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ABSTRACTS
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The prognosis of acute myocardial infarction is unpredictable because the importance of cardiac insufficiency, the direct consequence of the damage to the myocardium, is outweighed by secondary complications. The number of patients who die immediately is twice, or perhaps three times greater than the estimated number of patients who develop irreparable cardiac damage. The important sequelae of myocardial infarction, which can be considered potentially preventable causes of death, are serious arrhythmia, thromboembolic phenomena, and shock. DURANT.
Flaxman, N. : Digitoxin Poisoning. Report of 30 cases. Am. J. M. SC. 216:179 (Aug.), 1948. In thirteen months digitoxin poisoning was seen in thirty patients who had received the regularly prescribed doses of this isolated digitalis glycoside. The age and sex of the patient or the type of underlying heart disease had no relation to the occurrence of the poisoning. Symptoms, such as are known to be due to digitalis overdosage, occurred infrequently in these patients. Signs of disorders of the cardiac mechanism, especially the more serious conduction disturbances, were the earliest and most frequent clinical and electrocardiographic manifestations. Considerable caution should be exercised in the administration of the digitoxin preparations in the regularly advised dosage and form to any patient suffering with congestive heart failure, because the action may be rapidly intoxicating to the cardiac musculature and its conduction system. The factor of safety for this particular digitalis purpurea glycoside seems to be cxtremely narrow. DURAKT.
DeMuth, W. Report of A case is with lesions in one other case literature.
E., and Rawson, A. J.: Pseudomonas Septicemia and Endocarditis. a Case. Am. J. M. SC. 216:195 (Aug.), 1948. reported of protracted sepsis by Pseudomonas aevuginosa (Bacillus pyocyaneus) many organs and massive acute endocarditis involving the aortic valve. Only of endocarditis of the aortic valve caused by this organism has been found in the DURANT.
Thompson, J. L., Jr., and Kistin, A. D.: Hoarseness in Heart Disease. Ann. Int. Med. 29:2.59 (Aug.), 1948. Two cases of rheumatic heart disease associated with left recurrent laryngeal nerve paralysis In one, a 30-year-old man who died following an attack of acute rheumatic fever, are reported. necropsy showed minimal scarring of the mitral valve and only slight enlargement of the left auricle. The other was a 31-year-old man in whom angiocardiographic studies revealed considerable enlargement of the left auricle. Common to both cases was dilatation of the pulmonary artery. Because of the peculiar anatomical relations between the left recurrent laryngeal nerve and the pulmonary artery and aorta, the dilatation of the pulmonary artery was considered to be responsible for the left vocal cord paralysis noted in the two cases. The authors also suggest that there may be another but unknown factor contributing to the left recurrent laryngeal nerve paralysis in view of the large number of cases with comparable dilatation of the pulmonary artery which do not exhibit pressure effects upon the nerve. The many reports dealing with the subject of recurrent laryngeal nerve paralysis in heart disease are also reviewed and analyzed.
Altshuler, S. S., Hoffman, K. M. and Fitzgerald, P. J.: Electrocardiographic Changes in Diphtheria. Ann. Int. Med. 29:294 (Aug.), 1948. In the American Zone of Germany, 600 patients with proved diphtheria were seen from September, 1945, to December, 1946. This number included twenty-six cases of cutaneous diphtheria. The youngest patient was 18 years of age, the oldest was 43, and the average age was 23.4 years. An electrocardiogram was recorded as soon as diphtheria was suspected clinically or when a positive culture was reported. Thereafter, electrocardiograms were recorded at weekly intervals or more often when indicated.