radical excision were significantly lower than in those with maximal diameter of mass > 3cm, TNM IV, lymphnode metastasis, adjacent invasion and non-radical excision. Univariate Kaplan-Meier analysis showed differentiation, maximal diameter of mass, TNM, lymphnode metastasis, adjacent invasion, operation protocol, Prothymosin and parathymosin α expression were closely associated with overall survival in both SC/ASC and ACs. Survival of patients with Prothymosin and parathymosin α positive expression was significantly lower than those with negative expression. Multivariate Cox regression analysis showed poor differentiation, tumor size > 3cm, TNM III/IV, lymphnode metastasis, adjacent invasion, non-radical excision, Prothymosin and parathymosin α positive expression were negatively correlated with postoperative survival rate, positively correlated with mortality in both SC/ASCs and ACs. They were independent predictors of poor prognosis in SC/ASC. Conclusions: Our study suggested overexpression of Prothymosin and parathymosin α is closely related to the development, metastasis, invasion and poor prognosis of gallbladder cancer. They maybe important biomarkers and independent prognostic factors in SC/ASCs.
Oral Session (Oral presentations categorized by each organ) O2
9
3
Li Xiong1, Jane Yu2, Xiongying Miao1, Yu Wen1, Kuijie Liu1, Fusheng Wang2, Zhulin Yang1, Yang Sun2 1 Second Xiangya Hospital 2 Dana-Farber Cancer Institute, Brigham and Women’s Hospital, Harvard University
abstracts
Background: Squamous cell/adenosquamous carcinomas (SC/ASC) are rare and little is known about the differences in clinical, pathological and biological characteristics between them.
© The Author 2014. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: [email protected].
Downloaded from https://academic.oup.com/annonc/article-abstract/25/suppl_5/v62/2240313 by guest on 26 October 2019
PROTHYMOSIN AND PARATHYMOSIN α ARE PROGNOSTIC MARKERS IN SC/ASC OF GALLBLADDER
Methods: Prothymosin and parathymosin α expression were examined in 46 SC/ASC and 80 AC samples using EnVision immunohistochemistry and analyzed their correlations with clinicopathological characteristics. Results: Prothymosin and parathymosin α positive expression in SC/ASCs and ACs with mass maximal diameter ≤ 3cm, TNM staging I/II, no lymphnode metastasis, no adjacent invasion and radical excision were significantly lower than in those with maximal diameter of mass > 3cm, TNM IV, lymphnode metastasis, adjacent invasion and non-radical excision. Univariate Kaplan-Meier analysis showed differentiation, maximal diameter of mass, TNM, lymphnode metastasis, adjacent invasion, operation protocol, Prothymosin and parathymosin α expression were closely associated with overall survival in both SC/ASC and ACs. Survival of patients with Prothymosin and parathymosin α positive expression was significantly lower than those with negative expression. Multivariate Cox regression analysis showed poor differentiation, tumor size > 3cm, TNM III/IV, lymphnode metastasis, adjacent invasion, non-radical excision, Prothymosin and parathymosin α positive expression were negatively correlated with postoperative survival rate, positively correlated with mortality in both SC/ASCs and ACs. They were independent predictors of poor prognosis in SC/ASC. Conclusions: Our study suggested overexpression of Prothymosin and parathymosin α is closely related to the development, metastasis, invasion and poor prognosis of gallbladder cancer. They maybe important biomarkers and independent prognostic factors in SC/ASCs.